Document VjzxKdDbo8qpKVNy5JJrqGxXw
3M General Offices
3M Center St.Paul,MN 55144-1000 612733 1110
May 18,2000
VIA EXPRESS MAIL
Dr. Charles Auer Director Chemical ControlDivision OfficeOf PollutionPreventionAnd Toxics United States EnvironmentalProtectionAgency 401 M Street,Southwest Room 403 East Tower (MailCode 7405) Washington, D. C. 20460
Re: Information On Perfluorooctane Sulfonates And Related Compounds
Dear Charlie:
Pursuant toour recentcommunications, 3M isenclosingadditional informationon perfluorooctanesulfonatesand relatedcompounds. The enclosed informationsupplements informationsubmittedto you previouslyunder cover ofour April21, 2000 and May 4,2000 lettersA.gain,we are providingthisinformationon a voluntarybasis as partofour continuingdiscussionswith EPA regarding fluorochemistry.Please note thatsome of thisinformationqualifieass confidential business information(CBI);we also have enclosed a sanitizedversionof CBI documents.
The enclosed informationcovers perfluorooctanesulfonatesand certain relatedcompounds listedinTable 1 of the document entitled":Sulfonated PerfluorochemicalsInThe Environment: Sources, Dispersion,Fate And Effects"a,t 12 (March 1,2000). Specificalltyh,e informationcovers thefollowingchemicals:
Perfluorooctanesulfonatesi,ncludingCAS numbers 1763-23-1 (acid)2;9081-569 (ammonium salt)7;0225-14-8 (DEA salt)2;795-39-3(potassium-salt2)9;45772-5 (lithiusmalt).
=> Perfluorooctanesulfonfyluoride
CharleAsuer May 18,2000 Page2
=> Perfluorooctanesulfonamide
=:> Perfluorooctsaunlefonylam(iedtohyalc)etate
=:> Perfluorodecanesulfonate
=> Perfluorohexsaunlefonate
=> N-ethyplerfluorooctanesulfonamide
=> N-methyplerfluorooctanesulfonamide
=:> N-ethylperfluorooscutlafnoenamidoethanol
=> N-methylperfluorooseutlafnoenamidoethanol
=:> N-ethylperfluorooctanesulfonaacmriydloaettehyl
=> N-ethpyelrfluorooctanesuldfooentahmyailcrylate
=:> N-ethylperfluorooctanesulfonmaemtihdaocertyhlyalte
=> N-methyplerfluorooctanesulfonamaicdroyeltahtyel
3M hasprovideydouwithinformatioonnperfluorooctsaunlefonates previousulnydercoverofourApri2l1,2000andMay 4,2000letterWse. areenclosing someadditionianlformatioonnperfluorooctsaunlefonatleoscateadsparotfour continuifniglseearchF.oreachoftheforegoirneglatecdompoundst,heenclosed informationncludetshefollowing:
=> Copiesofpost-9176studieasndcertaoitnheirnformatiroenlatitnogthefollowing environmentsacliencaereas:(ip)hysicalndchemicaplroperti(eisi;) environmentfalteandtranspo(riti;ein)vironmentmaolnitorianngd;(iv) ecotoxiciFtoyr.eachstudy3,M hasprepareadsummaryintheHPV "robust summary"format3.M alreadhyasprovideydouwitha generaelxecutive summaryaddressinegachoftheseareasundercoverofourMay 4,2000letter.
Copiesofpost-9176studieasndcertaiontheirnformatrieolnatitnogthefollowing healtehffecatrseas:(ia)cutetoxici(tiyig;)enotoxic(iitiyri;e)peated-dotsoexicity; (ivp)harmacokinet(ive)tse;ratoloagnyd;(vim)edicaslurveillaanncde epidemiolog3yM.hasincludeaddetailienddexofthiisnformatisounbdividbeyd eachcompound.
CharleAsuer May 18,2000 Page3
Listsofallstudiesinprogressand plannedstudies,alongwithstudyprotocolsor studyplans,where available.
A bibliographoyfpre-1976 studiessubdividedby each compound.
A bibliographoyfacutetoxicitsytudiessubdividedby each compound, except thatwe are providingcopiesofkey acutestudies(withreferencetothe HPV guidance).
=> A bibliographoyf publishedstudiesin3M's possession.
