Document vOvqDO0xYZkdVpwqd0vjYQ19
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5] HHAAZZLLEETTOONN
FINAL REPORT
AR26-0969
Roger 6. Perkins, PhD Toxicology Services
BSut.ildPianugl, 2M2N0-2E5-501244-1000
HWI Number: 40200470
ioloi)
Study Title:
Primary EyeIrritation/Corrosion Study of T-5898 in Rabbits + (OECD Guidelines)
ARoEad Qo,icSoMns"
2
fee
=
0008118060
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Signed:
peTan
SAtcuudtye TDiorxeicctoolrogy
We
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hone
sam.2n
005766
HUT Number: 40200470 Sample: T-5898
Acute Toxicology
SSttuedvyenDiH.recGtloarza Manager SSttuedvyenCoR.ordSionraetnosron PIant-rTiicfieaSuPpaedgrhvaimsor RReopsoertM. SuBrpiedrgveisor
Page 2
KEY PERSONNEL
Laboratory AnimalMedicine
DCiipnldoymaJt.e,CarAyC,LAMDVM Supervisor
CONTENTS
Page
OKbejyecPteirvseonnel
32
TTeesstt SMaytsetreimal
33
SPurmomcaerdyureosf Results
64
RDeifsecruesnscieosn
1100
Appendix ~ Raw Data
1
005767
HHT Number: 40200470
Page 3
Sample: T-5898
OBJECTIVE Tchoerroosbijoenctipvreoduocfedthifsollsotwuidyng waas stionglaesseesxspostuhree roeflaativteestlevmealteroifaljrtroitaotneione/ye
of albino rabbits.'
AAlclt pRergoucleadtuiroenss.usedIninthethiospinsitoundyofaretheinSpcoonmspolrianacnde wsittuhdythdeireAcntiomra,l Wtheelfasrteudy did not unnecessarily duplicate any previous work.
TEST MATERIAL Identification yTehlelotewstTiqmuaitde.rial was identified as T-5898 and described as a clear, light-
Purity and Stability T(hienclSupdoinnsgorunadsesurmetsestrecsopnodnistiiboinlsi)t.y for purity and stability determinations
Storage and Retention Twihlel tebestrmeattuerrnieadl twoasthestoSrpeodnsoart raofotmerteimspseuraantcuereo.f thAenyfiunnaulsedreptoerstt maactceorridailng to Hazleton Wisconsin (HHI) Standard Operating Procedure (SOP).
SafetyPrecautions
The test material handling procedures were according to HHI SOPs and policies.
TEST SYSTEM
TestAnimal
AanddultmaianltbaiinnoedrabatbittsheofHaztlheetHorna:Wi(sNcZo)nSsPiFn sftarcaiilnityweraet p38r0o2curPeadckefrrsomAHvRePn,e,Inc. Moaudtilsionne,d Wiinsctohnesi"nG.uidAenifmoarl thheusCbaarnedryandandUsehouosfinLgaboatratHWoIrycAonmipmlaylsw"i.t:h sTthaendards ahnuimmiadlisty-wceorentrionldlievdiduqaualrltyerhso,usepdroviindesdcreaecnce-sbsotttoomwactaegersadin1tiebmipteurnataunrde-a and mfeoarsuarnedaccalniomuanttioonf LpearbioordatoorfyatRablbeiatstDi7etdayHsF. #53T2h6e, fePeMdI Fiesedrso,utiInnec.l,y aanndalyhzeeldd _ by the manufacturer for nutritional components and environmental contaminants.
