Document gDQR9RXM0kmrXMw3LNkjpMNja

J i-- mca mwomci memo n Calc August 9, 1976 Mr. Driver Subjects Additional Studies on Vinyl Chloride The funded portion of MCA projects on Vinyl Chloride have been completed except for receipt of final reports on the long term inhalation and epidemiologic studies. At its meeting on April 28, 1976 the Technical panel on Vinyl Chloride Research recaasnendad continuation of metabolic studies at Doe, expected to take about one year at a cost of $130,000 including contingencies and administrative costs* is anticipated that this additional work will abolic aspect of the VC research. At the same meeting the Panel reco--sided proposal by Dr. Tamburro at the university of search for new diagnostic tools for the early disease due to VC exposure. The projected cost for the first year is $220,000, including administrative expenses and contin gencies. It is predicted that continuing support for this program will be requested the following two years at shout the same rate. Twenty-seven of the participating thirty cos^anies have indicated willingness to support continuation of the metabolic investigation. Of those opposed, two no longer produce vinyl chloride or polyvinyl chloride* Twenty-two companies favor support for the first year of the proposed university of Authorization is requested to invoice eoetrticipate in each of these projects for (hares. available |rs with the continuation of research on oroposed, subject to funds becoming Approval George I. Best A. C. Clark Approved, M. J. Driver Date Date cc: Mr. Best Mr. Barackman prepared for Mr. Clark's signature by M. Freifeld/ec CMA 002561 a ALBERT C. CLARK VICE PRESIDENT technical director MANUFACTURING CHEMISTS ASSOCIATION 1825 CONNECTICUT AVENUE, N.W. WASHINGTON, D. C. 20009 (202) 483-6126 May 20, 1976 Subject to "rots .tin Ross v, . ' , ; 1: 14th J-: i :V;rV Calcasieu Parish, leuiciana Subject: Proposed Additional Vinyl Chloride Studies The funded portion of Vinyl Chloride projects being adminis tered by MCA are completed or nearing completion. Final reports have been received on the Dow metabolism investigation and tera tology study. Also the experimental portion of IBT's chronic inhalation and the tabulating of data in the Equitable Environ mental Health (formerly Tabershaw-Cooper Associates) epidemiology study have been completed and final reports are expected soon. The results were recently presented orally to the Vinyl Chloride Technical Panel. It is felt, however, that further metabolic work should be undertaken to finish this investigation. At their meeting on April 28, the Panel recommended two proj ects for management approval: (1) additional Dow studies to complete the investigation of vinyl chloride metabolism, and (2) a proposal by Dr. Tamburro at the University of Louisville to search for useful diagnostic tools. The additional metabolic studies are designed to investigate the in vivo binding of vinyl chloride to macromolecules, includ ing those with sulfhydryl groups. This is postulated as the possible mechanism for detoxification of vinyl chloride. Parallel studies investigating in vitro metabolism and binding properties are also planned. A cost of $115,000 is expected for this work, which will require about one year. It is anticipated that no further funding will be needed in this area when above is completed CMA 002562 2- - 11;^ 50*4337 Calcasieu Paris! Louisiana Dr. Tamburro's team is examining workers exposed to vinyl chloride. The bulk