Document k992Q9mbNvKX6NnxyX5nVoQeV
VAPOR PRESSURE
EST SUBSTANCE
Identity: NN--aEtthyFlOpSeErfAllucoorhooolctoarneFMs-u3lf4o2n2a.mi(d1o-eOtchtanaonle;sumlafoynaamlisodeb,eNr-eeftehryrle-d to as C1,A1S2,2#.136,931.4-,949,-52,5),6,6,7,7.,8,8,8-heptadecafluoro-N-(2-hydroxyethyl)-,
rRoeommartkesmp:eratMuartee.riaTlhies
a white waxy sold. report indicates the
sItaimspclhearwaacste9ri9z%edpaurseb.eing
stable
at
METHOD:
Method followed:
OECD Guideline Method."
104,
"Vapor
Pressure
Curve,
Dynamic
GLP: Yes
Year study was performed: 1998
Remarks:
T"Whheilfeoltleoswtiinngg qtuesotteitfermo,mthteheaitrecsotnrdeepnosrterdewsacsribuessetdheinopnllaycteeosftwdaevtiearticoon.ndenser
bCoercpaoursaetioofn)locwurmreelnttinscgiepnotiinftiocfktnhoewlteesdtgeiteamn.d Tunodtehrestbaensdtinogf,outrhs(AdeSvIiation
should have
report).
no
effect
on
the
outcome
of
this
test."
(Quote
taken
from
the
test
No note was made of any decomposition. RESULTS
T0.h7e9v2aPpao,rapnrdes1s.u2r2e7sPaat,1r0esCp,ec2t0ivCe,ly25baCs,edanodn 3t0heCdewcerreeas0i.n1g94prPeas,su0r.e504 Pa, regression equation.
Remarks: "The estimated vapor pressures for the increasing and decreasing
pressure conditions differ by 42-50 percent."
CONCLUSIONS
The vapor pressure in the atmosphere.
suggests
this
material
would
exist
primarily
in
the
gas
phase
DATA QUALITY
006131
Reliability: Kiimisch ranking = 2. This study meets all the criteria for quality testing. However, the 99% purity may not be correct. The value was assigned by NMR which is incomplete. Possible non-linear plot (not enough data points). As described above, the vapor pressures calculated while pressure was. increased vs. decreased differ by 42-50 percent. However, third party consultant review of the data concluded the study is valid. REFERENCES Determination of Vapor Pressure Curve by Dynamic Method for U1463 (ET FOSE), AScl Repor#t 044-VP.R3M, AScl Study ID #5030-044-01, November 6, 1998. OTHER Submitter: 3M Company, Environmental Laboratory, P.O. Box 33331, St. Paul, Minnesota, 55133 Last changed: 5/18/00
006132
AN,
:
ke
AASSclSuRdepyorItDFO#54043-0V.P0R6O40M1
RIGIN AL STUDYTITLE
FcFr-ee1!0
Determination of Vapor Pressure Curve by Dynamic Method for U1463 (ET FOSE)
DATASTANDARD
`OECD Guideline 104, "VaporPressure Curve, Dynamic Method"
COW
C
AUTHORS
Mike Signorelli Linda Christensen
`Phillip Marquis
ne November 6, 1998
TESTINGFACILITY
EAnSvcilroCnomrepnotraaltiToens/tiAnSgclD-iDvuilsuitohn 4444 Airpark Boulevard Duluth, MN 55811-5712
Tel. No. (218) 722-4040
.
~.
STUDY IDENTIFICATION NUMBERS
AScl Study IDF 5030-04-01
:
3M Company Environmental Technology and Safety Services Sponsor Study ID# U1463
s*tTuhdiysisstkuedpyt roenpofritlecoanttAaiSncsIa-DtEotTaDl .of 26 pages. The raw data package (33 pages) supporting this
SponsorSandyIDFUt4sa
006133
LM
. -
ASe Report SOULVP RM
AScl Study ID #5030-044-01 Page 2
PTroactthiecebersetguolfatmiyonskn(o1)w.ledge, this study was conducted in accordance with OECD GoodLaboratory
AScl Study Director
ao
Name (signed):
Name (yped)LindaChristensen
. (4sfaT
Sponsor Study D4 Utd
606134
AS Report FOULVERM
3
AScl Study ID #5030-044-01
Page3
STAOTFQUEALIMTYAESSUNRANTCE
The study data were reviewed by the AScl Quality Assurance Unit to assure that sandard operating
prerfolceecdtuiornesofantdheguriadweldianteas.
used
The
ttoypceosndoufcatudthiitss
spteurdfyorwmeerde
ffoorlltohwiseds,tuadnyd
atrheislirsetpeodrtin
isthaen
faoclclouwriantge,
table.
ASI"STtyupdeyofIDAFud5i0t3f0or08401
[oro
TT
Management DateReptoo Studr y Dit rece tord and | a Ts
(roe bossiponn|vim | summon |
AScIs Quality Assurance Unit Auditor
Name (signed):
. [67%
Meme (ypedy0 AlaMozol0000000
SponsorStudyIDF 1463
006135
.
mr
Pag4e
TAOFB COL NTEE NTS
CERTIFICATION OF GOOD LABORATORY PRACTICE COMPLIANCE trterecisranes?
STATEMENTOF QUALITY ASSURANCE ...........................3. TABLEOF CONTENTS ...........tuininnininninanineanann.4n STUDY SYNOBSIS ..outta LO INTRODUCTION ...............ccoiiiinseiniiiin8i
2.0 TEST METHODS fr rerertrraa tira arts e tars ene 8
30 TREATMENT OFRESULTS ...............................1..0
4.0 RES ANU DDIL SCUT SSIS ON treatin. 10
5.0 CONCLUSIONS ...... trie trrss nts sitsre neris tanssanass QT
6.0 DEVIATIONFROM APPROVEDTEST PROTOCOL Tred e..120
7.0 REPORT SIGNATURE.................................... ~~. Rr
:
80 REFERENCES ....................ccooceiiiiie2i
TABLE 1.
TABLE 2.
TABLE 3. TABLE 4.
TatolIuncerneeas(iRnegfPerreenscse uItreem).:..Booili.ngoPooin.ts loots (T) and Corresponding Vapor Pressures Toluene (Reference Item): Boiling Points (T) and Corresponding Vapor Pressures (5)
atDecreasing Pressure ....................................14 (TTo)lDueetneer(mRienfeedrfenrcoemIEteqmu)a:tiEosnti1matSerd rVkaspotrsrPrseasstusrersn(iPr) rat eDrifefserenntiTtermpcerranteusresIS (TTo)lDueetneer(mRienfeedrfenrcoemIEtqeum)a:tioEnsti2mat.ed..V.ap.o.r.P.re.s.su.r.es.(.p)..at.D.i.ff.er.e.nt.T.e.mp.e.r.at.ur1es6
SponsorSwdy IDW U1463
666136
ASclReport FOULVP.RIM
AScl Study ID #5030-044-01
Page 5
TaofbConltenets (cont.)
TABLES. Range of Vapor Pressure Values for Toluene by the Dynamic Method from OECD
andEEC-LaboratoryIntercomparisonTestingProgram (4) . . ............. 17
TABLE 6.
ET FOSE (Test Item): Boiling Points (T) and Corresponding Vapor Pressures (p) at IncreasingPressure trrrese tar ctetrt rat tet reat nnr naar ns 1B
TABLE 7.
TABLES.
TABLES.
DeEcTreFaOsSiEng(PTIeEsStSUIItEem): Boiling oPooi.nts (T) and Corresponding Vapor Pressures a10 ET FOSE (Test Item): Estimated Vapor Pressures (p) at Different Temperatures (T)
Determinedfrom EQuation 3 . . ............,............... .. 20
DeEtTerFmOiSnEed(fTersotmIEtQemU)I:toEnsti4m.at.e.d Vap.o.r P.res.sur.es .(p) .at .Diff.ereont uTemoperiatuuress(2Tl)]
TABLE 10.
ET FOSE (Test Item):
Involvedinthe Study
Responsibilities, Signatures, and Initials of Key
.......................ii
Personnel
2
FIGURE I. A Representative Plot of Log p (Pa) and I/T (K) Toluene at Increasing Pressure . 23
FIGURE 2. A Representative Plot of Log p (Pa) and U/T (K) Toluene at Decreasing sre .24
=
FIGURE 3. A Representative Plot of Log p (Pa) and 1/T (K) ET FOSE atIncreasing
FIGURE 4. A Representative Plot of Log P (Pa) and I/T (K) ET FOSE at Decreasing Pressure 26
RAWDATA PACKAGE
APPENDIX A. Approved Study Protocol #044-VP.P3M and Amendments
APPENDIX B.
