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AR RRE- HIS --- ~ 19 ~ 000208 L dD SEE Ef E. 1.50 Pont of Nevouns5 Company' -- . EusHarsoennsRW.oOwLsu,onoNumeasruoetns,rDMmeesTcosaxecmaao7n7 n1ye1 ~| CeiTRALRESEARGHANDDEVELSPHENTBe ARTMENT Bugust 25,1982 PERSONAL AND CONFIDENTIAL . : 3P.OL6Y.UExRosPRcOaDmUaCvToS DEPART:MENTN. ~ i Hd , PARKERSBURG site, pe A55 || 3AMUONTUNPTENRFHLOIONROOBCLTOAONDOMTE (C-8) v || FoTt{eoRfenltsoe.nInntAicWorgonerufkoeiefrsreisAnt)rcimeioTohtnwoiiounuyndloPdueriF1nJiltukuleesyrtf,poo2ro9cem,ttaaka1nt9s8ias2ote7fnevelrCs1a-t0l8-i8e]birlmopitonoodrtBRl.aconooc3d:nScouZfegigpneftse-lr"a: | ) Js ;. . tions "humRiaekne1 in workers isvery important in Unde ]bodcyhrhraenldalteasrtCe-8theanhd uhorw aocrcourraaitoellYy rstanding oouar naniinmaa)l how the mmooddeellss 7 bhtt | | | "these data, consider the following modifications: " - sith iim. iw | or | * pOoTvrfheieraatc0ect.uh0me0tu6olaavcpteapirlmoalngbeilwtohooefadnn9l1ie"tvadevawleyorsuaiglsedoftbceeeormmnpmeclodeornyeatmrea"anprttpa.irtooen:" :iii ||i | dTcaheyenstargvaeitrviaeogsnet(hb0el.o5po4l6datplepemnv)se,ltohorfats0iH-oo0er0de6ypcbplimoajssdeesel)yy xcon91 Tepresents the dynamic aspects of expesire and . eriaination. | || + pTl(rih3ote)teercisa`n)el,q.cuualtlahSteitinooVcanetshwCe-oa8sbuslluo5dmosedawcatactuoveamlorpllayursmtoebmleuebonlcftelodosaniensssdytrhti(aib3n.udt5tshieo.n: | i; !| vToilcuemres/7o0f ktgotmaaln)b.ody water (approximately 42 1i | ComraanySantzed.DossnotcontainTSCA CBI 2 rns sna - - -- t- 000209 ' Aw 9G tesemtave, |v Til2- bate TUR CA August 25, 1982 . - 3 : . * ia0nntoitchreiepabtaoecddcyuwraisattwheellcylonatsasisnepsirsededthilecoytr-ebltleevoneotldioelnxepvooeslfusrCe-,8 fcoergmiuzleansccanomboenlsyapluosyeedd.to estimate drugstherspy -x - - TEITLREE3 BTos EES wl -nDy ...EsE | Hale ee TA | mn | Assumptions' : ~("stathbeesao`drbypl-toisoodtnaltaeenv)edl,ceolniCcmp,einntairtsaiatotinoanappp(lriacotexesiaumate7ly'. equal), . ah : ~ tTohtealvobloudmye woaftedri,stroirbu4t2iolni,teVras,. is in' 7 ~ -Thedaily dose (0/1) `is 0.081 mg/day. : . estthiemealtiendinaftrioonnihaLlift-elriafteu;retre1/p2o,rt3o5n - E i di LYe oBnuet icnodinvdivduaalylyC.onTshiedevraalbuley.is 655 days, lSioRn. ITtiY is iSanAfroRm GoodnR anandT . Gilmah (1970): ow E TRN OUT S er R Ee ee La evap) Lene TiE) - cree Been va Tut OF RE =where= fraction absorbed ie i = SoG lviT ng A for , " = a AEN. CP= E ReVEeS T E 0.506 ma/le 20 0L lay ~ then: Sa c@aays) | _ cas 31693076 "ea1ll0ss0es i RR] - _s absorbea e10sE0sd 30 c--o chin . ". * eoaTsnbhltsuyiso'n,rabtt`eheddae,.tpebgnu`rdTteihainustgnetiroisnlhitawnhenegeka3nnc0oetwruaaotllfheaatgtarm1ceo/ts2sum,paehlnwetertiwcci1at/Cn2h-e6vyseotiuiowrmialtle anbostorbpetiaobnl.e to accurate>ly calculate fractio sal - ee 000210 | "a a tosses | HEE & -- vie rARE En susust 25, 1902 = cae _ + ReYgouarrdsiunggg'etshteisoenscailncuslhaetiJounlsy a3n5dmeinnorreesnpbounmse to Tote hana dati1aweceseary From two . : 1s.o" u=rccOeufsr:preln.a..tteenmFp(ilsgotyeeewaedesyo-ftsotratideek)tercGe omnicneanttieoan- i Sons . 2." "aGSiopploBGyieteaRsmnHionEaTtoinoS gneorfee xthpeo.sseeidoeetbd.'C&:41"/2 . Era at ~ SWenahlaevieap'eorffotrhmeeddirsatdriiobcuhteimoincaalndaenfdfebisoecshoefmicca.fl: iCse aGH heR e Siegul d Comh sTEeE . : ||| EaEi TE E fR oseO e R rq l n [2 TRE RSFE ~ | . i piEs REAR ese noxA icolomst| . | D. wier ama CEpengRSE iy eo a 2 TE. I wpe nie noes Bh 00 DERE Go " + | sash RS i . SERIE Te aL whoa CR nd An . 8 BESI Cory AVAILABLE : 000211