CorrpoorsrateOOcccaupations Medias 25M1CC7eo3nte4r2,3bB0uidiTngetgho2n0e-305 1733 068 Fax AR226-0473 3M 5a.t PChoytstiacgieanGrPolvanet(S19u7m8m-a19r9y1)Reports Regarding Medical Surveillance Program Following reports of the finding of organic fluorine in sera samples, a fluorocheical medical surveillance program began at 3M manufacturing facilities in the mid 1970s "The surveillance program has generally consisted of annual or biannual tests ofclinical chemistries, pulmonary function, blood counts and abiomoritoroffluorochemical + exposure.

Extent and Route of Excrettiioonnaqnw@@ u Distribution of Total Carobotnn- in Rats after a Single Intravenous a .of pC-95-14C December 28, 19 30@_OGY Conducted at: During: Conducted by: Report by: Reviewed by: Riker Laboratories Inc., Subsidiary of 3M St.

AR R86 _ 0785 ACUTE TOXICITY TO INVERTEBRATES (FIDDLER CRAB) IesTsuBsTA 000NCE Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-206 or L3243. (1-Octanesulfonic acid) (CAS# 2795-39-3).

BACK TO MAIN BIODEGRADATION (Pure Microbial Cultures) TEST SUBSTANCE Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: The 3M production lot number was 217 (TN-A-2130).

HYDROLYSIS (ALKALINE) TEST SUBSTANCE Identity:N-ethylperfluorooctanseulfonamidoethanolm;ay alsobe referredto as N-ETFOSE Alcoholor FM-3422.

BIOACCUMULATION (ANALYTICAL ONLY) TEST SUBSTANCE Identity:N-ethylperfluorooctanseulfonamidoethanol;may alsobe referredtoas N-ETFOSE Alcoholor FM-3422. (1-Octanesulfonamide,N-ethyl1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-N-(2-hydroxyethyl)-, CAS # 1691-99-2) Remarks: Materialisan off-whitew,axy solidofuncharactedzed purity.

lo Submitted to: BIOSEARCH, INC. pc. box 8598 philsdelphis, pennsylvania 19101 telephone: (215) 848-4499 Project Number - 78-1161A 33H CCoemnptaenry St.

BIOACCUMULATION TEST SUBSTANCE Identity: N-methylperfluorooctane sulfonamidoethanol; may also be referred to as N-MeFOSE Alcohol, FC-790, or FM-3925. (1Octanesulfonamide, N-methyl-1,1.2,2,3,3,4,4,5,5,6,6,7,7,88,8heptadecafluoro-N-(2-hydroxyethyl)-, CAS # 24448-09.7) Remarks: Material is an off-white, waxy solid of uncharacterized purity.

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ACUTE TOXICITY TO FISH TEST SUBSTANCE Identity:Perfluorooctanoiaccid,ammonium salt;may alsobe referredto as PFOA ammonium salt,Ammonium perfluorooctanoateP,FO, FC116,FC-1 26,FC-1 69,or FC-143.

ACUTE AQUATIC TOXICITY TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may also be referredtoas PFOS, FC-95, or as a component of FC-203. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may also be referredto as PFOS, FC-95, or as a component of FC-600. (1-Octanesulfoniaccid,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-p,otassium saltC,AS # 2795-39-3) Remarks: The 3M productionlotnumber was notnoted.

ACUTE TOXICITY TO FISH (BLUEGILL SUNFISH) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredtoas PFOS, FC-95, or as a component of FC-780B. (1Octanesulfoniaccid)(CAS # 2795-39-3).

BIOCONCENTRATION TEST SUBSTANCE Identity:N-ethylperfluorooctasnuelfonamidoethanolm;ay alsobe referredto as N-ETFOSE Alcoholor FM-3422. (1-OctanesulfonamideN,-ethyl1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-N-(2-hydroxyethyl)-, CAS # 1691-99-2) Remarks: Materialisan off-whitwea,xy solidofuncharacterizepdurity.

lo BIOSEARCH, INC. p.c. box 8598 philadelphia, pennsylvania 19101 telephone: (215) 848-4499 Submitted to: 33HM CCeonmtpearny sSts.iolpaul, Minnesota Haterial: 3M Conpany - T-1395 Sample Received: December 6, 1975 Date of Report: Test: Object of Test: Method of Test: Results: March 4, 1976 Primary Eye Irritation Study - Rabbits wThoicdhetetrheminseubjtehcetdmeagtreereiaolf miaryritpartoidounc,e wIhfenany, Tihnisstiltelsetd wianstopetrheforemyeeds oifn aorldbeirnotorabcbliatsss.ify StuhibsstamnacteesriaLlabeulnidnegr Atchte.