APPENDIX C.
Test Item Information
Test Item Receipt and Usage
APPENDIX D. Raw Data Sheets
`Sponsor Swdy IDF U1463
006137
.
ASAeSlelSuRedpyor1tDF1O50U3V0P-.04R4I0M1
Page 6
Title: 3
STUDYSYNOPSIS
Determination (ET FOSE)
of
Vapor
Pressure
Curve
by
Dynamic
Method
for
U1463
Test Method: ~~ Dynamic method as described in AScl Protocol 044-VP.P3M Key Findings: 1) 2Th0eCesatnidma0t.e7d9v2aPpoaratpr2e5ssuCr.es of the test item, ET FOSE, arc 0.504 Pa at
StudySponsor
Company:
3M 935
Environmental Bush Avenue
Technology
&
Safety
Services
Building 2-3E-09
St. Paul, Minnesota 55133-3331
Study Representative: Dr. Rich Purdy
Ecotoxicologist
Phone:
(612) 778-5379
Fax: Tst Chemi
(612) 778-6176
4
.
i
Trade Name: Eberlin).
ET FOSE.
Lot/Batch Number:
61691-16 (Technical Laboratory Book, John
Sponsor Study Identification Number: U1463
Molecular Formula: CgF,7S0,N(CH,CH,)CH,CH,0H
Chemical Abstract Service Registry#/Code#: TradeSecret
Physical Description: White waxy solid
Percent Purity Representative.
(%
active
ingredient):
99% Based on information supplied by Sponsor's
Sponsor Sudy IDS ULE
06138
"
Stability Data: Stable at room temperature. Storage Conditions: Room temperature in darkness.
ASAeSlclSuRdepyorItD 0#35403-0V0P4R4.O0M1 Page 7
Company:
AEnSvcilroCnomrepnotraaltiToens/tAiSncgl-DiDvuilsuitohn (AScT) 4444 Airpark Bivd Duluth, Minnesota 55811-5712
ASC Study Director:
Linda Christensen
Phone:
(18) 722-4040
Fax:
@18) 722-2592
Reference Item
Trade Name: Toluene. LovBatch Number: 8608KTMH. CAS Registry#/Code#: 108-883. Percent Purity: 99.9%.
Source: Mallinckrodt. Date Container Opened: 4/3/98.
Study Initiation Date: 3/30/98.
`ExperimentalDates
.
.
Terminasi .
VDeatpeorrmiPnraetsisounreof
413/98
418198
:
H
.
:
}
cCoermtpilfeiteedd,copafiteesrwwihlilcbhe, atrhcehiSvpeodnsaotrtewsitlilngbefaccoilnittayctfeodr ftiovdeeyteearrmsinferofmurtthheerdaditsepotshietsiotnudoyfiasll records.
SponsorStudy IDF U1463.
06139
-
ASAeSlHSRuedpor1tD H1054043-0V0P4R4O.0M1
Page 8
1.0 INTRODUCTION
v`haaCrzhiaeromduissc.agloTsvhuebemsmtaeasnnscteesasslmieanngtternoocdifuecesen.dviiArncotcnoomtrehdneitnaeglnlvyfia,rteoonnamenednotfefptfhreeecstteeonsfttstphiosetestneotisdauelbtsdetirasmnpiconesesalitshaenredvqaurpieorerendtrbyy pderseisrseudreproefassusruebastnadncteh.en Ivnapthoirs perxepsesruirmeenatn,d tbhoeiltiensgt iptoeimntbaorielicnogrrpeolianttedi.s determined at a
`iTnhdeicvaatepsorthpereprsosbuarbeiloiftya osfubpshtaasnecetriasnasintieonnv,irvoolnamteinltizaaltliyonre(lleivqaunidt/pgarso)peorrtysubbelciamuasteio(n1) it
(solid/gas),
behavior of
of a chemical,
chemicals, (3)
(2) it helps substantiate predictions
chemical vapor pressure and water
regarding
solubility
the environmental
allow for the
calculation of chemical volatility
whether photochemically induced
from an aqueous
degradation can
solution, and (4)
be determined in
it is useful indeciding
the homogenous gas
`phase or in an absorbed phase (OECD 1993).
20 TESTMETHODS
2.1 Glassware. All glassware employed were cleaned before use by performing the following:
1
Washed in hot detergent water and rinsed three times with warm tap water.
2)
Immersed in 10% HNO; acid bath and then rinsed with deionized water.
.
3)
Rinsed three times each with acetone followed by hexane.
:
Aidlelntgilfaiscastwiaorne. used were labeled with the relevant information required for proper
22 wTeesrtelrteecme.iveTdheattAesSteilteomn, MEaTrcFhOS27E,, 1m9a9t8e.riaTlhseafteetsyt diatteam swhaesetsi,n aonnde cgelratsisfibcoattteleofaanndalwyassis stored at room temperature in darkness as received. All relevant information about the `test item is described earlier in this report. In this test, 14.21 g of test item was used.
2.3 ReferenceItem. Reagent-grade toluene was used as a reference item. All relevant
irenffeorremnacteiointeambowuatsthueserde.ference item is described earlier in this. report. In this test, 35 ml of
2.4 TestApparatus. Thetest system consisted of:
1
5-L Ballast bulb to vary pressure in double-neck distillation flask.
SponsorStudyIDF 146)
06140
-
AsAelSuRedpyorItDP150o3V0uP0R48t0M1
Page 9
2)
3)
4)
5)
a)
7 8)
Closed-tube mercury manometer to measurepressure.
100-m! double-neck distillation flask.
iCnentthiegrdiasdteilltahteironmofmleastke.r, + 0.2C, with one hole rubber stopper to fit
Reflux condenser.
Heating element.
`Vacuum pump. Aspirator.
9)
Boiling stones.
10)
Nitrogen cylinder.
2.5 Determoif VnapaortPriessourne. The procedure to determine the vapor pressures of test
and reference items was as follows:
nH
Placed the item in double-neck distillation flask at a volume about one-
third the flask volume, and added three to four boiling stones.
2) iFnlatnhgeesdystetsetmsywsatsemadjtuosgtetehderusainngd vpuarcgueudm.it with nitrogen. The pressure
3)
Heated the chemical gradually until temperature equilibrium was
reached, that is, when a constant boiling temperature was found.
4
At (in
this point, C).
recorded
total
pressure
(in
mm
He)
and
boiling
poinTt
-
5
5)
For
new
at least five dif
total pressures
fere
and
nbtopirleisnsguproeis,ntisnwcrheeanseedqupirleisbsruirae
and
were
recorded
reached.
6
`To obtain the second set of data, recorded total pressure and boiling point as the
pressure was lowered.
Sprioesnsor StudySyBIDrA UtGe14 s
06141
.
ASel Report #044-VP ROM
ASel Study ID 4503004401
Page 10
3.0 TREATOM FRE ESN ULT TS
pmFoolirinptela(ycTih)ndwgaatstahecsoeotnbvwseiertrthveedtdetsmtoialnlKdimbreyetfeaerdrdmeinecnregcui2rt7ye3m.ps1r,e5tsosttouarltehperweiostbshsuer1re3v3we.da3.scCSoibnmoviiellraitrnelgyd,ptootihnPeta.bouiTnlihitengblyog
Voafptoortalprpersessusruerecu(rPvae)svfso.r(e1a/cTh)
from item.
tVheapiondrivpirdeusaslurdeastafosrettshewteersetirteegmresasnedd
to develop the the reference.
item were equations.
determined
at
10C,
20C,
25C,
and
30C
using
appropriate
linear
regression
4.0 RESANU DDIL SCUT SSIS ON
ReferenceItem: Toluene
`The and
2o,bsreerspveecdtidvaetlayofbotraitnoelduenfeo.r
iTnchreeacsailncgulaantdeddercergereasssiinogntchuerpvreesssfurroematrheesphlootwtnedincuTravbelse,s
1
Figures 1 and 2, are:
Increasing pressure:
log p = 10.27-1994 r=-099,n=5
(IT)
(1)
Decreasing pressure:
Fr)
'
rlo=g -p 0=91908.3n5-=20523 (1/T) @
eTshteimtawtoeddvataaposrelpsraersesusriemsilaatr
and have correlation 10, 20, 25, and 30C
coefficients greater are listed in Tables
than 0.990. 3 and 4 for
The the two
toluene data sets. dynamic method
frToamblient5erlliastbsortahteorryancgoempoafrviaspoonrs
pressure (4).