005768
HUI Number: 40200470
Page 4
Sample: T-5698
Scaomnptlaemsinaonftstheinwtahteerfeaerde opreriwoadteircaltlhaytawnoaullydzedhabvye HiHnIt.erfeTrheedrewwietrheornoafkfnoewcnted the results of the study. Tanhdremeaifnetnaailneedaccdulriimnagtedtheanismtauldsy, iwneitghehinsgamefrmoamnn2e,r628astofor2,7t2h2e ga,ccwleirmeatisoenlected peexriisotde.d, tIhfeyvawreiraetiodnoscumfernotnedtheandreqcuoinrsiedderteedmpetorathuarvee ahandd nhoumiaddivteyrseconedfifteicotnson mtahteersitauldyadoumticnoimset.ratiTohne aunsiimnaglss'odieuyensfwleuroeresecxeaimnineddyeonprotcheedudraeys.befOonrleyttehsotse aindiemnatlisfiewdithbynoanismiagln onfumboecrulaarndicnojrurreyspoorndiirnrgitaetairontagw.ere used. Animals were
Justification for Species Selection Hchiositcoericbaalsleyd,ontheitsNewlaZrgeealaonrdbitWhiantde anlobnipniogmernatbebditihraiss. been the animal of
PROCEDURES
PrepaofrTa est tMaiteorin al
Twhaes tdeesttermmiatneerdiatlo wbeas7.a6d.ministered as received.
The pH of the test material
Treatment
eEvaechrterdabbliotwerrec1eidiveodf 0t.h1e rnlighotf etyhee, uwnidtihluttehde tTeesftt meayteersiearlvinpglacasedthientountthreeated cpornetvreonlt. loTssheofupmpaetrerainadl Toawnderth1eindsrweelreaesegde.ntlyTheheledyestoogfethtehre froarbbiItssecroenmdainteod unflushed.
Reason for RouteofAdministration
Historically, the ocular route has been the route of choice based on the
method of Draize.'
Observations
T96hehoturresateadndeyDeasyswe7reandobs1e4rvaefdterfotrreoactumleanrt.irriItrartiitoantioatn
1, 24, 48, was graded
72, and
and scored
atoccoairddinign troevetahelinDgraipzoessitebclhenicqouren.eal Soidnijuumryflatuor72escheoiunrsexanadminDaaytsion7sanwdere14.used _
005769
HNL Number: 40200470
Page 5
Sample: T-5898
Ainnitmearlvsalswertehrowuegihgohuetd tjhueststbuedfyo.re test material administration and at weekly
Termination
Aetuthtaenrimziendatiaonnd odifsctahredeedx.perimental phase, all animals were designated to be
Statistical Analyses
No statistical analyses were required by the protocol.
LocationofRawData,Records.andFinalReport Tahrechirvaewsdaotfa,AMIrecionrdasc,coradndancaecwoiptyhofHWItheSOPf.inal report will be retained in the
005770
HHI Number: 40200470
Page 6
Sample: T-5898
SUMMARY OF RESULTS TSeosutrceA:nimaHlR:P, AIlncb.i,noKaRlaabmbaiztoso,-HMrIa: (NZW)SPF Date Animals Received: 02/17/94 Experimental Start Date: 02/24/94 Experimental Termination Date:
03/10/94
Average Primary Eye Irritation Scores
Observation
--Peried
Average
Score
21 4 HoHuorur
226..37
4728 HHoouurr
15.0 10.3
D96ayHo7ur
74.33
Day 14
0.0
* Tshceoreavefroargeallprithmearyaniemyaelsirdriivtiadteidonbysctohree nisumbteher otoftaalnimeaylesir(3r)itaattieoanch observation period.
005771
HHI Number: 40200470
Page 7
Sample: T-5898
Animal
Number
Fa9828" F49829" F49795"
Table 1
Individual Eye Irritation Scores
Cornea
Iris
a
B
Conjunctivae
o
E
E
1Hour
1 1
1 2
1 1
2
2
2
3
z z
1
1
by
2
2
2
Mean
Total
Score
22.0 29.0 22.0
2.3
F49828
1
F49829
1
F49795
1
F49828
0
FF4499789259
2H4ours
1
1
2
3
I
2
1
r
2
48 Hours
0
9
1
21 Is1
22
2
1
20.0
3
2
34.0
3
3
26.0
Mean
26.7
0
0
2.0
21
02
2176..00
Mean
15.0
Cornea
Iris
Conjunctivae
AB -- ADreegareeofofinvooplavcietmyent
- Diergrreietaotfioinridal
DE -- RCheednnoessiss F - Discharge
+b TBoltaanlcshicnogr.e = (Ax Bx5) + (Cx5) + [(D+E+F) x2]. dc PClueraurlendtiscdhiasrcghea.rge. i Injected. tJ NCoornpeaailn erpeistphoenlsiealafpteeerlitnegs.t material instillation. u Excessive pawing at the treated eye after test material instillation.
