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lo Submitted to: BIOSEARCH, INC. pc. box 8598 philsdelphis, pennsylvania 19101 telephone: (215) 848-4499 Project Number - 78-1161A 33H CCoemnptaenry St. Paul, Mimesota 55101 Haterial: 3H Company - T-20380C Sample Received: 1/5/78 Study Initiated: 1/9/78 Study Completed: 1/12/78 Date of Report: 2/2/78 Tests Primary Skin Irritation Study - Rabbits Object of Test: To determine the degree of irritation, if any, wSThpeiobcbihiltesdt.heto sutbhjeecitntmaactterainadl ambaryadepdrodsukcien wofhenalbino Method of Test: Tahned mtehtehosdcoerimnpgloyoefdthien trheesulttesstwinags, siemviallauratitoon Stuhabtstadnecsecsribaendd airntiScelcetsi,on ad1m5i00n.i4s1tra-tiHoanzaarnddous Enforcement Regulations, Federal Register, Vol. 38, No. 187, P. 27019, 27 September 1973. In carrying out the study the experimental sample wSTaiasdtehiutsosefdwteahrsee asncuilpmipapllipsee'dd. obvaeAckrsgraowwausipdeoafbraarsediaex.d alatbOinneoone Stihteeswtirtahtum3 cloarnnceetunsubuftficnoitentelnyterdeetphetdoerpmeanettroate . vparsoduaclelowbeldeedtiongr.emaiTnhe isnktaicnt.of Athe0.5othgenr posridteion of material was applied to an abraded and an intact Stkhienn spliatceedonovtehre tshaeme trreababtietd. arGesasuzeandpaatncheisnpweerrveious mOfatetrhiealaniwnasalswratpopehdoldsnutghleypaartocuhneds tihnepltarcuen.ks Tfhoeurwrhaopuprinpgerwiaosd arnedmovtehde arteattheedenadreaosf wtehree tewxeanmtiyn-ed: TRheeadiDnrgasizweormeethaoldsoofmadsecoraifntgerwasseveemnptlyo-ytewdo. hours. 004371 3H Company - T-2038CoC, Primary Skin Irritation Study. Results: Conclusion: See Table 1. Bthaesedsubojnectthemaatcecroimaplanwyoiunlgd tnaobtle,be acllbaisnsoifireadbbiatss awiptrhiimnarytheirdreiftainntititoon of () the (4) Acantd-Rerfeeqrueinrcees: noSecctaiuotnion1a5r0y0.3 labeling with respect to that section. KDairrlectL.or Gabriel, V.M.D., Ph.D. 004372 Material: TABLE | Primary Skin Irritation 3M Company - T-2038CoC, as supplied. Erythens and Escher Formation Reading (Hours) Rabbit Number 1 23456 Average Intact Skin Intact skin Abraded Skin Abraded skin 2 000000 0.00 72 000000 0.00 2 000000 0.00 72 000000 0.00 Subtotal 0.00 Edema Formation Intact skin Intact skin Abraded Skin Abraded Skin 2 000000 0.00 72 000000 0.00 2 000000 0.00 7 000000 0.00 Subtotal 0.00 Total 0.00 Primary Irritation Score: 0 004373