of the funding for this project is from The National Cancer Institute and covers only accepted methods for diagnosis and treatment. Dr. Tamburro has requested MCA's support at the rate of about $200,000 per year for the development of new diagnostic tools. The Panel recommends favorable action immedi ately for the first year and in the future will probably suggest continued support for two more years. The Panel also considered the advisability of proposing an epidemiology study dealing with birth defects. Work by Dr. Infante and others of National Institute for Occupational Safety and Health appears to implicate vinyl chloride but has a very weak data base. However, action was deferred pending the outcome of studies under way by The Center for Disease Control. It is expected that the remaining contingency funds will be adequate to cover administrative costs and contingencies for the new projects. Please complete the enclosed form and return one copy to me by June 11 indicating whether you favor supporting the additional proposals or plan to withdraw from the project when the current studies have been completed. Sincerely Enclosure/2 CMA 002563 MANUFACTURING CHEMISTS ASSOCIATION VINYL CHLORIDE SPECIAL PROJECT _co:Tr~-^ Object r~^r'.:vr1;- ' 7# ,1 _ 7 ^3lcasiey I AT, Referring to A. C. Clark's letter of May 20, 1976 on proposed additional studies, I FAVOR u OPPOSE u PROJECT Continuation of Dow metabolism studies ESTIMATE $115,000 u University of Louisvilledevelopment of diagnostic tools, first year (with similar requests for each of the next two years likely^ $200,000 I m. I My Company LJ Z7 DOES DOES NOT plan to terminate support for the Vinyl Chloride Special Project when the current studies are completed. Name (signed)______________________________________ Name (Typed)_____________1 /___________________ Company^ Date_____ PLEASE RETURN ONE COPY NO LATER THAN JUNE 11, 1976 TO: Mr. A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N. W. Washington, D. C. 20009 COtiFIZIHTIAL Subject to Protective Cr^r in Eoss v. Conoco, Inc . be b-,J~4337 14th Judicial District Court Calcasieu Parish, Louisiana CMA 002564 MANUFACTURING CHEMISTS ASSOCIATION VINYL CHLORIDE SPECIAL PROJECT Referring to A. C. Clark's letter of May 20, 1976 on proposed additional studies, I FAVOR U OPPOSE U PROJECT Continuation of Dow metabolism studies ESTIMATE $115,000 ^y u University of Louisvilledevelopment of diagnostic tools, first year (with similar requests for each of the next two years likely)- $200,000 | | My Company ^y n DOES DOES NOT plan to terminate support for the Vinyl Chloride Special Project when the current studies are completed. Name (Signed)______________________________________ Name (Typed)_____________ X___________________ C ompany <~ Date------------------------ - PLEASE RETURN ONE COPY NO LATER THAN JUNE 11, 1976 TO: Mr. A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N. W. Washington, D. C. 20009 CONFIDENTIAL / Subject to Protective Crier in Boss v, Conoco, Tn-c^ , ':-j. 17-4337 14th Judicial lictrict Court Calcasieu Parish, Louisiana CMA 002565 ALBERT C, CLARK VICE PRESIDENT TECHNICAL DIRECTOR MANUFACTURING CHEMISTS ASSOCIATION 1825 CONNECTICUT AVENUE, N.W. WASHINGTON, D. C. 20009 (202) 483-6126 May 20, 1976 * louisiana Subject: Proposed Additional Vinyl Chloride Studies The funded portion of Vinyl Chloride projects being adminis tered by MCA are completed or nearing completion. Final reports have been received on the Dow metabolism