Document VJ36nJy3GdYyXEj322QyQNwaw

June 26, 19^8 Mr. C. H. VanHartesveldt, Thompson Vita-Meter Corporation, 64o2 Cedar Avenue, Cleveland, Ohio. Dear Mr. VanHartesveldt: I send you herewith two copies of a' memorandum dealing with the subjects which we have discussed with your people from time to time. In this memo I have outlined very briefly the experimental work which is to be done, and have indicated its probable cost, and have made certain suggestions for a formal agreement in this regard. I have been rather slow in getting this into your hands, but I have been tremendously busy, and I have considered that I was fulfilling my responsibilities to you and your associates by getting the work under way on the basis of our general understanding, with out worrying too much about the formalities. We have taken the necessary steps to get the work started in order to save as much time as possible, and I am glad to report that everything is in order in this regard. I believe the memorandum will clarify any further matters between us. I suggest, therefore, that at your convenience, attention be given to the form of agreement under which this work is to be done. If you are quite content on these matters, after giving them con sideration, I would suggest that you prepare four copies of the agreement and execute them, sending them to me for execution by the Board of Directors of the University in due course. If the simple form of agreement attached to my memorandum is satisfactory, you need only fill in the dates and the sum of money involved, making the four copies indicated. If there is anything that is not clear about our position, please do not hesitate to bring it to my attention. We are not troubled about the details of the agreement, or about the money, so long as we understand each other in a general way. On the other hand, it is our general practice to have the money paid In in advance, so far as possible. This can be done on a quarterly basis or in a lump sum for the balance of this year. In view of the fact that we have no funds to draw on, I consider it advisable for Dr. Kitzmiller to send his expense account for reimbursement at this time. Accordingly I attach it hereto. If you wish, this same procedure can be followed out subsequently, with respect to traveling expense, or it can be taken from the funds provided to us for all experimental purposes. Hey I suggest that it is inadvisable that'any statements concerning Mr. C. H. VanHartesveldt - {2) - June 26, 1948 this work, and more particularly -concerning any apparent results of the work, "be issued to the public press, or technical journals or elsewhere without our being specifically consulted as to the form and content in any such statement. By this means we shall all be saved from embarrassment or from any possibility of a mis-statement or misinterpretation of Information of this type. In making this suggestion I am deliberately calling attention to a news clipping which appeared in the May 19 National Petroleum News on the "Health Question" involved In the use of Vitol. I do not consider that the statement issued in this publication is particularly important or that it creates any embarrassing situation. Nevertheless the statement was issued prematurely, and it goes beyond anything we would be willing to say at this stage of the game. It Is not wise toypromise your own position, nor to compromise your consultants in this'matter, by issuing statements which do not lean over backwards In their critical repre sentation of the facts. Vlth best regards. Cordially yours, EAK ef Enc. Bobert A. Kehoe, M. D. 0020648 mmimm o k ib v t h ig a ^iq k o f iiAgAEPg OF U oT" "vTlOh'* OK BilHALF W TiiOSIfSbK Fh<^UCfga IKC. 1 -us investigation as contemplated by ourselves end agreed upon in principle at a conference in Cleveland* Ohio, on April 2j , 1*43* is to be pursued in two general end complementary phases, namely; (a; determination of the potential hazard of contact of the skin with the "Vitola mixture containing * sal. of tetraethyl lead per gallon* by subjecting experimental animals to such cutaneous contact with the product under conditions and by means comparable to those employed In the investigation of the potential hazards of cutaneous contact with gasoline containing j) ml. of tetraethyl lead per gallon* Ibj termination of the apparent hazards of lead absorption on the part of persons who nave been,and are to be, exposed to such hazards in the conduct of work which involves the preparation* handling and use of "Vitoi% by carrying out a systematic program of clinical and analytied examinations of available personnel, (the lattax' work is to be carried out by methods comparable to those used in the investiguti of the hazards associated with the manufacture, distribution and us of leaded gasoline* with such improvements in technique as have been found to be useful in recent years.; It would appear from our experience that the proper execu tion of these investIg&tions may be expected to yield a fairly definitive answer to the queeiion of the degree of hazard associated with such exposure as may occur among garage mechanics, other main tenance personnel, and filling station handlers of the pxoduot. Phis does not mean that other questions may not arise, or that new and unanticipated hazax-dc may not be created by subsequent developments and procedures in this business. Nevertheless, this type of invest!