ACUTE TOXICITY TO FISH (RAINBOW TROUT) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may also be referredtoas PFOS, FC-95, or as a component ofFC-203. (1Octanesulfonicacid)(CAS # 2795-39-3).

, 3M MEDICAL DEPARTMENT, CORPORATE TOXICOLOGY Protocol for Study No.

i-3 EETR226 -- 1017 :~ i i - rn CENTRAL SCIENCE LABORATORY >> i i [reid i, LY L. a i, e Ly STUDY NUMBERHTS602 PERFLUOROOCTANESULFONATE, POTASSIUM SALT(PFOS): _ TiTTHHE EHONEHONYEYBBEEEE & MAFF - 000002 CSL Study Number HT5602 STUDY NUMBER: HTS602 PAENRFALCUUOTREOOORCTAALNTEOSXUILCFIOTNYASTTEU,DPYOWTIATSHSITUHMESHAOLNTE(YPFBOS0)2: REPORT AMENDMENT NO | EPPO GUIDELINE 170 OECD GUIDELINE 213 i AUTHOR: 3 Paul Wilkins STUDY INITIATION DATE: 11Sepember2000 STUDY REPORT DATE: 23 March 2001 SUBMITTED TO: Evir3oMnCmoerpnorLaatbioornatory ScPa9u3,5 MBuiUsmshnkAevseonu5e5106 : Pertrming Laboratory: 3 EmEinvriornomnemnenttlalBRo&gDsTGeeaomnp 7 Central Science Laboratory = YorkSYanOdu1Hut1t1o7n, UK Environmental LaboratoryorFPrroect NumbPeargeU2l7of235 000003 (CSL Study Number HT5602 CENTRAL SCIENCE LABORATORY `CONFIDENTIAL Study title Test fucilty Study number Numberofpages: REPORT AMENDMENT 1 tPoexrifcliutoyrosotcutdaynwesiutlhftohneatBeo,nePyotbaesesium Salt (PFOS): An acute oral Environmental R&D Team, CSL, Sand Hutton, York, UK HTS602 5| i Signature, ithe Date OS/otft @aimmiyy) SPEntWvuiidlrykoiDninmrseencttaolr R&D Team, CSL Authorisation of release of report amendment SEE sigmue___|[Athens Management Representative MHeHadBEenvwironmental Biology Group, CSL Date_:&-01 (dd/mmiyy) eee st 2 This amendment has been noted by Quality Assurance as correction othe report 4 A sigue Cl ass (Dulles Date|C8tel(ddimmyy) MQrAsACudVitWoarlker Central Science Laboratory Environmental Laboratory Prcject Nomber U2723 Page 2015 000004 CSL Study Number HTS602 "wRTheheiasrsehoantshfeboeTreeansmtceoInrideemmctehenadtd:tboeTPehenerrfmeliuswo-arsospoeclttaaynspeosPguerlrfafopunhoairtcoeao,lcPetoartnraeossusolnifupomanSgaetas,l7P(oPatFnaOdsS)s.ioumAtfShfalotrfmi(naPatlFiOrneSgp)ort 1 ceroreocrtheadd.occurred on page 7, which had obscured the lengthofexposure.

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Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 1 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Appendix G: Amendments and Deviations (Copies) Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 2 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 3 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 4 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 5 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 6 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 7 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 8 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 9 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 10 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 11 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 12 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________

StudyTide FC-143:TWoYEARORAL TOXIITY-ONCOSGTUEDNYICNIRATTYS PEER RevoFiOveanwes Authors Peter C.

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AR226-2565 EGA Technical Subgroup Monitoring Landfill Monitoring and Exposure Summ Goal for Today Understand the contribiition of landfills PFOA levels in the environment Environmental Assessment F Manufacturing Facilities/Land 1.

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AR226-2700 AR226-2700 TORONTO WORKSHOP MATERIALS September 13-14,2004 John Gannon DuPont Central Research & Develop Wilmington, DE of in the Is the Sources?

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