Document n96qRRNrmDBOX710kG8dgkd2X

N-ETFOSE Alcohol Bibliography Synonyms: FM 3422, FM 3923, FM 4635, FM 4120. F 9353, FC-10 Physical/Chomical Properties Title lwater solubil!ty Laboratory or Author 3M Env.Lab Date Completed 1 11/15/77 Type Robust summary, relevantpages from "Analytical Methodology on FMI 1 3422" LetterReport. BoilingPointInformation DeterminationofVapor PressureCurve by Dynamic Method forU1463 (Et FOSE) InternaMlerilo- MeltingPointof FM-3923 N-EthylFOSE Alcohol ASci 11/30/98 ASci 3M SMMD Analytical I Lab 11/6/98 11/22/99 Robust summary, lettereport Robust summary, finalreport Robust summary, lettereport Environmental Fate and Transport Title Laboratory or Author Tech Report - BiodegradationStudiesofFluorocarbons,Request forLaboratory work - BOD/COD, Memo - ChronologicalReview of BiodegradationStudieson FM3422, Tech Report - BiodegradationStudiesof Fluorocarbons- 11.(Robust summary for4 documents) 3M Env. Lab Tech Report - Bioconcentrationof FM3422 inBluegilSlunfishand inChannel Catfish,Tech Report - AquaticFate ofa Fluorochemical:FM 3422 Tech Notebook copies - Analyticaflrom fishbioconcentratiosntudies 3M Env.Lab G. Vraspir Alkalinehydrolysis 3M Env. Lab Completion Date Type 8/12J76, July,1977, 8/12/77, l/9t78 Robust summary, 2 technicalreports, work request, reviewdocument 5/17/1977. 10/14f77, 3/8/93 1/15/76- 2/1178 11115f77 Robust summary, 2 technicalreports, critiqubey J.W. Gillet(tComel) ??? Robust summary, relevantpages from "Analytical Methodology on FM 3422* Pilotstudieson soiladsorption Evaluationofthe BioconcentrationPotentialof FM 3422 itech Report -AdsorptionofFM-3422 on Soil 3M Env. Lab 3M Env. Lab I 3M Env. Lab 10,13,78, 5/19/93, 12/30/75, 317177, 4/12177, 5/9/77 8/16/78 9/l/78 Robust summary, page from technical notebook, critique from S. Boyd (MSU) and 2 pages ofdata summaries. Robust summary, critiquferom G.W. Gillet(tComell), technicalreport Robust summary, critiquferom S. Boyd (MSU), technicalreport Environmental Fateand Transport Title Laboratoryor Author Tech Report -AnalysisforFluorochemicalsinBluegilFlish 3M Env. Lab Tech Report - BioaccumulationofFluorochemicals inTenn. River,Tech Report FluorochemicalsinTenneessee River Fish. 3M Env. Lab TechnicalReport- Photo"is ofFM 3422 on Soil itech Report - FM-3422 PhotolysisStudy using Simulated Sunlight 3M Env.Lab 3M Ag. Product Completion Date 5/1179 Type Robust summary, critiquferom J.W. Gillet(tCornell), technicalreport 5/22179, 12/28/79, 3/8/93 12/10179 11/81 Robust summary, 2 technicalreports, ciritquferom i.W. Gillet(tCornell) Robust summary, technicalreport, critiquferom S. Boyd, MSU I Robust sumniar7,y] technicalreport Summary Reports Title Tech-Report - AnalyticalMethodology on FM 3422 Laboratory or Author 3M Env. Lab Completion Date 11115/77 Type Technical report., Critiqueby S.Boyd (MSU) Exerpts from thisreport appended to solubilitaynd alkalinehydrolysis robustsummaries. Tech Report - AnalyticalMethodology and Support Ecotoxicity Elements Title The Effectsof Continuous Aqueous Exposure to 78.01 on HatchabilitoyfEggs and Growth and Survivalof Fryof Fathead Minnow (Pimephales promelas , Summary of HistopathologicaElxaminations of Fathead Minnow (Pimephales promelas) Exposed to78.01 for30 Days.. Tech Report - MuWi-Phase AlgalAssay Test Method. 3M Env. Lab 1/17/79 Technical report. Exerpts from this reportappended to solubilitayl.kaline hydrolysis.volatility, distribution coefficients.oil adsorption, biodegradation.and fishchronictoxicity robustsummaries. Laboratory or Author Completion Date Type EG&G Bionomics 3M Env. Lab June,1978, Sept. 1978_ 12130/81 Robust summary. 2 technicalreports, exerptfrom Tech Report - Analytical Methodology and Support(Ill7179) Robust summary, technicalreport. N-MEFOSE Alcohol Synonyms:FM 3925,L4528,L-4309,PPA-791,PPA790 (Me &Et FOSE mix) cc 796-10,FM 3974,cc 7963 Physical/ChemicalProperties Title itech Report - Solubilitoyf FM 3925 Laboratory Date Type or Author Completed Robust summary, tech report, excerptfrom Tech report- 3M Env. 1/8/79, AnalyticalMethodology and 1 Lab 1 1/17/79 ISupport,1/17/79 EnvironmentalFateand Transport le r Laboratory Completion Type I orAuthor Date I I Tech Report - BiodegradationStudieson FM 3925, Tech Report - Chemical Oxygen Demand of FM 3925 3M Env Lab Tech Report - Distributiocnoefficienotf FM 3925 inn- 3M Env. OctanolANater Lab 1/8/79, 1/8/79 1/10/79 Robust summary,2 technical reports Robust summary, technical report Tech Report -Adsorptionof FM-3925 on Soil 3M Env. Lab 3/22/79, Robust summary, critiquferom 5/19/93 S. Boyd (MSU), technicalreport Tech Report -Bioaccumulationof Fluorochemicalsin Tenn. River Fish,Tech. Report -Fluorochemicalsin Tennessee RiverFish,Ar No. 7238 -Determinationof ,FluorinateAdlcoholsinFish Extracts 3M Env. Lab 5/22/79, Robust summary, critiquferom 12/28179, J.W. Gillet(tCornell)3, 10/23179 technicalreports Summary Reports ititle None Laboratory Completion Type orAuthor I Date I EcotoxicityElements Title Tech Report -AquaticToxicityStudies:FM 3925 Laboratory Completion Type or Author Date Robust summaries forfishand 3M Env. daphnia,copies ofdata sheets, Lab 1/8/79 technicalreport N -Ethylperfluorooctanes uIfonam ide = EthylAmide Synonyms: ETFOSA, ETPOSA, U1464, FX-12, F6309 Physical/ChemicalProperties Title DeterminationofVapor Pressure curve by dynamic Method forU1464 (ET POSA) LetterReport. BoilingPointInformatino Laboratory or Author ASci Corporation AScl Corporation Date Completed 11/6/98 11/30/98 Type Robust summary, report IRobust summary, report final letter EnvironmentalFateand Transport Title TechnicalReport - Bioaccumulationof FluorochemicalsinTenn. River Fish, Technical.Report - FluorochemicalsinTennessee RiverFish EnvironmentalLaboratoryFinalReport forBOD/COD Laboratory or Date Author Completed Type 3M Env.Lab 3M Env. Lab 5/22179, 12/28/79 6/12/84 Robust summary, 2 technicalreports,1 critiquferom J.W. Gillett ofCornel (3/8/93) Robust summary, copy of labreport EcotoxicitEylements Title Fathead minnow staticacute toxicittyest- FX-12 Daphnia magna staticacute toxicittyest- FX-12 Acute Toxicityof U 1464 to Ceriodaphniadubia Aucte ToxicityofU1464 to LarvalFathead Minnow (Pimephales promelas) InhibitioonfU1464 forActivatedSludge RespirationInhibition Acute ToxicityofU1464 to Daphnia magna Laboratory or Date Author Completed 3M Env.Lab 4/6/84 3M Env.Lab AScl Corporation AScl Corporation ASci Corporation ASci Corporation 4/8/84 5/4/98 5/4/98 5/15/98 5120/98 Type Robust summary, data sheets Robust summary, data sheets Robust summary, final report Robust summary, final report Robust summary, final report Robust summary, final report PerfluorodecanesulfonateA,mmonium Synonyms: FC-120, FC-121, LR J2904 Salt(PFDS) Physical/ChemicalProperties Title None Available Laboratory or Co Date Author mpleted Type Environmental Fate and Transport Title Laboratory or Date Author Completed Type BOD/COD Testing Results FC-120 BOD/COD Testing Results FC-1 21 -X Pace Incorporated, Minneapolis, MN Pace Laboratories, Inc, Minneapolis, IMN 12/4191 Robust summary, lab report Robust summary, lab 11/3/87 ,report Summary Reports Title None available Laboratory or Date Author Completed Type EcotoxicityElements Title ToxicityofFC-121-X to Microtox ToxicityofFC-121-X toactivatedsludge Acute ToxicityofE2566-1 to Dat)hniama-qna (FC-121-X) Laboratoryor Completion Author Date 3M Env.Lab 1987 3M Env.Lab 10/30/87 ABC Laboratories, Columbia, MO 1/9/88 Type Robust summary, test summary sheet Robust summary, test summary sheet Robust summary, final report