Document YGMGR19ZGa82gzZrO4KQLdpXD

' 226_ ; #Raz Hi 7 M2 735 02813 gig SEP 122M MEMORANDUM SUBJECT: FROM: Meeting Summary; August 30, 2002 EPA/Industry Meeting on Selected Toxicology Studies of PFOA Oscar Hemandez, 7- War Risk Assessment Division (7403M) TO: Administrative Record File AR-226: PFOS, PFOA, Telomers, and Related Chemicals 2 23 = 33 pit 2 25 5 >= On August 30, 2002, a meeting was held with toxicologists from EPA and the `FgleunoerraotpioolnyrmeeprroMdauncutfiavcetutorxeircsitGyrsotuupdy(aFnMdG6)-mtoondtihscmusosnktheeyrsetsuuldtysoofftthhee aremcmeontnliyucmomspalltetoefd two perfluorooctanoic acid (APFO). This meeting was held as a follow-up action item from a meeting held on August 13, 2002, with Steve Johnson, the Assistant Administrator of the Office of Prevention, Pesticides, and Toxic Substances, and the corporate executives from seven companies involved with the FMG and the Telomers Research Program (TRP) at EPA headquarters. The data submissions for these two toxicology studies can be found in the Administrative Record for perfluorooctanoic acid, AR 226. The meeting agenda and the list of meeting attendees is attached to this memorandum. Industry scientist provided a verbal summaryofthe findings ofthe two generation reproductive toxicity study. As part ofthis summary, industry scientists pointed out some. difficulties in interpreting the data on estrus cyclicity due to the manner in which the contract laboratory had reported the data. EPA scientists made recommendations to redo the analysis uitmiplliaznintgataiodinflfoesrseenst. apBportohacrh.ecoImnmaednddiatitoino,nEsPwAerseciaecnctiespttsedsubgygetshteedintdhuasttraynsacniaenltyissitss,beanddonteheoyf will be sharing their results with EPA scientists as soon as possible. Industry scientists then provided a verbal summaryof the findings ofthe 6 month monkey study. Following discussion with the EPA scientists, no outstanding issues were identified. No further meetings were scheduled. Ifnecessary, a teleconference call will be scheduled to discuss the follow-up analysesof the estrus cyclicity and the implantation loss data. Attachments: Agenda, Attendee List CONTAIN NC 1 PFOA Mech Sfrfer iz, J me Beale fl, E = o) Sean Sea waofocer 200-5C1703Y sealyong. John Tutealgf M Toxicdwy E51 723/742 jlbutennolienias Clea La fee ford HG SH SRT fo ch en Gyf Jutsu Makes 04/wteD 703-205-522 prukn'S.susan gor Carole Kimme[ SPALLINITR 20% EF "20% bamme] opis Greer Reaves; Plow (Hockey 30 36-59% Girl, Lenn, me SREPROTETe A Rene USL outs cum nga rn C207 RAD (BERD, 02 SLs TUR fan aga WSienrelYeaongr\ sn =E=CHEAT 2c 02 GiSRr) Le IE FRnc os. Sap (fcvomue EAI 200-5900 Loan oar Efe Fala fhszeqoscles Cole Hodes - epfoter/em 2er- ste-Hib cer ESOTRID 202-511-2y hades colefice Pa. qo RG mia Hoeeer Rosman 477 Fm- (95)as1-342% hubertgaeisswn: com 2 MEETING ON RECENT TOXICOLOGY STUDIES ON APFO AUGUST 30,2002 ROOM 4225 EPA EAST IL Introduction IL Overview of two generation reproductive toxicity study I. General discussion IV. Overview of 6-month monkey study V. General discussion VI Wrap Up 3