3M EnvironmentaLlaboratory FinalReport-AnalyticSatludy Single-DoIsnetravenouPsharmacokinetSitcudyofT-6054inRabbits In-VivSotudyReferencNeumber:HWI#6329-138 StudyNumber: ANMT-122094.2 TestSubstanceF:C-129(T-6054) Name and AddressofSponsor: 3M SCD Division 367 Grove Street St.Paul,MN 55106 Name and Address ofTestingFacility: 3M EnvironmentalTechnology& Services 935 Bush Avenue St.Paul,NlN 55106 Method Numbers AMDT-M-1-0, AMDT-M-2-0, AMDT-M4-0, AMDT-M-5-0, AMDT-M-8-0, and Revisions: Thermal ExtractionofFluorideby Means of a Modified Dohrinann DX2000 OrganicHalideAnalyzer-Liver FluorideMeasurement by Means ofan Orion EA940 Expandable Ion Analyzer ExtractionofFluorochemicalsfrom RabbitLiver Analysisof RabbitLiverExtractforFluorochemicalsUsing ElectrospraMyass Spectrometry Analysisof FluorideUsing the SkalarSegmented Flow Analyzer with Ion SelectivEelectrode InitiatioDnate: See attachedprotocol Author:James D.

ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE .IdentityP:erfluorooctanesulfonylamido(ethyl)acemtaaytea;lsobe referredtoas PFOSAA, FC-1 28 or as the major component of FC-127, FC-1 29, FC-109, or FC-1 09-X.

ACTIVATED SLUDGE RESPIRATION INHIBITION TEST TEST SUBSTANCE Identity:[2-(N-Ethylperfluorooctanesulfonameitdhoy)lacrylatem;ay alsobe referretdoas B1228, D-1, ETFOSEA, orFX-13.(2-Propenoicacid,2[ethyl[heptadecafluorooctyl)sulfonyl]amiensot]eert,ChAySl # 423-825) Remarks:MateriiaslanambersolidS.amplepuritayndnotrecorded3.M lot number 13.

6 all Extent and Route of Excretion of Total Carbon-14 in Pregnant Rats 14 After a Single Oral Dose of Ammonium C-Perfluorooctanoate June 30, 1983 Conducted At: During: Conducted by: Riker Laboratories, Subsidiary of 3m St.

MICROTOX(D TOXICITY TEST TEST SUBSTANCE Identity:Perfluorooctylsulfonadtied,ecyldimethylammonium salt;may also be referredtoas Fluoroalkyalmmonium derivative[.1Decaminium, N-decyl-N,N-dimethyl-s,altwith 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-loctanesulfoniaccid (1:1)C,AS # 251099-16-8] Remarks: The 3M productionlotnumber was Lot 1.

IN VITRO MICROBIOIDGICAL MUTAGENICITY OF 3t4 COMPANY'S COMPOUND T-3651 ASSAYS Final Report February 1985 V it I By: b&Ak:&@ Kathleen Okamoto, Microbiologist Microbial Genetics Department and ave@,6@, &C:t@7 Edward S.

TOXICITY TO AQUATIC PLANTS TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonawthei,ch may alsobe referredtoas PFOS, FC-95 or as a component of FC-201AF. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ACUTE TOXICITY TO AQUATIC INVERTEBRATES (DAPHNIA MAGNA) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonawthei,ch may alsobe referredtoas PFOS, FC-95,oras a component ofFC-203. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ACUTE TOXICITY TO FISH (RAINBOW TROUT) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonawthei,ch may alsobe referredtoas PFOS, FC-95,oras a component ofFC-203. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ACUTE TOXICITY TO AQUATIC INVERTEBRATES TEST SUB-STANCE (DAPHNIA MAGNA) Identity:Mixturecontainingperfluorooctanesulfonatwehich may also be referredtoas PFOS, FC-95, or as a component of FC-203FC. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ACUTE TOXICITY TO FISH (FATHEAD MINNOM TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatew,hich may also be referredto as PFOS, FC-95, or as a component of FC-206C and 81-2/8. (1-Octanesulfonicacid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecaflpuootraos-s,ium salt,CAS # 2795-39-3) Remarks: The 3M producton lotnumber was not noted.

ACUTE TOXICITY TO FISH (BLUEGILL SUNFISH) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredto as PFOS, FC-95, or as a component of FC-783. (1Octanesulfoniaccid)(CAS # 2795-39-3).

SUMMARY FOR FOAMING STUDIES DONE ON VARIOUS AFFF PRODUCTS TEST SUBSTANCE Identity:Mixturescontainingperfluorooctanesulfonatweh,ich may also be referredtoas PFOS or FC-95 oras a component ofAFFF products.

ADVANCE UNEDITED DRAFT p. 1 AR oq a6_ 36/1 DRAFT RISK PROFILE OUTLINE EXECUTIVE SUMMAR Y I INTRODUCTION 1 .1 Chemical Identity of the proposed substance Mention who has made the proposal and when Spell out the specific chemical identity and particular considerations related to that 1 .2 Conclusion of the POP Review Commi tt ee of Annex D information "POP RC has evaluated Annex D (add reference to the meeting and the decision) information and has concluded that . . . " 1 .3 Data source s short overview of the data sources provided by the proposing Party and/or used by the POP RC in Annex D screenin g short overview of data submitted by Parties and observers (NB : a more elaborated summary of the submissions may be provided as a separate POP RC INF document) information on availability of national and international assessment reports ; [1 .4 Summary of available risk informatio n brief summary of the submitted evaluations and other information referred to in Annex E, point f Alternatively, can be summarised in a separate POP RC INF document ] 1 .5 Status of the chemical under international convention s 2 SUMMARY INFORMATION RELEVANT FOR THE RISK PROFILE 2.1 Sources production, trade, stockpiles uses releases to the environment 2 .2 Environmental fate Further elaboration of information referred to in Annex D, paragraphs (b) - (d) ; based on all relevant available information Monitoring data available integrated under the subheading or alternatively dealt with under separate heading "Monitoring data" Could be split in : 2 .2 .1 Persistence 2 .2.2 Bioaccumulatio n 2 .2 .3 Long range environmental transpo rt 000222 p. 2 y 2.3 Exposure Summary of relevant information concerning exposure in local areas (both near the source and in remote areas) Summary of relevant information concerning exposure as a result of LRET Information on bioavailability 2.4 Hazard assessment for endpoints of concer n Further elaboration of information referred to in Annex D, paragraph (e) ; based on all relevant available information Monitoring data on effects include d 3 SYNTHESIS OF THE INFORMATIO N synthesis of the information under chapter 2 tha t focus on information that is leading to the conclusive statement under chapter 4 4 CONCLUDING STATEMEN T Is the chemical likely, as a result of LRET, to lead to significant adverse human health and/or environmental effects, such that global action is warranted Note : No Annexes ; all other data provided as POP RC INF documents Target size not longer than 20 page s 2 000223

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