005772
HHI Nunber: 40200470
Page 8
Sample: T-5898
Animal Number
F49828 FF4499789259
Table 1 (Continued)
Individual Eye Irritation Scores
Cornea
a
B
Iris
Conjunctivae
bo
E
E
1H2ours
0
0
0
1
0
0
1
11
01
22
11
10
Mean
Total Score*
2.0 1181..00 10.3
9H6ours
FF4a99882298
10
01
00
Fa9795
1
1
0
20
10
00
101..00
2
1
0
110
Hean
7.3
FF4499882298
00
00
F49795
r
1
Cornea
BA -- ADreegareeofofinvooplavceimteynt
Day7
00
01
0
2
00 1
Mean
Iris
C - Degirrereitaotfioinridal
+b TBoltaanlchisncgo.re = (Ax Bx5) + (Cx5) + [(D+E+F) x2]. i CIlnejaecrteddi.scharge. 3 Corneal epithelial peeling.
00
20..00
0
1.0
4.3
Conjunctivae
DE -- CRheednnoessiss F - Discharge
005773
HWI Number: 40200470
Page 9
Sample: T-5898
Animal
Number
F4F499882298 F49795
Table 1 (Continued)
Individual Eye Irritation Scores
Cornea
Iris
Conjunctivae
A
B
a.
L
E
E
Day 14
00
00
00
0
0
0
00
00
00
0
0
0
Mean
Total
Score*
00..00 0.0 0.0
Cornea
AB -- ADreegareeofofinovpoalcvietmyent
Iris
- Deigrrreietaotfioinridal
+ Totalscore = (Ax B x5) + (Cx5) + [(D+E+F)x2].
Conjunctivae
DE -- RCehdenmeosssis F - Discharge
Animal Number Sex
FF4499882298 FF Fag795 F
Sodiun FluorTeasbcleein2 Examination
PO reinib tiats ione1r 2Hov ur a PeriDt oady 7io Dayn 14
NNEEGG
NNEEGG
NNEEGG NNEEGG
NEG
POS (5%) POS (5%) NEG
NPOESG NPeogsaittiivvee ssttaaiinn rreetteennttiioonn. (area of cornea involved).
005774
HWT Number: 40200470 Sample: T-5898
Page 10
DISCUSSION pTohteentteisatl maitnerriaablb,itsT,-58p9r8o,duwcheedncoervnaelaulateadndfoirridiatls ipnrviomlavreymeenyte ainrdrimtoadteiroante to asepvpeeraeranccoenjubnyctDiavyal14iarfrtietartitorne.atmeAnltl. treated eyes had returned to a normal
REFERENCES 1. a"nAdcuDteeveElyoepnIernrti'tsatGiuoind/eCloirnreossiofno,r"TOersgtainnigsaotfioCnhemfiocralEsc,onoSmeicctioCnoo4p0e5ration
(adopted May 12, 1981). 2. NIH Publication No. 86-23 (revised 1985). 3. FDoroadisz,e,DrJ.ugsH.,and"ECyeosMmuectoiscas,"- DIen:rmalAppTroaxiicsiatly,ofAstshoeciSaatfieotny ooff FCohoedmicaanldsDriung
Officials of the U.S., pp. 49-50 (1959).
