Document 2Jk5Ob7oBgra5jzKamqbQnR1a
FOR DU FONT USE ONLY
AR226-2966
Du Font HLO 706-91
Study Title
100-Person Repeated Insult Patch Test e'ish
Study Completed On October 11, 1991
Contracting Laboratory Biosearch, Inc. P. 0. Box 8598
Philadelphia, Pennsylvania 19101
Author
Armand Affrime
for
Haskell
E. I. dti Pont de Nemours and Company
Laboratory for Toxicology and Industrial Elkton Road, P. 0. Box 50
Newark, Delaware 19714
Medicine
Study Monitor Scott E. Loveless
Laboratory Project ID Haskell Laboratory Report No. 706-91
Page 1 of 17
'Company Sanded. Does not wWn T<S^ ^
____________ 'g^QBy;Ssniffee"d.Does not contain TSCA CBi
Material Tested?
Medical Research HO.! Hastell Ho. t
Bioscarch Project No.
Baskell Test Code No.
Tamyr
Physical Form;
Composition;
GENERAL INFORMATION
Du Font HLO 706-91
Contaminants; Synonyms; Other Codes;
Stability.'
Sponsor;
Materials Submitted By?
Study Initiated - Completed; In-Life Phase Initiated - Completed;
In the absence of visible evidence to the
contrary, the test materials were assumed to be stable under the conditions of
administration.
Du Font Chemicals
I. E.
du Font de Bemours and Company
yiImingfon, Delaware
font Chemicals
I. E.
du Font de Nemours and Company
Jackson Laboratory
Chambers Berks
7/15/91 - 10/11/91
7/15/91 - 8/16/91
. -^a/'vSsSdI-S''::^;^ !^i^Si^ 'i^. ~
l^a..
GENERAL INFORMATION (CONT.)
Du Font HLO 706-91
There are 17 pages in this report. Distribution:
^- 3 1S8inpanySanize"dD. oes noi contain T8CA
W FONT CENTRAL RESEARCH AND DEVELOPMENT HASKELL LABORATORY FOR TOXICOLOGY AND INDUSTRIAL MEDICINE
Du Font HLO 706-91
October 11, 1991
Du Font Chemicals
Jackson Laboratory
Chambers Works
100-Person Repeated Insult Patch Test vith
Attached are reports from Biosearch, Inc. (Project 91-7346H). In the reports are patch test methods, results and conclusions.
Included
During the induction and challenge phases of this studyUBBHHBB^
produced no adverse skin subjects who vere active
responses in 100 and participants.
100%,
respectively,
of
those
on
Based upon the the skin during
effects observed with the test material_Blaced repeatedl
both the induction and challenge phases^JUIHBHb
not considered a skin irritant
prevailed in this study.
or
sensitizing
agent
under
fnecondTtionsthat
J^/^C Jr^^}
Scott E. Loveless, Ph.D. Senior Research Toxicologist
SEL/alw
4 -
-
^ooraalnTSC^
Du Font
BIOSEARCH INCORPORATED
P.O. Box 8598, Philadelphia, Pennsylvania 19101 Telephone: (215) 739-4499 Fax: (215)423-9210
HLO 706-91
CiJLNuinhec: Tgstmg Facility:
Spaaasa/E.
Test Article: Test ArHpfe Description: Test Article ReceivedStudy Initiated-
DateofReppiflest:
Object frf TP<^-
Method of Test-
91-7346H
Biosearch Incorporated
'V 3408-50 Street
Philadelphia, PA 19134
E.I. Du Font De Nemours & Company P.O. Box 50, Elkton Road Newark, DE 19714
H-18,790
White milky liquid
07/12/91 07/15/91 08/20/91
Study Completed: 08/16/91
Modified Draize Repeated Insult Patch Test Study in Human Subjects.
