AR226-3339 --------------------^^ Roy S Thompson (AstraZeaeca, Brixham, UK) Haria Colombo Watze de Wolf (Seh'ay Sotexis, BaHate, Stely) (OuPoBt, Mechelt'n, Belgiaaa) David G Fanrar Robert A Hoke Jacques L'Haridon (laeos C&ior; Ruacorn, UK) (DaPont, Newarfe, BE, USA) (CST, Evreux, Fraace) for.

AR226-3378 Abstract Perfluorooctanoic acid (PFOA) is a Fluoroorganic surfactant that has b production of a variety ofFluoropolymers.

E.I. duPont deNemours and Company Haskell Laboratory for Health and Environmental Sciences 2 December 2004 iToxicokinetics in the Rat: Pilot results Study Director: W.J.

R226 - 3546 ATTACHMENCT italte Deoa0 000175 Ee LSORLEY)AY SaAlRih ie `Nove1m1,b2e00r3 `MGEsP.laLsytnincHsall 2148North 2753" Road Ottawa, IL 61250 Dear Lynn, Ihave attaachcoepdyof the C8 report.

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3M Environmental L boratory FinalReport- AnalyticalStudy Single-doseDermal Absorption/ToxicitSytudy ofT-6049 inRabbits In-Vivo Study ReferenceNumber: HWI#6329-130 Study Number: AMDT-020895.1 Test Substance: FC-95 (T-6049) Name and Address of Sponsor: 3M SCD Division 367 Grove Street St.Paul,MN 55106 Name and Address of Testing Facility: 3M Environmental Technology & Services 935 Bush Avenue St.Paul,MN 55106 Method Numbers AMDT-M-1-0, AMDT-M-2-0, ANMT-M-4-0, AMDT-M-5-0, and Revisions: Thermal Extractionof Fluorideby Means of a Modi:fied Dohrmann DX2000 Organic Halide Analyzer-Liver FluorideMeasurement by Means of an Orion EA940 Expandable Ion Analyzer Extractionof Fluorochemicalsfrom Rabbit Liver Analysisof RabbitLiver ExtractforFluorochemicalsUsing ElectrosprayMass Spectrometry InitiationDate: See attachedprotocol Author: James D.

Multi-City PortSt.L ri MULTI-CITY STUDY FINAL FIELD REPORT FOR COLUMBUS GEORGIA AND PORT ST.LUCIE FLORI]DA - BATTELLE DUXBURY ACTMTIES For ProjectNumber' N100672-01 Submitted to Conride'nt'ial October 26,1999 Prepared by KeUy A.

PffYSICAL - CIffEIN/fICALPROPERTT-ES A Robust Summary, FinalReport, and Protocol on the physical-cbemicaplropertiesof perfluorooctanesulfonataere includedfor each of the followingparameters: PAR-KWTER DATE OF REPORT RESULTS ;MeltingPoint/MeltingPointRange Vapor Pressure n-Octanol/Water PartitionCoefficient Air-Water PartitionCoefficient Solubilitiyn ppre water SolubilityMeasurements on FC-95 2/24/99 5/5/99 2/11/00 3119/00 5/3/99 2/6/81 4000C 3.31x 104p (4@200C Not calculablet;hr" 0(<2xlO-) 570mg/l 1080mg/l phases The data presentedinthe study "SolubilitMyeasurements on FC-95," was determined by indirectmeasurement, not by actualanalysis.Therefore,the data isnot reliable.

HAZLOZON LABORATOIQIES ANAERICA. lrJC. 3301 KINSMAN BLVD.

EFFECT OF DEGRADATION ON FOAMING TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredtoas PFOS, FC-95, or as a component of FC-203A or FC203 NFP. (1-Octanesulfoniacid)(CAS # 2795-39-3).

MICROBICS MICROTOXO TOXICITY TEST TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may also be referredtoas PFOS, FC-95, oras a component ofFX-3104. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ATTACHMENT TO LETTER TO C.AUER DATED AUGUST 31,2000 SUPPLEMENTAL SUBMISSION FOSA or PFOSA Perfluorooctanesulfonamide MedicalSurveillanacnedEpidemiologic See item I under PFOS: InterimReport #1,Determinationof Serum Half-Livesof SeveralFluorochemicals,June 8,2000.

A Convention on Long-Range Transboundary Air Pollution p P1 age I of I R .2 2 6 _ 3 61 7 ~ UNEC E United Economic Commission. for Europe SEARCH ' , Convention News Histo ry of the Conventio Convention on Long-range Transbounda ry Air Pollution Protocol on Persistent Organic Pollutar nProtcls (POPS ) Organizational Cha rt Executive Body EMEP Steering Body The 1998 Aarhus Protocol on Persistent Organic Pollutants (POPs) Working Group on Effects Working Group o The Executive Bod y adopted the Protocol on Persistent Organic Review and nStraegis CAPACT Publications Pollutants on 24 June 1998 in Aarhus (Denmark) .

._ _-____ 8) OECD 407, Repeat dose oral toxicity (with FOB & histopathology), 132-007 SANITIZED JAN 0 9 2004 A 28-Dav Oral Toxicitv Studv in SPraque-Dawlev Rats Studv Number: 132-007 SAN ITlZED A 28-DAY ORAL (GAVAGE) TOXICITY STUDY OF T-7485 IN SPRAGUE-DAWLEY RATS STUDY NUMBER: 132-007 SPONSOR 3M Corporate Toxicology 3M Center, Building 220-2E-02 P.O.

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