Acute ToxicityofE2566-1 to Fathead Minnow (Pimephales promelas ABC Laboratories, Columbia, MO 1/15/88 Robust summary, exerpts from finalreport StaticAcute Toxicityof FC-120 Pimephales promelas to the Fathead Minnow, EnviroSyste ms Division, Resource Analysts,Inc. Robust summary, Hampton, NH March,1992 _report final StaticAcute Toxicityof FC-120 tothe Daphnid, Daphnia magna OECD ActivatedSludge RespirationInhibitioTnest #209 - Toxicityof FC-1 20 Microbics'MicrotoxTest -FC-1 20 EnviroSyste ms Division, Resource Analysts,Inc. Hampton, NH Feb., 1992 3M Env. Lab 3/9/92 3M Env. Lab 1 4/20/92 Robust report Robust sheets Robust sheets summary, summary, summary, final data data Perfluorooctanesulfonylamido(ethyl)acetat=ePFOSAA Synonyms: FC-1 09,FC-1 09-X, FC-128, FC129, E2113, E2566-2, R1904 Physical/ChemicalProperties Title EnvironmentalFateand Transport Title Tech. Report- Fate ofFluorochemicalsinthe Environmental(sic)(Warburg respirometemrethod forbiodegradatioonf FC-128) Ready BiodegradabilitoyfFC-128 - BOD/COD Laboratoryor Author Date Completed Laboratoryor Author 3M Env. Lab Date Completed 8/12/76 3M Env. Lab 7/8/77 Tech report- AnalysisforFluorochemicalsinBluegill 3M Env. Lab Fish Ready biodegradabiliotfyFC-127 - BOD/COD 3M Env. Lab 5/l/79 8/19/81 Ready biodegradabiliotfyFC-109-X - BOD/COD Pace Laboratories, Minneapolis,MN 12/31/87 Type Type Robust summary, technical report Robust summary, copiesof data sheets Robust summary, technical report Robust summary, copiesof data sheets Robust summary, copy of computer resultsfrom archives Summary Reports re Laboratoryor Date Type Author Comt)leted EcotoxicitEylements riltle Acute toxicitoyf FC-1 28 tofatheadminnow Acute toxicitoyf FC-128 tofatheadminnow Acute toxicitoyf FC-128 tofatheadminnow Acute toxicitoyf FC-127 tofatheadminnow Toxicityof FC-127 toactivatedsludge respiration Laboratoryor Completion Type Author Date 3M Env.Lab 3M Env. Lab 3M Env. Lab 3M Env. Lab 3M Env. Lab 5/18/74 6129/74 8/26/77 7/24/81 8/14/81 Robust summary, copiesof data sheets Robust summary, copiesof data sheets Robust summary, copiesof data sheets Robust summary, copiesof data sheets Robust summary, copiesof data sheets Ready Biodegradability":ModifiedOECD Screening Test'forFluoradFC-129 RCC, ltingen, Switzerland M icrobicsMicrotoxToxicityTest - FC- 109-X ActivatedSludge RespirationInhibitio-nFC-109x Acute Toxicityof E2566-2 to Daphnia magna Acute Toxicityof E2566-2 to Fathead Minnow (Pimephales promelas) Biodegradation(methyleneblue active substance) Acute Toxicityof R 1904 to Daphnia magna Growth InhibitioonfR 1904 forGreen Alga (Selenastrum capricomutum) Acute Toxicityof R1904 to Fathead Minnow (Pimephales promelas) MicrobicsMicrotoxToxicityTest - FC-129 InhibitioonfRl 904 forActivatedSludge Respiration R 1904 BOD Report for3M Company 3M Env. Lab 3M Env. Lab ABC Laboratory, Columbia, MO ABC Laboratory, Columbia, MO Pace Laboratories, Inc., Minneapolis, MN AScl Corporation, Duluth,MN AScl Corporation, Duluth,MN ASci Corporation, Duluth,MN AScl Corporation, Duluth,MN ASci Corporation, Duluth,MN AScl Corporation, Duluth,MN 9/19/84 10/15/87 10/30/87 1/9/88 1/12/88 2/15/89 6/17/97 6/18/97 6/27/97 7/9/97 7/10/97 Jul-97 Robust summary, memo about studyreliabiliftiyn,al report Robust summary, copiesof data sheets Robust summary, copiesof data sheets Robust summary, final report Robust summary, final report Robust summary, computer report,copiesof data sheets Robust summary, final report Robust summary, final report Robust summary, final report Robust summary, copiesof data sheets Robust summary, final report Robust summary, final report Synonyms: FX-8 POSF Physical/ChemicalProperties Title .Water solubilietsytimate(screen) Laboratoryor Author 3M Env.Lab Date Type Completed 5/11/84, Robust summary, critiqueby 3/l/93 E.Tucker, labworksheets EnvironmentalFateand Transport Title EnvironmentalAspects of POSF Reappraisalof POSF EnvironmentalFate Summary Reports Title None EcotoxicitEylements Title 96-hour Toxicityto Fathead Minnow 7-Minute Exposure ActivatedSludge Toxicity ITest Laboratoryor Author 3M Env.Lab 3M Env.Lab Completion Date 9/l/83 12/15/83 Laboratoryor Author Completion Date Type Technicalreport Technicalreport Type Laboratoryor Author 3M Env. Lab 3M Env. Lab Completion Type Date Robust summary, 4/6/84 sheets Robust summary, 5/10/84 1sheets data data MethylFOSEA Physica[/ChemicaPlroperties Title Laboratoryor Author Studyof StabiliotfyMEFOSEA inAqueous Buffers Using Gas Chromatography withAtomic Emission Detection 3M Env.Lab Date Completed 6/14/99 Type Robust Summary and Technical Report Environmental Fate and Transport Title Determination of the PartitionCoefficient(NOctanol/Water)of T-5969.4 Laboratory or Date Author Completed 3M Env. Lab 11/9/94 Type Robust Summary and Technical Report Ethyl FOSEA Synonyms: FX-13, B1228, D-1 Physical/ChemicalProperties Title Laboratoryor Date Type Author Completed Determinatioonf Physico-chemicalPropertieosf Sample D-1 Mitsubishi Chemical Safety InstitutLetd., Yokohama, Japan 2/14/96 Robust summary, finarleport EnvironmentalFateand Transport Title Ready biodegradabiliotfyFX-13 (BOD/COD) Laboratoryor Author 3M Env.Lab Completion Date 4/26/84 Type Robust summary, copiesof data sheets Ready BiodegradabilitTyest of D-1 Mitsubishi Chemical Safety InstitutLetd., Yokohama, Japan 10/31/95 Robust summary, final report Mitsubishi Chemical Safety BioaccumulationStudy of Sample D-1 withCarp InstitutLetd., (gy-Lnu-sofli o-) lyokohama, Japani 11/30/95 1 Robust summary, final report EcotoxicitEylements Title Acute toxicitoyf FX-1 3 tofathead minnow Laboratoryor Author 3M Env. Lab Completion Date 4/l/84 Type Robust summary, copiesof data sheets. FC-128Documents Synonyms:L-1161,PFOSAA Title Author Tech Report - Biodegradation Studiesof fluorocarbons E. Reiner Tech. Report - 2nd Quarter Report - 1978 A. mendel Tech Report -Analysisfor Fluorochemicalsin BluegilFlish G. Braspir/A. Mendel Date Description Recommend ed Action 3/12/76 7/18/78 Initibailodegstudies (Warburg and SCAS, FC-95, FM 3422, FC-128 Summary ofprojects. Mentions effluentand sludge analyses ofDecatur -Find these Reports FM 3422, FC-95, FC. 128 Use FM 3422, FC-143, FM 3925, FC-95, FC 807, FC128 Use? 5/l/79 FM 3422, Effluentand riverwater FM 3923, exposure. No write-upof fish FC-95, FC. exposure. FC-128notfound 143, FC- infish 128. Use LaboratoryEnvironmentaSltudiesinPlanned and inProgress iChomiMM Study PhysicaUChemlcParlopordn N cEoTFoOlSE A[ h SolubilitiynWater - Inprogress r-isee Dogmdationand Tmnspoit next page F-INone Ecotoideology planned iconducted By ExpeCted Completon idate Wildlife Intemational, Easton, MD Sept.,2000 ExpectedCompletioDnatesfor Degradatioannd TransporSttudiesinProgress Photolysis Chemistry buffer/H202 humicmaterial Solis POSF FOSA October2,000 August,2000 October,2000 August 2000 October,2000 Aug@st, 2000 N-ETFOSA August,2000 August,2000 Not applicable N4WeFOSA December, 2000 December, 2000 Not applicable N-ETFOSE Alcohol July,2000 July,2000 July,2000 N-MEFOSE Alcohol February,2001 February,2001 Not applicable N-ETFOSEA September, 2000 Septem6e-r,2000 Not'applicable F0203 October,2000 August,2000 Not applicable Not applicable July,2000 Not applicable Not applicable T!02 October,2000 August,2000 Not applicable Not ai@licable July?,ooo Not applicable Not applicable Chem!