investigation and tera tology study. Also the experimental portion of IBT's chronic inhalation and the tabulating of data in the Equitable Environ mental Health (formerly Tabershaw-Cooper Associates) epidemiology study have been completed and final reports are expected soon. The results were recently presented orally to the Vinyl Chloride Technical Panel. It is felt, however, that further metabolic work should be undertaken to finish this investigation. At their meeting on April 28, the Panel recommended two proj ects for management approval: (1) additional Dow studies to complete the investigation of vinyl chloride metabolisln, and (2) a proposal by Dr. Tamburro at the University of Louisville to search for useful diagnostic tools. The additional metabolic studies are designed to investigate the in vivo binding of vinyl chloride to macromolecules, includ ing those with sulfhydryl groups. This is-postulated as the possible mechanism for detoxification of vinyl chloride. Parallel studies investigating in vitro metabolism and binding properties are also planned. A cost of $115,000 is expected for this work, which will require about one year. It is anticipated that no further funding will be needed in this area when above is completed. CMA 002566 _C0IT?ID3ITTIAL "2" Subject to Frocs;tiv-3 Ros3 v. _Cor.O"0, In-:,, ;>j. in 3T7 14th Judicial I'jat.'lrt .'curt Calcasieu Pariah, Louisiana Dr- Tamburro's team is examining workers exposed to vinyl chloride. The bulk of the funding for this project is from The National Cancer Institute and covers only accepted methods for diagnosis and treatment- Dr. Tamburro has. requested MCA's support at the rate of about $200,000 per year for the development of new diagnostic tools. The Panel recommends favorable action immedi ately for the first year and in the future will probably suggest continued support for two more years. The Panel also considered the advisability of proposing an epidemiology study dealing with birth defects. Work by Dr. infante and others of National Institute for Occupational Safety and Health appears to implicate vinyl chloride but has a very weak data base. However, action was deferred pending the outcome of studies under way by The Center for Disease Control. It is expected that the remaining contingency funds will be adequate to cover administrative costs and contingencies for the new projects. Please complete the enclosed form and return one copy to me by June 11 indicating whether you favor supporting the additional proposals or plan to withdraw from the project when the current studies have been completed. Sincerely, Enclosure/2 CMA 002567 MANUFACTURING CHEMISTS ASSOCIATION VINYL CHLORIDE SPECIAL PROJECT Referring to A. C. Clark's letter of May 20, 1976 on proposed additional studies, I FAVOR OPPOSE PROJECT Ay Continuation of Dow metabolism studies ESTIMATE $115,000 UU University of Louisvilledevelopment of diagnostic tools, first year (with similar requests for each of the next two years likely) $200,000 ^ ? My Company Ay Z7 DOES DOES NOT plan to terminate support for the Vinyl Chloride Special Project when the current studies are completed. Name (Signed)______________________________________ Name (Typed)_____________1 ___________________ Company Date PLEASE RETURN ONE COPY NO LATER THAN JUNE 11, 1976 TO: Mr. A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N. W. Washington, D. C. 20009 nomSSHTlAL , Subject to Protective ^ Ross v. Conoco^--------TIth Judicial District uourt