values
determined
by
the
`
iTnhteertloalboureanteorvyapcoormpparreisssounress.
deTtheermvianleudesfdreotmeremqiunaetidonfr1omareequwaittihoinn
2thaerreanslgiegshtlliystleodwfeorr
the at 10
and 20C. established
iTnhtehevapprootrocporles(s2u.r9e-3f.o1r
toluene at 20C X 10 Pa). The
(2.8 X vapor
10 Pa) pressure
is lower than for toluene at
the criterion 10C
(1.6 X 10 Pa) is problem occurred
wliotwherthtehasnysttheemcarsittehrieonprsetsastuerdeiwnarsedfeecrreenasc4eed.(1.T7o-1.g8etXth1e0t7olPuae)n.e
A to
boil
as the pressure was whether this would
decreased, more have affected the
boiling chips temperature
were added and pressure
to the item. It measurements.
is
not
clear
Sponsor Study IDF U1463
06142
"
ASATSSRuepporItD o1s30t3v0p04601
Page 11
The experimental design
provide data comparable
presented here for
to that reported in
determining
reference 4.
vTahpoerrpergersesssuiroencucruvrevsesapapreealrisnetaor
for
both increasing and decreasing pressures.
Test em:ETFOSE
The
and
7o,bsreerspveecdtidvaetlay.obtTahienecdalfcourlaitnecdreraesgirnegssainodn
dceucrrveeassifnrgomthtehpereplsostutreed
are shown
curves of
in Tables
log p vs
6
(1/T), Figures 3 and 4 are: -
Increasing pressure:
log p = 11.09-3278 (1/T)
3)
r=-098,n=5
Decreasing pressure:
log p = 11.42-3435 (1/T)
")
r=-094,n=5
The regression line for decreasing pressure is more linear. than the increasing pressure
regression line.
8 and 9 for the
The estimated
test item. The
vapor pressures
estimated vapor
patre1s0s,ur2e0s,f2o5r,thaendin3cr0eaCsianrgealnidstdeedcrineaTsaibnlges
pressure conditions differ by 42-50 percent.
"
50 CONCLUSIONS
L
aTchceurpaltea,cesmteenatdyoftetmhpeertahteurrmeommeetaesrurienmethnetsa.ppaTrhaetusplparcoevmeednttoofbethpeivtohtearlmionmeesttearblfiosrhitnhge test
item
`were
was different than that
performed prior to the
of the reference
test reported to
item. Two previous
determine the correct
trials with
placement
the test
of the
item
thermometer. The thermometer was placed approximately one inch above thebubbling test item in the collection flask. The thermometer for the reference item was placed in the neck
of the collection flask.
Based on the decreasing pressure regression equation, the vapor pressures at 10C, 20C,
25C, and 30C were 0.194 Pa, 0.504 Pa, 0.792 Pa, and 1.227 Pa,respectively.
SponsorStudy IDF U1463
10614
06143
ey
.
e4e56pRehgorsyouaktRoobe
Page 12
60 DEVIATIONFROMAPPROVEDTESTPROTOCOL `The deviation which occurred while conducting this study is: D `bWehcialueseteostfilngowtesmtelittienmg, ptohienatirofcotnhedetnessteritweam.s used in place of water condenser
7T0o etfhfeecbtesotnotfheouorutcucrormeentosfciteinstitfeisct.knowledge and understanding, this deviation should have . 7.0 REPORTSIGNATURE
AScl Study Director
Name (signed):._--71~
: (oA
Name (typed): i Responsibilities, signatures, inital, and names of key personnel involved in this study are in
Table 10.
80 REFERENCES
by
GWOuarisgdahenilinizgnatetosino,fnorDfCoTr.esEtcionngoomficChCeomoipcearlast.ioOnEaCnDd DPuebvleilcoaptimoenntIn(fOorEmCaDt)i,on 1C9e8n5t,erO,ECD
. :
2)
SMhcoGermaawk-eHri,llD.BPo.okanCdo.C,.Wpp..
Garland.
162-163.
1962.
: Experiments
inPhysicalchemistry.
3)
Organization for Economic Cooperation and Development (OECD), 1997. *
Environment Directorate, Chemicals Group and Management Committee. OECD
NSeurmibeseron1.PriOncEipClDes PorfinGcoipoldesLoabnorGaotoodryLaPbroacrtaitcoeryanPdr`aCcotimcpel,ianceMonitoring.
:
`SponsorStudy IDF U1463
06144
.
mrmm an
Page 13
TABLE 1.
Toluene (Reference Item): Boiling Points (T) and Corresponding Vapor
Pressures (p) at Increasing Pressure
CC -- vewmmeipm-- an --
[ OObeserrveedTTaeemnperature]]
[e =nTTe+e[Twe eee |o 7a00a0 |vweeoso|[oworaewnn||| 47
ass |
-- | mo | sams
0.003245 NH
FeTo ew oeme Tswes Toeoe oowwn]|
sient
06145
.
mTmr m
- Page l4
TABLE 2.
PTroelsuseunrees(R(ep)feartenDceecrIetaesmi)n:g BPorielsisnugrePoints (T) and Corresponding Vapor
C [= vo TomL [veo | von [won| V Mase mdi Pesmn ie
7[wr"Oi bset rvede Tempen nnue
[ eeeo e [Toea Tw e 5e0T Ten se oeemwee]] :
C=Ton Tw m0 | ws T som]
CC
seori
006146
CL
)-
AS Report JOULVP FIM
ASC Sudy ID #5030.04401
Page 15
TABLE 3. T`Toelmupeenreat(uRreefser(eTn)ceDeItteerm)m:ine-EdstfirmoamteEdqVuaatpioornP1ressures (p) at Different
Co [ 7Veorrmamen|ToorProse Garayni]|
[=
wwe
me
= | owe
* Equation 1 -- Log p = 10.27-1994 (111)
'
Sponsor Study ID# UL463
006147
.
r Pp S
Page 16
C T oTTr ee rm m Tereeem] ] TABLE 4.
Toluene (Reference Item): Estimated Vapor Pressures (p) at Different `Temperatures (T) Determined from Equation 2%
=
we
es
Bein Lop = 035303 0m
resporni
006148
:
TABLE 5. *
PAepSeRastvi0d
Page 17
Range OECD
oafnVdaEpEoCr-LPraebsosruarteoVraylIunetsefrocromTpoalruiesnoenbTyestthiengDyPnraomgircamMe(t4)hod
from
x
eae
SomerSty 1 Us
006149
-- =~
ASel Stwdy ID #5030-044-01
Page 18
TABLE 6.
ET FOSE (Test Item): Boiling (p) at Increasing Pressure
points
(T)
and
Corresponding
VaporPressures
Com Tm)
[ 5Te e o oeem Tewweeee n eeeesw oaewen] |
C 1 onTT oo 1 von | som |
reer rs
006150
.
mmme rsr
Page 19
TABLE 7.
E(pT) aFtODSeEcre(TaessitngItPerme)s:suBroeiling points (T) and Corresponding Vapor Pressures
=nToo [wow [ve CC OobwwnvaerdPrmesasuree
7 [
Treo | wre o"OwbsreriveTdoTmemumepers]
[ o e o |e eownTT [o T e wme oa |a eon sn |ooomwa]n
Co Ton 1 se | me | wes ooms |
re rts
(06151
-
ASAeSlclSuRceypIoD O45A03V0-.04a60M1
Page 20
TABLES. ETeTmpFeOrSatEur(eTesst(TI)teDme)t:erEmsitniemdatferdomVaEpqouratPiroenss3ures (p) at Different
[TCO
"VaVporewbePreses won -- T VaVpapoorrPPrreossuurse (mmatity)p]|
|
ee Toe]
Equatio3n ~Log Pa = 11.09-3278 (17)
Example Calculation Log Pa = 1109-3278 (rm)
10C = 283.15 Log Pa = 1109-3278 (1283.15) LogPa = 11.09-11.5769
Log Pa = 0.4S869S
P0326
FormmHg = 01.3332.63 = 2.X41049
2
:
SponsorSwdyID# U1463
006152
.