*" POSF FOSA N-ETFOSA N-MEFOSA N-ETFOSE Alcohol N-MEFOSE ,Alcohol IN-ETFOSEA Hydrolysis buffers December, 2000 August,2000 __ August,2000 September, 2000 July,2000 September, 2000 ISeptember, 2000 Solis Not applicable Not applicable Not applicable Not ap licable July,2000 Not applicable 1Not applicable Adsorption/ Chemistry POSF FOSA N-ETFOSA N-MEFOSA N-ETFOSE Alcohol N-MEFOSE .Alcohol IN-ETFOSEA orption I November, 2000 January,2001 January,2001 March, 2001 September, 2000 March, 2001 March, 2001 Atmospheric Ph Chemkdrv POSF FOSA N-ETIFOSA N-MEFOSA N-ETFOSE Alcohol N-M&FOSE Alcohol N-EtIFOSEA IYSNIW August, 2000 Not applicable Not applicable Not applicable September, 2000 Not a licable Not applicable Allstudies underway at the 3M Env. lab AttachmentstoLettertoC.Auer datedMay 18,2000 Studieasnd OtherInformatioonn Certain PerfluorooctaSnuelfonate-RelatCeodmpounds 1. POSF Perfluorooetanesulffolnuyolride AcuteToxicit 1) Primary Skin IrritatiToenstwith T-3874 inAlbino Rabbits,Pathologyand Toxicology,RikerLaboratoriesP,rojectNo. 0386EB0135, 3M ReferenceNo. T3874, April14,1986 2) T-3607 Acute InhalationToxicityTest,Bushy Run Research Center,ProjectNo. 47527,3M Reference No. T-3 607,December 19,1984 3) Acute Oral ToxicityStudy - Method, Sununary, Pathologyand Raw Data Appendix, Hazleton LaboratoriesAmerica, Inc.,ProjectNo. 40703983, October 5, 1984 Genotoxicit 1) In VitroMicrobiologicaAlssays of 3M Company Compounds T-2540 CoC and T2541 CoC, SRI InternationaPlr,ojectNo. LSC 4442-16,3M Reference No. T-254 1.1 (FC-3452),August,1979 Ongoing Research/StudyProtocols 1) Protocol,PharmacokineticStudy of POSF inRats,3M StrategiTcoxicology Laboratory,3M ReferenceNo. T-7098.1 Pre-1976Studies(bibliogrmhyonly) 1) Skin Irritatiaond Eye IrritatiSotnudy Report,WARF InstitutIen,c.,ProjectNo. 5091241, 3M ReferenceNo. T-1329, September 9, 1975 2) Acute Vapor InhalatioTnoxicityStudy inRats,IndustriaBlio-TestLaboratories, ProjectNo. 663-07513,3M Reference No.,T-1329, October 23, 1975 AttachmentstoLettertoC.Auer datedMay 18,2000 Studiesand OtherInformatioonn Certain PerfluorooetaSnuelfonate-RelatCeodmpounds 2. FOSA Perfluorooctanesulfonamide AcuteToxicit 1) Acute Oral ToxicityScreenwith T-3421 inAlbino Rats,SafetyEvaluation Laboratory,Riker laboratorieIsn,c.,ProjectNo. 0883AR0287, 3M ReferenceNo. T3421 (KTZ-15),January17,1984 2) Acute Ocular IrritatioTnestwithT-3421 inAlbino Rabbits,SafetyEvaluation Laboratory,RikerlaboratorieIsn,c.,ProjectNo. 0883EB286, 3M Reference No. T3421 (KTZ- 15),August 24, 1983 3) Primary Skin IrritatiToenstwith T-3421 in AlbinoRabbits,SafetyEvaluation Laboratory,Riker laboratorieIsn,c.,ProjectNo. 0883AR0288, 3M Reference No. T3421 (KTZ-15),August 9,1983 Studiesin Progress 1) Protocol,Feces Method Development Metabolism Study forPerfluorooctanesulfonate Derivatives[N-EtFOSE, PFOS, and FOSA], 3M StrategicToxicologyLaboratory, Study Nos.,T-636.17;T-6295.21;T-7132.3;ST-41, In-LifeStartDate November 22, 1999, In-LifeEnd Date November 24, 1999 2) Protocol,PharmacokineticStudy of PerfluorooctaneSulfonamide [FOSA] inRats, 3M StrategicToxicologyLaboratory,Study Nos.,T132.2;ST-39, In-LifeStartDate October 4, 1999, In-LifeEnd Date November 2, 1999 3) Protocol,CellProliferatioSntudy with N-Ethyl PerfluorooctanesulfonarniEdtohanol (N-EtFOSE; 3M T-6316.11),PerfluorooctaneSulfonicAcid PotassiumSalt(PFOS; 3M T-6295.16),and N-EthylPerfluorooctanesulfonamid(ePFOSA 3M T-709 1.1)in Rats,Pathology AssociatesInternationalS,tudy No. 1132-100 -2- AttachmentstoLettertoC. Auer datedMay 18,2000 Studieasnd OtherInformatioonn Certain PerfluorooctaSnuelfonate-RelatCeodmpounds 3.PFOSAA Perfluorooctasnuelfonylamid(oethyl)acetate AcuteToxicit 1) Acute Oral Toxicity- Rats,Biosearch,Inc.,ProjectNo. 77-1108A, 3M Reference No. T-1983 (FC-128, potassiumsalt100%, solid)J,anuary5,1978 2) Acute Oral Toxicity- Rats,Biosearch,Inc.,ProjectNo. 77-1127A, 3M Reference No. T-2001 (FC-128),January6, 1978 3) Primary Eye IrritatioSntudy- Rabbits,Biosearch,Inc.,ProjectNo. 77-1127A, 3M ReferenceNo. T-2001 (FC-128),January6,1978 4) Primary Skin IrritatioSntudy- Rabbits,Biosearch,Inc.,ProjectNo. 77-1127A, 3M ReferenceNo. T-2001 (FC-128),January6, 1978 5) An Acute InhalationToxicityStudy of T-2307 CoC intheRat,Bio/dynamics,Inc., ProjectNo. 78-7186, 3M ReferenceNo. T-2307 (FC-128),February8, 1979 AdditionalAcute ToxiciiyStudiesNot Submitted(Bibliogrgphyonly) 1) Acute Oral Toxicity-Rats, Biosearch,Inc.,ProjectNo. 78-1191A, 3M Reference No. T-2081 (FC-129,approximately40-50% insolution)M,arch 2,1978 2) Primary Eye IrritatioSntudy - Rabbits,Biosearch,Inc.,ProjectNo. 78-1191A, 3M ReferenceNo. T-2081 (FC-129),March 2, 1978 3) Primary Skin IrritatioSntudy - Rabbits,Biosearch,Inc.,ProjectNo. 78-1191A, 3M Reference No. T-2081 (FC-129),March 2, 1978 4) Acute Oral ToxicityScreen with T-3290CoC in Albino Rats,SafetyEvaluation Laboratory,Riker LaboratoriesI,nc.,ProjectNo. 088AR0362,3M ReferenceNo. T3290 (40 % WPFOSAA in 3 % ETOH, 17 % EPA and 40 % H20, L-6778,F-6873, Lot 501),November 5, 1982 5) Primary Skin IrritatioTnestwith T-3290CoC inAlbino Rabbits,SafetyEvaluation Laboratory,Riker LaboratoriesI,nc.,ProjectNo. 088EB0423, 3M ReferenceNo. T3290 (40 % K+PFOSAA in 3 % ETOH, 17 % IPA and 40 % H20, L-6778,F-6873, Lot 501),October 15, 1982 6) Acute Ocular IrritatioTnestwith T-3290CoC inAlbino Rabbits,SafetyEvaluation Laboratory,Riker LaboratoriesI,nc.,ProjectNo. 088EB0424, 3M ReferenceNo. T- -3- AttachmentstoLettertoC.Auer datedMay 18,2000 Studieasnd OtherInformatioonn Certain PerfluorooctaSnuelfonate-RelatCeodmpounds 3290(40% K+PFOSAA in3 % ETOH,17 % IPA and40 % H20,L-6778,F-6873,Lot 501),October26, 1982 Genotoxicit 1) BacterialReverse Mutation Testof v-1,Hita Research laboratoriesC,hemical BiotestingCenter,Chemicals Inspectionand TestingInstituteS,tudy Code: KOI1815,Report No. T-4663, 3M Reference No. T-6668.1,FC- 129 (approximately4050% insolutionof waterand organicsolvent)O,ctober,1996 2) In VitroMicrobiologicalMutagenicityAssays of 3M Company's Compound T3290CoC, SRI InternationaPlr,ojectNo. 3145,3M ReferenceNo. T-3290 (40 % K@PFOSAA in 3 % ETOH, 17 % EPA and 40 % H20, L-6778, F-6873, Lot 501), November, 1982 Pharmacokinetig Studies 1) 28 Dermal PercutaneousAbsorption Study with FC-1 28 inAlbino Rabbits,Safety EvaluationlaboratoryR,ikerLaboratoriesI,nc.,ProjectNo. 0979ABO629, 3M Reference No. T-3991, March 15, 1981 2) 28 Day Dermal PercutaneousAbsorptionStudy with FC-129 inAlbino Rabbits, SafetyEvaluationlaboratoryR,iker LaboratoriesI,nc.,ProjectNo. 0979ABO627, 3M ReferenceNo. T-3989, March 14,1981 3) FinalReport- AnalyticalStudy:Single-DoseDermal Absorption/ ToxicityStudy of T-6051 and T-6054 inRabbits,3M EnvironmentalLaboratory,Study No. ADMT0 13195.1,invivo Study ReferenceNo. HWI 6329-133 (HazletonWisconsin,Inc.), 3M ReferenceNos. T-6051 (FC-129 treatedfabric)and T-6054 (FC-129 solution), November 22, 1995 4) FinalReport,AnalyticalReport and Single-DoseIntravenousPharmacokineticStudy ofT-6054 inRabbits,3M EnvirorunentalTechnology & Services,In-VivoStudy ReferenceNo. HWI#6329-138, StudyNo. AMDT-122094.2,3M ReferenceNo. FC129,November 22, 1995 Studiesin Progress 1) CorporateToxicology Study Outline,FC-129 PreliminaryADME StrategiTcoxicology Laboratory,July,1998 ScreeninRats,3M -4- Attachments to Letterto C. Auer dated May 18,2000 Studiesand Other Information on Certain PerfluorooctaneSulfonate-RelatedCompounds Pre-1976Studies(bibliogaphyonly) 1) Skin and Eye IrritatiAosnsay Report,WARF InstitutPer,ojectNo. 