005775
HHI Number: 40200470 Sample: T-5898
APPENDIX Raw Data
Page 11
005776
Name
Rose M. Bridge
Anthony Cass
Cindy J. Cary, ovM
Donna J. Clemons, OVH,
John A. Disch
Charles W. Fritz
Kari Garfoot Steven M. 6laza
Kevin Grossman
Jeff Hicks Sharen L. Howery Wayne A. Madison
Doug McConnell Eileen McConnell
Bud McDonald Albert Oleson Patricia Padghan
Steven R. Sorenson
Annette R. Turner
Tamra L. Walker
Lana H. Weeden
HTauotheer 4G.pAeReLr S
-
(62/10-06-93)
PERSOANCNUETLE STIOGXNIACTOULREOGYSHEET
WI: Sl0200870.
Job Title
Spey
Initial
Report SupervisorBiB. 8
Lab Aninal Technician Lehn,Cam ac
Lab Aninal Veterinarian Aa).
MS Lab Aninal Veterinarian
&
Lab Animal Caretaker
Diseh Jn
Lab Aninal Technician (Ahab, Wi, ZZ 7
Lab Animal Technician
i
ay
Manager
_Se
Lab Animal Caretaker
N
46
Lab Animal Technician
ZH
Research AssistantWri
Su
Supervisor
Cpe2122S utr
Lab Animal Technician LossAR Clonal]Coon
Staff Assistant
Cit Pheorca"Learnt
Study Coordinator BdPhomal)
rer
Lab Animal Caretaker _COBA/)boon pO
In-life Supervisor Lis lad
22
Study Coordinator Se ALL ARS
Staff Assistant
Ze
Staff Assistant
2d
aStbafbfoAisesidsCtaantntorKAtahoas.)1 P1eabssed
pu)
itl
Lob ueCaroler.fe fLeE Te
- vv
rr
eee eee
005777
WI No: HOON TEST MATERIAL ADNINISTRATION RECORD
TPehsysticMaalterDieaslc:ription---:secqueEyAR(IGHT0V0J0 EL0I0 OW0L0I0Q0 UI0D000 PH Result: 2:6 with Corning pH Meter No. 05510 PH was determined on: .~ undiluted material / wa dilution of wn %wA/mn
U - Unable to determine pH due to
NE
".
Storage conditions of test material: ROOM TEAPERATILRE.
--_ Approximately wn are_test material instillation 2 drops of 0.5% psurrofpaacreacaoifne HCl (Oepyhet(hsa)inoefLeoatch rabbit. Tech./Twtemree/dpaltaac:ed on the corneal
Group ia Do0.)smLe /Al:AY (alanL equivalent) Time: Fr4 om :T0 o14, :08 + Unflushed la eFleushoefd:exc_hnJan_nuaslecyoansdsflaufstehredtveistthmAatelrdaal imnLstoilflaltuikoenv,irathetaptest water for _n\A_ seconds / minutes. Time:From AJA To ala
Group Das
9 (nl equivalent) Time: From
To,
--_ Unflushed
__ Feyleushoefd:ea_ch__an_imaslecwoansdsfalfutsehredtewsitthmata nltiation,rmthetaptest water for _____ seconds / minutes. Time: From
1 813 DDoossee wvaass aaddmaiinnissttoerreedd uussiinngg aa 1-_nuLn_d_iosuplosagbllaesssysryirinnggee..
AlJaa DDoossee wwaass wpeliagcheedddiirnetcotlayndonadmtihneisctoerrneeadlussiunrgfacaeweoifghtihnegripagphetr.eye. The eyelids
Dowseree wraesleapsleadced{miendtioattehleyewvietrhtoeudtlofwoerrced11dblionfktihneg orrigmhatniepyeu.latiTohne.upper and
J
OTtohweerr: 14pdsAwere
gently
held
together _
for
one second --_--
and
then
released.
