ADDRESS BY DR.

internal corresponds From: To: Subject: C.R.

INTERNAL CORRESPONDENCE GA 1076 FROM R* ^ Cheng TO H.

INTERNAL COr^E5PONDNC GULF 10973 - A FROM TO Dr.

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J i-- mca mwomci memo n Calc August 9, 1976 Mr.

Page 46 March 17, 1975 vc v.2_d FOOD CHEMICAL NEW'S s Contamination of Feeds Alleged in Letter A regulatory letter from FDA to Orson E.

MANUFACTURING CHEMISTS ASSOCIATION 1825 CONNECTICUT AVENUE, N W.

CONFIDENTIAL Subject to Protective Order in Boss v.

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1098 Till I ASCII, Ml\ I Mill K 29, 1975 ANINCmiAI rv AND SPINA HIHIH IN OHIO M,TI AMI IN l-AIM Mil I | IIONriTAI , OHIO Year 1970 1971 1972 1973 1974 19701974 Anencephalu* Spina hitiJj Painesville State Pamesv tile Stair No. of No. ol No. of No o| cases Rate* cases Kate cases Rate CIVs Rati 0 0 0 26 50 3 31 2 54 11 1 I 10 3 38 73 3 30 9 44 M ^ 3 35 31 6 3 0 0 0 47 9 ft 2 24 9 27 5-4 2 24 9 40 9 2 0 00 22 45 1 l 1 29 6 0 6 14 1 144 t-t 9 21 2 224 N 9 * Per II) 000 laid (hue bin hi the discrimination of vector of means can be tested for signifi cance. * high discrimination between the malformation group and its matched controls appeared within the first 10 of the 24 variables (see accompanying figure).

METABOLISM OF VINYL CHLORIDE MONOMER IN THE LIVER OF RATS i J.

;6ibereic'ht) ITEM 2 (c) %7/B 4us don Institut fUr Toxikologie der Universitat Tubingen und den.

ETHYL CORPORATION INTER-OFFICE To Distribution Address From Subject D.