Calcasieu Parish,, Louisiana / CMA 002568 . MANUFACTURING CHEMISTS ASSOCIATION A*' VINYL CHLORIDE SPECIAL PROJECT Referring to A. C. Clark's letter of May 20, 1976 on proposed additional studies, I FAVOR u OPPOSE u PROJECT Continuation of Dow metabolism studies ESTIMATE $115,000 U U University of Louisvilledevelopment of diagnostic tools, first year (with similar requests for each of the next two years likclyV $200,000; My Company u LJ DOES DOES NOT plan to terminate support for the Vinyl chloride Special Project when the current studies are completed. Name (Signed) Name (Typed) PLEASE RETURN ONE COPY NO LATER THAN JUNE 11, 1976 TO: Mr. A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N. w. Washington, D. C. 20009 CMA 002569 / MANUFACTURING CHEMISTS ASSOCIATION VINYL CHLORIDE SPECIAL PROJECT 0^ ReL:n l . i proposed additional. .rVs ]"t: t.udie:;, I ' FAVOR u OPPOSE D PROJECT Continuation of Dow metabolism studies ! . >j on ESTIMATE $115,000 y // // University of Louisvilledevelopment of diagnostic tools, first year (with similar requests for each of the next two years likely) $200,000 My Company U DOES DOES NOT plan to terminate support for the Vinyl Chloride Special Project when the current studies are completed. Name Name company Monsanto Company Date_______6/7/76____________________ PLEASE RETURN ONE COPY NO LATER THAN JUNE 11, 1976 TO: Mr. A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N. W. Washington, D. C. 20009 C0JTFIP51T7IAL Subject to Frotosbivc q-^t- in Boss v. /kno?o, j: n:n ---.a'j? 14th Judicial rictr-Lc t 0 t; Calcasieu Parish, LouUd-n* CMA 002570 / t Wo H rOivJS.TO .iTL ^ COKFIDSUTT SuVjMt to -~-V~7....G'V,. P;:-. 7, ' ." U'"`: Calais;, u - i Louisiana 1 -1/ 1 dU 1 / I iH't/ 1 / hJ t.vi/m/, ijI '*[K C 1 I Aivi>Jr* oCT1J KiO' ' UK v ' I > f > .-o "i('C i hT L i t I 1 (Jr)OK! r,GTI GO T i r. }.'). Who H i r.lii TO i.) G * IjTL< [>ri. H.'UiSH dl'i ill) I'lr, ( K r. TO ho ~,i i l'*"' -. r'Grvt !i '> U I 3 r,1 > OITM fOOK Oht' u LcTl'^tt "I (HOI T1ii'J hL Wi'ifL GH.WInl l)t. S'JIS'It') S If I ''''i :'Oil i .^rJ I'n FL.V'lo i'll Tori-i I 'H-lTr, oiJi-'.-'MK T r'M OG SHc.GIhL rOKiJr.CT OHt\i GO rtk.v'> f ~>TJOih-> Hrtr, Go !'J1. r, T ".)> OLWtelrt O'tiHrt if) - 'in'-loH'irn (jo #+ MCh wsh of LmOIS in -t '-UiM', hOTO ifL o P* f"it -a wan JULY `A* IPV6 Subject to V _ : : F.0 35 V. S''"'' " i4th %. Calcasieu Louisiana :^TTW: MK. *A* C . i;l^(.'< MCH HL YO'JH Trlt.'.< JUMr. yj T r,Md :.00 WILL TMvIIl'irtTr, rti'IY d r'l-'H rtT Op T H it PHOGrtH-'P> LOO r^liJ-.D li'l YOiJK Lp/fTr.K Op' -UY lw/o HULOrtlH I'Jti PHOPOb LD mOUITIOUhL UIMYL LHLOrU Oh -> LJ'>i p,,S . y. < KIT TLH T p'MhGn CH PL'i I CiALd j `IGM WSH I ML " MiJODp,X Pi-MY MD4 \J.1 rl CMA 002572 MANUFACTURING CHEMISTS ASSOCIATION VINYL CHLORIDE SPECIAL PROJECT JUN 2 4 19; Referring to A. C. Clark's letter of May 20, 1976 on proposed additional studies, I FAVOR OPPOSE PROJECT ESTIMATE Continuation of Dow metabolism studies $115,000 University of Louisvilledevelopment of diagnostic tools, first year (with similar requests for each of the next two years likely) $200,000 My Company terminate support for the Vinyl Chloride Special Projec studies are completed, n 'CONFIDENTIAL Subject to Protective Or'1.In Itt ~ 3 v. Conoco !_!-- :'c. 14th Juiic'Vi Court Calcasieu Parish,, Louisiana Name (Signed) en th( current PLEASE RETURN ONE COPY NO LATER THAN JUNE 11, 1976 TO: Mr. A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N. W. Washington, D. C. 20009 CMA 002573 / }?' C PIT? ID ~'< ZIAL wu 1MFOMoSTtiH 4 MCrt WSH Qb/jA^C l 7 5 J'JJ'rfe.ST ZCZG Mrt AjjJI '.