Document peMzarGn0r9VNMVZpjRg6Y5xD

off AR 226 _ 1054 MR# FAT 4] Bada DuPont Chemical Solutions Enterprise September 24, 2001 Karen Lannon UD.oSc.uEmPeAn,t OCoPnPtrToSl Center 401M Street, S.W. (TS-7407) Washington, DC 20460 Reference: AR266 Dear Ms. Lannon: AR 23.6 63 ol peooo 6 z= Toa TE 3 1 have once again prepared authentic sanitized copies ofthe two presentations we gave on February 21, 2001. A paper copy of each presentation is enclosed for the public record. These presentations are as follows: "DuPont Research Program Update and Status Report" - February 21, 2001 and "Telomer Research Program Update and Status Report" - February21, 2001 Eachofthese reports has been company sanitized. They do not contain TSCA CB Each and every chart that has had CBI removed has been marke: with the following note: "CBI Information has been redacted." Pclaenarseealceht mmee vkinaopwhoinfeyoonu (h3a0v2e)9a9n2y-a3d6d7i2tioornaflaxquoenst(i3o0n2s)8o9n2-t1h1e3s5e. twMoydoecmuamielntasd.dresYsoius stephehn korzeniowski@usa.dupont com. i. With regards, 2 L. RSuHaKch/aKelros awn SMtaerpkheetn&H.BuKsoirnzeesnsioMwasnkaiger 3== 1} Company Sanitizeq | was | DuPont Research Program Update and Status Report Presented to U.S. EPA, OPPT 21 February, 2001 | | z =< PER Chemical Solutions Enterprise "CompanySanized,Bes Not Contain | 4 Agenda * Overview Toxicology & Descriptive Biology Environmental Fate Environmental Effects Summary & Path Forward OD,ChemicalSotuions Enterprise "CompanySaniized. Does Not Contain > ammo | | > DuPontEffortOverview : wean | CBI Information has been | redacted OR ChemicalemicalsotuiSolnustions EwEentrerpprise "Company Sanniitziezde.d.DDoones Not Contain s uw DuPont Fluorotelomer Product Groups: Intermediates, Surfactants, Polymers 1) Intermediates CECE, (TFB) SalesProducts | CECE) (Telome&r) F(CF,CF,),CH,CH,I (Telomer B) 2) Surfa "Molecules" + Anionic - Phosphate. Carboxylat. + SNulofonnatei- Eothnoxyilacte + Betaine F(C|F,CF),CH,CH,OH (TelomerBA) Straight Chain Alkyl F(CF,CF,),CH,CH,0C(0)C(R)=CH, 3) Po+lydemrpelrics Ester + Amide + Urethane + Urea Zonyl TM cn ; Zonyl TAN wn PR ChemicalsemicalSolSuotluitoinosns EEnntteerprrise "Company Saniitteizde,d.BD os o Note Conts ain s | . Toxicity Database : High Production Volume Chemicals AcuteOTroaxl,icIinhtaylation +Eye, Skin Irritation Skin Sensitization Repeat OraDlos,e DermTaolxo! Inhalation (AEL) Genetic Toxicity velopmental Toxicif Ecoe -toxiciy l Environmental Fa&Eftfecets S US TTC #4546 | Requests ReproductiveToxicity WIRChemicalSolutions Enterprise "Company SanTiStiCzAed.CBDIo"es Not Contain c | | | 5 TOXICITY DATABASE - DuPont Fluorotelomers | Acute Toxicity Oral Dermal Absorption Inhalation I\rrriittaattiioonn ---- SEkyien Skin Sensitization ntermediates Surfactants Polymers CBI Informati. on has been redacted Repeated Dose Toxicity Oral Dermal | Inhalation IRRChemicalSolutions Enterprise "CompanySanitized. Dogs Not Contain 6 7 TOXICITY DATABASE -- DuPont Fluorotelomers Intermediates Surfactants Polymers Genotoxicity Gene Mutation Ames Others CBI Information has been ChrInoVmiotrsoo(mCeHOA)berration redacted In Vivo | Developmental Toxicity Rodent Non-Rodent Reproductive Toxicity Structural Evaluation Functional Evaluation GRR Chemical Solutions Enterprise "CompanySoniigha,boss Not Contain 7 5 TOXICITY DATABASE -- DuPont Fluorotelomers Intermediates Surfactants Polymers EcoAtqouxaitcicitTyox. Fish Daphnia Algae . | CBI Information has been Environmental Fate Log Kow Biodegradation Accumulation Persistence redacted PRY Chemical Solutions Enterprise "Company Sanitized. Does Not Contain 8 TSCA CBI" 1 DuPont Toxicology Studies Timeline | CBI Information has been redacted IBY Chemical Solutions Enterprise "CompanySaized, Dogs Not Contain 9 10 Toxicology Studies : ZonylXXX + Repeated Dose Toxicity: + Genetic Toxicity: + Developmental Toxicity: * Reproductive Toxicity: CBI Information has been redacted Biopersistence: 10 day oral rat | + Environmental Toxicity: GPR ChemicalSolutions Enterprise "Company Se.boss Not Contain 10 0 Zonyl XXX Studies : Update + 90 Day Oral Gavage, One-Generation Reproduction | CBI Information has been redacted PRRChemicalSolutions Enterprise "Company ene Not Contain nn 2 Zonyl XXX Studies : Update Present Findings 90-day CBI Information has been redacted Reproduction | PRChemicalSolutions Enterprise "CompanySapiseq, boos Not Contain 2 13 Zonyl XXX Studies : Update + Developmental Toxicity | + Genetic Toxicity: + Aquatic Bioconcentration Screen : CBI Information has been redacted GW. ChemicalSolutions Enterprise " "GompanySenlized.Dogs Not Cantain Bo | DuPont Toxicology Studies : Timeline CBI Information has been redacted BY Chemica Solutions Enterprise "CompanySanpizad,Dogs Not Contain " is ZonylXX Kinetics | CBI Information has been redacted WHRChemicalSolutions Enterprise "CompanySatinboss Not Contain 1s Kinetics CBI Information has been redacted PR: ChemicalSolutions Enterprise "CompanySagicel,Tags Wet Contain " "n Radiolabeled Telomers F(CF,)s-CH,CH,-X Neededfor Pharmacokinetics & Environmental Fate Studies CBI Information has been redacted PBRChemicalSolutions Enterprise "Company Saniase.Does Not Contain 1" 8 | Radiolabeled : Synthesis Route "A" CBI Information has been redacted GIR Chemical Solutions Enterprise "CompanySariiasyBags Not Contain 18 "q Environmental Compartments | based on emissions assessment | CBI Information has been redacted GPRChemical Solutions Enterprise "Company Sarsay.Doss Not Contain 19 20 Environmental Fate & Effects Work Plan Environmental Fate: Abiotic Hydrolysis | + Adsorption / Desorption PhysicalProperties Indirect Photolysis in Air + UV/Visible Spectrum + Water Solubility + Adsorption to Glass EnvironFmateen:Btioatilc + Anaerobic Biodegradation* Air-Water Partition Coefficient * Aerobic Biodegradation (* Radiolabeled Material) CBI Information has been redacted IR Chemical Solutions Enterprise Environmental Effects | * Bioconcentration Factor + 90 Day Early Life Stage Study -- Rainbow Trout + 21 Day Invertebrate Daphnia Study "CompanySantized, Cogs Not Contain 2 a DuPont Environmental Fate & Effects Studies * Focus on : -- Acute Aquatic Toxicity (Daphnia, Algae, Fish) -- Adsor/pDetsoirpotinon -- Biodegradation -- Chronic Aquatic Toxicity (Daphnia, Trout) -- Bioconcentration Screening CBI Information has been redacted PRRChemicalSolutions Enterprise "CompanySarat,Dogs Not Contain 2 22 Zonyl TEL-X F(CF,CF,),CH,CH,X n=3-6 CBI Information has been redacted | PRLChemicalSolutions Enterprise "Company Sadao Dose Not Contain 23 2 | DuPont Environmental Fate & Effects Timeline CBI Information has been redacted | | I: Chemica Souions Enterprise "CompanySanitzed. Does Not Contain 2 24 BCF Screening Protocol Objective: To compare the uptake and depuration in fathead minnow for a series of fluorotelomer intermediate, surfactant and polymeric products. Method: + uptake (14 days continuous exposure) and depuration (14 days) phases + analytical confirmation of test concentrations and tissue residues analysis by total organic fluorine on a dose-normalized basis Results: * Whole fish bioconcentration factors for the series of test materials HRY Chemical Solutions Enterprise "Company SanTitSiCzeAd.CBDIo"es Not Contain 25 | | 2% DuPont Path Forward Items * Toxicology & Descriptive Biology Environmental Fate * Environmental Effects * Summary & Path Forward COR ChemicalSoluions Emerprise = "CompanySanized. Doge Not Contain | | | 2|