To determine the irritating, fatiguing and sensitizing properties of the test article. The method employed in carrying out this test was similar to that described in "Appra'sal of the Safety of Chemicals in Foods, Drugs and Cosmetics" by J.H. Draize and published by the Association of Food and Drug Officials of the United States. The test involved the application of the test article to the upper arms of a group of 113 volunteer subjects. One hundred and six subjects completed the study (see Subject List). These subjects were all determined to be in good general health and free of any visible skin disease or anomaly in the area to be patched. Each subject was required to read, understand and sign an informed consent statement The test artide was tested as a 50% w/w dilution in distilled water.
^ ^ ^ wri.l.T"-1'""
-5-
Project Number: 91-7346H
Du Pont
E.I. Du Font De Nemours & Company - H-18,790
Modified Draize Repeated Insult Patch Test Study in Human Subjects
HLO 706-91 Page 2 of 9
Method of Test: Induction Phase
A 0.2 ml portion of test article, as prepared, was placed on a 3/4" diameter lintine disc (Filter Fabrics, foe., Goshen, IN 46526), affixed to 2" Dennicel hypo-allergenic doth tape (Johnson & Johnson, New Brunswick, NJ 08903). The patch was then applied to die contact site
and remained in place for 24 hours.
At the end of this period, the patch was removed and the site was examined for any dermal response. Scoring of irritation was in accordance with the scale in the Appendix. The subjects were then rested for a 24 hour period after which the skin site was again examined.
A patch was then applied to the same site as previously used. The second appHcanon was identical to the first and remained in place 24 hours. This procedure was repeated on Mondays, Wednesdays and Fridays until a series of nine applications had been made. Patch applications made on Friday were removed by the subject on Saturday. The subjects examined the site for any dermal response and reported their observations prior to the next application. The same site continued
to be used throughout the study.
Challenge Phase
After the 9th application, a rest period of approximately 2 weeks elapsed
after which a challenge application was applied in the same manner and to the same site described above. A duplicate challenge application was
also applied in the same manner to a virgin site (previously untreated) on the other arm. The challenge application was removed after 24 hours and the sites were examined for signs of irritation or sensitization. Follow up examinations were conducted at 48 hours after the challenge application.
Results: Conclusion:
The subjects involved in this study ranged in age from 16 to 67 years of age.
See accompanying table, summary and appendix.
From the results obtained in this study as described above with the particular group of subjects tested, the test article is most likely not a primary skin irritant. The test article is most likely not a fatiguing agent. The test article is most likely not a sensitizing agent.
-
6 -
BIOSEARCH, INCORPORATED - P.O. BOX 8598 - PHILADELPHIA. PENNSYLVANIA 19101
Project Number. 91-7346H
Du Font
E.I. Du Font De Nemours & Company - H-18,790
Modified Draize Repeated Insult Patch Test Study in Human Subjects
HLO 706-91 Page 3 of 9
Signatures:
Submitted by Biosearch, Incorporated:
^g^z/L : Uxbach, M.D.
consultant Dermatologist
Armand Affrime, AJ| Study Director
Raymi Medical Director
{
-'
U
-
/
'A^6 oC/^^^/
Kari L. Gabriel, V.M.D., Ph.D.
President
con^"^-- ICompany Sanilfaed. Does not
-
7 -
BIOSEARCH, INCORPORATED. P.O. BOX 8598 - PHILADELPHIA, PENNSYLVANIA 19101
iy
Project Nuoben
A91t -7f43J"L""U
E.Z. Du Font De Neaours & Company - H18,790, as prepared. Modified Draize Repeated Insult Patch Test Study in Human Suojects
Table 1
^ductipn Phase
Subject
Number
1
24 48
2
U 48
3
24 48
4
24 48
5
24 48
6
24 48
'10 00000000000000000000 000000000000000000 00000000000000
00 00 00 i 0000 0000 0000 'S? 00 00 00 00 g! 0000 0000 1 00 00 '^
00 S 00 00 00 S
00 00 00 I 00 00 00 0; 00 00 00 0 00 00 00 00 0000 00 g 00 00 0000 2.
o
i
t?.
