3M Environmental Laboratory ARG-015T / fz Final Report- Analytical Study Single-Dose Intravenous Pharmacokinetic Study of T-6053 in Rabbits In-Vivo Study Reference Number: HWI#6329-136 Study Number: AMDT-010495.1 Test Substance: FC-99 (T-6053) `Name and Address of Sponsor: 3M SCD Division 367 Grove Street St.

BESTOW {aero HAZLETON eowonessvencanc Chemical & BloAMRSe2ci-denc0ies1Dci2vais0ilo7n SoTRINGHAN BLS. 70.50 54S MADISON, WISCONSIN 53707 + PRONE608 241P4l4TCaX7T35i008tFAZRAL MDSUo / REPORT OF ANALYSIS I Diz ayh uTMw.IONXNCI.ECSOOLMTOCAGCYORMMSIIENCRIKVNIGCEASND MANUFACTURING 7.

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a 226 [0] ES $ b2olocoon (& -R @ EPA--FMG Meeting = ARAL 2 2 Boon Washington March 7, 2001 TE Room 526 East Tower 1 EPA/FMG Meeting Purpose Review the background = Summarize and obtain feedback on the toxicology program Summarize the mass balance data ) = Review industry commitment for upgrading containment 1 Secure continued supply of fluoropolymer processing aides going forward Y WHAT WE NEED/WHAT WE WILL DO WHAT ELSE DO YOU NEED?

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' 226_ ; #Raz Hi 7 M2 735 02813 gig SEP 122M MEMORANDUM SUBJECT: FROM: Meeting Summary; August 30, 2002 EPA/Industry Meeting on Selected Toxicology Studies of PFOA Oscar Hemandez, 7- War Risk Assessment Division (7403M) TO: Administrative Record File AR-226: PFOS, PFOA, Telomers, and Related Chemicals 2 23 = 33 pit 2 25 5 >= On August 30, 2002, a meeting was held with toxicologists from EPA and the `FgleunoerraotpioolnyrmeeprroMdauncutfiavcetutorxeircsitGyrsotuupdy(aFnMdG6)-mtoondtihscmusosnktheeyrsetsuuldtysoofftthhee aremcmeontnliyucmomspalltetoefd two perfluorooctanoic acid (APFO).

Telomer Research Program FV De ACC TR = Clariant TUPOND -------------------------------- RMuetpaotritonTitAlses: aPyurwiiftiheda Co-n2fiAlrcmoahtoolr:y Salmonella Assay Escherichia coli/Mammalian- Microsome Reverse Author(s): Leon F.

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sipf AL R26 0620 RECEIVED OPPT CEC WIKAR20 ANIL Sulfonated Perfluorochemicals in the Environment: Sources, Dispersion, Fate and Effects Prepared by 3M March 1,2000 * 000002 Table of Contents 1.0 PREFACE . 4 2.0 EXECUTIVE SUMMARY 5 3.0 INTRODUCTION TO FLUOROCHEMICALS 9 4.0 PHYSICAL-CHEMICAL PROPERTIES OF FLUOROCHEMICALS 13 5.0 ANALYTICAL TEST METHODS FOR FLUOROCHEMICALS 7 6.0 SOURCES OF FLUOROCHEMICALS 19 61M6.a1n1uWfaasctteurSitnregaWmaCshtaeracStterreizaamtsion 612 Air 222 66..1134 WSaosltiodwWaatsetre 2 2 62 Supply Chain Waste Streams u 63Releasesfrom WasteTreatmentandDisposalMethods u 7.0 ENVIRONMENTAL TRANSPORT AND DISTRIBUTION 2 8.0 ENVIRONMENTAL SAMPLING FOR FLUOROCHEMICALS 27 8.18E.1n1viHrisotnomreicnatlaDlaLteavels

RECEIVED OPPT MCIC AR 226 - 06IS REGEN ore .

AR 226.0704 ACUTE TOXICITY TO AQUATIC INVERTABRATES (DAPHNIA MAGNA) IEsTsuBSTANCE Identity: Mixture containing perfluorooctanesulfonate which may also be r(e1f-eOrcrteadnteosualsfoPnFiOc Sac,idF,C-1,915,,2.o2r.3a,s3,a4,c4o.5m,p5o,n6,e6n,t7,o7f.8F,C8,-82-01F. heptadecafiuoro-, potassium salt, CAS # 2795-39-3) Remarks: The 3M production lot number was 1.

bn Te wt oe an al } `DuPont HaskellLaboratory Disecior,Applied Tox . benTuxicology DuPoat Haskell Laboratory v P.0.Box 50 Elkton Road Newark,Delaware (9714-0050 : Phioge: (302) 366-5259 OS a v Hai kae aa rr ocr 40 220-1559 * Dumcas Control Office (7407) `Room G99 East Tower ATTN: FYT 4OUf0Sf1.icMEevoSftirrPeoeotln,lumSteiWon.ntPPrreovteencttiioonnaAngdeTnocxyics `Washington, D.C. 20460-0001 .

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AR226-1737 Toxicological Summary PFOS Dietary Chronic Pilot Reproductive Study: Mallard Test Substance: Perfluorooctanesulfonate (PFOS) Structure: 1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoropotassium salt, CAS# 2795-39-3 Test Remarks: The test substance is a white powder (3M Lot #217).