-MSHIMOYno DG *0, THX 71G3470FJG G Hr., PP'^'-iGG F i 0 oTTN f-Irt I 1! GHtrtT Ai'iKI CAM GHK'UGoL linriHOriaTIOi'l F-V.- V. 14?n - .> galeae I'-.-u H? ^tCaJ.Sh OF 0 I 'l t,r-h f-,, 'IT 'lit-*.'! S F ko I YHOSr. Hr.S F o .0 .' 1: it? T'"' GY Lr-TTiK OF M oY Fj (hi FoO.->n.i-,l.) OHJYL GHLUHXOr., .STOOir.S oT THG iJI'Il OkH.S I TY OF LlUJ X SI LIO-. .-ill.) X MCO irJ f.T k, HM'uHMS lli-i THr. COHTii-iO.OTinui OF M-,T.-VOl.l.i i w('HX oT ITOOK FXOMKT Ki-.PLY FXPKiviS IMG Y'i'JK VIkvLS "/OULO ~*K . iK JKc,G 1 oT -.0- P. 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J r -iTT'-I I:i 1- ' KJM'I ~> T iAiJ KK f.K CM;-. :I0 iL G1 v 1f ^,1. i'*fn ZGZG 4GGJ7 vM.-i H 1 I , r1 >. .i ijG TLX (J444M0 !HJUl)-.< Fw if mTTI'I '-IH FHnhK .MI l'TKit TKHriKCn GHF'ilG.iLS IMG Ji f < ; 1-j/ij 7.CZC nGGGn :!`\-> M i ' 11; P r ' `>0 FMS. `Ml Tri'l : ^ .J . '/ H O.MmG K M. 10 G n Itj 1 if HnTGO GHr.'IGoL 01 'I Sin.: F 0 -<nx 27 r 0 Ri)S t I'i.X1'/ <KrtS of ...ov-i.i -I ) --- o.ij FT Mi-fi-uiM-ro C ACGGFTKU ^JGGGI THKO ^1G 'j.j'T) rt GiJ.XGT Kl > H'jj'Jn jif'J.SOnGX r'Hf /I nGG--.-' r-.o oGvjGV ThHO 'i . j , * 1 -PG t-i-vi IS V-i. j-V ', l `-.nr CMA 002575 .11 S ^ C01T?ID2:T'TAL Subject to Protec::;-'T~r~j Boss v. Ccocco, = ,,* r 14th_Judicial r'st/iofc c... Calcasieu Parish, Louis! V -V-y' / , WU INFOMASTER ' + MCA WSH ' ' 0375340175 094JEST .. :>. ZCZC 43006 WASHINGTON DC JUNE 33, TWX 7 10457 3566 S T AIJFFEH WePT -.- w.fr 1 ATTN MH L 8 KUHN STAUFFER CHEMICAL COMPANY 1976 V : ' . BT , * ' BECAUSE OF DIVERGENT VIEWS FROM THOSE RESPONDING TO MY LETTER OF MaY 30 ON PROPOSED VINYL^CHLORlDE STUDIES AT THE ' UNIVERSITY OF LOUISVILLE AND INCOMPLETE RETURNS ON THE , CONTINUATION OF METABOLISM WORK AT DOW, YOUR PROMPT HEPLY EXPRESSING YOUR VIEWS WOULD BE APPRECIATED* * A C CLARK ,fn ! "\ - 1 s1, r' . . MCA TLX 69617 MCA WSH CERTAIN-TEED PRODUCTS CORPORATION PIPE & PLASTIC GROUP P.O. Box 860 Valley Forge. Pa. 19482 215/687-5000 CERTAINTEED June 10, 1976 JUN 14 197R Mr. A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N. W. Washington, D. C. 20009 Calcasieu Parish,, Louisiana Dear Mr. Clark: Certain-teed will continue to support the special vinyl chloride projects. Enclosed is the survey form that you requested, approved by Mr. W. A. Krivsky, President of Certain-teed's Pipe and Plastics Group. Please notify me when Certain-teed's share of the program cost is available. Sincerely yours, JGH/mgEnclosure J. G. Heil Manager - Health & Safety CMA 002577 *J EXXON CHEMICAL COMPANY 1251 Avenua of iha America*. Nw York, N Y 10020 PLASTICS DEPARTMENT RAY 9 NESBITT Vice President Jun i u m %pH CHEMICALS June 8, 1976 Mr. A. C. Clark Manufacturing Chemists Association Id-S - I.,:*- ,, V . V . Washington, D. C. 20009 Dear Mr. Clark: We plan to continue our support of the MCA VCM studies until the end of the Dow program but would like to with draw prior to the start of the work proposed by Dr. Tarnbur ro . Our decision is based on the fact that we neither use nor produce VCM in the U.S. and we feel we have supported this project long enough. Very truly yours RBN: lm Attach A division of EXXON CORPORATION CMA 002578 MANUFACTURING CHEMISTS ASSOCIATION VINYL CHLORIDE SPECIAL PROJECT JUN i o 1976 Cu^ Referring to A. C. Clark's letter of May 20, 1976 on proposed additional studies, I FAVOR OPPOSE PROJECT ESTIMATE & U Continuation of Dow metabolism studies $115,000 / / / /X/ University of