AR2%6-0161 ors 3M ME- DSTI4C3:ALStaDndEaPrdAPRroTceMdEurNeTfo,r LCivOerRSPubOceRluAlaTrEFraTctOioXnaItCioOn L- OGY Study Objective: 0R-S Perfluorochemical compounds suchas perfluorooctane sulfonate (PFOS) have. been linked with reduction in serum cholesterol levels and liver has been identified as the primary target site.

18 VITvE VeICR.OBTOCLOoGErCAoL M1I-T3A60C5BVLCITY ASSATS ac-- September 1984 oO, THiTteraueiaeGrefnietelic,siiDetpbarc(meeT5notR)iet ant a | A FTeaH rrrainY SGeencettollircseeReDseeptoacretnatsnDt TFcEe ------ e3e4 ceeoupapfnyaarceens,ntoH Center pen Sel Acteation: TBmLlcoHenCoonraSicpkectatss -- SKI Project 150-3145 Approved by: teoomn 3GeonerrtieelsaaDnesp,usiDaierencttor [so7fn 9o.lReitao, DfirrectSorT Ton sna Laboratory 4i.

SBCcoroEtsAi HetiIt.S tn 608.241.4471 608.241.7227 Fax AR260322 CORNINGHazleton 3M St.

AR226_ 1057 ft. sERoor-15057 sw @UPIND3 sanuary 17,2002 aor Eros 5 wpele DRArtootceofnumtmieo8ofnn4:t2P88oP(relo)ceCeonsosrPidrniognvaCetemonirtoenr (Mail Code and Toxics 7407M).

foes R226 -- 359 SRPT T7001 MIN 315/022356 PERFLUOROOCTANESULFONYL FLUORIDE (POSF) T-Tebl> IN VITRO MAMMALIAN CHROMOSOME ABERRATION TEST IN HUMAN LYMPHOCYTES Sponsor 33MMCCeanrtpeorrt Toxicology SBiupilding T0250 UMsNa551333220 Page t0r3t ResearchLaboratory WHouomilnlgydRoenaLidfe Sciences Ld AHocnoinnbguiroyn PCeaamstradkgesire ENGLAND Reporsued 22 Osober 2002 001542 CONTENTS MIN3157022356 Page COMPLIANCEWITHGOODLABORATORY PRACTICESTANDARDS... 4 QUALITYASSURANCESTATEMENT. ccm eS RESPONSIBLE PERSONNEL... 6 INTRODUCTION sss 8 EXPERIMENTALPROCEDURE...

fR 226 _ 1357 FINAL REPORT `ONE GENERATION REPRODUCTION STUDY OF PFOS - MEVALONIC ACID/CHOLESTEROL CHALLENGE AND NOEL INVESTIGATION IN RATS SPONSOR'S STUDY NUMBER: T-6295.25 FINAL REPORT DATE: 16 DECEMBER 2002 000433 TITLE- ONE GENERATION REPRODUCTION STUDY OF PFOS - MEVALONIC 'ACID/CHOLESTEROL CHALLENGE AND NOEL INVESTIGATION IN RATS ARGUS STUDY NUMBER: 418-018 SPONSOR'S STUDY NUMBER: T-6295.25 SUBJECT ABLE OF CONTENTS PAGE L SUMMARY AND CONCLUSION It A Methods.

AR22G _ 1497 INTHE CIRCUIT COURT OF WOOD COUNTY, WEST VIRGINIA JACK W.

ARARG - ISIS | - --| || TSh CA NCm IC NOTIFICATI-ON FORM FOR CBI DOCUMENTS || Docker Numeer: OR 336 DOCUMENT CONTROL NUMBER: 630300 codf DOCUMENT DATE: ___F- 4-22 Document Type: Doc TE 4> 3323 soe =E B3355 @ 2 C(TFHCElTD)SOUCCNAUDMREEERNQSUTEIRCRETEFISEOERNEP1NA4CTOEOFDPATRHBOEOTVTEEOCXTIISCFCRSLOUAMIBMSPETUDABNALCSIECCSDOINCFSOICNDLTEONRSTOUILRAELASCBCTUBS(IITNSOECBSATS)A.IINNEFTDOHRAUMTNADSTEEIRCOTNION RTESLCEAA,SAEONDRDITIIMSPOCSELSCOROISMFUISNURACLEHPEINNAFLOTRIMEASTIFOONR.