ASAeSlelSuRdepyorItDJ4O5U0-3V0P0.4R40I1M
Page 21
TABLE 9. E`TTemFpeOrSatEur(eTsest(TI)teDme)t:erEmsitniemdatferdomVaEpqouratPiroenss4ures (p) at Different
[TCO
1 v"VeaporrPremssuwre (oPa) Tver Presure (uitp)y]|
r emT Tw
Equatio4n ~ Log Pa = 11.42.3435 (1)
Spontor Study IDI L463
06153
i
Sciomnmn
Page 22
[oe| min [meTm our] TABLE 10.
ET FOSE (Test Item): Responsibilities, Signatures, and Initials of Key Personnel Involved in the Study
[iotaCriveoms[soir [FUT77
To)
[pinLC oa SG Za ]7
006154
425 EEPEuen Figure 1. ARepresentativIencPrleoatsoifngLoPgrepss(uPra)e and 1/T (K) for Toluene at
4.20
4.15
4.10
|g 40s 2400
Sass
3.90
385
3.80
375
8 000300 0.00305 0.00310=~ 0a00m3)15 0.00320 0.00325 0.00330
;
|
. am 4.40 Figure 2. A RepresentativDeecPrleoatsoifnLgoPgrpes(sPuar)eand 1/7 (K) for Toluene at
Page 24
430
| 4.20
&
= 10
i
2 4.00
.
.
3.90
3.80 :
000295
000300
000305 000310 AT (K)
000315
o 00320
0.00325
3
-
2
& ssrr
.
Figure 3. A Representative Plot of Log p (Pa) and 1/T(K) for ET FOSE at
Increasing Pressure
Page 25
4.15
4.10 -
4.05
.
s 4.00
i
2 395
.
8 3.90
3.85
3.80
|
3.75
3.70
-
0.00212
&82
asp rs
0.00214
0.00216
.
0.00218
TK)
0.00220
0.00222
.
0.00224
.
sm
Page 26
Figure 4. A Representative Plot of Log p (Pa) and 1/T(K) for ET FOSE at Decreasing Pressure
4.15
4.10
405
:
4.00
& 395
:
2= 390 5 38s
i 3.80
:
375
.
)
370
:
365
RN 0.00212 0.00214 0.00216,,0.00218 0.00220 0.00222 0.00224 0.00226
8
.
UT(K)
. co
AASSclSuRedpyorItD#1054043-0V0P4.4R0I1M
APPENDIX A. Approved Study Protocol #044-VP.P3M and Amendments
APPENDIX B. Test Item Information APPENDIX C. Test Item Receipt and Usage APPENDIX D. Raw Data Sheets
LCoOPN) ple
t
.
;
Sponsor Sudy IDF Usdes
5
Pa| g of3e
006159
& wm Sw m_ AScl Corporation
November 4, 199.8424148)4A7i2rp5a4r0k4B0oulevard, DuluthF,axMi(n2n1e0)so7t3a25.52851912
To: Study File 5030-044-01
lee
From:
Alan E. Mozol, QAU Manager
RE:
Raw data package deficiencies
The following deficiencies were noted by the Sponsor when editing
DRAFT report and raw data for thisstudy:
b1.y ASTChIe-EcnhvaiirnonomfenctuasltodTyesptrionvgidDeidvisbyionthe(ETSHp)onspoerrsownansesn.ot ssoiognned
MatiitetcsehtAmaSeCEilItT-emEFSTiOwgDSanEsoorn(ep3lMrMlaoiprC,ecorhmlpwyah27no,ynloLgi1ags95eb8dn.oReinqlTuohenfesgoetlrlsoNaweumimmpnpblgleeoryAweaSUdsC14I6-as3Ete)TvDAeSlwLaogIseo-drErRsbehuoc.Be-i0vieTndhme.
The "Test Item Receipt and Shipping Form" was properly completed
wniaosstcionnngottaMiasnriecgdhned2i7n,a'sth1ea9n98roavwaesdrasttihagehtdoantbyepdagheer.ec25ei.igvneodTr.heelTCihhieaicnoomoprl-ectuecdtosfyorm
2. on page 31 in the raw data, an entry vas crossed out and not
Teplaced by 93 which provides a correct value. The correct value properly error coded by the technician. The initial value was
3.39101 and the 39 after the decimal were crossed out and
is a calculated value and not a raw data point. The lack of
proper error coding was a technician error.
FP
-
The following explanation is also provided for clarity:
5
on page 33, some
These entries do
entries are
not pertain
blacked-out to make them unreadable.
to the vapor pressure study, but do
apply to other studies conducted on the test item.
pace[rot 22
06160
a
to
5AcSclSRueppor1tD#s034a4s-0V0Pk.iRoInM
APPENDIX A. . Approved Study Protocol #044-VP.P3M and Amendments
Sponsor Sud 104 1463
PY
0614 61
.
AASSeell SPurodoycoIlDsF05034V0P0.4p44o0m1.
Fal Version
Pugs 1orn2
AScl CORPORATION/AScl-DULUTH ENVIRONMENTAL TESTING DIVISION Determination of Vapor Pressure Curve by Dynamic Method
ASc Protocol 044-VP.P3M
ASel Study IDF 5030-04-01 TestItem: ET FOSE
@
:
Sponsor Stdy IDF Utes
Pade. 2 a3
coc162
.
AASSeel SPruodceIlDsI054043-0V.P0.4P430M1
Fina Version
Pagerariz
The following information
Practice regulations (GLP)
and signatures are necessary
and/or AScl's Policy.
to
be
.
in
compliance
with
Good
Laboratory
INFOTROMBAETICOONMPPLREOVTIEDDEBDYBAYScSITBUADSYESDPOONNSOR
.
StudySponsor
Company:
3M Company
SiteAddress:
3M Center
St. Paul, MN 55144-1000
Mailing Address:
Dr. Rich Purdy
3M Company
Environmental Technology & Safety Services
B9l3d5g.Bu2s-h3EA-v09e,nuPe.O. Box 33331
St. Paul, MN 55133-3331
Phone:
Fax:
612/778-5379
FAX 612/778-6176
`
"
-
Number: U1463.
Lol/BatchNumber: 61691-16 (Technical Laboratory Book No., John Eberlin).
ChemicalAbstractServiceRegistr#/Code#: TradeSecret.
MolecularFormula: CgF;7S0;N (CH;CH) CH,CH,OH.
`PhysicalDescription: White waxy solid.
Sponsor uty 01 lies
r+pe agefof ?%
06163-
.
AASSeell SPruodtyocIoDlIG540430v-P0.4P430M1
Fiat Veion
Page 3of 12
Percent Purity(%active ingredient): 99% Based on information supplied by Sponsor's Representative.
`StabilityData: Stable at room temperature.
MeltingPoint: Not determined. BoilingPoint: Expected tobe less than 350C. StorageConditions: Room temperature in darkness.
ReferenceItem: Toluene
cNhoetmei:caTlh.e sponsor will provide the Material Safety Data Sheets and other relevant information for test AuthorizationtoReturnTestChemicalandSample(s): Sponsor's authorized agent to receive samples
and any remaining test chemical.
Name:
Dr. Rich Purdy
Tide:
Ecotoxicologist
Shipping Address:
E3nMviCroonmmpeanntayl Technology & Safety Services
`?
'5
935 Bush Avenue
Building 2-3E-09
St. Paul, Minnesota 55133-3331
:
Phone:
Fax:
612-778-5379
612-778-6176
|
`
SponsorStudy IDF ULeea
as &
# 5%
PaIgeof2172
;
C06164
' . or
5ASacl PSroytocoolrF0so4oa4lv-0VV0Pe0_rePom3nMn Pe doriz
Protocol Approval (The following is to be signed by the appropriate study personnel.)
ive:
Name (signed): "
;
\
AZ Marek 28
Name(yped ___ DrRichPudy
Te
Fcoogoologit
Spoor Sud 108 1463
or staf
rona23 Te
006165
:
"
AScl Protocols 044-VP.PIM
EJv ASel Study IDF 5030-04-01
`TO BE COMPLETED BY AScl
Study Conducted By
Address:
AScl Corporation/AScl-Duluth
En4v4i4r4oAnimrepnatraklBoTueslteivnagrdDivision (AScl) Duluth, MN 55811
Phone:
(218) 722-4040
Fax#:
(218) 722-2592
"The study director is located at this facility.