An indexofstudiesin3M's possessionbelievedto be inthe FIFRA docket. Please notethatthisindexhas been submittedas CBI. 3M alreadyhas provided theAgency witha lisotfallfluorochemical-relastuebdmissionsmade by 3M to theTSCA Section8(e)docket.
3M iscontinuingitsfilereviewand willsupplement theenclosed informatioans appropriateA.s you reviewthisinformationw,e ask thatyou bear severalpointsinmind:
The enclosedinformatiosnpans severalboxes. We have organizedthe informatioinneach box withlabeledfilfeoldersand indicesto aidEPA's review. To ensure thatyou and your staffare abletoaccess themost pertinent informationw,e alsoareattachingtothislettetrheindicescoveringstudiesand otherinformation.
Many ofthe studiesrefertothetestsubstanceonlyby a 3M productidentification number witha uT","L"or "FC" prefix.Althoughanalysisofthetestsubstancehas been included,where availablei,tisoftennotpossibletodeterminefrom the studyreportitseltfhe identitoyfthetestsubstance.Thus,we have used the indexto providethisinformatiobnased on 3M's historicraelcordskeyed tothe 3M productnumber to determinethecompositionofthetestsubstanceand have providedspecifiicnformatioonn the index,such as percentcomposition,solvent context,saltform and puritygrade. Pleasenotethattheterm on the index"wide range"referstoa lowerpuritygrade ofthecompound, and "narrowrange"refers toa higherpuritygrade. Finallyi,tshouldbe recognizedthatproduct formulationhsave evolvedover theyears,and thus,some ofthe testsubstances do notconstitutceurrentproducts.
We have includedsome additionasltudieson perfluorooctanseulfonateslocated as partofour continuinfgilereview.As we have discussed,we plantoprovide you withinformatioonn mixturescontainingperfluorooctanseulfonatesinthe near future.Please be advised,however,thatwe alreadyhave providedyou withstudiesand otherinformatioonn aqueous and/orsolventsolutionosf
CharleAsuer May 18,2000 Page4
perfluorooctsaunlefonateAss.totheforegoirneglatecdompoundst,he enclosedinformatiolnikewiseincludesstudiesand certainotherdocuments on both thecompounds as wellas on aqueous and/orsolventsolutionosfthese compounds. We are not'providintgoyou today,however,informatioonn other typesofmixturescontainingthesecompounds and would liketodiscusssuch informatiownithyou.
Consistentwiththeinformatiopnreviouslyprovidedon perfluorooctane sulfonates3,M has notprovidedyou withallanalyticaclhemistryreportson these relatedcompounds. Rather,we have enclosedcertainanalyticaclhemistry reportswhich may prove usefulto EPA ininterpreticnegrtainstudies; understandingthedetailsofanalyticaclhemistrymethods; or verifyinhguman and biomonitorindgata.
We providedpreviouslyunder coverofourApril28,2000 lettetroOscar Hernandez a "Use And Exposure InformatioPnrofileo"r "UEIP"for perfluorooctanseulfonates.Our presentintentioinstoprovideyou with completed UEIP formsforthese relatedcompounds earlynextweek. 3M needs additionatlimetoclarifiyndustriahlygieneand otherreleaseinformatiotno ensure thatthedata isaccurateand placedinappropriatecontext.
=> The informatioonn perfluorooctanseulfonatesentunder cover ofour May 4, 2000 letteirncludeddocuments relatintgo ongoing mechanisticresearchby Dr. Ken Wallace oftheUniversitoyfMinnesota. Pleasenote thatthisresearchalso encompasses theserelatedcompounds. InadditionD,r.Marion Anders ofthe Universitoyf RochesterMedicalCenterisperformingcomparativemetabolism researchrelatintgo perfluorooctanseulfonatesand these relatedchemicals; thereare notdocuments yetavailablerelatintgothisresearch.
CharlesAuer May 18,2000 Page 5
3M looksforwardtodiscussingthe enclosedinformatiownithyou and otherEPA staff.Inthe meantime, pleasedo nothesitatetocontactme withany questions.
Very trulyours
Enclosures
WilliamA. Weppner, Ph.D Directorof Environmental,Health,Safety And RegulatoryAffairs SpecialtyMatedals Markets 3M Bldg 236-1B-10 3M Center St.Paul,MN 55144 (651)733-6374(phone) (651)733-1958(fax) E-mail:wawopner(@,mmm.com