Dosing Technician/Date:Qcacsaauae
Tine of 1-hour scores: _is:aq Technician/bate:
__Qc / 2-34-94
WA Rot applicable. ocey error ac 9-24-94
-
(E8/12-09-92)
Final data review by/Date: _ J2// aoa 2
005778
WI No.: IO200470 BODY WEIGHT / TREATMENT EFFECT RECORD
Test Material: _T- S898
Species/Source Strain/Location: Babi ras(NISPE/OAL
Date Animals Receivedd:: 22-1-0 O0y0
Initiated in Room Number:: IQyf
nl flS$ 0 rove rr eT ET
[amas1[LTUTT TheT e[T ep T [T aun[omT a] |
I~
T rTr S = T=
* Sodium Fluorescein examination, | NPEOGS NPeogsaittiivvee,. NAV VoNcoatlaipzpaltiicoanb.le.
NE NEoxncee.ssive pawing of treated eye.
FECES AT ASLon sag
mOantetrhiealdayadmoifnitsrteraattmieonnt., all animals were weighed and appeared normal before test
Technician/Date: _Qc/2-84.94
Surviving animals were designated for sacrifice and discard.
Technician/Date: in/3-)0-Qck
(2/12-09-92)
Final data review by/Date: _C 7 3-//-94
005779
WH No: SORrnuy70
PRIMARY EYE IRRITATION OBSERVATIONS
Test Material--: T=sees
Group: _n/n
0000000000
Test eye: _Right
mr LOObservation Period: _a _| ur
[ot veiwpjJopopTome [ape N_[1]
teCorneal
I oma
to] T NN ASST ASN SR MA
bee
rel ToTr Tr Tr
INC NT
|Conjunctivae
mes geste]
|5[98Toe 3[5Tp
|[ TINN] |
i
Seiten Frees wlaon1 | aon Jo2m|| T|T|] \
Technfctan: ac
Date:
2-24-94
Eve Irritation Score: 24.3
CaVlecruilfaiteedd bbyy//DDaattee:: --_p _2a7c[_g /2-e v-94
AA PNeottitaepphleimcoabrlreh.aging. B ClBleaanrchdiinsgc.harge. E0 HPauirrdileonstsdiasrcohuanrdget.he eye. &F UPnoasbslieblteonveicsruoatliiczeardeause.to H Nsoeverreeactcioonnjuntcotilviaglht.swelling. 1 Injected.
JK L
CCoorrnneeaall eeppiitthheelliiaall ppietetliinngg.. Corneal' edema.
HNM Pp
HCoyrpnoepaylon.neovascularization. Pannus.
R Usneavbelree ctoornveiasluaolpiazceitdyu.e to
PS$OS PGorsaintuilvaetiosntaisncarretteinstsiueo.n.
NEG Negative stain retention.
(E3/07-15-92)
Final data review by/Date: _e7 a/g-pv 005780
WMI No: Hoorng7o
PRIMARY EYE IRRITATION OBSERVATIONS
Test Material: ___T- 5898
Group: _nfp
Test eye: _Right
Observation Period:
HOUR
LCoorcnaetaion of
in RN SANA [mn
Pre
CX
NN
Is N
vel
TrTrTR
a [0
TSC
T=[ew|[NI]
Redness
N
| ts | Cremer Chsews1 | [oa p[a oc TT-- TN]
Technician: Ca Date: 2-25.94
AA" NPoettitapeplhiecmaobrlreh.aging. 3 Baenacriindgis.charge. b Hpauirrutleonstsdiasrcohuanrdget.he eye. Epos able tonevcirsoutailcizearedaues.to
severe conjunctival swelling. H No reaction to light. I Injected.
Eye Irritation Score: 2007 CalVceurliaftieedd bbyy//DDaattee:: _" _f=7 //22 2r.g57-2 ych
JK CCoorrnneeaall eeppiitthheelliiaall ppeietltiinngg.. 4 foroepsyton.edems. \ Coamnnauts. neovascularization. R sUenvaebrlee tcoornveailsuaolpaidcizutye. to
S Granulation scar tissue. POS Positive stain retention. NEG Negative stain retention.