=
^
2
>
1 2 3 4 5 6 7 8 9
H
12 13
u
o
l5
o *
16
0 *
17
18
0 0
19
20
21
22
23
24
25
24 " Reading 24 ho 48 " Reading 48 ho - " Missed reading * " Missed appi* D Discontinuei.
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
-
0
-
0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
r
n
.
u
-
0
urs after application. urs after previous application
Ion. JK personal reasons.
-
0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
but just
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
before
Q
7 24 48
8 24 48
00
-
0
0000 0000
0000 0000
00 0
00
-
-
0
-
0
00
0000
00 00
0000
0000 0000
00 *
00
-
-
D
- *
-
D
0000 0000
0000 0000
0000 0000
0000
00 00
00 00
next application.
9 24 48
0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 D D D D 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
BIOSEARCH, INCORPORATED -
P.O. BOX 8598 -
PHILADELPHIA, PENNSYLVANIA 19101 -
(215)
Project Numberi
91-73'!46H
E.I. Du Pont De
Modified D raize
Hemours & Company - H-lt3,790, as
Repeated I[nsult Pat ch Te?st Study
prepared. in Human Subjeacts
Table 1 (continueid)
Inducttoia Phase
; 4 -;i
"'.
.. ?
'.^
N
'
'
,
~'<
fe.
t?
<;
fc i
5-i
5"'
-- e;
Cl
^i
0
SWsi i
,
iISubject lumber
1
24 48
2
24 48
2f .G6.
27
28
29
30
31
32
33
ii
34
\3 35 1 36
37
1
38
39 40
41
42
43
44
45
46
47
48
49
50
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2k 48
"
Reading
24
hours
after
Reading 48 hours after
" Hissed reading.
* Missed application.
D - Discontinued for persona
3
24 48
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
applicati
previous
1 reasons
4
Z&-M
0 0 Q 0 0 0 0 0 0 0 Q 0 Q 0 0 0 Q 0 Q 0 0 0 0 0 0 0 Q 0 Q 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
on. appliLcation
5
24 48
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
-
0
0 0
0 0
0 0
0 0
but Just
6
24 48
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
before
7
24 48
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 > 0 0 0 0 0 0 0 0
00
8
2jLA8
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
-0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0 -
-
next application.
9
21Jfl
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
BIOSEARCH, INCORPORATED
P.O. BOX 8598 -
PHILADELPHIA, PENNSYLVANIA 19101
(215
^ss ^:^
J^J <?<;(. Vmher t
91-7346;H
s .1. Du Pon t De ModiLfled Dr aiz e
Nenours & C;onpan y - H-18. 790, a 8 Repe ated Inisult Pate h Tes t Study
prepared, in Hunan 5 ubje<cfcs
Tabie 1 cont inued)
Indue tion Phase
5 ubj ect
Mumb.
i5 M- 51
52
53
54
55
56
57
58
59
i
6C
~
61
0
62
i 63
64
65
66
67
68
69
w
70
71
72
1 73
0
74
75
1
24 M
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2
.24 48
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0 "0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
-
0
0 0
0 0
0 0
3
14 M
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
4
&SL-&
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
5 . 24 48
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
-
0
-
0
6
2A-StS.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
7
2A-
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
a
M.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
I 24 "
48
Reading 24 hours after application.
1 -e Beading 48 hours after previous application but just before next applicatLion.
" Missed readincg. sr * " Missed application.
5* 3 " Discontinued for personal reasons
f
21.M
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Q
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
>
0
3K
BIOSEARCH, INCORPORATED - P.O. BOX a'.oa - BWTI ? BUT* BB.UMCV. >."* ,
Prolfpet Number;
91 -7346H
E.I. Ou Font De
' SiodifFled Draize
lenour s & Co mpany - H -18,790 . as
Stepeat*ed Ins ult Patch Test 5 tudy
iprepia red. .in HiJinan Subj(acts
Tab Ie 1 (con tinuled)
i
"
'
1
.*<
ys
S,
g
a B 0 <B 0
e"SE
0 0 3
w
S.
