Pathology Review of Reported Tumorigenesis in a Two Year Study of FM-3924 in Rats November 25,1998 BY Pathology Associates International 6217 Centre Park Drive West Chester, Ohio 45069 Telephone (513) 779-9600 Fax (513) 779-9603 003099 Pathology Review of Tumors Reported in Rats Given FM-3924 Introduction: This report presents an independent assessment of tumorigenesis data obtained from a study to determine the chronic toxicity and carcinogenic potential of the fluorochemical FM-3924 in rats.

A R S 2 6 . 0705 ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE___________________________________________ Identity: Mixture containing perfluorooctanesulfonate which may also be referred to as PFOS, FC-95, or as a component of FC-201F. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: The 3M production lot number was 1.

Ak R A 6 - 0 7 6 3 MICROBICS MICROTOX TOXICITY TEST TEST SUBSTANCE____________________________________________ Identity: Mixture containing perfluorooctanesulfonate which may also be referred to as PFOS, FC-95, or as a component of FC-203FC. (1Octanesulfonic acid) (CAS # 2795-39-3).

/)R Z X 6 -0 I MICROBIOS MICROTOX TOXICITY TEST TEST SUBSTANCE_______________________________________________ Identity: Perfluorooctanoic acid, ammonium salt; may also be referred to as PFOA ammonium salt, Ammonium perfluorooctanoate, PFO, FC-116, FC-126, FC-169, or FC-143.

A R r ) & -o & 5 FINAL REPORT PROTOCOL 418-013 ORAL (GAVAGE) PHARMACOKINETIC STUDY OF PFOS IN RATS SPONSOR'S STUDY NUMBER: T-6295.12 FINAL REPORT DATE: 24 JUNE 1999 00780 PROTOCOL 418-013 ORAL (GAVAGE) PHARMACOKINETIC STUDY OF PFOS IN RATS SPONSOR'S STUDY NUMBER: T-6295.12 TABLE OF CONTENTS SUBJECT I.

V j-R _ O l S NITRIFICATION INHIBITION TEST SUBSTANCE______________________________________ Identity: Mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-203CF-X or FC-203CF. (1-Octanesulfonic acid) (CAS # 2795-39-3).

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ACUTE TOXICITY TO FISH TEST SUBSTANCE Identity:Perfluorooctanoiacid,ammonium saltm;ay alsobe referretdo as PFOA ammonium saltA,mmonium perfluorooctanoatPeF,O, FC-1 16, FC-126, FC-1 69, FC-143, oras a major component of FX-1003.

TOXICITY TO AQUATIC PLANTS TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may also be referredtoas PFOS, FC-95, or as a component of FC-203CE. (1Octanesulfonicacid)(CAS # 2795-39-3).

ACTIVATED SLUDGE RESPIRATION INHIBITION TEST TEST SUBSTANCE Identity:MixturecontainingPeffluorooctanesulfonatmea;y alsobe referred toas PFOS, FC-95, oras a component ofFC-3072. (1Octanesulfoniaccid)(CAS # 2795-39-3).

: ei :i g Soa * 35M M''ssFFCC CCoommmmiitleteisCcChheaarsrtt Page 1 he oi dt cue mdf io sr gg at ds et The following chart describes 3M's current understanding of various committees, groups, and teams that had direct involvement wi Er in FC issues.

am Cottage Grove T `WWee''rreeCCeleelebbrraattiinngg OOuurr NNeeww NNaammee ----33MM CCoottttaaggee GGrroovvee 118 Ia : Forme 3H remit Gon PUBLISHED FOR OUR EMPLOYEES, THEIR FAMILIES AND THE COMMUSNoImTmYer199 Formerly 3M Chemolite Center PUBLISHED FOR OUR EMPLOYEES, THEIR FAMILIES AND TIIE COMMUNITY Summer 1993 Think Globally--Act at Home VeYeoenuceumaycran elml etmh e bLear tthheswSaommrlmddwieide ehnelvdirimonnRmeelndtiaeolJcnnoconifresr- clLairsttossuanummckaienn~ca.bar.olulPRtceodotphpetelheceffiiEr-vooiammrrtohmnmmSooeurrnemthtmhaaainntd118t8hh0e0eclfcdououtiununnreRtriiooefsdommeuerJetatpnltteooaigngretoed,thb-cBBhreeehthdoiinntddalkhtthhaaeeebhobceueoatradptlnhoiernsae,etsni, ovccnioosruuonnnndtemdlsesetsnohtoatehhnedirnttmmhreeeecestfttuiienntudggrsserwwgoeeafrreoieuzbbraeepioinlnnaggsnet. hHealkd csohathnactecorpooffreartiotnhseianpduotthearndinrtcerccosmtemdenodragtainoiznastions had a chance to offer their input and recommendations.

BIODEGRADATION (Modified MIT Test) TEST SUBSTANCE Identity: 5)[2-(N-Ethylperfluorooctanesulfonamido) ethyl acrylate; may also be referred to as B1228, D-1, EtFOSEA, or FX-13. (2-Propenoic acid, 2[ethyl[heptadecafluorooctyl)sulfonyljaminojethyl ester, CAS # 423-82- Remarks:byMastpeornisalori.s Tanheampubreirtys/odleindt.itRyepofortthelitsetsstssaumbpslteanacse>c9a9nn%o,tabseprovided substantiated.

FINAL REPORT PROTOCOL 418-008 PERCIONMABTIANLE/DPOOSRTANLAT(AGLAVRAEGPER)OFDEURCTITLIIOTYN,TDOEXIVCEILTOYPSMTEUNDTYALOFANPDFOS INRATS SPONSOR'S STUDY NUMBER: 6295.9 FINAL REPORT DATE: 10 JUNE 1999 50133 PROTOCOL 418-008 COMBINED ORAL (GAVAGE) FERTILITY, DEVELOPMENTAL AND PERINATAL/POSTNATAL REPRODUCTION TOXICITY STUDY OF PFOS IN RATS SPONSOR'S STUDY NUMBER: 6295.9 TABLE OF CONTENTS SUBJECT I.

FOR DU FONT USE ONLY AR226-2966 Du Font HLO 706-91 Study Title 100-Person Repeated Insult Patch Test e'ish Study Completed On October 11, 1991 Contracting Laboratory Biosearch, Inc.