Data Standard
`OECD Guideline 104, "Vapor Pressure Curve, Dynamic Method."
--
"
,
Experiment:
Starting Date:
Termination Date:
:
Vapor Pressure Curve Determination April 3, 1998
April 3, 1998
sncwyiorios
peoe sb<y6
rage TITS
006166
AASScEl SPtruodtyocIoDlF054043-0V0P4.47021M
Final Version
Page Gor12
ProtocolApproval (The following is to be signed by the appropriate study personnel.)
AS]StudyDirector:
:
Name (signed): Z..
LA
. 3[3:/95
Name (typed): =~
Tide
LindaCheistensen
AmlelChemiy
0
ASd]ProjectManager:
Name (signed): Name (typed):
_
3/30/35,
Tide
DepuyDiregr
00000000000
`SponsorStudy IDF U1463
>
rage 8 ot 22
cce167
. 1.0.0 INTRODUCTION
AASSeSl SPtruodoycoIlDsI054043-0V0P4.4P031M Final Version Pus Torn2
Chemical
hazards.
substances introduced into the environment present potential disposal
The assessment of environmental fate and effect of these substances is
and reentry
required by
various governmental agencies. Accordingly, one of the tests is to determine thevapor
dperseisrseudreproefssaurseubasntdantchee.n vIanpotrhipsreesxspuerreimaenndt,botihleintgesptoiinttemarbeoicloirnrgelaptoeidn.t is determined at a'
The vapor pressure of a substance is an environmentally relevant property because (1) it
indicates the probabilityofphase transition, volatilization (liquid/gas) or sublimation (solid/gas),
of a chemical, (2) it helps substantiate predictions regarding the environmental behavior of
chemicals, (3) chemical vapor pressure and water solubility allow for the calculation of
chemical volatility from an aqueous solution, and (4) it is useful in deciding whether
photochemically induced degradation can be determined in the homogenous gas phase or in an
absorbed phase (OECD 1993).
4
200 QUALIFYINGSTATEMENT
"
The dynamic method is restricted to test items that do not undergo chemical reaction, for
example, autoxidation, rearrangement or degradation, at temperatures below the boiling points.
In this study, if the test item boiling point is greater than 350C or if the test item froths, then
the test substance vapor pressure will be not be determined via the Dynamic Method.
Sponsor Sudy IDF U1s3
3
ose at22
006168
. 3.00 ORIECTIVE
AASSe SPurdyoDt1o3u0t3V00P4P401 Fi Vein Pus sorn
The objective of the present study is to develop if possible, the vapor pressure curve for the test
item using the Dynamic Method.
With the test objective, and GLP regulations in mind, ASel has prepared the following:
protocol.
4.0.0 TESTMETHODS
4.1.0 TestApparatus. The test apparatus (Figure 1, Shoemaker and Garland 1962) will consist of:
(1) 5-L Ballast bulb to vary pressure in double-neck distillationflask;
@) Closed-tube mercury manometer to measure pressure;
(3) Double-neck distillation flask;
(4) Centigrade thermometer (accuracy + 0.1C) with one hole rubberstopper
to fit the distillation flask;
(5) Reflux condenser;
(6) Heating element;
@ Vacuum pump;
Nitrogen cylinder; and
.
`
(9) . Boiling stones to avoid bumping in boiling liquid.
.
"
Sponsor Sudy IDF 1463
rage(Cot >
C6169
"
AASSeell SPrwodtyocIoDlF054043-0v.P0.4p430M1
Fal Version
Pages or 12
4.2.0 DetermoifVnapaortPriesosunre . The procedure to determine the vapor pressure curves for "test and reference substances will be as follows:
(1) Place test substance in double-neck distillation flask at a volume not exceeding one-third the flask volume, and add two or three boiling stones;
: (2) Flange the apparatus together and vacuum it;
(3) Adjust the pressure in the apparatus to 103 Pa using nitrogen;
(4) Heat the test substance gradually until equilibrium is reached, that is, when a constant boiling temperature is found;
(5) At this point, record the total pressure (Pa) and boiling point (T); (6) Increase pressure and record the new pressure and boiling point when
equilibrium is reached; (7) Continue this procedure for at least at 5 different pressures for up to 105
Pa pressure;
To obtain a second set of data, record pressures and boiling points as
.
pressure is lowered to 10 Pa.
:
5.0.0 TreatofmReesunltts. For each data set, log of total pressure (Pa) will be calculated and
boiling point (T) transformed to Kelvin (K). The log Pa and 1/T (in K) will be then used to develop two vapor pressure curves. From each vapor pressure curve, the test substance vapor pressureat three temperatures in the rangeof0-50 C, and at 25C will be determined by data interpolation or extrapolation and reported.
Sponsor Study TDN UL463
2
page Lat37
606170
.
AASseel SPtruodtyocIoDlF05404-3V0P0.47430M1
Final Version
Page 100112
6.0.0 REPORTPREPARATION
The final report will be prepared according to instructions presented in OECD Series on Principles of GLP and Compliance Monitoring, Number 1, OECD Principles on GLP 1997. The report will include (1) Cover and descriptive title, (2) Test and reference item identifications (3) Characterization of test item including purity, stability, and homogeneity, (4) Information describing the test sponsor, test facility, and contributors (5) duly signed statements regarding GLP Compliance and Quality Assurance, (6) Study Synopsis, (7) Introduction and Objectives, (8) Materials and Methods, (9) Results and Discussion, (10) Conclusions, (11) any Deviations from the Approved Study Plan, (12) Study Director's Report Signature, (13) a list of personnel involved in the Study and their Functions, (14) Literature References, (15) Raw Test Data, including the plot of log P versus 1/T, and (16) Appendices.
7.0.0 QUALITYASSURANCE
Test procedures, documentation, records and reports will conform to GLP Siandards as
promulgated under the OECD Chemicals Group and Management Committee, Environment :
Directorate, 1997. The ASel Quality Assurance Unit will perform one in-life phase audit during
the test, and will also audit the study plan, test data and report. The test will be unacceptable
if vapor pressures of reference item (toluene) are not in the following ranges: 1.7 + 0.1 x 10%
at10C; 3.0 + 0.1 x 10 at 20C; and 4.9 + 0.1 x 10 at 30C.
:
During the study, if ASel realizes a need to amend the approved study plan, we will document reasons for such changes and contact the Sponsor for approval. The changes will also be signed and dated by the Study Director and maintained with the study plan. After acceptance of the final report by the Sponsor, ASI wil return thae portion of the remaining test substance 10 the Sponsor, and a portion will be retained for archiving.
Sponsor Sudy IDF Las)
006171
Page. Dt 4
TTT
}
aii St t. m
as
motion
Raw data from this study, study protocol, pertinent written and telephone communications, and
"final report willbearchived forfiveyears at AScl. Diring the fifth year, AScl will contact the
Sponsor regarding further storage of all records.
8.0.0 REFERENCES
Organization for Economic `Cooperation and Development (OECD), 1993. OECD Guidelines for Testing of Chemicals. OECD Publication Information Center, `Washington, DC.
.
Shoemaker, D.P. and C.W. Garland. 1962. Experiments in Physical chemistry. McGraw-Hill
Book Co., pp. 162-163.
Organization for Economic Cooperation and Development (OECD), 1997. Environment Directorate, Chemicals Group and Management Committee. OECD Series on Principles of
Good Laboratory Practice and Compliance Monitoring. Number 1. OECD icy on Good i
Laboratory Practice.
'
.
soir sis
pa(5goi3e%
006172
.
wn r rmr nlusisngrs
_----
FIGURE 1. APPARATUS FOR VAPOR PRESSURE DETERMINATION
0
nce]
Caer
i
=r le
WEES A
ae
ZY
NA
iT
,
.
.
Vis
Stopencs .
----
mmr sty 08 rk
5
pose LL
006173
iE TL. 0
N
\ R pp (ASCI Protocol 044-VP.P3M)
AACSEcIsPtraMoytaoncTcooarl!asno0t4sS4a-oV4r/Pi2.o7Pa0in8H
Q following amendments have been instituted for Protocol# 044-VP.P3M, Sponsor Study ID# U1463,
0C200C. i The centigrade thermometer used for the study will have gradationsof 0.2C and not 0.1C. * This is due to the commercial availability of thermometers in the expected test range of
2. `Thedistillation flask will be 100 ml instead of 500 ml to accommodate the smaller sample size. 3. `The distillation flask will be insulated with foil during the experiments to minimize heat loss.
