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Laboratory Report
Interim Report of Preliminary Data for 26 Week Capsule Toxicology Study with PFOS in Cynomolgus Monkeys
Laboratory Repo`CrotvaNnoce.6F32A9-C2T23-TOX-030
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Testing Laboratory
3M Environmental Technology & Safety Services Fluorin3e AMnaElnyvtiircoalnmCehnetmailstLrabyoTraetaomry(FACT)
2-3E-09 935 Bush Avenue, St. Paul, MN 55106
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Laboratory Contact Kris Hansen, Ph.D.
Bldg. 2-3E-09
St PauPl.,0.MBNox553133331-3331
`Phone: (651) 778-6018 FAX: (651) 778-7176
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Requester
Andrew Seacat and Marv Case
3M Company
`Toxicology Services 220-2E-02 St. Paul,MN
03677
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PAGE 10F5.
- TOT IMENVIRONMENTALLABORATORY smtsyeR pet clE ahPaFTS doetynsE aveer do hcapso cvnin ceirsr `amountsofPFOSinlactosewithin agelatincapsule.Therewerethreedosegroupsandonegroupofcontrol etbes wn seEms i as `animals.Serasampleswerecollectedfrom alltestanimalsat11differenttimepointsoverthecourseofthe
quanfotrpeirflt uoroaoctt ane siulfvonae te (l PFOyS). `Serasampleswereextractedusing anion-pairingextractionprocedure.Theextractswerequantitatively. `analyzed using high-pressureliquid chromatography/taendleemmcatssrspoesctprormeatyry
TATETe a nanndAanabieta oturnshy `metisadetbermoineldbi yintspeectis on. fot oc PS lsply nerdrh vk epi. Arlt increaseoccurredbetween theweek 2andtheweek 4samplinginterval.MaleandfemalePFOSlevels a ca osaoPeALmvois ysaskriai.ooAtorsi.mic ie OF peaohrcid Rigorousqualitycontrolmeasuresand 3MEnvironmentalLaboratoryStandardOperatingProcedureswere FE re EER me ARTA A Behre re `Serasamples wereshipped 10 theEnvironmentalLabby CovanceLaboratory.Samples includedinthis a Toass onenetaagavi sEsEl LCESHES NS si E ansmr SER
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4!" Methods - AnalyticalandPreparatory |
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'TcnoBluPmLPnL,CB,LaasnsOioqfu/noorhdoEeeftaefaxfSiitlnreiadtMcytuofaSihnljeaeaMtcrtvleedSynwod:frpokr.sthdestahornoaugrhyaprheavseerisnephheasceoiluimdn rcehlartoimveto0grhaephiiic d mtPciatioenpchPxatFsrOeaScmteadfnyocymhegerofu6mrd0evmaniedstenfosir.Rsceaatnreataliycsoiiniswsteiirnceeasmbmaoetutcnwtheoednfonmseha.neFdHaoPrdLc PCOsySsa tse otlm 3o wnaintahdnp ianrt1hde% oFrgacontiiclocnolHfomPooLlCmewcsuelippaiarrnnascotoihngosin,nu,igsESpnSueMoarSdolMcShpseoripocev,lriasdt.eedsEarlalpeiadtceanlodymsacaicpnluirdrnaiitapzeaemtyreiaao,nntsrefesocanMahloyzusilsngdeaipvcraiirqdmuaeiroliurnliayezneefgsdoe,rof obstepernimtacreylfios,oncs hcraetetSaslloef soeeaconndaary,nsiseclegctiede.Tshiusonnestbo hoepmriabrwyiiahonh,irwghhi-c<dnheagerye3d5,
i{Fhsioefgrsrheeatxghammaeopnvnlteeae,hdrfioynmrtorPeoFatOhgcSehrea(irsoCan1cs5d7seu5tce0hcat)4esad98n9aa0alnyadmsmaicsua,pir(bocineomrau4rr9esy9sopdiosntnso,debidlniuegfctft1dee0rdSlean0tse5it)adht,eeaPccnFhhdaeOrmSa2icf3ct0raeroalimcmstoouimbcp(poeCsrr;iiFctmSioaoOmrn5yps)ioao.unnEn.ddaTschhihsoaifton "ecioonfrangmendtatiion aresy.
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5.1 CAamliimdbdretvaetsli,eodxnha.ctCeadlmlraasioncaclhiebcrkaStiaonndhaencksarencdoamrpdliisaantlyfzerdaemverny5-1r0esaponpsesistwoimbriint+or094 hQueaienxspaede con voamfltauehb.aegceovaensablaycskiisnbgaecdhongrlionuepaorfegsraemspiloen.aQnalyusisa(weniogfhcteadchUixa,riflayprtisobipasieodaion)fnthe npsomneenotfaneofmrepetedaughterforesng ulreponsemonitoringmode of he
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`LaboratoryControlSamplesarenot acomponentofthisstudy.
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