Lo eff ~~ 8 | ~ AR2R-6 3433 37 000370 did il | ' r---- ---- --.Ak% 2% d croc procsanes m sioon swerss = - ma A-- Polymerization -- ---- So ---y .

--_-- AR 226 _ 3566 IMENVIRONMREENRTOARLTLNAG.BOER9A8T5O6R6Y% Amended Final Report Analysisof PFBS, PFHS, PFOS and PFOA in Water Samples Collected at 3M Guin Laboratory Request Number: E05-0662 Method Requirement: 3M Method ETS-8-154.1 (modified) Testing Laboratory 3M EHS Operations. 3M Environmental Laboratory Building 2-36-09 935 Bush Avenue St Paul, MN 55108 Requester Gary Hohenstein 3M Building 42-02-E-27 PO Box 3331 `Saint Paul, MN 55133-3331 Phone: (651) 778-5150 Fax (651) 778-7203 `SMCONFIDENTIAL 2 Pago 101 13 34 ENVIRONMHEENRTARLLHAOB.OREAosTOouRsY SaHw EETniemiocnimLeenmaaaoaabnReerinspttoAaynanlge,rValk. rRes.genP,H0. , EoRnCoraayrCCaotosanr, nspepc ea Prsoofessorc LoSbaOvposn Parse!

Name: Chine Sakr, MD MPH ' Robin Leonard, PhD 2 Mark Cullen, MD 1 Program Affiliation: Address: Phone: Fax: Email: `-Yale Occupational and Environmental Medicine Program 2Epidemiology Program at DuPont Haskell Laboratory for Health and Environmental Sciences 135 College Street, 3rd floor New Haven, CT 06510 856-816-1539 203-785-7391 carine.sakr@ yale.edu TITLE Twenty-five year longitudinal study of serum total cholesterol related to a serum biomarker of exposure (serum perfluorooctanoate or PFOA) in a polymer production plant.

& 3M ENVIRONMENTAL LABORATORY METHOD EXTRACTION OF POTASSIUM PERFLUOROOCTANESULFONATE OR OTHER FLUOROCHEMICAL COMPOUNDS FROM URINE FOR ANALYSIS USING HPLC- ELECTROSPRAY/MASS SPECTROMETRY/MASS SPECTROMETRY Method Number: ETS-8-96.0 Adoption Date: 7-28-44 Author: Lisa Clemen, Glenn Langenburg Revision Date: NA Approved By: \ 1] Ze Laboratory Mhnager Date 5/77 Lit hn Group Leader 28/95 Date on A Cloman Technical Reviewer Hara Date 10 SCOPE AND APPLICATION 11 oSrcooptehe:r Tfhliusormoecthehmoidcails fcoormtphoeuenxtdrsacftrioomnoufrpinoet.assium perfluorooctancsulfonate (PFOS) 12 Applicable compounds: Fluorochemicals or other fluorinated compounds. 13 Matrices: Human, rat, and monkey urine or other fluids as designated in the validation report.

REPORT AMENDMENT NO. 1 | TWO YEAR ORAL(DIET) TOXICITY/CARCINOGENICITY STUDY OF FLUOROCHEMICAL FM-3924 IN RATS Experiment No.0281CR0012 The attached of the Summa pages include revisions in the first paragraph on page 3 The ry and revisions were in the third paragraph made to clarify of page 22 of the Discussion.

AR 226 _ OS TH SUMMARY OF A STUDYSUCLOFNODNUACTTEE(DPFWOIST) HATPODTUAPSOSNITUM PERFLUOROALKYL Type: Biopersistence Screening Study Species/Strain: Sex/Number: ~~ RMaatles//SC/rgrlo:uCpD.SD(IGS)BR Exposure Period: Frequency of Sor 10 days; 94 daysofrecovery Treatment: Exposure AAdmmloibnitiuummfoprerSfloruo1ro0odcatyasnoate: 20 mg/kg Levels: Method: SPioxtagsrsoiuupms poefrfraltusorwoearlekyaldsmuilnfiosntaetreed(PaFmOmS)o:ni1u0mmg/kg 5pecrofnlsueocrouotcitvaendoaatyes,a1ndgrtohuepotrheecrei5vegdrotuhpestersetcseuibvsetdatnhceetfeosrt bsulbosotdawnaces fcoorll1e0ctdeadysf. roAmpeparcohxirmaattferloym 2thheougrrsouapftdeerstihgenafitrestd dfoosre, 2dohseosu.rsTphoesst-edossaimneg,raatnsdwbelroeodsaacrnidfilcievderosnwteerset dcaolyle5ctaepdp.roTxhiemately wreemraeisnaicnrgifgircoedupasndrehcaedivbeldotohdeatnesdt lsiuvbesrstacnoclelefcotred10ondatyess.t dFaiyvse 1r0ats of(2thhoeurbslopoodstw-daossed)e,te1r3,mi2n4e,d5b2,yoursi9n3g/9a4.WiTchkebotlotdaltofrlcuhorine content sceolmebcutisvteioelnecmtertohdoe.d, Bfoodlylowweeidgbhytsanaanldyscilsinwiicatlh saigfnlsuowreidree iroencorded throughout the test.