Louisvilledevelopment of diagnostic tools, first year (with similar requests for each of the next two years likely) $200,000 My Company - /~X/ LJ DOES DOES NOT plan to terminate support for the Vinyl Chloride Special Project when the current studies are completed. (Signed) Name /'^j --' N ame (Typed) R. B. Nesbitt ComoanV Date Exxon Chemical Comoanv June 8, 1976 PLEASE RETURN ONE COPY NO LATER THAN JUNE 11, 1976 TO: Mr. A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N. W. Washington, D. C. 20009 ' ; -COffPISZlUT u Z Subject" , 14,ij J " ' ^ - .17. Calc` 002579 Q^ MANUFACTURING CHEMISTS ASSOCIATION VINYL CHLORIDE SPECIAL PROJECT Referring to A. C. Clark's letter of May 20, 1976 on proposed additional studies, I FAVOR zy OPPOSE zy PROJECT Continuation of Dow metabolism studies ESTIMATE $115,000 // // University of Louisvilledevelopment of diagnostic tools, first year (with similar requests for each of the next two years likely) $200,000 My Company /xZ zy DOES DOES NOT plan to terminate support for the vinyl Chloride Special Project when the current studies are completed. Name Name Company Monsanto Company Date_________________ 6/V76 PLEASE RETURN ONE COPY NO LATER THAN JUNE 11, 1976 TO: Mr. A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N. W. Washington, D. C. 20009 C0HFIDE5TIA] Subject to Pro- in Roes v`. Co'~c~o, 14th Judicial Sioirdcf d.uvc y Calcasieu Parish,, Louisiana CMA 002580 MANUFACTURING CHEMISTS ASSOCIATION VINYL CHLORIDE SPECIAL PROJECT JUN i o 1^/6 0^ Referring to A. C. Clark's letter of May 20, 1976 on proposed additional studies, I FAVOR OPFOSE u PROJECT Continuation of Dow metabolism studies ESTIMATE $115,000 U LJ Requests for subsequent years will be considered on their merits on a case by case basis. University of Louisvilledevelopment of diagnostic tools, first year (with similar requests for each of the next two years likely) 5200,000 My Company DOES ___ plan to terminate U/ DOES NOT Presently. Future support will depend on needs and merits at the time. support for the Vinyl Chloride Special Project when the current studies are completed. CONFIDENTIAL' Subject to Prof Name (Signed) Name (Typed) Richard J. Reynolds companv Shell Chemical Company Date________June 8. 1976 PLEASE RETURN ONE COPY NO LATER THAN JUNE 11, 1976 TO: Mr. A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N. W. Washington, D. C. 20009 CMA 002581 or unemicais Limited JUN 1119/6 n 7 Devonshire House. Mayfair Place. Piccadilly, London W1X 6AV Telephone 01 -629 8867 Mr A C Clark, Manufacturing Chemists Association, 1825 Connecticut Avenue, N.W. Washington, D.C. 20009. osts 8 June 1976 Dear Mr Clark, I am returning the questionnaire on the Vinyl Chloride Special Project, with apology for the delay. Yours sincerely G Harrison Operations Manager - Plastics cc Mr A P Jenkins - Dr B W Duck Mr K H C Bessant 002582 MANUFACTURING CHEMISTS ASSOCIATION VINYL CHLORIDE SPECIAL PROJECT / Referring to A. C. Clark's letter of May 20, 1976 on proposed additional studies, I FAVOR & OPPOSE D u& PROJECT ESTIMATE Continuation of Dow metabolism studies University of Louisvilledevelopment of diagnostic tools, first year (with similar requests for each of the next two years likely) ---**; $115,000 ' ^f 5 % $200,000. ' jJ " s"' ' s.5i A. . -p- - My Company n DOES DOES NOT plan to terminate support for the Vinyl Chloride Special Project when the current studies are completed. /kX Name (Signed) Name (Typed)_ A P JENKINS Company BP CHEMICALS LIMITED Date Q JUNE 1976 PLEASE RETURN ONE COPY NO LATER THAN JUNE 11, 1976 TO: Mr. A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N. W. Washington, D. C. 20009 C 01TFI DE'T 71AL Subject to Pronoot;t . .