2031046, 3M Reference No. FC-128, Apyil24, 1962 (plusDecember 29, 1966 lettecrontaining individualeye scores) -5- AttachmentstoLettertoC. Auer datedMay 18,2000 Studiesand OtherInformatioonn Certain PerfluorooetaSnuelfonate-RelatCeodmpounds 4. PFDS Perfluorodecanesulaftoen AcuteToxici 1) FinalReport,Acute DerynalToxicityStudy inRabbits,HazeltonLaboratories America,.Inc.,3M ReferenceNo. T-4102, Sample No. T837389-410 754,January 21, 1988 2) FinalReport,Acute Oral ToxicityStudy inRats,Hazelton LaboratoriesAmerica, Inc.,3M ReferenceNo. T-4102, Sample No. T837389-410 754, January 25, 1988 3) FinalReport,Primary Eye Irritation/CorrosiSotnudy inRabbits,Hazelton LaboratoriesAmerica, Inc.,3M Reference No. T-4102, Sample No. T837389-410 754,January 20, 1988 4) FinalReport,Primary Derinalh-ritation/CorrosiSotnudy inRabbits,Hazelton LaboratoriesAmerica, Inc.,3M Reference No. T-4102, Sample No. T837389-410 754, January 21, 1988 Genotoxicit 1) MutagenicitTyestwithT-6357 intheSalmonell-aEscherichicaoli/MammalianMicrosome Reverse MutationAssay,Coming Hazleton,Inc.(CHV), ProjectNo. 17387-0-409,3M ReferenceNo. T-6357, FC-120, April1,1996 2) MutagenicityTest on T-6357 inan In Vivo Mouse MicronucleusAssay, Coming Hazleton,Inc.(CHV), ProjectNo. F7i87-0-409,3M ReferenceNo. T-6357, FC-120, April23, 1996 PharmacokineticStudies 1) FinalReport,AnalyticalReport and Single-DoseDermal Absorption/ ToxicityStudy of T-6052 inRabbits,HazletonWisconsin,Inc.,ProjectNo. HWI 6329-135,3M ReferenceNo. FC- 120,T-6052 (0.02% inwater),November 20, 1995 2) Single-DoseDermal IntravenousPharmacokineticStudy ofT-6052 inRabbits, Hazleton Wisconsin,Inc.,ProjectNo. HWI 6329-134,3M ReferenceNo. T-6052 (0.02% inwater),November 20,19995 -6- AttachmentstoLettertoC.Auer datedMay 18,2000 Studiesand OtherInformatioonn Certain PerfluorooetaSnuelfonate-RelatCeodmpounds Pre-197S6tudie(sbibliogaphoynly) 1) Acute Oral ToxicityStudy with T-1019 inMale Albino Rats,IndustriaBlio-Test LaboratoriesI,nc.,ProjectNo. 601-05394, 3M Reference No. T-1019, August 6, 1974 2) Skin IrritatioEny,e IrritatioAnc,ute Oral LD50, WAR-F InstituteI,nc.,ProjectNo. 4053 863, 3M ReferenceNo. T-992,May 24, 1974 3) Acute Oral CholinesterasSetudy with T-1019 inMale Albino Rats,IndustriaBlio- TestLaboratoriesI,nc.,ProjectNo. 601-05394, 3M Reference No. T-1019,August 6, 1974 -7- Attachments to Letterto C. Auer dated May 18,2000 Studiesand Other Informationon Certain PerfluorooctaneSulfonate-RelatedCompounds [5. PFHS Perfluorohexanesulfonate See confidentiaslubmissionunderletteorfMay 15,2000 from Dr. John L.Butenhoff for one item includingPFHS data -8- AttachmentstoLettertoC. Auer datedMay 18,2000 Studiesand OtherInformatioonn Certain PerfluorooctaSnuelfonate-RelatCeodmpounds :)SA IN-ethylperfluorooctanesulfonamide AcuteToxicit 1) FinalReport,Acute OcularIrritatiToenstwith T-3608 inAlbinoRats,Riker LaboratoriesI,nc.,3M Reference FX-12, Study No. 0984EB0367, September 5, 1984 2) FinalReport,Primary Skin IrritatiToenst with T-3608 inAlbinoRats,Riker LaboratoriesI,nc.,3M Reference FX- 12, Study No. 0984EB0368, August 13, 1984 3) FinalReport,Acute Oral ToxicityScreenwith T-3066CoC inAlbino Rats,Riker LaboratoriesI,nc.,3M Ref No. FX-12, Study No. 0981AR0146, July 13, 1981 Acute ToxicityStudiesNot Submitted(Biblio"a hy Only) 1) FinalReport,Acute OralToxicityStudy ofT-6684 inRats (OECD Guidelines), Coming Hazelton Inc.,3M Ref.No. L-14394 (slurry)S,tudy No. CHW 61101149, January 31, 1997 2) FinalReport,Primary Dermal Irritation/CorrosSitoundy of T-6684 inRats (OECD Guidelines)C,oming HazeltonInc.,3M Ref.No. L-14394 (slurry)S,tudy No. CHW 61101150, January 31, 1997 3) FinalReport,PrimaryEye Irritation/CorrosSitoundy of T-6684 inRats (OECD Guidelines)C,oming HazeltonInc.,3M Ref.No. L-14394 (slurry)S,tudy No. CHW 61101151, January31, 1997 Genotoxicit 1) FinalReport,Protocoland two amendments, MutagenicityTest on T-6294 inan In Vivo Mouse MicronucleusAssay, Coming Hazelton,Inc.,StudyNo. 1785-0-455, May 10,1996 PreviouslysubmittedwithMay 4,2000 letterA,dvanced BioanalyticaSlervices,Inc., AnalyticalReport,AdditionalCharacterizatioonf Metabolitesof T-6292,T-6293 and T6294 from Rat and Human Hepatocytesby TurboIonSpray LC/MS and LC/MS/MS. Semi-QuantitativeAnalysisof T-6295 inRat and Human HepatocytesIncubatedwith T6292,T-6293 and T-6294 by LC/MS/MS, January28,1998, Report 98AGKPOI.3M -9- AttachmentstoLettertoC. Auer datedMay 18,2000 Studiesand OtherInformatioonn Certain PerfluorooetaSnuelfonate-RelatCeodmpounds Mechanistic 1) T. J.Cross and R. G. Schnellmann,Mechanism of Toxicityof a Unique Pesticide N-EthylperfluorooctanSeulfanomide (NEPFOS), and itsmetaboliteperfluorooctane Sulfonamide(PFOS) toIsolateRdabbitRenal CorticalMitochondria(RCM), Abstractfrom 1989 SocietyofToxicology Meeting Previouslysubmittedwith May 4,2000 lette-r QualitativIenvestigatioonf the InVitro Metabolism of T-6292 (n-ethylFOSE), T-6293 (n-ethylFOSE phosphatediammonium salt(esterT)-)6,294 (n-ethyplerfluorooctanseulfonamide)and T-6295 (perflurooctane sulfonateb)y Rat and Human HepatocytesUsing Ion Spray LC/MS and LC/MS/MS, Advanced BioanalyticaSlervices,Inc.,[PreliminaryA]nalyticalReport,Report 96ADEM01.3M, November 12,1996 Previouslysubmittedwith May 4,2000 lette-rAdvanced BioanalyticaSlervices,Inc., AnalyticalReport,AdditionalCharacterizatioonfMetabolitesof T-6292, T-6293 and T6294 from Rat and Human Hepatocytesby TurbolonSpray LC/MS and LC/MS/MS. Semi-QuantitativeAnalysisofT-6295 in Rat and Human HepatocytesIncubatedwith T6292,T-6293 and T-6294 by LC/MS/MS, January28,1998, Report 98AGKPO1.3M AnalZical 1) Analyticaland.ResearchPropertie-s 3M IndustriaHlygiene Laboratory,January 1993 -10- Attachments to Letterto C. Auer dated May 18,2000 Studiesand Other Information on Certain PerfluorooctaneSulfonate-RelatedCompounds EtFOSATIN-ethyl perfluorooctanesulfonamide BibliographyShowing Studiesin 3M's PossessionBelievedTo Be In FIFRA Docket. REDACTED AttachmentstoLettertoC.Auer datedMay 18,2000 Studieasnd OtherInformatioonn Certain PerfluorooctaSnuelfonate-RelatCeodmpounds MEFOSA N-methylperfluorooetanesulfonamide AcuteToxicit I) Acute Oral Toxicity- Method, Summary, PathologyQAU Report,Hazleton LaboratoriesAmerica, Inc.,ProjectNo. 50503499, 3M ReferenceNo. T-3752 (F7075-4,water-washed,acidwashed),July 12, 1985,with Protocol 2) Primary Dermal Irritatio-nMethod, Summary, Pathology QAU Report,Hazleton LaboratoriesAmerica, Inc.,ProjectNo. 50503500, 3M ReferenceNo. T-3752 (F7075-4,water-washed,acidwashed),June 24, 1985,with Protocol 3) Primary Eye Irritati-onMethod, Summary, PathologyQAU Report,Hazleton LaboratoriesAmerica, Inc.,ProjectNo. 50503501, 3M ReferenceNo. T-3752 (F7075-4,water-washed,acidwashed), June 24, 1985,with Protocol 4) Acute OralToxicity- Method, Summary, Pathology;Primary DerinalIrritati-on Method, Summary; Primary Eye Irritati-onMethod, Summary; QAU Report;Raw Data Appendix, Hazleton LaboratoriesAmerica, Inc,.ProjectNo. 