ARm -OHlC B IO SE A R C H .
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M A 2 6 - 07/6 ACUTE TOXICITY TO FISH (BLUEGILL SUNFISH) TEST SUBSTANCE____________________________________________ Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-203. (1Octanesulfonic acid) (CAS # 2795-39-3).
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28 Day Percutaneous Absorption Study with FC-95 in Albino Rabbits Experiment No.: Conducted At: Dates Conducted: Conducted BY: Reviewed BY: dc: M.
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I MICROBIAL INHIBITION (DEHYDROGENASE ACTIVITY TEST) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonawthei,ch may alsobe referretdoas PFOS, FC-95,oras a component ofFC-203.
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ACUTE TOXICITY TO FISM (MUMMICHOG) TEST S[JRqTAMr'P Identity:A mixturecontainingperfluorooctanesulfonawthei,ch may alsobe referredtoas PFOS, FC-95, oras a component ofFC-206 or L3243. (1-Octanesulfoniacid)(CAS # 2795-39-3).
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FFLLUUOORROOCCHHEEMMIICCAALLSS IINN HHUUMMAANN BBLLOOOODD DRAFT IInnttrroodduuccttiioonn TTahnhdee presence of two tporeaselenscseeroefxttweont ,ssppepececirfiffiilccufoflrluouooorrcootccahhneeommaiticecaal(lsPs,,FOppAee)rrf,flluuiosorrdooeooscccttraainnbeeedssuuilnlffohonnuaamtteae n((PPbFFlOoOoSSd).),, aTy`Tenhhadeerstpporraeeagssolee.ennsccsPeeeFrooOfefAxaatnnehnaootsrr,ggpbaaeenneirifccnluffsooourrromsmopecooctffatffnlelu0duooarrotiiefnnebe(ePiiinFnnOghhuAuamm),saaiinnsgndibbfelloisocoocaddrnitbwwecaadossmipnooobbhsnsueeemrrnvvtaeenddofb33tlo00hiosd.
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* Sf { | A International Research and Development Corporation 249% 1 sPoNSOR: conpouND: susJECT: 3M Company R-3022 TNoixnteeclyeyDayStuSduyb.acute Rhesus Monkey hn SVidcweinPrI.esiGdoblndcancahnadl, Ph.D Director df Research Collaborators: i D.DiC.reJcetsosrupo,f PRhe.sDe.a,rchAssociate - } R.anGd.
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lo Submitted to: BIOSEARCH, INC.
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: oF al - AR22G-O u1q Sune 20, 1974 BLOOD LEVELSOFRF/F INSELECTEDEMPLOYEES: Bdeegtienrnmiinnge itnhe19a7m6ouwnetboefgaonrgtaoniscamfpolreinseele(cRt-eFd)IaMndemipnolrogyueneisc tfoluoride (F) ICnontthaecitr wbiltohodf,iuoOruarchseumbijceacltss.haBdevcaaruysiengofdethgereteeschonficeaxlpdoisfufrieculatnide/soarnd hmeembteenrgiohfosfubtjiemcetsneveedsteedd.0 pEearcfhorsumbjtehcettweaatts,inwteerwveireewedliminitaend aitnttehmept TheavGeevheardmiinneadwdhiattiopnotsositbhleeircownotrakctexwpiothsufrleu.orilneemors fsiuucohriadse thhoeuysemhaolyd pSirbojdeuccttss,inwcaltuedreds(u1p)pllyo,ngdeanntdi{srhiocrets,tidmreugfsl,uaeriocc.h,emwiecrael cpornosdiudcetrieodn, i"nxdpovseupreersviosveerry2w0orykeearrss,ag(e2s) l(a3)batreacthonriycawlorskeervrisc,e ienmcplluodiynegesthwosheo wwiotrhked - ilfaotctihiloinftsil,erso(3ac)nhdoaimf(i6i)ccsacowlnotprrrkooeldrsu.sctisn, cl(4o)veweperrosxiomfiftiyvetro oftuheermeicchaelmciocnatlaipnriondgucstkiimon tWhiethnoonrlmyatlwolietxecreaptturieonlse,veilnsor.ganOincefolfuotrhiedeexlceevpetlisownsermeadfohuandd 4torebceonwtithin HLeFngbtuhrnof, tiImnegetnhaetrahla,d wbeeefnousnpdenetlebvyattehde aRm-pFlodyeeveelsinprtohepoprrtoidouncatlitoon tahreent. fWoer a1i5s-o20foyuenadrst,hathaldabeolreavtaotriyonwsorofkeRrFs,(awbiotvhefLotremrearruerxepomsourrae,lsb"u)t nboorne of low magnitude.
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AR226-00!
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ACUTE TOXICITY TO BLUEGILL SUNFISH TEST SUBSTANCE Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: The test substance is a white powder (3M Lot 583) of uncharacterized purity.
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Covance Studies The attachedreportsummarizes the resultsfrom the assessment of mitochondrialbioenergeticosf hepaticmitochondriaisolatedfrom ratstreatedfor3 weeks with one of4 doses(pluscontrolo)f dietaryFC10.
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ACUTE TOXICITY TO FISH TEST SUBSTANCE Idenfity:Perfluorooctanesulfonylamido(ethyl)acetmaatye;alsobe referredto as PFOSAA, FC-128 or as the major component of FC-127, FC-129, FC-109, or FC-109-X.
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CentreAnal!
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