-'j 14th iuOicjrl PCourt Calcasieu Parish,, Louisiana CMA 002583 May 28, 1976 Mr. Freifeld: We received the following responses re: A. C. Clark's letter on Proposed Additional Studies for Vinyl Chloride: PANTASOTE - In favor of both studies & does not plan to terminate UNION CARBIDE - In favor of both studies & does not plan to terminate I will keep you informed. CMA 002584 4r VUI X KJt 0 " ' o. . INDUSTRIES PPG INDUSTRIES, INC./ONE GATEWAY CENTER/PITTSBURGH, PENNSYLVANIA 15222/AREA 412/434-2357 May 28, 1976 F, C. DEHN, Director of Environmental Affairs Chemical Division Mr. A. C. Clark Vice President Technical Director Manufacturing Chemists Association 1825 Connecticut Avenue, N.W. Washington, D.C. 20009 co: Subject bo Pcs5_ v. : 14th j.;.. Calcasieu T t- T, Lou lana Oear Mr. Clark: PPG's response to the vinyl chloride special project continuation is enclosed. My following comment provides additional explanation. PPG favors the proposed continuation of the vinyl chloride metabolism studies at Dow to complete this investigation. We will likewise acknowledge the judgment of the technical panel and favor the University of Louisville program for the development of diagnostic tools for this first year. Thereafter, we will make a judgment based upon the program and the progress. Such a program may have broad application and could perhaps be supported by all MCA memberships. I realize MCA cannot provide a concise judgment on the member costs until all management contacts have responded. Nonetheless, most of us have budget limitations to live with and would appreciate some indication of the financial coonitment Involved in the balloting. /elm Attachments cc: H. C. Twiehaus Z. G. Bell, Jr. F. C. Dehn CMA 002585 jun i iy/b MANUFACTURING CHEMISTS ASSOCIATION'- COZFIBzjj TIA L Subject i?o ?"c-i-4-'T7U7-r7J VINYL CHLORIDE SPECIAL PROJECT p.-'fil v, ....... ?r f irl: ' - ; c I r,, Referring to A- C. Clark's letter of May 20, 1976 on proposed additional studies, I FAVOR & OPPOSE U PROJECT Continuation of Dow metabolism studies ESTIMATE $115,000. >.. &u University of Louisvilledevelopment of diagnostic tools, first year (with similar requests for each of the next two years likely) $200,000 My Company n DOES DOES NOT plan to terminate support for the Vinyl Chloride Special Project when the current studies are completed. Name (Signed1 ) Name (Typed). C ompany________ Date Dr. Fred C. Pehn PPG Industries, Inc. May 28, 1976 PLEASE RETURN ONE COPY NO LATER THAN JUNE 11, 1976 TO: Mr. A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N. W. Washington, D. C. 20009 CMA 002586 June 3, 1976 Mr. Freifeld: re: ACC's letter of May 20, 1976 on Vinyl Chloride The following company responded to the proposed additional studies: B. F. GOODRICH CHEMICAL COMPANY Favor - Continuation of Dow metabolism studies Favor - University of Louisville DOES NOT PLAN TO TERMINATE cma. 0lSay co: ' -* '.ilh "> ' " MCA INTEROFFICE MEMO AT. iar.a June 2, 1976 A. C. Clark SUBJECT: Air Product* Ballot on Continuation of Vinyl Chloride Project*, May 20, 1976 - t- , ' _i. Mrs. Thorn informed me today that the ballot received Or. Adams of subject company had all the boxes favoring a osition checked. This includes not only approval of the p Dow and University of houisville projects but was also an tion the