PathologyAssociateslntemational A Company ofScienceApplicatioInnsternatioCnoarlporation AA Empbya&Owrad CaMwy SECOND DRAFT CELL PROLIFERATION REPORT 104-WEEK DIETARY PERFLUOROOCTANE CHRONIC TOXICITY AND CARCINOGENICITY STUDY WITH SULFONIC ACID POTASSIUM SALT (PFOS;T-6295) IN RATS COVANCE STUDY NUMBER 6329-183 PREPARED FOR: 3M TOXICOLOGY SERVICES BUILDING 220-2E-02,3M CENTER ST.

KendalBl.WallaceP,h.D.

26-Week CapsuleToxicitSytudywithPerfluorooctanesulfoAncicdPotassiumSalt (PFOS) inCN-nomolausNlonkeys CurrentSummary asof,Nfav4,2000 T'hepurposeof thistudywas toidentiftyheearliecsltinicalmleyasurablebiologicraelsponsefrom repeateddailyexposure topotassiumperflucrooctanesulfonate(PFOS) and to correlatethisresponse to set= conc@-nrtabonfsorpurposesof riskassessmentard medicalmonitoringof exposedpopulations.

ACUTE TOXICITY TO FISH TEST SUBSTANCE Identity:N-Ethylperfluorooctanesulfonamidmea;y alsobe referredtoas U 1464, ETFOSA, ETPOSA, F-6309,or FX-1 2. (1Octanesulfonamide,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-N-ethyl-C,AS # 4151-50-2) Remarks: Materialisa white solid,lot505 (cc842-3,F6309, L-1089).

28 Dermal Percutaneous Absorption Study with FC-128 in Albino Rabbits Experimnt No.: Conducted At: Dates Conducted: Conducted By: Reviewed By: dc: M.

BIODEGRADATION TEST SUBSTANCE Identity:Perfluorooctanesulfonylamido(ethyl)acetmaatye;also be referredto as PFOSAA, FC-128 or as the major component of FC-1 27, FC-129, FC-1 09, FC-1 09-X or Rl 904.

CORNINGHazlcton MUTAGENICITY TEST WITH T-6342 IN THE SALMONELLA - ESCHEPICHL4 COLIMAMMALIAN-MICP,(>SOMt MUTATION ASSAY RE-1@ERSE FINAL REPORT AUTHOR Timothy E.Lawlor,M.A.

InternCaolrrespondence To:P.

ACUTE TOXICITY TO FISH TEST SUBSTANCE Identity:Perfluorooctanoiaccid,ammonium saft;may alsobe referredto as PFOA ammonium saltA,mmonium perfluorooctanoateP,FO, FC116, FC-126, FC-169, FC-143 or as the major component ofFC1015.

ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredtoas PFOS, FC-95 or as a component of FC-201 AF. (1Octanesulfonicacid)(CAS # 2795-39-3).

ACTIVATED SLUDGE RESPIRATION INHIBITION TEST TEST SUBSTANCE Identity:Mixturecontainingperfluorooctanesulfonatweh,ich may also be referredto as PFOS, FC-95, or as a component of FC-203CF-X or FC-203CF.

ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredtoas PFOS, FC-95, or as a component of FC-3017. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfbnatweh,ich may alsobe referredtoas PFOS, FC-95, or as a component of FC-3031. (1Octanesulfonicacid)(CAS # 2795-39-3).

oro ~ i ~ praz6 - HH07 i" 000152 | } ~ Exygen, d Ri ARa%6-- 3407 \ TITLE HodofAoki fieDerm ofPectin cd (PFOA) Se \ AutHoR \ `EmilyDecker N\ DATEISSUED | \ January8, 2004 | \\ SPONSOR | `Haskell \Baboratoryafposor HiBealathxse o& Ens viroomental Sciences.

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