AR226-3347 Analytical challenges in determination of Telo Alcohol and Telomer-derived fluorosurfactan polymers4n biological and environmental ma Bogdan Szostek^^lteith B.

Perluorooctanpsulfonate: PK During Pregnancy and Lactation + Analytical Protocol M. ."

I I PFOS: A 96-Hour StaticAcute ToxicityTest with the Freshwater Mussel (Unio complamatus) I ACUTE TOXICITY TO AQUATIC INVERTEBRATES MUSSEL) (FRESHWATER TEST SUBSTANCE Identity:Perfluorooctanesulfonatmea;y alsobe referredtoas PFOS or FC-95. (1-Octanesulfoniaccid,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-p,otassium saltC,AS # 2795-39-3) Remarks: The testsubstance isa whitepowder.

3M ENVIRONMENTAL LABORATORY Protocol-AnalyticalStudy QuantitativeAnalysisofPerfluorooctaneSulfonicAcid PotassiumSalt (PFOS, T-6295)inCynomolgus Monkeys FollowingAdministrationofa 4- Week CapsuleToxicityStudy 3M ET & SS StudyNumber: AMDT-041598.1 In-VivoStudyReferenceNumber: Covance6329-222 TestSubstance:PerfluorooctaSnuelfoniAccid PotassiumSalt(PotassiuPmerfluorooctane SulfonateC),F17SO3-K'(PFOS,T-6295) Name and AddressofSponsor: 3M ToxicologyServices Building220-2E-02,3M Center St.Paul,MN 55144-1000 Name and AddressofBiological-PhaFsaecility: Covance LaboratorieIsnc.

ACUTE TOXICITYTO AQUATIC INVERTEBRATES - Ceriodaphnidaubia TEST SUBSTANCE IdentityN:-Ethylperfluorooctanesulfomnaaymaildseo;be referrteodas U 1464, ETFOSA, ETPOSA, F-6309, orFX-1 2. (1Octanesulfonamide,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluo ro-N -ethyl-C,AS # 4151-50-2) Remarks: Materialisa white solid.Sample purityand lotnumber were not recorded.

ACUTE TOXICITY TO FISH TEST SUBSTANCE Identity:N -EthyplerfluorooctanesIufonamide; may alsobe referredto as U 1464, ETFOSA, ETPOSA, F-6309, or FX-1 2. (1Octanesulfonamide,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-N-ethylC-A,S # 4151-50-2) Remarks: Materialisa whitesolid.Sample purityand lotnumber were not recorded.

Experiment No.: Conducted At: Dates Conducted: Conducted By: Acute Ocular Irritation Test with T-3608 in Albino Rabbits 0984ES0367 Pathology and Toxicology Riker Laboratories, Inc.

ACTIVATED SLUDGE RESPIRATION INHIBITION TEST TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredto as PFOS, FC-95, or as a component of FC-206A. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ACUTE TOXICTTY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredtoas PFOS, FC-95, oras a component ofFC-3041. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ACUTE TOXICITY TO AQUATIC INVERTEBRATES (DAPHNIA MAGNA) TEST SUBSTANCE Identity:A mixturecontainingperfluorooetanesulfbnatweh,ich may alsobe referredtoas PFOS, FC-95, or as a component ofFX-3104. (1Octanesulfoniaccid)(CAS # 2795-39-3).

AR RRE- HIS --- ~ 19 ~ 000208 L dD SEE Ef E. 1.50 Pont of Nevouns5 Company' -- .

app ~ ~ { ~ ARZAE_ 3ySE 60 000471 @ || || pe 3 | | AR R26 _ 345% Rese or i 10s iv 0 c.0mooLvs FT cRoEemensttTstsvrsnece8spTnee eovneE rTsrreioe eooosnmB,Ts.0hweoersetnpna erceaeerr theaapveo0brnp-e a8ti,ee4s0sn phpopoosseuSrfo38Eac9eTeAnCs .

lit ~~ AR2R6 _ 34.70 ] 1 2 000714 ARRRG- 3470 B TJ o Cul ysA-- EPon-- @OuRn-- t CSloypliohcatrl arlu1sv6mcei7o0o,n7bh0csmCehieoamnvmpgebireirvhseeissWoS.ouutcsapOnedrruoenPoativ6id7n5.eb75odonMcaonnntoasinneePdritahemeCharmbesrsWWoorrkkssHoda IaPBIbnkasc1oe6ki7vg8her,odpSurnSnoddphmpeoecfdChyoiowarfahocroeatswbrpdykaooacrltslweyrhcoa0m0psbaensyttehDxeupeaonsvePescceortannfunori avreoshcaIbbo, nOoU SFo{eeionnadcsoeeIssaTnmorenhvtoiouefwcroofommsaaecrktcconahcsoeatfmaoiGonclsoef esscFooaetyGraoedvDeerapnopsyeesepsbteopseooom ioaaprlyrAheCcvae4sc9l)h7e SPCC0ego0ron0sueomoinneoaedanrAhdaTtlofeh5edhcse2roanmdtalrhapmaOrotcidoonoewrassschiounesdseucratsenvdotontdSeyanE ytTrcnao of oseo, Nnomao RhaaomctbcoohTrWarerskoseemmeopelnoTtyaebeswroberoaKebrretaskitnhoth1Jaod1sasoby paHoiggoesnniytts.AvB itnhlp2o1nteforI expats 00 ~D3 Fo nulpn ofdDaurPoyncthfefkwitphhyesriscalsstoan sainnWdiangoo,Fosoonro0 no TtHe,Eo A GU iMneomeraeli ant0eaco summr aorfitzi eedinn pTeabGlg reo2up.aInndad0d0iniodnitotdhevblsoodnmoonitora ing, hs emedi, ca)sar1oeeweodd || [ssignment Timberidentified Number Tested Cs =TGs [Historical (Total Te 5 ee 55 *Employeeswhopreviouslyheldoneoftheother dentiedassignments TJ ableS2NaBelmbooo-- odrTsoesfotvingsaDassta Ra pom) Wedon 9231500.38gpmarganictorn ristwoutr 10.8pmand78 0084p 000715

EEE TT TI ~~ SS SS 0 #R286 - 3472 f --_ { Pp 000719 | ee __ARARE_THTZ FIER lh It fail 1 i i !

~ 3N1 Corporate ToxicologN and 3M Center.