S3
-S <e 0
ys
Ind act*
- <iubje ct &tUBlbeJE
iteo
77 78 79 80 81 82 83 84 65 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100
1
24 48
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2
&.ifi
0 0
0 0
0 0
0 C
0 0
0 0
0 0
0 0
0 0
0 0
0 0
a o
0 0
0 0
0 0
0 0
0 0
0 0
0 0 0 0
0 0
0 0
0 0
-
0
0 0
i 3
niM
0 0 0 0 C 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 * 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
4
24 48
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
-
0
0 0
0 0
0 0
0 0
0 0
0 0
-
0
0 0
0 0
0 0
0 0
0 0
0 0
5
M-Afi
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
0 0
0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
-
r u
24 " 48 "
"
*
"
D '
Reading Reading
24 48
hours
after
application.
Missed
hours reading.
after
previous
application
but
Hissed applicatican.
Discontinued for personal reasons.
on PIbftse
( 5
M.Jfi
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 * 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
7
2&.J&
0 0
0 0
0 0
0 0
0 0
0 Q
0 0
0 0
0 0
0 0
0 0
0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0 0
0
-
0
just before next
8
24 48
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 D 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
00
9
1&.Jt&
0 0 0 0 0 Q 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 D D 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 n 0
application.
a ro
BIOSEARCH, INCORPORATED -
P.O. BOX 8598 -
PHILADELPHIA. PENNSYLVANIA
19101
?w,ject Hubert
91-734 6H
S.I Du Font De Hodi tied Draize
Nemo>urs 6 Company - H- 18,790, a s
Repe ated Iinsult Patch lest Study
prespared.
in Hunan Subje CIS
N3
^fc;:j
"s'
. .><
K'
'
Sv
5
{'
u;
*"!?
S'f
^"i, f^
Tabi e 1 (cont inue d)
Subj ect Numb
101 102 103 104 105 106 107 108 109 110 111 112 113
1
24 48
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2
j24 48
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 *
3
2A-^3
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
0
4
,2U8
0 0
0 0
0 0
0 0
0 0 0 0
0 0
0 0
0 0
0 0
-
0
0 0
-
*
Indue tion Phase
5
i24 48
6
&L48
0 0
0 0
0 0
0 0
0 0
0 0
0 0
-
0
0 0
0 0
0 0
0 0
-
D
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 D D
24 " 48
Reading Reading
24
hours
after
application 4
-
" Hissed
48 hours reading.
after
previous
application
but
just
before
* " Missed application.
D Discontinued for personsil reasons.
7
&L-48
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 D 0
G }
M.M
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 D D
next application.
j ?
M.M
0 Q 0 0 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 D D
Vi
s
CK
BIOSEARCH. INCORPORATED -
P.O. BOX 8598 -
PHILADELPHIA, PENNSYLVANIA 19101
(215
Protect Nwl???-.
91-7346H
E.I. Du Font De Nemours 6 Cocspany - H-18,790. as prepared. Nodified Draize Repeated Insult Patch Test Study^in Human Subjects
Summary of Table 1
Induction Phase
1--2-4,,5-6..7-8.,9. 2A-48
Total Subjects 8 113 113
Readings
2&^g
113 113
24^48 113 113
24.48 113 113
244g
113 113
24^g
113 113
^j,g
113 113
2 ft8 113 113
24 Ag 113 113
0
113 111 109 112 112 112 108 112 106 112 112 111 105 109 107 109 106 106
^ *
MD
1+
S
2+
^
3+
^ 24
m
48
5
jg" *
p, D
1
000C000002<00040'000001000l00000001500000000001070000000010000100000110700100000220400200000400300400300400 Reading 24 hours after application.
MReisasdeindg re48adhinogu.rs after previous application but just before next application. Missed application. Discontinued for personal reasons.