AmendmentApproval
Re
:
Name (signed):
Name (typed):
Date: ShAol 1595
Title:
et
Ecotoxicologist
Name (signed): G4 {
_
Name (typed):
Linda Christensen
Title:
Analytical Chemist
4
,
Date: 4 3/:77
:
eee
~
ASclProject Manager:
Name (signed):
7z
Name (typed): `Title:
Joe Amato Deputy Director
------
Sponsor Sudy [DF U1463
pagal 30
co6174
.
AASSeCllSuRdepyorItDF04U540-3V0P0.4R630M1
APPENDIX B.
Test Item Information
.
t
.
Sponsor Study IDF Utd
asm (632
006175
wy
MDAATTEARISAHLEESTAFETY aMM canter
Ui4p3
(Intermediate) 1SSt8.810404P--a3u1l60,40-03M6i7n7nesorota(612) 77-6501 (24 hours)
AiCLonLpfyorrriaigaghthtit,osn r1Te9os9re7,rvtehMdei.npnuersCpoootpsayeinWgiofniannpgdr/ooparenrdldyMoanunltuoifaladiciztniungrginosg is allowed provided thas:
tGroisspany. products
1) 2)
ndpteirhisiettohrrieirnb.afugotrtreahmdeeastweciinoottpnhyiistnoohreoc.boittphnaietieendonetrdiiinogrnifonumoalfllSheiW.asirtnharinengsngooladchpoarrnogfoeitstheurtnwnlieassreson.
MDAITFVFE-ILRaSUII9DAO0RLN5OS:CHFE-N8SI5PC6EA0CLIAALLTCYOHMOALTEFRHI-A3L0S20DIFVHI-S0I8ON24FH-4084 FH-4120 F-4121 F-3904
I1S0SUNEUDK:BERO:cto4b1e-r216-032007,-0009-10394097-244-5.41.42610-02-780000-54-0184-741-24610-02-780906-04-1620-041-4217-0307-03052451.971-7
DSOUCPUENRESNETD:ES:04M-a1y16025,. 1996
1. Incacotent
as wo.
N-AELTCHOYHLOPLE.RFLUOROoOcG.TANESULFoONeAeMnIOoOsETHrYeLe. 1601-08-2
2. PHYSICAL DATA
Te :
vBaOpIoLnINpGrPeOsIsNurTe::..1..1.1..1.1..1.1..1.... EN/yA pasa EVVAAPPOORRDAETNISOINTRYA:T.E.S.....1....1.1..1.1... Nii@ob131F pPSShEPOeRELCCUEIBNFITILVCIOTGLYRAAITVNIILTWEYA::TE1R:...L1..11..11..11..1]. CBnaeYvgli1g%. waters WvELTiINGspotiLiioILs11iItIIvIiII MVEA APPAnEbAoRrA,NCEwarAyNDso0b0i0dM.:
percent 100
:
:
.
i
*,
ASCl Study 104 5030.044.01
Abbreviations: N/D - Not Determined N/A - Hot Applicable Ga - Approximately page (101 33
006176
sity Su
OMcStDSo:berFF-L83U90O0,R0O51C9FH9-E70M0I6C0AL
ALCOHOL
FM-3923
FM-3924
FM-4084
FM-4120
FM-4121
F-8904
PAGE
2
"a. FIRE AND EXPLOSION HAZARD DATA
FFLoAuSwHsPeOLIENTL:InoiT.s o"oL.E.C.T w> a300 F PHO
FLAMMABLE LIMITS - UEL:........ N/A AUTOIGNITION `TEMPERATURE: ...... N/D
EXWTaItNeGrUISspHrIaNyG, MECDaIrAb:on dioxide, Ory chemical, Foam
AScl Study ID# 5030-04401
SPWEeCaIrALfuFlIlREprFoItGeHcTtIiNvGePcRlOoCtEhDiUnRgE,S: inoludirg helmet, self-contained,
.
Ppanordsoittepaicnvtteisv,eprcebaosnvsdeusrrienagroorfuonprdreesarxsmpusor,seedwdaeiamsratensdsanbodrfelaetthghesi.,nghefaaadcp.eparmaatsku.s, andbunker coat
UNSUeSeUAHLazFaIrRdEoAusNDDeEcXoPnLpOoSsIiOtNioHnAZAsReDcSt:ion for products of combustion.
NFPA HAZARD ODES: HUENAULSTUHA:L 2REACFTIRIEO:N H1 AZARREDA:CTInVoInTeY: 0
47 ReacTIvVITY DATA
:
STABILITY: stable
INoCOnMePAKTnIoBwInL.ITY - MATERTALS/CONDITIONS T0 AVOID:
HAZARDOUS POLYMERIZATION: Hazardous polymerization will not ocour.
HAZARDOUS DECOHPOSITION PRODUCTS:
Carbon Monoxide and Carbon Dioxide, Hydrogen Fluoride.
.
5. ENVIRONMENTAL INFORMATION
SPOPIlbLasLceerRevseipnopanrseecc:laousteidoncsofnrtoaminoetrher sections. Collect spilled material. REPpICrrnOoocMddiEuunNcceDttrEsaDitnWeiDlaIilnSfPaOiaScnnAicLlli:iuntddyeusHptFer.rimailDtitoserpdocstoaomlmaecraocleitpaetrlnaeftahiceviaeli:istsyl.bWiasrpCrooess:sbusotfiomnaste
.
- .5
i
d
006177
Abbreviations: N/D - Not Determined N/A - Not Applicable CA - Approximately
PageBo 22
Sy. 180: FF-L8U9O0R5OCFH-E8N9I6C0AL ALCOHOL FH-3023 FH-3924 FH-4084 FM-4120 FM-4121 F-8904
Jctober 30, 1997
PAGE 3
5. ENVIRONMENTAL INFORMATION
(continued)
NVNIoRtONdMeEtNeTrAmiLneDdA.TA:
AEVCoUlLaAtTiOlReY OIrNgFaOnRiMcATICOoNs:pounds: N/D.
AS Study 1D 5030.04.01
VOC Less H20 & Exempt Solvents: N/D.
Sbienfcoere rdeigsuploastailo.ns EPA Hazardous.)
vU.aSr.y,
EcPoAnsHualztardaopupslicWaabsltee :
Mruemgbuelrat=ionsNonoer
a(uNtothorUi.St.ies
SPFIORREA HHAAZZAARRDD:CLNAoSS:PRESSURE: No REACTIVITY: No AGUTE: No CHRONIC: No
6. SUGGESTED FIRST AID
eveNoconneteadctf:or first aid is anticipated.
SKWIaNshCONaTfAfCeTc:ted area with soap and water.
INHIfALAsTiIgOnNs:/syaptons occur, signs symptoms continue,
craelmlovae
ppheyrssiocniatno. fresh
air.
If
IFNoSHAnLeLeOdWEfDo:r first aid is anticipated.
@
.
7. PRECAUTIONARY INFORMATION
EYAEvoPiRdOTEeCyTeIOcNo:ntact. Wear safety glasses with side shields. Hear full faceshield when handling molten material. SKIN PROTECTION: maAasvttoeeirrdiiaasllk.itnoWceopanrtreavceatnp.tprtoWhpeerraiaaratleapbgpulrroonvpser.si,atesucghloavsesNowmheexn, hWahnednlinhgantdhliisng this RESPCruOofUvfNiiEdcNeiDeEnDatpVpvErNeoTnpIrtLiiAalTtaIetOiNol:nocatlo emaxihnatuasitnwheemnisspiroondsuctbeilsowheraetceodm.rendPerodvide exposure Linits. If exhaust ventilation is not adequate use breviations: N/D - Not Determined N/A - Not Applicable GA - Approximately
006178
Page \ of 37
SDS': FFLoUoOnRsOCHFE-M86I6C0AL ALCOHOL FM-3923 FH-3924 FH-4084 FH-4120 FH-4121 F-8904
Jctober 30, 1997
PAGE 4
"7. PRECAUTIONARY INFORMATION (continued)
appropriate respiratory protection.
SESPIRATORY PROTECTION:
.
ASSRveeioRgrieubdclotartnbieoronenecasot:onhfciennghhtaelroffatTmiovaolasnipkooruosfio.nrgCgoaANnnItivOacoSniHidvnaapsbnoprcrpesraetravheneisddnpgirrianoetfsoapraei.ierroabrtFodouerrlnnslcefebamanawsstieetnrhoiroaynBleS.nHiAc
Vapor respirator, TULl-Tace supplied alr respicaton
PRWEaVsEhNTIhaOnNdsOFaAfCtCeIrDEhNaTnAdLlinIgNGaEnSTdIObNe:for eating. Do not ingest.