oo 0 = o 2 0 Sx 05 35 = =p = Eo aS a8 Q3s0 wd = AL226- 147 4 o &i:3 3 g 000041 =-- a ~ o Q & ~~ TM 3 oo Ec 5> oQ -o 28E o7a 0a er = Qc sesS <22 x Eosg - wc n OSs aLszN c53028 Q 335g Er a 0 Bs oo 32% c 3 Ss vo O 5E2 &88 g5e0g9e3l 2S3 = Oo =<=5 g3 eX R=8 c2 0 0 =8 S225 go QQ 3O So offx< 258 = 298C3c 55 E 83S58E5 Scs ECBc =S a wd wu 2 D2" 8s -- QL w5t T 5 u D s 2 XE 8s on =E 0 23 2S 0 S B2S28 S3 80 o8 m3 s5 a1 E0 Sx Segarra 53= 2 SwnES S - TTT G Exoa 7isiim s o 000042 g= e:= >S88 8Eg32 = 00 $pe < =f] ~|&f 18) 5_ 8 S2 i: S8E.S 2R5E EE Ey 2859553 3 E &g <o c 8 45 =2 8= 0Qo]H mn |] | | El = 2 , a=n| == = 8 LIE 8 | ~2 == ; 0000232 ErCoA7B10040105377 8Eg 5Ls 2wan gg @o 2 a Oo > c = L~ BEa Ts 8& 29 g 0 2 > 2Q 8Q 4 c 0 ~voETo --Q cwu 6 8SXE RoEo - 8 5 nw Eo > o =Bt cO= g 5 TO -= 25 S BE22os- 0 & _JgET -- O5o CS5e5E8 EcCaQS 8 S O 5 82Eso; Tc OO --- -- 2 S5 S 5c9v0 w PcDow o 28 8s SB al 2383 E2358 a3 o ET co gL 93 s <W OT >On | - Co 000024 cron camoo0srs 3 Hid = _-- -- Tf ` i 2 83 2s 1 $i: 2 2-- 1E --_-- =5] | |g | . 773 7 jo [{ 2 JJ JY Bn |4 ( / EE| Ebs ) i | One ERE E L WEE [ -- ={ A | |!

i P h o n e : (814)231-8032 BACK TO MAIN Fax: (814)231-1253 or (814)231-1 580 Analytical Report Fluorochemical Characterization of POTW Effluent Pensacola, Florida Centre Analytical Laboratory Report No. 023-014L (Revision 1) Revision Date 3/26/01 Testing Laboratory Centre Analytical Laboratory, Inc. 3048 Research Drive State College, PA 16801 3M Environmental Laboratory Contact Kent R.

3M IMedical Department Study: T-6295.12 BACK TO MAIN Analytical Report: FACT TOX-110 LRN-U2849 Study Title Oral (Gavage) Pharmacokinetic Study of PFOS in Rats Analytical Laboratory Report Title Determination of the Presence and Concentration of Perfluorooctanesulfonate (PFOS) in Serum, Liver, Urine, and Feces Samples Data Requirement' Not Applicable Author 3M Environmental Laboratory Study Completion Dipte at signing Performing Laboratories Urine Analyses Feces Analyses 3M Environmental Laboratory Building 2-3E-09,935 Bush Avenue St.

AR226-2091 WASHIHSTOH WORKS C-8 INDUSTRIAL HYGIENE EN6INEER2NS CONTROLS NORK RHLES, PROTECTIVE CLOTHING, RESPIRATORY PROTECTION, ETC.

AR226-2398 \ INTEROFFICE MEMORANDUM Dates Promt Dept: Tel No s SO-Jan-lseS OlslSprn ANTHONY J.

AR226-2700 AR226-2700 TORONTO WORKSHOP MATERIALS September 13-14,2004 John Gannon DuPont Central Research & Develop Wilmington, DE of in the Is the Sources?

Material Tested Copies to: E.

E.

AR226-3125 HASKELL LABORATORY FOR TOXICOLOGY AND INDUSTRIAL MEDICINE H-24119: STATIC, ACUTE 96-HOUR SCREENING TEST TO FATHEAD MINNOWS, Pirn ephales promelas PURPOSE: This is a rangefmdmg study designed to provide an estimate of aquatic toxicity using fixed test concentrations and data measurements at predetermined intervals.