AR226 0357 CHRONIC TOXICITY TO FISH TEST SUBSTANCE Identity: N-ethylperfluorooctane sulfonamidoethanol; may also be referred to as 1N,-1E,t2,F2O,S3,E34A,l4c,o5h,o5l,6o,r6,F7M.-73,482,82,.8-(h1e-ptOacdteacnaefsluulofron-Na-m(i2d-eh,ydNr-oextyheytlh-yl)-, CAS # 1691-99-2) Remarks: Material is an off-white, waxy solid of uncharacterized purity.

EEE 200 F-Y 050I 0- 1378 AtteacheststoanLtetOtetrhertoICn.foArumeartidoanteadn MCaeryai18n, 2000 AR126-0377 Perfluorooctane Sulfonate-Related Compounds `Bibliography Showing Studies in 3M's Possession Believed To Be In FIFRA Docket.

OCTANOLMWATER PARTITION COEFFICIENT EST SUBSTANCE Identity: NN--eEtthyFlOpSerEfAllucoorhooolctoarneFMs-ul3f4o2n2a.mid(o1e-tOhcatnaonle;sumlafoynaalmsiodeb,e referred N-ethyl- to as 1.1,2,2.3,3.4,4,5,5,6.6.7.7,8.8,8-heptadecafluoro-N-(2-hydroxyethyl)-, CAS # 1691-992) Remarks: Material is an off-white, waxy solid.

BIODEGRADATION TTEESSTTSSUUBBSTAANNCGEE 000000000000 Identity:Perfluorooctanesulfonylamido(ethyljacetate; may also be FreCf-e1r2r7ed, tFoC-a1s2P9,FOFSCA-A10,9,FCo-r1F2C8-1o0r9a.sX.the(Gmlaycjionre,coNm-petohnyeln-tN-of [(heptadecafluorooctyl)sulfonyl]-, potassium salt, CAS #299151-7) .

ACUTE TOXICITY TO AQUATIC PLANTS (ALGAE) TEST SUBSTANCE Identity: Perfluorooctanesulfonylamido(ethyl)acetate; may also be referred to as PFOSAA, FC-128 or as the major component of FC-127, FC-129, FC-109, FC-109-X or R1904.

OCTANOL/WATER PARTITION COEFFICIENT ~ TEST= SUBS STANT CE OoUBSTANCE Identity: aPserPflFuOorAooacmtamnooniciuacmids,alat,mAmmomniounmiusamltp;emrfalyuoarlosooctbaenoraetfee,rrFeCd-to p1e1n6t,aFdeCc-a1f2l6u,orFoC--,1a69m,moorniFCu-m14sa3l.t,(COcAtSa#noi3c82a5c-i2d6,-1) sRuebmjaecrtksc:ompoTuhned3iMs FpCr-o1d4u3c.tioInt'slopturniutmybwearswnaost snuoftfirceicenotrldyecdh.arTahcteerized, stuhbosutgahnccuerraenndt i0n--fo3rm.a5t%ioCns,inCd7i,caatnedsCitsipsearfmliuxotruoreanofal9o6g.u5e- c1o0m0p%outnedsts.

eeh Ran peAsFvabia[na NBrEaEs eset WS ITW OLSEN mie .- rs Srgag The mechanism underlying the hypolipemic effect of perfluorooctanoic acid (PFOA), perfluorooctane sulphonic acid (PFOSA) and clofibric acid Bente Haughom and @ystein Spydevold sae of Medco Biochem, Givers of Ol.