Document M49Gak0ZJm8r5YDzyBoVNdNYk

BESTOW {aero HAZLETON eowonessvencanc Chemical & BloAMRSe2ci-denc0ies1Dci2vais0ilo7n SoTRINGHAN BLS. 70.50 54S MADISON, WISCONSIN 53707 + PRONE608 241P4l4TCaX7T35i008tFAZRAL MDSUo / REPORT OF ANALYSIS I Diz ayh uTMw.IONXNCI.ECSOOLMTOCAGCYORMMSIIENCRIKVNIGCEASND MANUFACTURING 7. PAUL, MN 55101 SanpLE: T-3607 PURCHASE ORDER NUMBER: P-688709-405 SAMPLE NUMBER: 407039 DATE ENTERED: 07/157 REPORT PRINTED: 10/057 ENCLOSED: ARCAUWTEDATOARALAPTPOEXNIDCIXITY STUDY - METHOD, SUMMARY, PATHOLOGY StaneD: STEEN ne. lGLA)ZA Me ASTCUUDTYE TDIORXEICCTOOLROGY SY AND FOR HAZLETON LABORATORIES AMERICA, INC. AAMlERIDCAAT,A FIONCR. TMHAIDSISSOTNU,DYWAIRSECONKSEIPNT. ON FILE AT HAZLETON LABORATORIES ~ 000074 @HToAT KZONGLHAEN BLTVD.O+ FNoBOLXas5o3n5aToWnAeDsISaOvNe,nWcIaSCnOeNGIN S377 Chem& BilocMedaiclal Sciences Division +PHONE608)2414471 + LX70968HAZMRDSAULD SAMPLE NUMBER: 40703983 SAMPLE: T-3607 "EST COPY AVAILABLE pace 2 ACUTE ORAL TOXICITY TesZe t eAnimweo le:s YIonuntganapdehurelattuSrmoear-leequaanad-ndDahuuflneemiCyahdloiewtstysr-elacnbiodinnntworawoetrlererla,etsdpraonq(dcusuaprrhpeterdelo,rdxsi,mmfaaotripenrltoayavniindeedd in CTootliCmaatieonepsereiod taof PuatrinlaeasRtode7ntdays. BaeoceeclLii meateen d ana imsalxssawfrenreatraeoc.uhposseFnoofodatfoiannvrdeanoduavoneemdtrenrifisodrhwetenrttehipefeiraeisvdotaudidlbyyaj.bulseetniTemebsedetlfoIrneieunbmiibmteeurlns neaa t headsmtuidnyi,streaxtceipotn wfhoren food, but not water, was withheld. seaBsoonn Ffoor SpPeecai"es rSoealdesctaivoani:labiTlhietyr,at anids tlhaergeaniammeoluntclaofssibcaaclkglryouunsdeddadtuae. i Method: FiveTomrasle sianngdlefivdeossfaesmalleeverlatsofwe5i.g0hign/gkgbeotfusbeondy20w2eigahntd. 231 9 PreS opearL ationTaonTdatrAedamcihnbiysatngriamavatalgieo.nbasoefTdheTeuspdtoodnseeMnesitivtestoryliufsmaolefsiteu1da.sA8n1bo2d.ai7/ynn6diwi.evmiiigdshuktagl oafnddosbeaoddmyuion: onihuned Ubon the average bulk GbservTayti0o%ns:ind Th4e hoaunrismalfsolwleorueinaobsteesrtvedmatfeorriacllinaidcmailnisstirsantsioonn.d moThretality signs I2 nd twice fdanilty ufoerdmordtaailliytyt.hereafter for 14 days for clinical 541l1decaenimaanlds atwersetuduyeigtheerdminjautsitonb.efore test material administration, at pata hology: Athessrtuodpysyteexrammiinnataitoinonalalndanalilmalssbnwoerrmealietuitehsanswteirzeedr,ecosrudbejds:cted 000075 @ HAA ZLETONowroemeon vroncWnaneco TOCihra&rBnoXiaaol