50202473, 3M ReferenceNo. T-3727 (F-10034,Lot 7,distillewdide-range),May 7, 1985,with Protocol 5) Acute Oral ToxicityScreenwith T-3065CoC inAlbino Rats,Riker LaboratoriesI,nc., Experiment No. 098 1ARO 145,May 15,1981 Genotoxicit I) InVitroMicrobiologicaMlutagenicityAssays of T-3752, SRI InternationaPlr,oject No. LSC-3145, 3M ReferenceNo. T-3752 (F-7075-4,water-washed,acidwashed), June,1985 2) In VitroMicrobiologicaMlutagenicityAssays of T-3727, SRI InternationaPlr,oject Kc@ LSC-3145, 3M ReferenceNo. T-3727 (F-10034,Lot 7,distillewdide-range), March, 1985 -12- AttachmentstoLettertoC.Auer datedMay 18,2000 Studiesand OtherInformatioonn Certain PerfluorooctaSnuelfonate-RelatCeodmpounds 8. N-ETFOSE alcohol N-ethylperfluorooetasnuelfonamidoethanol I AcuteToxicit 1) CorrectedFinalReport,Acute InhalatioTnoxicityStudy inRats,3M ReferenceNo. T-2991 IT,Hazelton LaboratoriesAmerica, Inc.,Study No. 154-157,February2, 1981 Genotoxicity 1) FinalReport,MutagenicityTeston T-5710 in an In VivoRat MicronucleusAssay, Hazelton Washington, Inc.,Study No. 15516-0-454,April23, 1993 2) FinalReport,GenotoxicityTeston T-5710.1inthe InVivo/InVitroUnscheduled DNA Synthesisand CellProlif6ratioinnRat LiverCells,Hazelton Washington, Inc., Study No. 15516-0-494,September 14, 1993 3) FinaRleportM,utageniciTteystonT-6292inanInVivoMouseMicronucleuAssay, Hazelton Washington, Inc.,Study No. 17384-0-455,May 2, 1996,with Protocoland Protocolamendments 4) EvaluationoftheMutagenic Activityof T-6906 inan In VitroManimalian CellGene Mutation Testwith L5178Y Mouse Lymphoma Cells,NOTOX Study No. 223458, 3M ReferenceNo. FM-3923 a) FinalReport,December 22,1998 (seelettebrelow) b) Letterfrom SteveR. Haworth, Ph.D.,Covance Laboratoriesr,eviewingthe NOTOX study and concludingitwas technicalliynadequateand should be repeated Note: 3M isrepeatingthestudy Rgpeated-Dose Toxici 1) FinalReport,NinetyDay SubacuteRat ToxicityStudy on FM-3422, International Research and Development Corporation,Study No. 137-086,November 10, 1978 -13- AttachmentstoLettertoC. Auer datedMay 18,2000 Studiesand OtherInformatioonn Certain PerfluorooctaSnuelfonate-RelatCeodmpounds 2) FinalReportN,inetyDay SubacutRehesusMonkey ToxicitSytudyo,n FM-3422, InternationaRlesearch and Development Corporation,Study No. 137-088,January 16,1979 3) Two-Year DietaryStudy a) Report,Volumes 1-5,Two Year Oral(Diet)Toxicity/ CarcinogenicitSytudy of FluorochemicalFM-3924 inRats,Riker LaboratoriesI,nc.,Study No. 0281CROO12, August 29,1987, Conducted duringApril 1981 - May 1983 b) ReportAmendment No. 1,Two Year Oral (Diet)Toxicity/ CarcinogenicitSytudy of FluorochemicalFM-3924 in Rats,RikerLaboratoriesI,nc.,StudyNo. 0281 CROOI 2, October 25, 1988 c) Xenos LetterdatedMay 24, 1991 with attachment:3M Response toFDA Letter ofDecember 10,1990 [re2 year cancerstudy],Food AdditivePetitionNos. OB4197 and OB4206 d) PathologyReview of Reported Tumorigenesisina Two Year Study ofFM-3924 inRats,Pathology AssociatesInternationaNlo,vember 25, 1998 e) Analyticalon retainedsample f)Review by Dr. WilliamH. Butlerof Two Year (Diet)Toxicity/Carcinogenicity Study of FluorochemicalFM 3924 inRats 4) Ongoing 2-Year Study a) Summary Reportof Week 53,104-Week DietaryCarcinogenicitSytudywith Narrow Range (98.1O/oN)-Ethyl PerfluorooctanesulfanoamidEothanol inRats, 3M ReferenceNo. T-6316.1,Covance Laboratories6,329-212 and -228 (draft finalreportexpectedfall2000) PhannacokineticStudies 1) Synthesisand CharacterizatioonfN-Ethyl FOSE 14C ,Riker LaboratoriesM,arch 17, 1981 2) FinalReport,Absorptionand BiotransformatioonfN-Ethyl FOSE and Tissue Distributioannd EliminationofCarbon-14 afterAchninistratioonfN-Ethyl FOSE 14C inFeed, Riker LaboratoriesI,nc.,January 19, 1983 -14- AttachmentstoLettertoC.Auer datedMay 18,2000 Studiesand OtherInformatioonn Certain PerfluorooctaSnuelfonate-RelatCeodmpounds PreviouslsyubmittewdithMay 4,2000lette-r-QualitatiIvnevestigatoifotnheInVitro Metabolism of T-6292 (n-ethylFOSE), T-6293 (n-ethylFOSE phosphatediammonium salt(esterT)-)6,294 (n-ethyplerfluorooctanseulfonamide)and T-6295 (perflurooctane sulfonateb)y Rat and Human HepatocytesUsing Ion Spray LC/MS and LC/MS/MS, Advanced BioanalyticaSlervices,Inc.,[PreliminaryA]nalyticalReport,Report 96ADEMOI.3M, November 12,1996 Previouslysubmittedwith May 4,2000 lette-rAdvanced BioanalyticaSlervices,Inc., AnalyticalReport,AdditionalCharacterizatioonf Metabolitesof T-6292,T-6293 and T6294 from Rat and Human Hepatocytesby TurboIonSpray LC/MS and LC/MS/MS. Semi-QuantitativeAnalysisofT-6295 inRat and Human HepatocytesIncubatedwith T6292, T-6293 and T-6294 by LC/MS/MS, January28, 1998,Report 98AGYPO 1.3M Mechanistic 1) FinalReport,Analysisof T-5877 ina CellProliferatioAnssay inRat LiverCells, Hazelton Washington, Inc.,Study No. 154-208,3M ReferenceT-5877 (widerange ethylFOSE), FM-3924, Lot 547, L-13202, November 1,1994,with Protocoland ProtocolAddendum, Key toFC Alcohol Tox Samples (includin5g877),and Analyticaldata Teratology 1) Oral(Gavage)Developmental ToxicityStudy ofN-ETFOSE inRats a) FinalReport,Oral (Gavage)Developmental ToxicityStudy of N-ETFOSE inRats, 3M ReferenceNo. T-6316.7,December 17, 1998 b) Summary N-EtfoseRat Teratology,Oral(Gavage)DevelopmentalToxicityStudy of N-ETFOSE inRats,3M Reference No. T-6316.7 2) Oral (Stomach Tube) Developmental ToxicityStudy of N-ETFOSE inRabbits a) FinalReport,Oral(Stomach Tube) Developmental ToxicityStudy of N-ETFOSE inRabbits,3M ReferenceNo. T-6316.8,January 11, 1999 b) Summary N-ETFOSE RabbitTeratology,Oral(Stomach Tube) Developmental ToxicityStudy of N-ETFOSE inRabbits,3M Reference No. T-6316.8 3) TeratologyStudiesofT-2999 (FM-3924) inRabbits -15- AttachmentstoLettertoC.Auer datedMay 18,2000 Studiesand OtherInformatioonn Certain PerfluorooctaSnuelfonate-RelatCeodmpounds a) FinalReport,OralRangefinderStudy ofT-2999CoC inPregnantRabbits,Safety EvaluationLaboratory,Riker Laboratories,Inc.,Study No. 0680RBOO 19,June 25,1981 b) FinalReport and Protocol,Oral TeratologyStudy of T-2999CoC inRabbits, SafetyEvaluationLaboratory,Riker LaboratoriesI,nc.,Study No. 068 1TB0212, 3M ReferenceNo. FM 3924 (88% ethylFOSE), January7,1982 c) 3M InternalCorrespondence realcoholsbeing used inRiker studiesf,rom DR Ricker toWC McCormick, datedDecember 10,1980 d) AnalyticalAnalyses of SuspensionofFM-3924, InternaMlemo, from TR Mathisen toEG Gortner,dated April8, 1981 e) 3M InternalCorrespondence,AnalyticalEvaluationof FM-3924, datedJune 22, 1982 4) OralTeratologyStudy of FM-3422 inRats a) FinalReport,Oral TeratologyStudy of FM-3422 inRats,SafetyEvaluation Laboratory,Riker Laboratories,Inc.,Study No. 0680TROO10, January 22, 1981 b) 3M InternaClorrespondence realcoholsbeing used inRiker studiesf,rom DR Ricker toWC McCormick, datedDecember 10, 1980 5) TeratologyStudiesof T-2999CoC (FM-3924) inRats a) FinalReport,SpecialLens Oral TeratologyStudy of T-2999CoC inRats,Safety EvaluationLaboratory,Riker LaboratoriesI,nc.,Study No. 0680TROO20, 3M Reference No. FM-3924, December 22, 1981 b) FinalReport and Protocol,SpecialLens OralTeratologyStudy ofT-2999CoC in Two StrainsofRats,SafetyEvaluationLaboratory,Riker LaboratoriesI,nc., Study No. 068 1TR0362, July20, 1982 c) 3M InternalCorrespondence re alcoholsbeing used inRiker studiesf,rom DR Ricker toWC McCormick, dated December 10,1980 d) AnalyticalAnalysesof Suspensionof FM-3924, InternaMlemo, from TR Mathisen to EG Gortner,dated April8, 1981 e) 3M internaclorrespondencere analyticaalnalysisof FM-3924, from EG Gortner toRM Payfer,datedJune 22, 1982 -16- AttachmentstoLettertoC.Auer datedMay 18,2000 Studiesand OtherInformatioonn Certain PerfluorooetaSnuelfonate-RelatCeodmpounds 6) Memo fromEG LambrechttoRikerStudyFilerseFetalLensArtifac-t-Summary of Developments toDate,datedNovember 6, 1981 PreviouslysubmittedtoTSCA 8e docket,FinalReport,Combined Oral (Gavage) FertilitDye,velopmental and Perinatal/PostnatRaelproductionToxicityStudy of N-ETFOSE inRats,3M ReferenceNo. T-6316.5,June 30, 1999 Note: weight gain effectsinF, generationcurrentlybeing reanalyzed.Report may require amendment StudiesIn Progress 1) Protocol,N-ETFOSE BileMethod Development inRats,3M StrategiTcoxicology Laboratory,Study No. T-6316.15;ST-30, In-LifeStartDate August 12,1999,In-Life End Date August 20, 1999 2) Protocol,Feces Method Development Metabolism Study forPerfluorooctanesulfonate Derivatives[N-EtFOSE, PFOS, and FOSA], 3M StrategicToxicologyLaboratory, Study Nos.,T-636.17;T-6295.21;T-7132.3;ST41, In-LifeStartDate