}
REKCoOoMpMEcNoDnEtDaiSnTOeRrAGcEl:osed When not in use. FIRE AD EXPLOSION AVOIOANCE:
ASCl Study 108 5030.04.01
Nat appiicabie.
ExvosuRe LINITS
neseorenT
VUE wT Tee Aum sks
AEUROL.TRYLPERFrLoUeOHOOGTOANRHIEOSOUETLHFY 0 Was TA wmv
tS*hneGSLKIupNdoitneNgnOtTmiAuaTlcIOoNuc:sonmterLmiibbsrutateindoensauntbdosteatynheco,esovoeLirtnahdleilrcabetyxe.pdoasiwurirbteohrnb*syY' torhu,endsceuertraeSnKeIpoNeursc.riecfrueoiruatretloy, by direct contact with the substance. Vehicles can alten skin sorption:
" :
SOaUnR:CE OFanEXPROeScUoRmEenLdIeNdITExDApToAs:ure Guidelines
o. WEALTH Hazan) BATA
)
eveWocoandTvaecrrs:e health effects are expected fron eye contact. ScParnodcuocnttaics:not expected to be irritating to the skin. H"axyanbegaabtsionreb.ed through the skin and persist in the body for an
006179
Abbreviations: N/D - Not Determined
N/A - Not Applicable
rP ae2a2 ofs 22
CA - Approximately
MBBS: FLUOROCHEMICAL ALCOHOL FM-3823 FM-3924 FM-4084 FM-4120 FM-4121 F-8904
October 30, 1997
PAGE 5
"8. HEALTH HAZARD DATA (continued)
DawaTeIOn: May be absorbed by inhalation and persist in the body for an extended
ILiness may occur ater a single swallowing of relatively large
OTHTEhRisHpErAoLdTuHctHAZ1A6RDn.otTHnFOoRuNnATItOoN:contain any substances regulated under
.
seTion Gianes bares
set Stuy 104 503004401
Aibrevistions: Nib Not Determined WA - hot Appiicabis Gn Mprerisstely .
:
HT5TE0RhRPeLGcIoRSErAnDrNf,eTocArtGTmIHaOLt5LIi.UToDYnINOiGnnt,hetFhTBiUTdasTVtEeSNN.SOaTtseFerOLsRdsIaeWdAlA.TSPEAaDRf5Teh0It.CMyUALRhDAEaRySt,aNPtoSooRhpewrasectsAeR(AoNnSILSEe)Ss,TaitsEeAobenoeLeliLeevredotto PERFORMANCE OR USAGE OF TRADE. User Lo. respoumiots vor serahing
3H provides snforsation in electronic fora 35 a sarvios to its customers.
in errors, omissions or alterations in this information, 3M makes no
iInnffoorrmmaattiioonn oinbtathieneHdOfSroamveaisdaatpatbeaspearmeanytsnobt ebe 3as8 current as the PageHo3f7
006180
See
7 MATERIAL INFORMATION TRANSPORTATION DOCUMENT
Divison: BE - SPECIALTY MATERIALS DIVISION
HIIsTsuSedD:ocu0m7e/n2t2'/9704-3216-1 *SupeSrrsaetduenss: c0o5m/p0e3r/e96
Watortal:
F-FLoUoO4R7OrCHGEoHoICALF-A09M9I1DE FM-4220 F-7604 F-7605 F-8005 F-8903 F-8929
Aion section
Statue: Comper bate:
09716795
D"ipvi,vR.eCuAoeunsttthaocortr:.: CTKAOEMOLMPLYEYRJBOOWMRINLGGRGOEINNTON
PPPrrhooonnneee::: 577233076---64411805382
Comment: aeFtlXe.tv1ha2itse(d4t1te-em2mp6pe0er0ra-at8tu9ur0re0e-.6t)o(6kW.0Li:LayL 91b5e-1Rc0eh5La0tr)agnedaanndtdoHiftsahcseitbtioatneksseeitrnutecaaksiyneadt
.
SdraiHnag.e. FX.12 easontiaity has ne fiasmporne (bp, tote
Specitic use: Fx.12
WTSAyThpEeeReIsoAtfLiTSYoGPrEi:ar:.1 ..a..v.. c.ioIvI1 oItonoIyoL ..I... aSAOeLID
.
Tested for Hammabio Soiiei 1111100 he
PPPRrrOooTttEeeCccTttIVrfErooSmmEHRVFeIraCeEtez:iRnE0gQ:UImR.EoHEm1N1TeS:n.I ..1. Nhoe
I
SWSTaOOtRNeADrG:ERRE1Qe.ULIREauHEvNc1TS1e: trinev.e.:. Clone Semsitiver 120101
hwIeenside;
Outoide
CHENICAL COMPATIBILITY WITH PACKAGING MATERIALS:
PGEoPplaloyganeant:Lhsiytneleeeoddnsen.S:e.oe..d.s.1....1I...1.I.cc1.Iuu1u..n1..Vv1VeNeOae
Stainess Stee1t1 .I .. ves
REpPrORoTAlBLeEuQmUAiNTiITiYiOdF mHAiZoARnDOtUSeSiUBaSnTANCE:
MPAORLIINUEEUPNOLLSLo UTANT Hr AZARDOUe S SUBSTo ANCE: No
HzARD OEEINITIONS:
:
:
:)
1 Sty 108 SOBA
Abbreviations: N/D T- Nnot DTeetreremmianeduseNo/Any- No"0t Applicable
PageLui 52
006181
De
04-3216-1
AUTHOR SECTION
MATERIAL INFORMATION TRANSPORTATION DOCUMENT
(continued)
Page 2
* HDEOETTSHANZOANRED OCFLATSHSEESHA(ZSAORLIDD)DEF*INITIONS HAZARDOUS MATERIAL:
Ingredients
No Ingredients Selected...
CAS. No.
Percent
TOXICOLOGY SECTION Name: LARA ANDERSEN
Status: Complete
HAZARD DEFINITIONS: + HTEoExTzScoNLOoNaEy O+F THE HAZARD DEFINITIONS
Date: 03/24/95 Phone: 612.737-0
"TRANSPORTATION SECTION
Status: Complete
|
I0/Sample Package Description
FSS A/G. FGC PSC Flash Pt
41-2600-8961-4 55 GAL/220 LITER METAL DAUM
4 aso A
Classifier: RAYMOND DUZYNSKI 05/03/96
41-2600-9391-3 C5l5asGsAiLf/i2e2r0: LRIATYEHRONMDETDALUZDWRSUKMI 07/22/97
4 as A
2
41-2600-8947-3 C5l5asGsAiLf/i2e2r0: LRIATYEHRONMDETDAULZYDNASUKMI 04/24/96 4 ass A
41-2700-4220-7 55 GAL/220 LITER METAL DRUM
4 asa A
Classifier: RAYMOND DUZYNSKI 03/29/95
41-2600-6903-5 CClAaRsGsOifTiAeNrK: TRAAUYCHKOND DUZYNSKI 04/09/96
3 asa A
:
41-2600-8929-1 C5l5asGsAiLt/i2e2r0: LRIATYEHRONMDETDALUZDWRSUKMI 09/18/95 4 asa A
ASel Study IDF 5030-044:01
AbbreviatioWnis0:|Not Determined Nia Net applicable
- 3M INTERNAL USE ONLY -
pendof 22
TT
006182
Br:
7#5 arenes CONTRACSTH LEANBVGIRRAOTMOERNYTAWLORKLAOBRODRAETRORBYY Save |
1
LAD REGLEST No. Uiess
CONTRACT LAB(S): asc
DPDRAREETOPREJAUERECTRSTHETECONERNTIO:V:NEAD0M0:2E61:103R/E26F/U1R9D9Y8
PDPERRAXOOTPNJEEECCCOTfMOoPL:LEEDTAADTE:ER::Ae05F/SU8R8FD/Y1558
DESC: ET-FOSE 5 and Ur Determinations
SH FAX RO: 612-778-6176
HE 3otCthleey rtlianbeleSdo:-sR-E0Xa 2 N.. ETFOSE Alcohol 6161-16
Do vagor pressure under GLP, determine boiling point as part of UP study.
serie bate cone
DESCRIPTION ResuLT
WoL or (95% 6.1.7
1 03/2n ErFose eee . AASSECL UEOmIeLr-PiTs-eE MwEAGRUOIRLIPSrReIsUsNurSeOILING FORT `+
* = CONTRACT Lo DATA = LeDATED DATA
pose Xo3
ASel Sudy 10# 5030-004.01 006183
Sg
.
