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FOR bU FONT USE ONLY AR226-2885 Copies to' E. I. du Font de Nemours and Cor'-.my Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711 HASKELL LABORATORY REPORT NO. 561-80 Haskell No. .13,674 Study Initiated/Completed 7/15/80 - 7/17/80 CD&P Dept. Jackson Lab Ltted by SKIN IRRITATION TEST ON RABBITS Procedure: Six male albino rabbits were clipped free of hair on the trunk and lateral area and placed in PDA-type stocks. Doses of 0.5 ml undiluted test material were applied to intact skin under 1 1/2" x 1 1/2" 12-ply gauze squares. Rubber sheeting was then loosely wrapped around the trunk and secured with adhesive tape. After 24 hours, the rabbits were removed from the stocks, the patches taken off and the reactions observed. Observations were also made at 48 hours. Results: 24-Hour Observation 48-Hour Observation Erythema Mild 3/6 Slight 3/6 Edema None 1/6 Slight 4/6 Mild 1/6 Erythema Mild 1/6 Slight 4/6 None 1/6 Edema None 6/6 .Company Sanitized. Does not contain TSCA CB( Summary '.^^H^SUiaed mild co slight: skin irricacion In 24 hours and mild Co no irrlcacToffTn 4fhours whan tested on ttu ahaved intact gkin of rabbits < Thia oafrial i a mild skin irritant. In the evenc of skin contact, good ^& industrial hyglaiw practice would ba to waah thoroughly with eoap and water. ^^ ^n^U^ 6{^'Ut aaportbyt (//y :-^:^J'^; ::. ." .^ ''; ~.".'^ " '?-\':' PoUTTUniBy Biochemist . ;'Appn>^^||^p^,flJ y , -!^ \. ^-^^^^^S^.&lii"Gerald^rLi.i.tioin.n,leid_y______ '[..: //^^.^]t^3F^ Afiuta'Invtti<atioW Saetion PAljyg ^ ';<' .^^': Study Direccon 0. L. DkBhiell 0t lBudt July ^ ia6CL : j J.B. E-21090, p. 67^ . aeport No. 561-80 j - 2 Company Sanitized. Does not contain 7SCA CB! '-