November 22, 1999, In-LifeEnd Date November 24, 1999 3) Protocol,CellProliferatioSntudy with N-Ethyl PerfluorooctanesulfonamidEothanol (N-EtFOSE; 3M T-6316.11),PerfluorooctanSeulfonicAcid PotassiumSalt(PFOS; 3M T-6295.16),and N-Ethyl Perfluorooctanesulfonamid(ePFOSA 3M T-709 1.1)in Rats,Pathology AssociatesInternationalS,tudy No. 1132-100 Pre-I976 Studies(biblio"ahy only) 1) FinalReport,OralLD 50 (4 levels)3,M ReferenceNo. T-961,WARF InstitutIen,c., Study No. 4043911, June 12, 1974 2) FinalReport,Acute Vapor InhalatioTnoxicityStudy inRats,3M ReferenceNo. T1260,IndustriaBlio-TestLaboratoriesI,nc.,July21, 1975 3) FinalReport,Acute Vapor InhalationToxicityStudy in Rats,3M ReferenceNo. T1259, IndustriaBlio-TestLaboratoriesI,nc.,July21, 1975 4) FinalReport,Skin and Eye IrritatioSntudy,WARF InstitutIen,c.,Study No. 5060080, 3M ReferenceNo. T-1260, June 17, 1975 5) FinalReport,Skin and Eye IrritatioSntudy, WARF InstituteI,nc.,Study No. 5060079, 3M ReferenceNo. T-1259, June 17, 1975 -17- AttachmentstoLettertoC.Auer datedMay 18,2000 Studiesand OtherInformatioonn Certain PerfluorooetaSnuelfonate-RelatCeodmpounds 9. N-MEFOSE alcohol N-methylperfluorooctsaunlefonamidoethanol I AcuteToxicit 1) Acute OralToxicity- Rats,BiosearchI,nc.,3M Ref T-2038CoC (L-4309,FC-5160) (75% in25% CaC03), StudyNo. 78-1161A, Feb.2,1978 2) Primary Eye IrritatioSntudy- Rabbits,Biosearch,Inc.,3M Ref T-2038CoC (L4309, FC-5160) (75% in25% CaC03), Study No. 78-1161A, Feb.2, 1978 3) Primary Skin IrritatiSotnudy - Rabbits,Biosearch,Inc.,3M Ref T-2038CoC (L4309, FC-5160) (75% in25% CaC03), Study No. 78-1161A, Feb. 2, 1978 4) Acute Oral ToxicityScreen with T-2574CoC inAlbino Rats,RikerLaboratoriesI,nc., Experiment 0979AR0037, September 26, 1979 Genotoxicit 1) GenotoxicityTeston T-571 1.1inthe InVivo/InVitroUnscheduled DNA Synthesis and CellProliferatioAnssays inRat LiverCells,Hazelton Washington, HWA Study No. 15515-0-494,September 14, 1993,and attachedprotocol 2) MutagenicityTest on T-5711 in an In Vivo Rat MicronucleusAssay, Hazelton Washington,HWA Study No. 15515-0-454,April30, 1993,and attachedProtocol and memorandum containinganalyticadlata 3) Evaluationof theMutagenic Activityof T-5874 intheAmes Salmonella/Microsome Test(withIndependentRepeat),NoTox Project115932,NoTox Substance38187, 3M Reference T-5 874.1,April 19,1994 4) Evaluationof the Abilityof T-5874 toInduce Chromosome AberrationsinCultured PeripheralHuman Lymphocytes (withIndependentRepeat),NoTox Project115919, NoTox Substance 38187, 3M Reference T-5874.2,May 5,1994 5) Evaluationofthe Mutagenic Activityof T-5874 in an InVitroMammalian CellGene MutationTestwith L5178Y Mouse Lymphoma Cells(withIndependentRepeat), NoTox Project115021, NoTox Substance38187, 3M Reference T-5874.3,April 19, 1994 -18- AttachmentstoLettertoC.Auer datedMay 18,2000 Studiesand OtherInformatioonn Certain PerfluorooctaSnuelfonate-RelatCeodmpounds Rgpeated-DosTeoxicit 1) 13-Week DietaryToxicityStudy with N-Methyl PerfluorooctanesulfonamidEethanol (N-MeFOSE, T-6314) inRats,Covance Study No. 6329-225, 3M ReferenceNo. T6314.1 a) AuditedDraftReport,May 25, 1999 b) Letterfrom Andrew M. Seacat,Ph.D.,Study Monitor,toPeterJ.Thomford, Ph.D.,Study DirectoratCovance, regardingerrorsindraftreport -Mechanistic 1) Analysisof T-5794 in a CellProliferatioAnssay inRat LiverCells,Hazelton Washington, Inc.,FinalReport,HWA Study No. 154-207,January 26, 1994, and protocoland analyticadlata 2) Analysisof T-5878 ina CellProliferatioAnssay inRat LiverCells,Hazelton Washington, Inc.,FinalReport,HWA Study No. 154-209,November 1,1994,and protocoland analyticadlata -19- AttachmentstoLettertoC.Auer datedMay 18,2000 Studieasnd OtherInformatioonn Certain PerfluorooctaSnuelfonate-RelatCeodmpounds 10.N-ETFOSEA N-ethylperfluorooetsaunlefonamidoethayclrylate AcuteToxicit 1) Acute Oral ToxicityScreenwith T-3493 inAlbino Rats,SafetyEvaluation Laboratory,Riker LaboratoriesI,nc.,ProjectNo. 0884AR0010, 3M ReferenceNo. T3943, February 7,1984 2) Primary Skin IrritatiToenstwith T-3493 inAlbino Rabbits,SafetyEvaluation Laboratory,RikerLaboratoriesI,nc.,ProjectNo. 0884EB0009, 3M ReferenceNo. T3943, February 7, 1984 3) Acute Ocular IrritatioTnestwith T-3493 inAlbino Rabbits,SafetyEvaluation Laboratory,Riker LaboratoriesI,nc.,ProjectNo. 0884EB0008, 3M ReferenceNo. T3943, January24, 1984 Immunotoxicit 1) Guinea Pig Maximization- Method, Summary, and Raw Data Appendix, Hazleton LaboratoriesAmerica, Inc.,ProjectNo. 40703984, 3M ReferenceNo. T-3609, October 5, 1984 (plusMay 13, 1985 reportamendment) Genotoxicit 1) Chromosomal AberrationStudy of Sample D-1 inCulturedMammalian Cells, MitsubishiChemical SafetyInstitutLet,d.,Study No. 2L 162,3M ReferenceNo. T6322.3 (FX- 13),October 23, 1995 2) MutagenicityTestingof 2-[N-ethyl-N-perfluoroal(kCy=lI-8)sulfonylaminoe]thyl acrylateinBacterialReverse Mutation Assays,BML, Inc.,StudyNo. 2862, 3M ReferenceNo. T-6322.5(FX- 13),April24, 1996 3) In VitroMicrobiologicaMlutagenicityAssays of 3M Company's Compound T-3609, SRI InternationaPlr,ojectNo. LSC-3145, September, 1984 Rgpeated-Dose Toxici 1) Twenty-Eight-Day Repeated Dose Oral ToxicityStudy of Sample D-1 inRats,BioMedical Research LaboratoriesCo.,Ltd.,Study No. BMR143C, 3M Reference No. T-6322 (FX- 13),February 16,1993 -20- AttachmentstoLettertoC.Auer datedMay 18,2000 Studiesand OtherInformatioonn Certain PerfluorooctaSnuelfonate-RelatCeodmpounds 11.N-ETFOSEMA N-ethylperfluorooctane @sulfonamideothylmethacrylate AcuteToxicit 1) Acute Oral ToxicityScreenwith T-3494 inAlbino Rats,SafetyEvaluation laboratoryR,iker LaboratoriesI,nc.,ProjectNo. 0884AR0013, 3M ReferenceNo. T3494 (L-1048,FX- 14),March 13, 1984 2) Primary Skin IrritatiToenstwith T-3494 inAlbino Rabbits,SafetyEvaluation laboratoryR,ikerLaboratoriesI,nc.,ProjectNo. 0884EB0012, 3M ReferenceNo. T3494 (L-1048,FX-14),February7,1984 3) Acute Ocular IrritatioTnestwith T-3494 in Albino Rabbits,SafetyEvaluation laboratoryR,iker LaboratoriesI,nc.,ProjectNo. 0884EBOOI 1,3M ReferenceNo. T3494 (L-1048, FX- 14),January 24, 1984 Immunotoxicit 1) Guinea Pig Maximization,HazletonLaboratorieAsmerica,Inc.,ProjectNo. 40703985, 3M ReferenceNo. T-3610 (NB No. 63601-32,FX- 14),October 9, 1984 Genotoxicit 1) InVitroMicrobiologicaMlutagenicityAssays of 3M Company's Compound T-3610, SRI InternationaPlr,ojectNo. LSC-3145,3M ReferenceNo. T-3610 (NB No. 6360132, FX-14), September,1984 -21- AttachmentstoLettertoC.Auer datedMay 18,2000 Studiesand OtherInformatioonn Certain PerfluorooctaSnuelfonate-RelatCeodmpounds 12.N-MEFOSEA N-methylperfluorooctane sulfonamidoethayclrylate Genotoxicit 1) Evaluationof theMutagenic Activityof T-5869 inthe Ames Salmonella/Microsome Test(withindependentrepeat)N,OTOX, ProjectNo. 115965,3M ReferenceNo. T5869.1 (FMZ-3 559,Lot 2408,wide-range),April20, 1994 2) Evaluationofthe AbilityofT-5869 toInduce Chromosome AberrationsinCultured Human Lymphocytes (withindependentrepeat)N,OTOX, ProjectNo. 115 943,3M ReferenceNo. T-5869.2(FMZ-3559, Lot 2408, wide-range)J,une 5,1994 3) Evaluationof theMutagenic Activityof T-5869 inan In VitroMammalian CellGene Mutation Testwith L5178Y Mouse Lymphoma Cells(withindependentrepeat), NOTOX, ProjectNo. 