CORNING Hazleton MUTAGENICITY TEST ON T-6342 IN AN IN VIVO MOUSE MICRONUCLEUS ASSAY + [EINALREPORT AUTHOR Hemalatha Murli, Ph.D.

co 17r EEE as16 O10 AR 226 _ 06/9 2 Phasing Out a Problem: Perfluorooctyl Sulfonate (PFOS) Mary F.

AR 236 - 0706 ACUTE TOXICITY TO FISH TEST SUBSTANCE Identity: rMeifxetrurreedctoonatasinPiFnOgSp,erFfCl-u9o5ro,oocrtaansesauclfoomnpaotneewnhticohf FmCa-y20a1lFs.o be (h1e-pOtcatdeacnaefsluulofroon-i,c pacoitda,ss1,i1u2m,2s,a3lt,,3.C4A.4S,5#,52,76,965.-73.97-.38.)8,8- sRaemmpalreksis: FC-T2h01eF3.MCpurrordeuncttiionnfolromtantiuomnbienrdiwcaatsesnotthantotFeCd-.20T1hFe ifsesat 8mi.x2t5u%reacorfy3li.c0f%oaPmFeOrS,,7.306%.0s%oddiieutmhyolcteynle sgullyfcaotle,bu6t.y0l%etshuelr,fo3n6at.e6d%awlkaytler, ether sodium salts, 3.0% triethanolamine, and 0.15% toy triazole.

AR 226-082 MICROBICS MICROTOX TOXICITY TEST TEST SUBSTANCE Identity: ArefmeirxrteudretocaonstPaiFnOiSng, pFeCr-f9l5uo,roorocatsanaesculfoonmatep, woohfinFchC-em2a0ny6CatEl.so be (1- Octanesulfonic acid) (CAS # 2795-39-3).

: AR 226 -- 0255 ACTIVATED SLUDGE RESPIRATION INHIBITION TEST JESTSUBSTANCE Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-603EF. (1Octanesulfonic acid) (CAS # 2795-39-3).

AR 226 - 076 ACUTE TOXICITY TO FISH (BLUEGILL SUNFISH) JESTSUBSTANCE Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-783. (1Octanesulfonic acid) (CAS # 2795-393).

SEHR . 0800-373 T6320) ead ARG-- 0966 arial L867 HeCBI 1 REPORT Twenty--eight--day Repeated Dose Oral Toxicity Study of Sample D-1 in Rats (BMR143C) ?

.

Toxicological Summary AR226-1752 PFOS Dietary Chronic Definitive Reproductive Study: Northern Bobwhite Test Substance: Perfluorooctanesulfonate (PFOS) Structure: 1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro, potassium salt.

BACK TO MAIN Executive Summary of Photolysis Studies 3M has completed a series of studies of the direct and indirect photolytic reactions of four materials; Table 1 lists the materials, their chemical abbreviations, and the relevant 3M report numbers.

BACK TO MAIN SANITIZED REPORT ,

BACK TO MAIN 3M Company EPI-0011 Page 1 of 5 INTERIM REPORT Epidemiology Medical Department 3M Company St.

Estrous Cycling and Natural Delivery/Litter Observation Data F1 Estrous Cycling Data, From Data Analysis Presented at EPA on August 30, 2002 a APFO Dose Group (mg/kg/day) 0 1 3 10 30 All 4-Day Cycles 3-5 Day Cycles 14/30 24/30 19/29 26/29 9/30 21/30 15/29 25/29 15/30 27/30 Cycle Length (Days) 2 3 4 5 6 7 8 Mean Cycle Length (Days) S.D. 1 2 75 18 5 1 2 4.3 + 0.8 Incidence of Cycle Length Per Group 0 1 80 16 2 1 0 4.2 0.5 5 7 57 32 5 0 1 4.3 + 0.9 2 5 84 14 3 0 0 4.1 0.6 5 5 86 17 0 0 2 4.1 0.8 Aberrant Cycles b Parental > 4 Days Diest. 2 1 1 4 1 > 3 Days Est. 17 13 15 16 13 F1 > 4 Days Diest. 5 3 3 5 3 > 3 Days Est. 25 25 29 11 14 Distribution of Cycle Status at Start of 21-Day Evaluation Period, F1 P 1 4 1 2 5 E 8 10 11 14 11 M 6 2 2 0 2 D 15 13 16 13 12 Distribution Rats in Estrous at End of 21-Day Evaluation Period, F1 End in Estrous 13 17 18 19 19 Mean Implantations, Liveborn, and Stillborn S.D. per Litter by Group" Parental Litters Implantations Livebom StiUbom 15.3 1.9 14.2 _: 2.2 0.1 0.3 15.6 2.1 14.2 + 2.6 15.2 2.3 13.4 3.6 0.4 1.4 0.2 0.4 F1 Litters 15.6 + 2.0 13.8 3.0 0.1 0.4 15.3 2.0 13.4 3.3 0.2 0.6 Implantations Livebom Stillborn 14.8 3.0 13.6 + 2.9 0.2 0.5 15.8 2.1 13.7 2.4 0.2 0.5 14.7 2.8 13.8 3.0 0.2 0.6 15.0 2.9 13.5 3.1 0.2 0.5 14.5 2.9 13.3 2.8 0.1 0.2 a Original analysis counted cycles from the day following estrous (or proestrous if diestrus followed proestrous without observation of estrous) to the day following the end of the next estrous.

Report E01-1256 PFOS: A Reproduction Study with the Mallard Study Title ANALYTICAPLHASE REPORTFOR PFOS: A REPRODUCTIOSNTUDY WITH THE MALLARD Data Requirement FIFRA Subdivision E, Section 71-4 OECD Guideline 206 Author Lisa A.

Toxicological Summary PFOS Dietary Chronic Definitive Reproductive Study: Mallard Test Substance: Perfluorooctancsulfonate (POS) Structure: 1-Octanesulfonic acid, 1,1,2.2,3,3,44,5,5.6,6,1,7,8.8.8-heptadecafluoro, potassium salt.