(E3/07-15-92)
Final data review by/Date: _72// pzu-2
05781
WE Nou: Hoo70ng
PRINARY EYE IRRITATION OBSERVATIONS
Test Material:
Group: _n/A
-58498
Test eye: _Right
Observation Period: 5pthee
z | Leorsnteoanls
[ema me
UpNO0 2
N o
AJND
SI \N1
[ZKR T
wel op 1a|TNC]
Te2 [or
ON]
{
Conjunctivae
mete |,|p
ews p [ge
[TN]
[1 TX
Technician: Date:
2 ya
5 Purses erecta NAA pNeottitaepphleimcoarbrlhea.ging.
ng. E HairurleJnotssardoiuscnhdartgeh.e eye. F& PUnoasbsliebletonevcirsoutailcizearedause.to
severe conjunctival swelling. H No reaction to Tight. I Injected.
Eye Irritation Score: __s0 CaVlecruilfaiteedd bbyy//DDaattee:: _a _J--ac /a /i-39vg zy
Ic XJ CCoorrnneeaall eeppiitthheeelliiaall ppietetliinngg..
P Panrneuis.
.
R Usenvaebrlee tcoornveiaslualoipzaecitdyu.e to
s Granulation scar tissue.
POS Positive stain retention.
NEG Negative stain retention.
(E3/07-15-92)
Final data review by/Date: __=/,3-.5-Qcf
005782
WHI Noo: Hooone70
PRIMARY EVE IRRITATION OBSERVATIONS
Test Material-- : T-8e08 Group: _ p/p
000 Test eye: _Right
Observation Period: _Z_Z4tone
|| Eicornea
NN () MAA I
wma [oT[FTTORT
Pee
wel ao[o , T TT I NN ]
conmmerae onjunc
2 + Tor|oo TN
tivae oeerts | 0 |,|, TN]1
Technician:
2
Date:
Zaz
AN"A NPoettitaepphleicmaobrlreh.aging.
B CBlleaanrchdiinsg.charge.
ED HaPuirrulleonstsdiasrcohuanrdget.he eye.
F &
UPnoasbslieblteonevcirsoutailcizeardeuase. to
H NsoeverreeactcioonnjuntcotiTviaglht.swelling.
I Injected.
Eye Irritation Score: __/p.2 CalVceurliaftieedd bbyy//DDaattee:: /a_1 cJ3/ 3/ o- uap9 -zy4
KJ CCoorrnneeaall eeppiitthheelliiaall ppietetliinngg.. MLH HCoyrpnoepaylon.edema. PNp PCoarmnneuasl. neovascularization. R sUenvaebrlee'ctoornveiasluaolpiazceitdyu.e to P$OS GProasniutliavetiosntaisncarretteinstsiueo.n.
NEG Negative stain retention.
(E3/07-15-92)
Final data review by/Date: _/_3=.5.Quf 005783
'
WI No: Hoorne7o
PRIMARY EYE IRRITATION OBSERVATIONS
Test Material:
Group: _n/n
-58498
Test eye: _Right
BT LAL ANA) [anteater
--
Corneal
Observation Period: _Q( HOUR,
lapzalomalansNT|
OY
N \)
YN
i
Leones eo [ 7 1 N_| |
fee
val o|[INC
ToTo2] TN]
contettas 20 on |2|5|
N_ |
arts | 5 |, IN]
Sottum Fluorescein oan yp | yp[on | | | |
' Technician:
Date:
io =
2-289
Eye Irritation Score: _2.3 Calculated by/Date: Un [2.2899 Verified by/Date: _/ _o3 c -39y
ear discharge. NA Not applicable.
A Petite hemorrhaging. 3 o)anching. D Jonem scharge. E fair Toss around the eye. F Possible necrotic rose: G Unable to visualize due to
severe conjunctival swelling. H No reaction to light. I Injected.
yon. J Corneal epithelial peeling.
K Corneal epithelial pitting. i oes edema.
N Comes?neovascularization.
P
annu.s
R Unable to visualize due to
severe corneal opacity.
S Granulation scar tissue.
POS Positive stain retention.
NEG Negative stain retention.