115954,3M ReferenceNo. T-5869.3 (FMZ-3559, Lot 2408, wide-range)A,pril20, 1994 -22- AttachmentstoLettertoC.Auer datedMay 18,2000 Studiesand OtherInformatioonn Certain PerfluorooctaSnuelfonate-RelatCeodmpounds 13. PFOS AdditionaSltudieson PerfluorooctaSnuelfonate AcuteToxicit 1) Acute ToxicityTestsforT-T-6684,Didecyldimethylammonium saltof perfluorooctanesulfonate: a) Acute Oral ToxicityStudy of T-6684 inRats (OECD Guidelines)C,oming Hazleton,Inc.,ProjectNo. CHW 61101149,3M ReferenceNo. T-6684 January 31,1997 b) Primary Dermal Irritati/onCorrosionStudy of T-6684 inRabbits(OECD Guidelines)C,oming Hazleton,Inc.,ProjectNo. CHW 61101150, 3M Reference No. T-6684 (didecyldimethylammonium saltofperfluorooctanesulfonate), January 10, 1997 c) Primary Eye Irritati/oCnorrosionStudy of T-6684 inRabbits(OECD Guidelines),Coming Hazleton,Inc.,ProjectNo. CHW 61101151, 3M Reference No. T-6684 (didecyldimethylammoniumsaltof perfluorooctanesulfonate), January 28, 1997 2) Acute ToxicityTestsforT-5898, lithiumperfluorooctanseulfonate3,M Ref.FC-94: a) FinalReport,Acute Oral ToxicityStudy of T-5898 inRats,HazeltonWisconsin, Study No. 40200468, April22, 1994 b) FinalReport,Primary Eye Irritation/CorrosiSotnudy of T-5898 inRabbits, Hazelton Wisconsin,Study No. 40200469, April7, 1994 c) FinalReport,Primary Dermal Irritation/CorrosiSotnudy of T-5898 inRabbits, Hazelton Wisconsin,Study No. 40200470, March 23, 1994 3) Acute OralToxicity-Rats, Biosearch,Inc.,3M ReferenceNo. T-1388 (perfluorooctanesulfoanciicd),March 4, 1976 PhannacokineticStudies 1) DraftReport,5-DailyDose Dermal Absorption/ ToxicityStudy of T-6684 in Rabbits,Covance LaboratoriesI,nc.,Study No. 6329-200, 3M Reference No. T-6684 (didecyldimethylammoniumsaltofperfluorooctanesulfonatsel,urry)J,uly 11,1997 -23- AttachmentstoLettertoC.Auer datedMay 18,2000 Studiesand OtherInformatioonn Certain PerfluorooctaSnuelfonate-RelatCeodmpounds 2) QualitativIenvestigatioonftheInVitroMetabolism ofT-6292 (n-ethylFOSE), T6293 (n-ethyFlOSE phosphatedianirnoniumsalt(esterT)-)6,294 (n-ethyl perfluorooctanseulfonarnidea)nd T-6295 (perflurooctanseulfonateb)y Rat and Human HepatocytesUsing Ion Spray LC/MS and LC/MS/MS, Advanced BioanalyticaSlervices,Inc.,[PreliminaryA]nalyticalReport,Report 96ADEM01.3M, November 12,1996 Teratplo.gy 1) Memorandum from E. G. Lamprecht reFetalRat Lens Artifac-t Summary of Developments toDate,Nov. 6,1981 Anal3Ltical Ion Spray LC/MC DeterminationofPerfluoroAnalyticalStandardsProvidedby 3M Medical Department,Advanced BioanalyticaSlervices,Inc.,No. 95NIYHWOI.3M, August 30, 1995 Studiesin Progress 1) Protocol,Feces Method Development Metabolism Study forPerfluorooctanesulfonate Derivatives[N-EtFOSE, PFOS, and FOSA], 3M StrategicToxicologyLaboratory, Study Nos.,T-636.17;T-6295.21;T-7132.3;ST-4 1,In-LifeStartDate November 22, 1999,In-LifeEnd Date November 24, 1999 2) Protocol,CellProliferatioSntudy with N-Ethyl PerfluorooctanesulfonamidEothanol (N-EtFOSE; 3M T-6316.11),PerfluorooctanSeulfonicAcid PotassiumSalt(PFOS; 3M T-6295.16),and N-Ethyl Perfluorooctanesulfonamid(ePFOSA 3M T-7091.1)in Rats,Pathology AssociatesInternationalS,tudy No. 1132-100 -24- Attachments to Letterto C. Auer dated May 18,2000 Studiesand Other Information on Certain PerfluorooctaneSulfonate-RelatedCompounds 13. PFOS AdditionalStudieson PerfluorooctaneSulfonate BibliographyShowing Studiesin3M's PossessionBelievedTo Be In FIFRA Docket. REDACTED -25- AttachmentstoLettertoC.Auer datedMay 18,2000 BibliographoyfPublisheLditeraturien3M's Possession 1. POSF - Perfluorooctanesulffolnuyolride No literatluorceated. 2. FOSA -Perfluorooctanesulfonamide ArrendaleR,.F.J,.T.StewartR,.Manning,andB.VitayavirasuDke.terminatiofnGX-071 and itsmajormetabolitienmt bloodby coldon-columninjecticoanpillaGrCy-ECD. Journalof Agriculturaanld Food Chemistr3y7 (1989)1130-1135. Cross,T.J.,and R-G. Schnellmann.Mechanism oftoxicityof a unique pesticideNethylperfluorooctanseulfonamide(NEPFOS), and itsmetaboliteperfluorooctanesulfonamide (PFOS) toisolatedrabbitrenalcorticamlitochondria(RCM). Toxicologis9t (1989)224. Grossman,M.R. Tissueanalysisofafluorinatedsu6ronamidepesticideA:n evaluationof distributione,liminationa,ndpotentialforbioaccumulationinorallyexposed rats.MS Thesis, Universityof Georgia,Athens,1990. Lofgren,C.S.,W.A. Banks, R.K. Vander Meer, and D.F. Williams.Residualtoxicitoyf some fluoroaliphatisculfonestothe red imported fireant,Solenopsisinvicra(Hymenoptera, Formicidae).FloridaEntomologist72 (1989) 140-146. Manning, R.O.,J.V.Bruckner,M.E. Mispagel,and J.M. Bowen. Metabolism and dispositioonf Sulfluramid,a uniquepolyfluorinateidnsecticidei,nthe rat.Drug Metabolism and Disposition 19 (1990) 205-211. Schnellmann, R.G., and R.O. Manning. Perfluorooctanesulfonamide:a structurallnyovel uncouplerof oxidativephosphorylationB.iochimica etBicphysicaActa 1016 (1990) 344-348 Vander Meer, R-K.,C.S.Lofgren,and D.F. Williams.Fluoroaliphatisculfones:A new classof delayed-actioninsecticidefsorcontrolof Solenopsisiniict(aHyrnenoptem:Formicidae).Journal ofeconomic Entomology 78 (1985) 1190-1197. Williams,D.F.,C.S.Lofgren,and R-K. Vander Meer. The red imported fireant,Solenopsis invictac:ontrolwith fluoroaliphatisculfonebaittoxicantsJ.ournal ofagriculturalEntomology 4 (1987) 41-47. 3. PFOSAA - Perfluorooctanesulfonylamido (ethyl)acetate No literaturleocated. 4. PFDS - Perfluorodecanesulfonate No literaturleocated. 5. PFHS - Perfluorohexanesulfonate No literaturleocated. AttachmentstoLettertoC.Auer datedMay 18,2000 BibliographoyfPublishedLiteraturien3M's Possession 6. N-ETFOSA - N-ethylperfluorooctanesulfonamide Appel,A.G.,andS.F.Abd-ElghafaTro.xicitys,ubletheaflfectasn,dperformancoef Sulfluramid againsttheGerman cockroac(hDictyopterBal:attellidaJeo)u.rnalofeconomicEntomology83 (1990)1409-1414. Appel,A.G. Laboratoryand fieldperformance of consumer baitproductsforGerman cockroach (Dictyoptera:Blattellidaec)ontrol.Journal ofeconomic Entomology 83 (1990) 153-159. Arrendale,R.F.,J.T.Stewart,R. Manning, and B. Vitayavirasuk.Determinationof GX-071 and itsmajor metaboliteinratblood by cold on-colurrminjectiocnapillaryGC-ECD. Journal of Agriculturaland Food Chemistry37 (1989) 1130-1135. Cross,T.J.,and R-G. Schnelhnann.Mechanism of toxicityof a unique pesticideNethylperfluorooctanseulfonamide(NEPFOS), and itsmetaboliteperfluorooctanesulfonamide (PFOS) toisolatedrabbitrenalcorticamlitochondria(RCM). Toxicologis9t (1989) 224. Forschler,B.T.,and Evans, G.M. Perimetertreatmentstrategyusing containerizedtomanage Argentineants,Linepithema humile (Mayr) (Hymenoptera: Formicidae)(abstract)J. EntomoL Sci.29 (1994) 264-267. Grossman, M.R., Mispagel,M.E., and Bowen, J.M. Distributioannd tissueeliminationinrats duringand afterprolonged dietaryexposureto a highlyfluorinatesdulfonainidepesticide. Journal ofagric.Food Chem. 40 (1992)2505-2509. Grossman,M.R. Tissueanalysisofafluorinatedsu@(onamidepesticideA:n evaluationof distributione,liminationa,ndpotentialforbioaccumulationinorallyexposed rats.MS Thesis, Universityof Georgia,Athens, 1990. Lofgren,C.S.,W.A. Banks, R.K. Vander Meer, and D.F. Williams.Residualtoxicityof some fluoroaliphatisculfonestothe red imported fireant,Solenopsisinvicra(Hymenoptera, Formicidae).FloridaEntomologist72 (1989) 140-146. Manning, R.O.,J.V.Bruckner,M.E. Mispagel,and J.M. Bowen. Metabolism and dispositioonf Sulfluramid,a unique polyfluorinateidnsecticidei,nthe rat.Drug Metabolism and Disposition 19 (1990) 205-211 Nabbefeld,DJ. An hivestigatioonftheEffectsof Fluorochemicalson LiverFattyAcid-Binding Protein.A thesissubmittedtotheGraduate School of theUniversityofMinnesota,April1998. Reid,B.L.,G.W. Bennett,and S.J.Barcay.Topicaland oraltoxicitoyf Sulfluramid,a delayedactioninsecticidaeg,ainsttheGerman cockroach(DictyopteraB:lattellidaeJ)o.urnalof Economic Entomology 83 (1990) 148-152. Schal,C. Sulflurarnirdesistancaend vapor toxicityinfield-collectGeedrman cockroaches (DictyopteraB:lattellidae()abstract)J. Medical Entomology 29(2)(1992)207-215. Schnellrnann,R.G.,and R.O. Manning. Perfluorooctanesulfonarnidea:structurallnyovel uncouplerof oxidativephosphorylationB.iochimica etBicphysicaActa 1016 (1990) 344-348 Schnelhnann,R-G. The cellulaerffectsof a unique pesticideSulfluramid(Nethylperfluorooctanseulfonamide)on rabbitrenalproximal tubules.Toxicologyin Vitro4 (1990) 71-74. AttachmentstoLettertoC.Auer datedMay 18,2000 BibliographoyfPublishedLiteraturien3M's Possession Smith,L.M.,Appel,A.G. Toxicitrye,pellencaen,deffectosfstarvaticoonmparedamong brown coclr,roac(hDeisctyopterBal:attida(ea)bstracJt.)E.con.Entomol8.9(2)(1996)402-410. Stump, DG; Nemec, MD; Holson,JF; PiccarilloV,J; Mares, JT. Study of theEffectsof Sulfuramidon Pre-and PostnatalDevelopment, Maturationand FertilitiyntheRabbit. Toxicology(1997)357. Su, N.