Pathology Associates International A Company of ScienceApplicationsInternationaClorporation AnarO&AOOWUd CW4POnY Sponsor: 3M St.Paul,Minnesota PROTOCOL Study Title: CellProliferatiSotnudy withN-EthylPerfluorooctanesulfonamEitdhoanol(N-EtFOSE; 3M T-6316.11), PerfluorooctanSeulfonicAcid PotassiumSalt(PFOS; 3M T-6295.16)a,ndN-EthylPerfluoroctanesulfonamide (PFOSA 3M T-7091.1)inRats Date: January12,1999 Performing Laboratory R.O.W.

Acute oral Toxicity Screen with T-3066CoC in Albino Rats 01981 Experiw.nt No.: Conducted At: Dates Conducted: Conducted By: 0981AR0146 Safety Evaluation Laboratory R:Lker Laboratories, Inc.

3M SpecialtyMaterials May 23,2000 3M Center St.Paul,MN 55144-1000 651733 1100 Dr.CharlesAuer,Director Chemical ControlDivision OfficeofPollutionPreventionand Toxics UnitedStatesEnvironmentalProtectioAngency 401 M StreetS,outhwest Room 403,EastTower (MailCode 7405) Washington,D.C. 20460 Re: Informationon PerfluorooetanSeulfonates and RelatedCompounds - AdditionalInformation Dear Charlie: Iam enclosingadditionailnformationthatdidnotgetsubmittedwiththerecentMay 18,2000 submittaltoyou on perfluorooctanseulfonateasnd relatedcompounds.

ATTACHMENT TO LETTER TO C.AUER DATED AUGUST 31,2000 SUPPLEMENTAL SUBMISSION N-ETFOSA N-ethylperfluorooctanesulfonamide AcuteToxicit 1.

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ADVANCE UNEDITED DRAFT p. 1 AR oq a6_ 36/1 DRAFT RISK PROFILE OUTLINE EXECUTIVE SUMMAR Y I INTRODUCTION 1 .1 Chemical Identity of the proposed substance Mention who has made the proposal and when Spell out the specific chemical identity and particular considerations related to that 1 .2 Conclusion of the POP Review Commi tt ee of Annex D information "POP RC has evaluated Annex D (add reference to the meeting and the decision) information and has concluded that . . . " 1 .3 Data source s short overview of the data sources provided by the proposing Party and/or used by the POP RC in Annex D screenin g short overview of data submitted by Parties and observers (NB : a more elaborated summary of the submissions may be provided as a separate POP RC INF document) information on availability of national and international assessment reports ; [1 .4 Summary of available risk informatio n brief summary of the submitted evaluations and other information referred to in Annex E, point f Alternatively, can be summarised in a separate POP RC INF document ] 1 .5 Status of the chemical under international convention s 2 SUMMARY INFORMATION RELEVANT FOR THE RISK PROFILE 2.1 Sources production, trade, stockpiles uses releases to the environment 2 .2 Environmental fate Further elaboration of information referred to in Annex D, paragraphs (b) - (d) ; based on all relevant available information Monitoring data available integrated under the subheading or alternatively dealt with under separate heading "Monitoring data" Could be split in : 2 .2 .1 Persistence 2 .2.2 Bioaccumulatio n 2 .2 .3 Long range environmental transpo rt 000222 p. 2 y 2.3 Exposure Summary of relevant information concerning exposure in local areas (both near the source and in remote areas) Summary of relevant information concerning exposure as a result of LRET Information on bioavailability 2.4 Hazard assessment for endpoints of concer n Further elaboration of information referred to in Annex D, paragraph (e) ; based on all relevant available information Monitoring data on effects include d 3 SYNTHESIS OF THE INFORMATIO N synthesis of the information under chapter 2 tha t focus on information that is leading to the conclusive statement under chapter 4 4 CONCLUDING STATEMEN T Is the chemical likely, as a result of LRET, to lead to significant adverse human health and/or environmental effects, such that global action is warranted Note : No Annexes ; all other data provided as POP RC INF documents Target size not longer than 20 page s 2 000223

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~ "( l`~ 3` _p( 1I ~ ~ "McCrea, Deborah" <mccrea@taftlaw .com> 08/13/2009 02 :41 PM To cc bcc Subject NCIC OPPT@EP,A "Bilott, Robert A."

Taft/ Taft Stettinius & Hollister LLP . 425 Walnut Street, Suite T800 /Cincinnati, OH 45202-3957 /Tel : 513 .381 .2838 /Fax : 513 .381 .0205 /www .taftlaw.com Cincinnati /Cleveland /Columbus /Dayton /Indianapolis /Northern Kentucky /Phoenix /Beijing ROBERT A.

e ehponi,ne.org Al226-354p7t EHENAVLITRHONMENTAL PERSPECTIVES Accumulation and Clearance of PFOA in Current and Former Residents of an Exposed Community Ryan Seals, Scott M.

VIA EMAIL AND OVERNIGHT MAIL October 14, 2015 Dr.

z c Perfluorochemicals in Mississippi River Pool 2: 2012 Update Fish, benthic invertebrates, water, and sediment were tested for PFCs in 2012.

AR 226 - 0297 BIODEGRADATION (MANOMETRIC RESPIROMETRY -- AEROBIC) TEST SUBSTANCE Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-3041. (1Octanesulfonic acid) (CAS # 2795-39-3).

AR226-1523 FINAL REPORT RECEIVED OPPT NClC 03 SEP 30 PM1:OO PROTOCOL 418-028 ORAL (GAVAGE) COMBINED REPEATED DOSE TOXICITY STUDY OF T-7706 WITH THE REPRODUCTION/DEVELOPMENTALTOXICITY SCREENING TEST SPONSOR'S STUDY NUMBER: T-7706.1 FINAL REPORT DATE: 3 1 JULY 2003 PROTOCOL 418-028 - ORAL (GAVAGE) COMBINED REPEATED DOSE TOXICITY STUDY OF T-7706 WITH THE REPRODUCTIONLDEVELOPMENTAL TOXICITY SCREENINGTEST SPONSOR'S STUDY NUMBER: T-7706.1 TABLE OF CONTENTS SUBJECT 1.