- K 0020649 N21966.01  gallon should give a clear Indication oi ttvs degree of hazard associated vith the handling' and use of this product, as compared vith that vhich lias been found in association vith the distribution and us of leaded gasoline * Scope and Duration of Investigations it Is anticipated that a period of approximate1# six months vi11 be required for the completion of the observations on animals. If the results are definitive, it is likely that no. further animal experimentation vill be required. If the results are uncertain or ambiguous, the experiments'vill require some modification or repeti tion under sossevbat different conditions, kbout four months of exposure of Vm animals vill be required and some? two months vill be required for the analytical study of their tissues that Is. expected to yield the pertinent infonaatlon. vtheae experiments were Initiated on dune 7, 1*48, after a period of pre-experiaental observation of the animals.) Periodic clinical examination and laboratory study of exposed personnel vill be carried out at quarterly Intervals (the first complete study of available personnel hae been made and data vill be available shortly) for a more or leas Indefinite period, i.e. until it can be cstabliabed that the lead exposure of the personnel is ilj too small to be measured, (2/ too email to have hygienic significance, or (p) too great to be vithln the limits of safety for indefinite periods of occupational exposure. It should be possible to obtain definitive infonaatlon on this point, insofar aa the existing condi tions of occupational lead exposure ai` concerned, in about tvelve months. This, according to present plans, vill involve four sets of complete physical examinations 11.. at quarterly intervals; and four series of da&lyses of the mine and blood of the available personnel K 0020650 lor their lead content It Is the intention of the staff of the lettering Laboratory to undertake and maintain this program of investigation, and at the same time to keep itself fully informed of the actual and anticipated developments of this phase of the fuel Industry, in order that any additions or modifications required to elucidate the teal and potential health bszaxds can be made. To this end, the full cooperation of responsible executives of Thompson Products lac. in providing pertinent information on their plans and progress, is solicited. Probable Cost of Investigations In accordance vi.th the general plan outlined, it is anticipated that the cost of the experimental program vill approximate i5' vithin the calendar year 1$48. The expense may be broken down, lor purposes of estimation, as follovss (a} of Animal Experimentation Expenditures for compensation of personnel actually engaged in the animal experiments rl, ; Preparation and analysis of tissues 1,2<3v ... Cost of animals and food for animals 2,a.-.;, normally distributed proportion of expense of general cost of operating laboratory (heat, light, power, janitor service, animal care* secretarial service, annuities and pensions* etc.; 1,2 ; Estimated expense v 2*7h j . - 0020651 lb} iJi-oawaa of Clinical Investigation of Exposed ^er&oianel~r Conducted in" juat, : es leader "and Seoctatoer Medical Services Analytical Services uccording and studying data and preparing clinical report (Traveling expense to be leimbursed directly J Estimated expense Total estimated expense $1 ,2p.>...- u J$** 9$ * ' *J policies of --no laboratory with reference to Pondact of Investinglion It seems advisable In the interest of all concerned that a general understanding concerning the policies of the laboratory in connection with this work be arrived at and recorded. Per this reason. a copy of a short fora of agreement in attached to this memorandum. It is apparent that the University of Cincinnati, as represented in this instance by the laboratory wishes to assert .and protect its position aa a publicly responsible institution. It is equally apparent that it accepts the obligation to protect the sponsor of the work against any unnecessary or inadvertent divulgence cl confidential trade information. The terms of this agreement otherwise deal with the willingness of the sponsor to defray the entire cost of the investigative program within certain agreed upon limitations with respect to overall sums of money within certain dates. These terns can be rewritten or restated for purposes of detail or clarity by the sponsor, so long as th principles of university responsibility are not violated. It is suggested that the present program be based on the calendar year 19^Bt and that funds be made available 0020652 pfor that pus-pose. Hovever, the agreement ay Include a statement or phrase that will permit of the extension of the work beyond December pi, lp48 without fa redrafting of a further formal agreement. neither ve, nor the Board of Directors of the University, are ''sticky ' about details so long as the conditions surrounding the conduct of the work are clear and mutually acceptable. It is also suggested that funds be made available to the end of'the" year, with the understanding ti^t any residual sum be returned.to the donor or otherwise applied against such further work as may be agreed upon mutually. 1 oocrt "h!"hehcei''*-''* "'*"" ri*'J,u"" Director, Kettering laboratory of Applied' Physiology, college of Medicine, University of Cincinna t.i u une t-p, j.i/%3 Kf 0020653 Karl V. Kitzmiller, M.D. Kettering Laboratory College of Medicine Cincinnati 19* Ohio June 23* 1948 Expense of trip to Cleveland for the Thompson Vita-Meter Corporation June16th to 19th, 1948 Railroad and Pullman Hotel Meals Taxi Tips, Telephone and Telegraph .... .... .... .... .... $27-32 4.50 12.00 6.10 4.45 TOTAL............................. . $54.37 Kg 0020654 N21966.02