1
5.
a
3
ij
^
BIOSEARCH, IMCORPORATED - P.O. BOX 8598 - PHILADELPHIA, PENNSYLVANIA 19101 - (21
.-.. -------
Project Number: 91-7346H
-
-
.-. ^
tiu u
E.L Du Font De Nemours & Company - H-18,790
Modified Dsasze Repeated Insult Patch Test Study in Human Subjects
m m-M
Appendix
GRADING SCALE Human Patch Test Studies
Reading
0
. 1+ 2+ 3+ 4+
Interpretation
negative suspicious slight erythema well defined erythema erythema with induration erythema with ulceration
DEFINITIONS*
Sensitization is a phenomenon which manifests itself by local effects on either skin or mucous membranes. It differs from primary irritation in that it may also involve tissues remote from the site of application. These reactions represent an allergy to a chemical which is not obtained on first contact, but requires a number of prior exposures for development.
Repeated patch applications of substances to both man and animals reveal that certain substances which, at a given concentration, do not produce primary irritation may e^dt severe skin reactions after a number of exposures. Nevertheless, these reactions may not be considered incidents of sensitization since after 10-14 days of rest the skin rec' vers its original resistance to injury by the substance. For the lack of a better term such reactions have been called "skin fatigue". This latter term is a misnomer in that it does not imply a condition in which the skin has lost significant normal physiological function. This phenomenon consists of a subtle change in which the skin no longer exhibits its original refractoriness or resistance to the continued or repeated action of an agent
* Draize, J.H. 1959. Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics. In DERMAL TOXICITY, p.46-53. Topeka, Kansas: Association of Food and Drug Officials of the United States.
- 14 -
BIOSEARCH, INCORPORATED - P.O. BOX 8598 - PHILADELPHIA, PENNSYLVANIA 19IOI
contain TSCA CB j
.____________________ftot
.---------------....,,.-.....-.-
Project Number; 91-7346H
..,............,_......................,,,
DujjeRii MLU ^A
E.I. Du Font De Nemours & Company Modified Draize Repeated Insult Patch Test Study in Human Subjects
Subject Number
Initials
33SSUJSi
Age Occupation
Allergies
1
M.O.
28
Homemake'-
2
L.M.B.
66
Retired
-
3
J.E.
30
Homemaker
4
D.M.
29
Animal Caretaker
-
5
P.L.
40
Homemaker
-
6
M.L.
39
Homemaker
.
7
M.F.
63
Honiemaker
-
8
M.E.
41
Homemaker
9
E-M.
48
Homemaker
10
M.G.
56
Homemaker
11
CD.
45
Homemaker
12
K.T.
22
Housewife
-
Fiberglass
-
13
I.J.
52
Homemaker
-
14
P.D.
67
Retired
15
K.L.
22
Homemaker
16
D.S.
24
Furniture Mover
-
-
Bee Stings & Raw On
17
A.M.
60
Homemaker
-
18
L.F.
44
Homemaker
-
19
S.L.
26
Unemployed
-
20
C.D.P.
40
Homemaker
Rose & Hay Fever, Ra
21
H.F.
43
Homemaker
22
J.F.
37
Saw Operator
Dogs, Hay Fever, Rag
-
23
H.S.
23
Dishwasher
-
24
A.R.
20
Student
-
25
A.S.
24
Homemaker
-
26
T.F.
55
Unemployed
-
27
K.C.
42
Teacher's Aide
-
28
N.S.
27
Homemaker
.
29
D.D.
43
Unemployed
-
30
M.G.
59
Homemaker
-
31
M.S.
33
Homemaker
32
R.B.
36
Homemaker
'
33
D.C.
32
Order filler
-
34
D.K-
40
Homemaker
35
G.M.
22
Unemployed
36
C.C.
27
Homemaker
Dust
37
L.G.
28
Homemaker
Cats, Penicillin
38
M.A.
61
Homemaker
.
39
B.R.
