Document Jny97BaR9JLda8nr36wo2ywv

Corporate ToxicologyStudy Outline July,1998 DT22; T-7121.1 FC-129 Title:FC-129 PreliminaryADNM Screen in Rats Thneline: InLifeStartDate:7/13/98 InLifeEnd Date:7/17/98 Purpose: Thisstudyisdesignedtoprovidepreliminariynformationon theabsorption, distributiomne,tabolismand excretio(nADME) ofFC-129. SigniricanceT:he resultosfthisADME screenwillbe compared tothetestresultfsrom similarstudieson othercompounds. Objective(s)T:he objectiveistorapidlyscreenFC-129 foritsADNffi characteristiicns, particulatrheformationofpersistenmtetabolites. Protocol: *CharlesRiverRats/SpragueDawley/CD/ 415-475 g *6 males *Singledose,oralgavage *0 and 5 mg/kg *3 ratspergroup *Individuallhyoused in matabolismcages o CommerciallyavailablceertifieLdaboratoryRodent Diet#5002 (PAU Feeds,St.Louis, MO) ad libitum *Water ad libitum *Urineand fecescollectedays 1,2,3 and 4 postdose *Necropsyday 4 postdose ouver and seracollected *Analysisforparentcompound and suspectedmetabolitesby KrisHansen, Ph.D.,3M EnvironmentalTechnology and SafetyServices. Sponsor: 3M SpecialtCyhemicalsDivision. PrincipleInvestigato/rLocation/ Cost: Andrew Seacat/ 3M StrategiTcoxicology Laboratory Report: Mean concentrationosfFC-129 and itsmetaboliteisnthecollectetdissuefsor each group willbe analyzedfordifferencebsetween means and consideredsignificanat thep--0.05level.