DATE: 03/26/1998
CONTRACTaNELAIBOIRARTOOWREYNTKAOLRKLOARBDOERRA.TO3RYPARAHETER Las Retest 0. Utha
coamact Lap + asc PROJECT MONEER : 05
sure: 3/78
PROJECT LEAD: ke Fury eee:
ot --
CoenComputer Test Name
- Sample Numbers SabSiamtipeilaesle Rbbeasstuelt
.
ROILPT-E EQUILIERIUN S01LNG POTTY
:
VAP-FRESS VAFOR PRESSURE
1
avers
03/27/1958
oserns
05/27/1558
re D>
Pa22gof3e2.
AScl Study 104 5030-04401
006184
| . SGhrainnttccuustsodytrors
cons B[ ETRedB y ER NY
mForrd:foodan(cSoineierFA ree I -- me
FLfOI963--\
Florey=
Alaa pad [1]
Wado ede [ITT [1]
IE rrr |
mH 2
1
Ere
rrr
Perr
EP E e
T I TTT I
[1
[tCeelm inasvos1 tyntivTionT | TI ime T | owIeTT|TsInoTpTes
[1
rory sso0100
1
|rectedtymision | rime | owe]
rr r rrTT
2
rrr
TT] 11
2RTE
--
TEET cre Dror oRy ] wde
Pn ASAeSlelSuRdepyoIrDt F4O50U3V0P0R44I0M1
APPENDIX C. Test Item Receipt and Usage
Sponsor Study IDF 1463
rage2s5|
006186
ECARe
)
E5rCmomppieruaubnse
R
TEST SUBSTANCE RECEIPT AND SHIPPING FORM
J instructions: File copyof completedform (both Pars 1 & 1 inthestudyfile.
PART I- Test Substance Receipt
-
isubance:
Eo
Ae
2M Eo,
-
_
--
f reso0o O eits i 3/10s 7 e ous ear
Br cod NumberofConnersReceive
_ of Sozfoy
:
1
ross eight ofContainer14 Tet Suboace: lig wits cp
f eof Trporo as ionecetot oriy.e 0g sey
---
p = E[wE e = Tw ee TJotenr aSiss Bone,
U 4L3
SuneLoopmeg weGICATG
' Fon
press
Tomy
feu) Ton
omens
Th
--_
Jon hd
froin: 07
ee TT --
TehSvbthen shmr ctu _
igioalMSDS 1ad Mailing Receipts FiialNoteebodok: Yes
2 LiF Starts
_
wt
_
--
erie. 150
Sof rede 20
Sel Study 10# 5030-04401
Page Bos12
006187
----
FP | RvENd}!
.
`TEST SUBST USA AGN EFC ORE M
structions: Acopyoftis form ustbe ledinthe StudyFile. -
Eseol CvoSroipnaenomssiiinogoiaSAvniSineias wi 58
Rl
ASel Study IDF 5030-044.01
e PART I- Test Substance
-
TetSubstance:
ML3
DateTest SubstanceReceived: 3/2 7fey
o
Spomsor: 3IM
Asc sudy Df: SOO --O4Y-0|
Type iretcpa andNumberof | Gest Comvtninan_ Opening Comin DatedInitials ofPerson WA 33s
B LE ee en | UevRermEerS Teosse
{
M54, witeap |3/27/54
i
.
| 4% 031% witcap | ft/s
i
[7
rr Te Subiance Lot No. Bach Now ie
ART I- Test Substance Usage Log
BFema
OT
fies
SR Cel ToulWemovellST]
:
Stalls Dated
agbofiy | 360mg |236mg hull,of [wk 3he:
2dlfay |is.esry. | ZI aN ap Pdoess look defi
ley model, | zante wp
lwfyld
illefsg [19.2028 | Hsuwa [l ufutyhs
i
[1 1
is
1 1
in
1
is
11
--
-- _coeiss
Bllcive: 11998
SOF Page 5 ofAO
rage] of)7. Paes
Vere tt`
AASlclSReporu ItD ##054d 043-0V.P0y .4R4I0M1
APPENDIX D.
.
Raw Data Sheets
Sponsor Swdy IDF U1463
Pagofe3?2
006189
{be
f Com si
:
VAPORPRESSURE DATA SHEET
4
Sele
Date: Ylelos
payee M5
Sudy ID#:_S2IO0I07
Tele [Yo
l= (E= [eo]
[erie| 35Torus[don|
455
|siger[0100357]
io[sv20 [vis[sie| seuss lovoomes |
[| rex aC mal s[a 505 ft user ja asend
Fe
T= 1]
at ree
Fe
se|
fe| soonnt|Ga FrToma] [test[577
| wwaas [30s
|Rrooninc|" [ouceons]
:
a[ose or en loin[50
[sae [owe Lois [ovoomis
| |
EE
pos
WL 5r
ead bo
ake gogo putin
|
|
Tl retth adotina femen' |
i eee
7 o Twepempou
mpg-i A 30s % 2e a --r 02an rr]
LL
S = 13T
PP erar s soa wn beww
Temp. (K) = 273.15 + Temp. (0) Peli onRage nowsost 000006 19g
Ee and
es med?
-
he
BEST COPY AVAILABLE. 7
VAPOR PRESSURE DATA SHEET
one 417h3i 8A _
a
Srteudmy eDm#:_SLA03109-603447/
EE!
rT ee
o5r [|huaonseias|[[sGsaaosmwoanss]|i[1(i7975.00|[[adveiouars[aaeooorrnre]||
o5 55TTToroaosuustta[[[hcioogttwsseorr|[|1j[4aa5.,e6b[||iwerrdes5n v0 [star
Jloowvoerriz } jLoowroeneet||
i iTTTaseoeurnsh[[eaesswomn||([7FT gf [|riirorr1 TJooemer||
e T e = = r
pPeeoTomyJon omans| |
* Ppa = 1333 Cre)
b Temp. (K) = 273.15 + Temp. (C)
page 2
006191
3
:3 MvNr (x
tem Pmm)
Toluene o4s7 0710
|e
PEs) LAPP)
6s2s6i521 3a7s9i6002l8 t1o3z3s3a0n o4.t12i48s3 tesm2 e2ies
H( e1b2I e6 Ds1e0irI 8n5,",, 333.422m6686 ess 49156" 3692 5io0s 1t7e0sse2s4 4432030200241 f7o1 1e0e8s1 44t0e161322218 s2 eons 3BO0pS
oo 212) T1m00O72D" 334.520185
Sry" 358
SIT (A719)
3567 36719
sues 4525 sTeaenss 337846a5s109r3d
6Bt 1e0s7t0173 43093530331055
% 127968 4107101
oootes
0000479
02508
06382
06008
0.1943
0o00i7e45 019592316 00.0108228
053 112130966399 4400493391038 645 se0a6s4e4 23985076037919 3 ast 3693032
o0o000i3z3r5 0041486912 O03T50T6 ODooooss2218 017008443 00..10539222
ee
) BEST COPY AVAILYABLE
TEC)
TH ATE)
a3r5a 45
0318413s5 000000338415 ales 000313
ra==008.8090S15 b=000001
SS1o2s 332293655 0000003300843
122005
228933.1155 2815
00.000033451312 0003S
3 30315 0003299
eS1727 3a3w403s5s O0p0oz0e0s2t Soe 3675 000306
ar==00..909088t2 b=-0000498
.
43s 3311811155 00000033211443
2100 228033.1455 00.000033451312
25 30
298.15 30345
0003354 0003299
{T74e6 444s72715s 0o0o0o2z3i32 jor 48035 000212
r0=.008083838 b=0.000298
iYoo0r2 4467303155 00000022115287
|
w
20
mes
28315
ose
000411
8
;
2350 230831155 00000033325949
olosrse lops
4seap7gss 0o0o0n221t3s2z 46135 0002168
ra==008.9004331 b=-0000287
ii776242 e44459355 0000002224254
210 220831155 000000381312 23 230083115s 00000033325949
foe Sat 3%
sel Study IDF 5030-04401
006192
