"The Toxicity of Tetraethyl Lead" by Dr.

Tetraethyl Lead Area Lead pot and furnace, lead-sodium alloy, steam jet refrigeration, nitrogen, TEL building and wash house, and fluid blending building, together with necessary storage, purification and general facilities.

cM be troll advised to survey tie health" and the load states f those:- ' employes la :*ir: Various ecstasies - who v$sh vilh tetraethyl lead or aay .other lead ocsSpooads. .

A cony of pour letter of March 3rd addressed to *r* >* A* Dnyder of the Ohemplln HofInins Company has been referred to me as medical consultant of the Bthyl Casollne Corporation* My associate and t have been studying the problems associated with the handling of leaded gasoline over a period of years* . and it is quit fair to say that w have never found any evidence that gasoline containing tetraethyl lead in capable of producing any injury sore than that associated with the effects of the gasoline itself* X have no doubts you are nail aware of the fact that gasoline applied to the shin say orduo burning and irritation* at least for brief periods of tly&* d* pendent upon the duration of'contact mid other conditions such 88 the presence of clothing etc* Sotinea* and particularly under sdakfed clothing* the skin may he so injured as to not heel promptly and it say become infected If It is not properly cared for* It seems probable from your letter that this is what occurred lu your case* and If this Is the situation* tte seems probable that by this time It has. cleared tip to a very largo degree* or perhaps altogether* 'These injuries sometimes require medical care* and in as much as you have consulted a doctor* X would osrpoct that by this time your trouble is well under control* if this has not occurred* % 'should b very glad If you would write me telling vm just what is your present condition* It would be still more useful if you would have year doctor srifc to me* describing your condition mad letting me know whet he has done for your treatment* 1 shall be glad to give him any advice or assistance which X can 0.3 based on our experience with this type of ailment* I can assure* however* that the type of contact with leaded gasoline which you describe in your letter* could not hove resulted in lead absorption or In the production of lead poisoning* It baa been quite veil established both by oxporiiaanfcai work ami by the ox** perlence of fee last thirteen years that lead poisoning 2 does not occur as a consequence of prolonged osr: oauro to gosol'no containing Sctrcefchyl lead* As a matter of fact, Mr* Snyder was quit right lt stating that none of the employees of his eonpany had over suffered lead poisoning as s result of hand!

Kelley undertook to submit recommendations for suitable breathing aparatus for use in connection with the handling of tetraethyl lead and "Etbyltt Fluid.

S*S;0SM course of their antiknock additive research that tetramethyl lead- ^ ^ .' is superior to tetraethyl,"lead in high*octane, high aromatic con- * 1~ tent fuels.

Kelley undertook to submit recommendations for suitable breathing aparatus for use in connection with the handling of tetraethyl lead and ,rEtbylw Fluid.

These groups had been supplied with a copy of the Public Health Service Publication No. 712 entitled, "Tetraethyl Lead in Motor Fuel" and, but with one exception, all agreed that they would raise no objection to our permitting our customers to in crease the lead limits appearing in our current Sales Agreements from 3 ml to 4 ml per U.

Tn view of the difference between the percutaneous absorption of tetramethyl lead and tetraethyl lead, it would certainly be interesting to evaluate our two compounds in this regard.

D. 0020648 mmimm o k ib v t h ig a ^iq k o f iiAgAEPg OF U oT" "vTlOh'* OK BilHALF W TiiOSIfSbK Fh<^UCfga IKC. 1 -us investigation as contemplated by ourselves end agreed upon in principle at a conference in Cleveland* Ohio, on April 2j , 1*43* is to be pursued in two general end complementary phases, namely; (a; determination of the potential hazard of contact of the skin with the "Vitola mixture containing * sal. of tetraethyl lead per gallon* by subjecting experimental animals to such cutaneous contact with the product under conditions and by means comparable to those employed In the investigation of the potential hazards of cutaneous contact with gasoline containing j) ml. of tetraethyl lead per gallon* Ibj termination of the apparent hazards of lead absorption on the part of persons who nave been,and are to be, exposed to such hazards in the conduct of work which involves the preparation* handling and use of "Vitoi% by carrying out a systematic program of clinical and analytied examinations of available personnel, (the lattax' work is to be carried out by methods comparable to those used in the investiguti of the hazards associated with the manufacture, distribution and us of leaded gasoline* with such improvements in technique as have been found to be useful in recent years.; It would appear from our experience that the proper execu tion of these investIg&tions may be expected to yield a fairly definitive answer to the queeiion of the degree of hazard associated with such exposure as may occur among garage mechanics, other main tenance personnel, and filling station handlers of the pxoduot.

First, we have no way of predicting what the valde for organic lead will be in any tank and consequently it won*t be of muoh help to a workman, to know that the mean value is 0.0h2 when the tapk which he is cleaning at the moment happens to Contain very much more tetraethyl lead.

First, we have no way of predicting what the valhe for organic lead will be in any tank and consequently it won*t be of muoh help to a workman, to know that the mean value is 0.0M-2 when the tapk which he is cleaning at the moment happens to Contain vary much more tetraethyl lead.

There are obvious questions raised by the re port* One of these is that only about 0.73 eo. of tetraethyl lead was found in the Ethyl gasoline* I do not know of any Ethyl gasoline carrying as little lead as this* The other is the apparent assumpt ion that all of the combustion products wore analysed* A rough calculation on my part would indicate that about ZbO cubic feet of air is necessary to burn one pound of gasoline and, therefore* the estimates given in the report of the percentage of lead removed are in error.

A TK IN S, PIRST VICS-PRESIDENT Senodntbhaeckfohlleorweoinf,gwmheiscshagaere, shuebrjeebcyt atogrteheed tteorms HEW YORK N T 009*' 9 1 98 4 SEARROTMOAfNlgRTOHRIO HABLYDHGURSCTOLUMBUS OHIO REGARDING THREE DEATHS INSANITY EIGHT WORKERS FROM TETRAETHYL BEAD i STANDARD O IL NEW JERSEY PROFESSOR HENDERSON WIRES US SALE TO PUBLIC I m*- .0 ?

Lewie*' Attached hereto is exchange of corraapondenoe vrlth Lei"TM*Doen of DowChemical in connection with the use of Ot hundred pounds of tetraethyl lead which we recently sent them.