Document OELRDG739dk9E20ogJ2vzz3JX

Telomer Research Program FV De ACC TR = Clariant TUPOND -------------------------------- RMuetpaotritonTitAlses: aPyurwiiftiheda Co-n2fiAlrcmoahtoolr:y Salmonella Assay Escherichia coli/Mammalian- Microsome Reverse Author(s): Leon F. Sankowski, Jr Contractor: Covance Laboratories, Inc, Vienna, Virginia Study DIantiteisa:tion: October 23, 2001 CIonmLpilfeet:ioOnc:tobFeerbr2u9a,r2y00111,-20D0e2cember 10, 2001 SlotcuudsyinObsjeevcetrialves:taTionseovfalSuaaltmeontheelleasttyarpthiicmleurfiorumth(eTaAbSiSli,tyTAto10i0nd,ucTeArLeSv3eSr,seamnudtTaAtiIoSn3s7)at.tahnedhiastttihdeine uyptophan locus in Escherichia col teste strain WP2urA in the presence or absence of an exogenous metabolic activation system (S9 microsomes). `wMiattherainadlswiatnhdouMtetthheo$d9s:mixT.heAltlestdeorsesst(riainncsluwdeirnegeaxpvoesheicdleoatnhde ptoesstitairvteiccloenvtiraolp)lawteeriencpolraptoerdaitniotnripbloitchate CTrhieteprliaatewserweerien pilnaccueba0teadssfourre5a2s:s4ayhrvaaltid3it7y2. TCoprbieorcotnoscioduenrteidngpousistiinvge,anthaeutteosmtaatreidlceolnoeneydecdoutnotperroduce atleast a 2-fold increase inthe mean number ofevertants per plate over the appropriate vehicle control Findings: No increase in revertants was seen in any of the tester strains. Data table follows. g432 g8z =z 3585 83 Does not contain TSCA CBI 1 TRP 23-Apr-03 Mean Revertants Per Plate with Standard Deviation Demme Senmam SO Wena0SB MeramisssSD Matmars SD MweemvnraSO VMteiicieorstomCeo:nteRa (DMSO) os ow 1 om sx 2 sou ramewwnwwSR0464 ww koN u woomow om dw owF s F aawnse s omE wees R3 RD 5 G W m dm FF4 Rn ow Dy wono 3 2x m recor Swen saws ew mw pViitee como ssw wom as 2 we 2 Tandm WaEeLWl M) 4 m m0o% fwOF omonomofor660T3 sawow 3a pm meesw o3 d3m 0%w k L 7 ovon on a8 0 5 r a nh d recom? msm we we wee wows TTTaaoimxos [ FSmiimonmieT rcmne T 223n3gige TrAaaIisoS prprirovovenetgrs Lvvoiiungnihoded TWhris oSmaemmbeceenre 2S3jngemowne hWihsmnA ea oraicooe Z1u9pp0a Conclusion: Purified 3-2 Alcohol was not mutagenic i his fest system. APu)blCiocvatainocnesS/tPurdeyse2n2t9a0t0i-o0n-s409 OECD, Dated 2/11/02 DB)onnReers.ulMt.s Ecirteexdsion:n,KeG.n,naendyd,SGt.anLk.,owJsuknig,, LR.,, IIw.ai",GeHn.e,tSihcinT-oYxai,coS.l,ogMyuropfh8y-,3 ST.e,lDormoeurotB, AN.l,coFhionll"ay,, C.. Toxicol. Sci. 72(S-1):209:2003. EI EE Does not contain TSCA CBI 2 "TRP 23-Apr-03