company intended to withdraw support from the VC I checked with Dr. Adams today by telephone via his secretary regarding the latter point. He indicated this was in error and the company did not intend to withdraw support from the vc project. MF:c Milton Freifeld CMA 002588 .COHFIDETITTJt, * rt j- - - * ,, Poss v. Cni'-r, ^ i`-th ~ Calcasioj P'.riji '-2j7 :urt ana June 1, 1976 Mr- Freifeld: re: ACC's letter of May 20, 1976 The following companies have responded to the proposed additional VC studies: QL . A-. AIR PRODUCTS - Favor the Dow Study Favor the University of Louisville Study an DOES PLAN TO TERMINATE ETHYL - Favor the Dow Study Favor the University of Louisville Study Does not plan to terminate GENERAL TIRE - Favor the Dow Study Favor the University of Louisville Study Does not plan to terminate CMA 002589 ' rnTTVID^TIAX. Subject to ?roteo-i-"_j^'_ ?os5 v. ^ 14th Jull'-i t : Calcasisu P , :r\ j L':"J June 4, 1976 Mr. Freifeld: re: ACC's letter of May 20, 1976 on Vinyl Chloride The following company responded to the proposed additional studies: Borden Chemical Favor - Continuation of Dow Studies Oppose - University of Louisville DOES PLAN TO TERMINATE CMA 002590 iUNIRQYAL JUN 7 1976 UNIROYAL, Inc. Oxford Management & Research Center Middlebury, Connecticut 06749 f. C June 3, 1976 '\ A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N.W. Washington, D.C. 20009 Dear Al: Enclosed is a signed copy of the yellow form you sent with your letter of May 20, If Dr, McCleary already sent one in, please disregard this one. Our continued support beyond the presently proposed projects would depend upon the need. I hesitate to commit to an unknown program. Very truly y.ours. WDH/df Enclosure cc: C. D. McCleary G. A. Anderson W. D. Harris, Ph.D. Corporate Industrial Toxicologist CMA 002591 manufacturing chemists association IAL VINYL CHLORIDE SPECIAL PROJECT -r :n JUN 7 1976 G*<-- icuisiana Referring to A. C. Clark's letter of May 20, 1976 on proposed additional studies, I FAVOR OPPOSE PROJECT Ax/ LJ Continuation of Dow metabolism studies ESTIMATE $115,000 , zv u University of Louisvilledevelopment of diagnostic tools, first year (with similar requests for each of the next two years likely) $200,000 My Company yy DOES plan to terminate DOES NOT Reserve judgement support for the Vinyl Chloride Special Project when the current studies are completed. Name (Signed) Name (Typed) Company Walter D. Harris UNIROYAL, Inc. Date_________________6/3/76 PLEASE RETURN ONE COPY NO LATER THAN JUNE 11, 1976 TO: Mr. A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N. W. Washington, D. C. 20009 CMa 02S92 (conoco) Conoco Chemicals Division Continental Oil Company P 0. Box 2197 Houston, Texas 77001 r J<*;n . Calcasieu P 'Court h, Louisiana June 21, 1976 Mr. A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N.W. Washington, D. C. 20009 Dear Al: Enclosed is the form indicating our support for the Dow metabolism studies and the University of Louisville Program. We haven't marked a box for the "plan to terminate support for the Vinyl. Chloride Special Project when the current studies are completed" because the statement is somewhat unclear. Our position with the University of Louisville studies as well as the other programs is that we will support them this year, but do reserve the right to review progress on an annual basis to determine whether continued support is warranted. K. L. Schurter Manager, Plastics / l75 Building On Thn Put For Th Future CMA 002593