(E3/07-15-92)
Final data review by/Date: __ oi 73-11-94
0057"
WI No.: Hoo70rn
PRINARY EYE IRRITATION OBSERVATIONS
Test Material:
Group: _ n/n
T-58498
Test eye: _Right
ee iin Corneal
|if
Cornea
LC XO Observation Period: __Da
NN AeNNN
we melo
[|
5
|o To
TF5H5% FTI N NC T ]||
I
BCpes emosis
S 0[T oF p H TN ETAN]
Coston Frweswcowen]a] oee[[n0e JT mmez] 1 T T|NN]{
Technician: ___ Qc
Date:
3-3-94
Eye Irritation Score: _4.3 Calculated by/Date: _/_q3c-3.99
Verified by/Date:--Un[3-599
HA"A NPoettitaepphleicmaobrlreh.aging. BC CBlleaanrchdiinsg.charge. DE HPauirruieTnostsdairsocuhnadrget.he eye. F& PUnoasbslieblteonveicsruoatliiczeardeause.to
severe conjunctival swelling.
H No reaction to Tight. I Injected.
JK L
CCoorrnneeaall eeppiitthheelli{aall ppeietltiinngg.. Corneal edema.
MNH Pp
HCPoayrmpnmoeupasyl.on.neovascularization.
R Usneavbelree 'ctoornveiaslualopiazceitdyu.e to
S Granulation scar tissue.
POS Positive stain retention.
NEG Negative stain retention.
(E3/07-15-92)
Final data review by/Date: Kg 13-5-94
005785
WI No: Si7n 0 e
PRIMARY EVE IRRITATION OBSERVATIONS
Test Material: ___T-5808
Group: _ng
Test eye: _Right_
Observation Period: __pa
[oLoocmatiowneoef r7)TY opopTY oppal) aosN_[ YX |]YN
| aocrtnoearls
NNN NNNI
]fem
2] 0[0[4 vel 0To To
KN [| IN
[T ve eTao| TN
Conjunctivae
pes oes]
6[0Jo[TN|
0|o[To |
IN]i
Sein Priweenmroen]|oee||noeeT[eTeon| [| TT | N|
Technician: ___ s(n
Date:
3-10.0f
Eye Irritation Score: 0.0
CaVlecruilfaiteedd
by/Date: by/Date:
itr __0c
/,3-10-Qp 73-11-94
AH"A PNeottitaepplhiecmaobrlreh.aging.
5B FuClBeralrsanecnhdiitngd.rechar3ge.
FE HPaoisrsiblloessneacrroountdicthaereaeyse.. 6 sUenvaebrlee ctoonjvuinscutailviazle sdwueelltiong. HI NIonjercetaecdt.ion to Tight.
KJ CCoorrnneeaall eeppiitthheelliiaall ppietetliinngg..
Lt
CGoorrnneeatan.eoodnos.eutatzation.
R UPnaanbnulse.to visualize due to
S$ sGervaenruelatcioronneaslcaropatciistsyu.e.
NPEOGS NPeogsaittiivvee ssttaaiinn rreetteennttiioonn..
(E3/07-15-92)
Final data review by/Date: _Qc /341-34
005786
. HHL No: clO200470
F-- E TE--
(1) Cornea
(A)
es-c Degri eeoft densy ity(areamostdense taken for reading)
LE TT vib, Se of oh ares
rs Saris
fl ronofo conis
EE
ee agg 11
prErs Thess
srr err
(2)Ins A) yal
ARES ronal ciRma ne0 A Se R GET Rs orco! tionof any thereof) iris is stil] reacting to light (sluggish reaction fs
(3)Co8n)tuRncatitvase(etrs to puae? and bbconvnscdtgcaread fi] orl oi id esml A
comms
SS TtNa ia TE eiSri of aheRNeait or
puch caf sae des nis sr SER
Scars itheemismoidh d A a i E siaRi R
Sore (+800) x2 Toa xin = 20
he Saat sere for th ae 1 the im of 411 sores hts fr the came, ri, ad confoer
* Indicates posit ae. (FISH Interpretation)
[r--
.
005787