3M Specialty Materials 3M Center St.

. : SE atheros &.Bvt,PD.

Page 1 FINAL REPORT Epidemiology, 220-3W-05 Medical Department 3M Company St.

Wildlife International, Ltd. "1" ProiectNumber454A-108 PFOS: AN EARLY LIFE-STAGE TOXICITY TEST WITH THE FATHEAD MINNOW (Pimephales promelas) ADDENDUM WILDLIFE INTERNATIONAL, LTD.

Wildlife International, Ltd.

PFOS: A PILOT REPRODUCTION STUDY WITH THE MALLARD FINAL REPORT WILDLIFE INTERNATIONAL, LTD.

Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendix E] Page 1 of 68 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _______________________________________________________________________________________________________________ Appendix E: Histopathological Findings Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendix E] Page 2 of 68 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _______________________________________________________________________________________________________________ Table 1: Summary of histopathological findings (all animals) FRAUNHOFER ITA 01G0002 Summary of histopathological findings (all animals) Page: 1 2 1 -A u g -0 0 -------------------------------------------------------------------------------------------------------------------------- !

COMMENTS OF 3M COMPANY TO THE EPA SCIENCE ADVISORY BOARD PFOA REVIEW PANEL Contact: Geary Olsen, D.V.M., Ph.D.

STUDY TITLE `Extraction of Po`tAansasliyusimsPUesrifnlugoHroPoLcCt:aFnleseucltfoosnpatreeyf/rMoamsRseSdpeBcltoroodmeCterllys and Serum for DRAETQAUIREMENTS Analytical Method Requirements STUDY DIRECTOR Sean Gallagher ANALYTICAL REPORT DATE June 2, 2003 PERFORMING LABORATORY/TESTING FACILITY 30E5x8ygReesneRaerscehaDrrcihve SuPthoeneC:ol8l1g4e-,2P72A-110638901 STUDYSPONSOR 3M EnvironmentaBluiTledcihnngo2lo3g5y-a0n9d Safety Services St.Paul PO MBoNx 5353133331:3331 .

Report E01-1245 PFOS: A Reproduction Study with the Nothern Bobwhite ARZ6-185:6 ANALYTSICtAuL PdHyASETiREtPlOeRT FOR PFOS: A REPRODUCTION STUDY WH THE NORTHERN BOBWHITE FIDFaRAtSaubdRiveisqiouniE,rSeecmtieonn7t1-4 (OECD Guideline 206 LisAa Au. tStheovernson Analytical PJahnuaarsy e31,I2n0i02tiation Date Analytical Phase Completion Date April 18, 2003 PerfoarmEnviirnongmenLtsaLabboortroay tory B5u05nugn2A3v6e.0n0e SL Pack MN 55105 3M EnPvirroonjmeenctatl LIabdoeranttoriyfSitcuad#tyiEo0n1-1245 `Wildife Intemational Ltd: 454-108 Total Number of Pages 26 NEnoviparrotnmoefnhtiasl rLeapboorrtatsorhyo.ulbd reproduced, except in ful, without witen approval ofthe 3M 3M Environmental Laboratory Page 1 6n0uit Report E01-1245 open ons PFOS: A Reproduction Study with the Nothern Bobwhite PFS: A rechcton Studywin na Nota Baile ~ GLP COS MtPLIeANeCm E nSTATEa MENT ss------ Study Tie: ABnoablwyhtiictael Phase Report for PFOS: A Reproduction Study wit The Northern Study Identification Number: EO1-1245 GTroiosdanLaalbyotricaatlorpyhaPsraectwiacse (coGnLdPu)cStteadnidnacrodmspwliitahntcheeweixlcheTpoixoincsSuibssetdanbecleosw:Control Act (TSCA) Exceptions to GLP compliance: + aAsuthoemaotreigdindaaltaracwoldacttai.on systems are ot validated.

Final Draft Guidance Document Telomer Research Program (TRP) AR226-1888 Guidance Document Best Analytical Practices for TRP Studies Author Marilyn Stadalius Critical Path Services 300 Foulk Road, Suite 1C Wilmington, Delaware 19803 Completion Date March 2004 RECEIVED OPPT NCIC 2004 DEC 22 AM 11:20 Sponsor Telomer Research Program Asahi Glass Co., Ltd.

. . 3M General Offices.

POLYMER PRODUCTS DEPARTMENT MANUFACTURING DIVISION AR226-2012 CC: R.

AR226-2129 file;///C|/WlNDOWS/TEMP/M) C-81-3-79 (hu 4-30-811 page-htm Test Results Sample Data Range Concentration Ranflft Action Lovel Industrial Hygiene 1/3/79 400/61 100% SamptaBt Samples Duration Type Employee Namo Pers BTO: LOC: 17 RESEARCH 019 WEIGH AND ADD C-8 TO POLYKETTLE 1/3/79 47591 Z Chemical C-8 1/4/79 47S32 2 0.8 Cone Unit Percont 0.05 PPM <0.05 PPM 0.0% 0.0% BTO: 17 RESEARCH tOC; 065 PPDSEMIWORKS 4/8/81 57356 Z C-B <0.0001 PPM 0.0% BTO: 17 RESEARCH LOC: 100 P/S-EPM WAREHOUSE -FORK TRUCK OPERATION 4/30/81 60221 Z C*8 0.0001 PPM 0.0% BTO: LOC!

AR226-2184 EXPOSURE EVALUATION FOR NEW PROCESS AT FAYETTEVILLESITE Prepared by DuPont Engineering Technology Debbie Klulrooney Cathie Barton August 20,2001 CAB000188 EID547037 TABLE OF CONTENTS i Executive Summary 1.