AR226-3226 FINAL REPORT IN VIVO RAT MICRONUCLEUS ASSAY 'COVANCE STUDY: 22900-0-454OECD STUDY SCHEDULE: Sudy nisionDate: 18-0012001 Initial Dose Date: 23-01-2001 StudyTerminatDiaoten: 19Nov-2001 Fina Report Date: 25.3202 STUDY DIRECTOR, TESTING FACILITY.

AR226_ 3316. } 498 AR226 3316 ~ Danae TRADE SECRET Study Title H-26137, H-26138, 2an8dDaH-y26S1t3u9d:y iRneMpelateRdatDsose DermalToxicity TEST GUIDELINES: U.S.

DuPont Fluorotelomer Supply Chain Update AR226-3329 Presented to 0 o I Supply Chain Team ^ (0 5 P- 3 December 2004 o 0 s5.' m $ o a Contains CBI - DuPont Confidential Surface Protection Solutions A Contains CBI DuPont Telomer-Based Product Manufacturing Processes PFOA is neither used nor added in the manufacture of D Telomer-Based Products - Research did reveal trace PFOA impurity levels as an un reaction by-product Launched wide-ranging product/process research & an w technology that will essentially eliminate trace levels of Example Reaction Profile and Resul DuPont Telomer-Based Product Manufacturing Processes wo ; a | !

Oral Teratology Study of FC-95 in Rats Experiment No.: Conducted At: Dosing Period: Study Director: 0680TROOOB Safety Evaluation Laboratory Riker Laboratories, Inc.

Corporate Health-Physics CorporateOccupationalMedicine CorporateProduct Responsibility Corporate Toxicology 3M Medical Department 3M Center,220-2E-02 PO Box 33220 St.Paul,MN 55133-3220 651733 1110 Working Memorandum on Data QualityAssessment(oftheMean and Range of PFOS (ppb)LevelsinCurrent and HistoricaHluman Populations) ThisreportdocumentsBattellee'vsaluatioonfthestatistiqcuaallitaynd defensibiliotfy 12 datasourcesof serum perfluomoctanesulfona(tPeFOS) levelsfound innonoccupationahluman populations.These datawere summarized inthe3M whitepaper, "PerfluorooctanSeulfonate:CurrentSummary ofHuman Sera,Healthand Toxicology Data" providedtotheEPA inJanuary,1999.The purposeof thisinitiaclollectioonf human non-occupationaslerum samplesby the3M Medical Department was to determinethepresenceor absenceofPFOS inhuman blood from currentand historical samples. 3M requesteda reviewofthesedata by Battellteo determinewhat additional inferencescouldbe obtainedby analysesofthesedata.Battellsetatisticiafneslthatonly thepooled serum from the 18 U.S.blood banks was judged defensiblefora statistical analysis.Of thesedata,thegeometricmean PFOS blood levelwas 28.2ppb (95% confidenceinterva2l3.9-33.3).Regionaldifferencecsouldnotbe explainedwithout additionadlata and analyses.

InternatioRneaslearcahndDevelopmenCtorporation SPONSOR: COMPOUND: SUBJECT: 3M Company FluoradS Fluorochemical SurfactanL, FC-95 Ninety-Day Subacute Rhesus Monkey Toxicity Study.

Protocol.PFOS: A 96 Marine Diatom (Skele -0--- PROTOCOL PFOS: A 96-HOURT03aCITY TEST WITH THE MARINE DIATOM (S7celetonecmoastatum) US.

BIOACCUMULATION TEST SUBSTANCE Identity:N-ethylperfluorooctanseulfonamidoethanol;may also be referredto as N-ETFOSE Alcoholor FM-3422. (1-Octanesulfonamide,N-ethyl1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-N-(2-hydroxyethyl).-, CAS # 1691-99-2) Remarks: Materialisan off-whitew,axy solidofuncharacterizedpurity.

BUSHY RUN RESEARCH R.

HAZLOMON LABCFUC%ORIEB ANAERICA. lNr- Chemical& BlaMedicaSlciencesDivision 3301KINSMAN BLVD. p.o.BOX 7545 MADISON,WISCR SIN53707 PHONE (6082)41-4471 TLX703956HAZRAL MDS UD FINAL REPORT AM@AYY iI c i ..ILLAS D.

ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity:Perfluorooctanesulfonylamido(ethyl)acemtaaytea;lso be referredto as PFOSAA, FC-128 or as the major component of FC-1 27, FC-1 29, FC-1 09, FC-1 09-X or Rl 904.

BIOCONCENTRATION TEST SUBSTANCE Identity:Perfluorooctanoiaccid,ammonium salt;may also be referredtoas PFOA ammonium salt,Ammonium perfluorooctanoateP,FO, FC116, FC-1 26, FC-169, or FC-143.

ACTIVATED SLUDGE RESPIRATION INHIBITION TEST SUBSTANCE Identity:Perfluorooctanoiaccid,ammonium salt;may also be referredto as PFOA ammonium saltA,mmonium perfluorooctanoateP,FO, FC-1 16, FC-1 26, FC-1 69, FC-1 43, or as a major component of FX-1003.

ACUTE TOXICITY TO AQUATIC INVERTEBRATES (EASTERN OYSTER) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonawthei,ch may alsobe referredtoas PFOS, FC-95,oras a component ofFC-203. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ACUTE TOXICITY TO AQUATIC INVERTEBRATES TEST SUBSI"N E (SCUD) Identity:A mixturecontaininpgerfluorooctanesulfonwahtiec,h may alsobe referredto as PFOS, FC-95, oras a component of FC-206 or L3243. (1-Octanesulfoniacid)(CAS # 2795-39-3).