-Y.,and R.H. Scheffrahn.Laboratoryevaluationof two slow-actingtoxicantsagainst Formosan and easternsubterraneantermitesJ.ournal ofeconomic Entomology 84 (1991) 170175. Su, N.-Y.,and R.H. Scheffrahn.Toxicityand lethaltime of N-ethylperfluorooctanesulfonamide againsttwo subterraneantermitespeciesIsopteraRhinotennitidaeF.loridaEntomologist71 (1988) 73-78. Su,N.-Y.,Tokoro, M., and R.H. Scheffrahn.Estimatingoraltoxicitoyf slow-actingtoxicants againstsubterraneantermites(IsopteraRhinotermitidae)(abstrwt).J Economic Entomology 87 (1994) 398-401. U.S. EPA OfficeofPesticidesand Toxic Substances.Pesticidefactsheetnumber 205: Sulfluramid.Washington, DC 1989. United StatesAir Force,Tyndal AFB, Florida.EnvironmentallyAcceptableLive FireTraining Facility5.pages. Vander Meer, R-K., C.S. Lofgren,and D.F. Williams.ControlofSolenopsisinvictawith delayed-actionfluorinatetdoxicantsP.esticideScience 17 (1986)449-455. Vander Meer, R-K., C.S. Lofgren,and D.F. Williams.Fluoroaliphatisculfones:A new classof delayed-actioninsecticidefsorcontrolof Solenopsisiniict(aHymenoptera:Fonnicidae).Journal ofeconomic Entomology 78 (1985) 1190-1197. Williams,D.F.,C.S.Lofgren,and R-K. Vander Meer. The red importedfireant,Solenopsis invictac:ontrolwith fluoroaliphatisculfonebaittoxicantsJ.ournalofagriculturalEntomology 4 (1987)41-47. 7. N-MEFOSA - N-methyl perfluorooctanesulfonamide No literaturleocated. 8. N-ETFOSE alcohol- N-ethylperfluorooctanesulfonamidoethanol Nabbefeld,DJ. An Investigatioonf the Effectsof Fluorochemicalson LiverFattyAcid-Binding Protein.A thesissubmittedtothe Graduate School of theUniversityofMinnesota,April 1998. 9. N-MEFOSE alcohol- N-methyl perfluorooetanesulfonamidoethanol No literaturleocated. AttachmentstoLettertoC.Auer datedMay 18,2000 BibliographoyfPublishedLiteraturien3M's Possession 10.N-ETFOSEA - N-ethylperfluorooctasnuelfonamidoethayclrylate No literatluorceated. 11.N-ETFOSEMA - N-ethylperfluorooctsaunlefonamidoethmyeltbacrylate No literatluorceated. 12.N-MEFOSEA - N-methylperfluorooctsaunlefonamidoethayclrylate Lawson,R.G.,JursP,.C.Clustearnalysiosfacrylatteosguidesamplingfortoxiciteysting (abstractJ)C.hem.Inf.Comput.Sci.30 (1990)137-144. Lawson, R.G.,Jurs,P.C. Clusteranalysisof acrylatestoguidesampling fortoxicittyesting (erratum).J Chem. Inf.Comput. Sci. 31 (1991) 361. 13. PFOS - Additionalreferenceson Perfluorooetanesulfonate PFOS Schnellmarm,R-G. The cellulaerffectsof a uniquepesticideSulfluramid(Nethylperfluorooctanseulfonamide)on rabbitrenalproximal tubules.Toxicologyin Vitro4 (1990) 71-74. PFOSH Derbel,M., Hosokawa, M., Satoh,T. Differencesintheinductionof carboxylesterasReL4 inrat livermicrosomes by variousperfluorinatefdattyacids,metabolicalliynertderivativeosf fatty acids(abstract)B.iological& PharmaceuticalBulletin19(5)(1996)765-767. Haughom, B.,and 0. Spydevold.The Mechanism UnderlyingtheHypolipemic Effectof PerfluorooctanoiAcid (PFOA), PerfluorooctanSeulphonicAcid (PFOSA) and ClofibriAccid. Biochim.Biophys.Acta.1128[l](1992)65-72. Henwood, S.M.,McKee-Pesik, P.,Costello,A.C.,Osimitz,T.G. Developmental toxicitystudy with lithiumperfluorooctanseulfonateinrabbits(abstract)T.eratology49(5)(1994)398. Costello,A.C.,Henwood, S.M.,Osimitz,T.G. Developmental toxicitsytudywith lithium perfluorooctanseulfonateinrabbits(abstract)T.oxicologis1t4(l)(1994) 161. Hato, M., and Shinoda,K. Solubilitaynd criticamlicelleconcentrationosf fluorinated surfactantisnwater(abstract)N.ippon Kagaku Zasshi91(l)(1970)27-31. He, M., and Fu, X. Kineticsand linearfreeenergyrelationshiopf superacidPOSA (perfluorooctanseulfonicacid)catalyzedesterificati(oanbstract)W.uli Huaxue Xuebao 6(6) (1990) 739-742. Hosokawa, M., and T. Satoh.Differencesin theinductionof carboxylesterasiesozymes inrat livermicrosomes by perfluorinatefdattyacids.Xenobiorica23 (1993) 1125-1133. Ikeda,T.,K. Fukuda, 1.Mori, M. Enomoto, T.Komai, and T. Suga.Inductionofcytochrome P450 and peroxisomeproliferatioinratliverby perfluorinateodctanesulphonicacid(PFOS). AttachmentstoLettertoC.Auer datedMay 18,2000 BibliographoyfPublishedLiteraturien3M's Possession PeroxisomeisnBiologyand MedicineH..D.FahimiandH. SiesE,ds.,BerlinS:pringer-Verlag, 1987, 304-308. Kozuka, H.,Yamada, J.,Horie,S.,Watanabe, T.,Suga,T.,Ikeda,T. Characteristicosf induction ofperoxisomal fattyacidoxidation-relatendzymes inratliverby drugs:relationshipbsetween structureand inducingactivit(yabstract)B.iochem. Phar7nacoL 41(4)(1991) 617-623. Lyon, P.A.,Tomer, K.B.,Gross,M.L. Fastatom bombardment and tandem mass spectrometry forcharacterizinfgluoroalkanesulfonateAsn.aL Chem. 57(14) (1985)2984-2989. Remde, A., and Debus, R. Biodegradabilitoyf fluorinatesdurfactantusnder aerobicand anaerobicconditions(abstract)C.hemosphere 32(8)(1996) 1563-1574. Sohlenius-,A.K.,A.M. Eriksson,C. Hogstrom, M. Yimland, J.W. Depierre.Perfluorooctane sulfonicacidisa potentinducerof peroxisomalfattyacidB-oxidationand otheractivitieksnown tobe affectedby peroxisome proliferatorisnmouse liverP.harmacology and Toxicology72 (1993)90. PFOS.K salt Brown,R.B. The Treatmentand DisposalofAqueous FilmFormingFoazn.MastersThesisin PublicHealthEngineering,Universityof New South Wales, Australia,1986. Cavalli,L.,A. Gellera,and A. Landone. Las removal and biodegradationin a wastewater treatmentplant.EnvironmentalToxicologyand Chemistry12 (1993) 1777-1788. Chan, D.B., and E.S.K.Chian. Economics ofmembrane treatmentofwastewaterscontaining firefightinfgoam. EnvironmentalProgress 5 No. 2,May 1986, 104-109. Chan, D.B. Disposalofwastewatercontainingaqueous filmforiningfoam (AFFF). TM No. M54-78-06,CivilEngineeringLaboratory,Naval ConstructionBattalionCenter,PortHueneme, Calif.93043, April1978,19 pgs. Chan, D.B. Disposalofwastewatercontainingaqueous fihnforming foam (AFFF) -by physicochemical processes.TM No. M-54-79-19, CivilEngineeringLaboratory,Naval Construction BattalionCenter,PortHueneme, Calif.93043, Sept.1979, 21 pgs. Chan, D.B. Toxic substance:Disposalofwastewatercontainingaqueous fihnforiningfoam (A.FFF)- A summary ofprogressto dateon development of allAFFF treatmentprocesses.TM No. M-54-80- 10,CivilEngineeringLaboratory,Naval ConstructionBattalionCenter,Port Hueneme, Calif.93043,August, 1980, 6 pgs. Chian, E.S.K.,T.-P.Wu, and R.W. Rowland. Membrane treatmentof aqueous filmforming foam (AFFF) wastesforrecoveryof itsactiveingredientsG.eorgia Institutoef Technology for U.S. Navy CivilEngineeringLaboratory,PortHueneme, CA 93043, Oct. 1980,10 pgs. Darwin, R. L.,R. E. Ottrnan,E. C. Norman, J.E. Gott,and C.P. Hanauska. Foam and the Environment: A DelicateBalance.NationalFire ProtectionAssociationJournal,May/ June 1995, 67-73. DiMaio, L.R.,and R. F.Lange. Effectof Water Qualityon FireFightingFoams. 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