40
K Mart Employee
-
40
N.R.
41
K Mart Employee
-
41
E.E.
38
Homemaker
-
42
E.H.
22
Homemaker
-
43
E.R.
19
Unemployed
-
44
E.G.
43
Homemaker
-
45
V.G.
18
Homemaker
-
HrOSfcARCH. INCORPORATED - P 0. BOX 8598 - PHILADELPHIA, PENNSYLVANIA 19101 - (21S) 739-4499 - 15 -
Project Number; 91-7346H
Du Font HLO 706-91
E.l. Du Font De Nemours & Company Modified Draize Repeated Insult Patch Test Study in Human Subjects
Subject Number
Initials
SUBJECT UST
Age Occupation
Allergies
46
W.L.
55
Unemployed
47
M.V.
42
Homemaker
48
A.T.
62
Homemaker
49
C.L.
41
Homemaker
50
I.F.
31
Unemployed
51
J.F.
36
Unemployed
52
C.S.
46
Homemaker
-53
M.V.C.
27
Homemaker
54
C.H.
61
Homemaker
55
D.H.
23
Homemaker
56
G.L
34
Homemaker
57
R.M.
59
Homemaker
58
P.H.
61
Homemaker
59
E.P.
37
Homemaker
60
V.P.
24
Unemployed
61
S.R.
60
Homemaker
Sulfa Drug
62
C.S.
40
Correctional Officer
63
R.J.
53
Homemaker
64
M.S.
46
Homemaker
65
A.S.
16
Student
66
B.N.
33
Cashier
67
J.N.
38
Unemployed
68
F.P.M.
49
Unemployed
69
M.M.
57
Ward Clerk
70
R.S.
37
Homemaker
71
C.N.
67
Homemaker
72
D.N.
26
Unemployed
73
M.W.
62
Homemaker
74
C.R.
52
Homemaker
75
H.C.R.
57
Unemployed
76
P.M.
50
Food Service
77
B.K.
66
Retired
78
R.G.
40
Landscaper
79
D.M.
25
Homemaker
80
E.C.
25
Homemaker
81
T.M.
18
Laborer
82
M.A.
62
Homemaker
83
A.B.
65
Homemaker
84
C.A.M.
41
Homemaker ,
85
C.C,
45
Homemaker
86
R.S.
43
Unemployed
Penicillin Starch
87
D.M.
19
Student
88
A.B.
62
Homemaker
89
E.W.
25
Homemaker
-
16 -
BIOSEARCH, INCORPORATED - P.O BOX 8598 - PHILADELPHIA, PENNSYLVANIA 19101 - (215) 739-4W
Company ganMzed. 8oeg rtot contam TJH.A * ;H
Project Number: 91-7346H E.I. Du Font De Nemours & Company Modified Draize Repeated Insult Patch Test Study in Human Subjects
Subject Number
Initials
SUBJECT LIST
Age Occupation
Allergies
90 91 92 93 94 95 96 97 98 99 100
101
102 103 104 105 106 107 108 109 110 111
112 113
B.P.
K.M. K.A. Y.H. H.R. C.R. D.E. S.A. A.C. J.C.
V.C. H.C. W.W. M.C. W.M. A.B. K.M. D.G.
J.G.
S.B.
L.C. M.C. L.P. J.I.
45
Homemaker
31
Homemaker
32
Shipper
35
Homemaker
33
Restaurant Worker
34
Homemaker
30
Technician
30
Homemaker
48
Homemaker
24
Homemaker
51
Homemaker
50
Unemployed
18
Student
25
Homemaker
16
Student
29
Homemaker
41
Shipper
33
Homemaker
21
Homemaker
33
Homemaker
18
Unemployed
20
Homemaker
26
Homemaker
22
Homemaker
Dust
-
17 -
BIOSEARCH. INCORPORATED P 0. BOX B598 PKtI.ADCl.PH' \, PENNSYLVANIA 19101 - (215) 739-4*99
i
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