ScAloncLes EDivi0s0on SANPLE NUMBER: 40703983 "Wig, [I iF SAMPLE: T-3607 acute ORAL TOXICITY continuo cumeny fT ant Amin nel: Albr ing Rate s -ieSpragRues-dDaeuley strain MSHeOetTtieOhdodtohofnAIdmAiTnisRtIratEiLonsEedOrRal Savagesate Test Completed: 08/17/84 eed anal OSD: mraetele- GCrreaetaertethheann25d.0 kgkeofoFbodhyeyusiSohnatne Mortality Summary CNober of Deaths) DbleoP sseeangsle HSHooTuurES s a2 2SOiUtLe A wse ode maEaER E on TEoR wee BavTeraoe SBeey uN siontsi(0) oie am we fomste 20 26 pathoLoGY Mfainimenomer nSy olCdSoeeTestrncaiyces eoe hecrvnopie sseyeComTLimeeeesniotnnossn.: emEerarnnooii eC le Lr ee, sea, grey fo aagGretemaoff[oooICu4 gz foo i SfhheoTovvIiiuzziibinliese Lbabeensiniiioeeonnsnsn.: ERE EI go0076 tof Ggrureiindndecslo eiLnses,ir tS eene , Eu Rnyis i.r)end mveenatsat)ea eFOOLrroatlsekrTieesxuiashRtaiieatonvycneysS,steOur1hdFye1i!5ons92P3eao.snFdtiPcBeiosdrteeisctifidecesesesnmdent ~ SrseeoudmsyewTeitsocveea:tes_AruDT tgelLo leea,f fTu osip eeistg eye MwEe <p7p-- 398--3 spectes: __Pak se: _ O07 osetime: {0pm peer of stale Mtecatiomeracin ist ooToles Isls Leal lls x pelselsLBeSsLId[lul ealel]d=] 5S I EE EE SE A CA EE A II A : SS 0 AA A SE I NU I rr Nrrrr NU SE Cr AN TTTTPIT --Tor oldrololeldT aloloT leloloT lolalTelNo] am eT lp ip th Lp[81214 Hl BM a1: 8 ayWPT HLANE so Ab eo Fl (80E05Flt Fh P| : Ea Ravieved by: ou) owen 20394 BESTCOPY App 000077 GROSS CLINICAL OBSERVATIONS i Scudy Ticle: _feudsLral Toxsty ---- resc arcicle: _T=BLD7 1 No. ADIPAPID } dosage Levels _QSDIMg Temes as ooctess __Pat = 2 Dose Tima: [00 sam oo be Phn sae s 5BLPd ls utlsel5 [d=] em TTTTTTET A EE EO A J SE AA o I SE A: A SE SE rr : ris rrrth ESE EE NUH A NW EE EE Tr HS NA TTTEEN --p Tolm ololPoFlPoAlelColAelPalPelEolRololoAlEgAlglAoEHl E secsrn[989 e1 PllFRevLiewed,by: 191h iaol)Plt EvTece4sD/fa9g BEST eg, 000078 Lr sors on cing ns o Test MaterialC3D7 a Eat 2 a hg Bulk Density _L:8) (afm) vemae MA Species Pak Source Haslam RTNo. UO70IER Date Received Z2Y4-Ed_ tat sot 2a os i p Re | Doses Vertis yl SA S51 wm | S [mm =oum) pmrao cos B [ee Joefone eis| = g 3 fo | fe rm emte o smtpTpeoanlEelI ma TS sosfsath | jo [72] wm ] SS = | 2[arsoease estmunsofJaH 2RTooAbwaR[AoEaBlR an {ana[oeae A \_| ja [7aVaoT H{Laani52a|J 2 beerie olSUA ES] wa 1 MOKTALLTY (WO. DIED/NO. DOSED) PN E[Smse b nm irl i iAp pAadbl DRLEEHARAa RATHTE EphEeRE a Fe Heeu ls Ref | L nny, POF3-80 "Revieved by Qu pareTL) IBE