B=E=f= ~~ Pathology Associates International 4ComofScpiencaeApplnicatyions Intemational Coporaton =r -pape-- AnEmplOwoedyComepae ny SECOND DRAFT CELL PROLIFERATION REPORT 104-WEEK DIETARY CHRONIC TOXICITY AND CARCINOGENICITY STUDY WITH PERFLUOROOCTANE SULFONIC ACID POTASSIUM SALT (PFOS;T-6295) IN RATS COVANCE STUDY NUMBER 6329-183 PREPARED FOR: 3M TOXICOLOGY SERVICES BUILDING 220-2E-02, 3M CENTER ST.

ACUTE TOXICITY TO FISH ARDE-0195 Frees TEST SUBSTANCE Identity: Perfluorooctanesulfonate, Ammonium salt; may also be referred to as PFOS NH," salt or FC-93. (1-Octanesuffonic acid, 1,1,2,2,33,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-, ammonium salt, CAS # 29081-56-9) Remarks: Test sample was taken from 3M production lot #1.

[ c ARA26G-0316TM =~ IN VITRO a, MICROBIOLOGICAL MUTAGENICITY ASSAYS : a September 1984 : sw _ Dela Lone. ite) G LL 2 E-- C-- 3M Company em Saal attentions 3031 tomate Yea. ti...

373 7 ff ORIGINAL COVANCE ARIRE- 0790 Sponsor: 3M St.

ARR26-- 1106 ACUTE TOXICITY TO THE EARTHWORM (Eisenia fefide) TEST SUBSTANCE Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-Octanesulfonic acid, 1,1,2,2,3,3.4,4.5,5,6,6,7.7.8.8,8heptadecafiuoro-, potassium salt, CAS # 2795-39-3) R3eMmalortknsu:mbTehre2t1es7t.sSubasmtpalnecewiassastwohrietde upnodwedrera.mbSiaemnptlceonwdaistitoanksepnriforrotmo etelsetmiengn.taPluraintayldyesteesrtmeicnhendiqtouebse. 86.9% by LC/MS, 'H-HMR, *F-NMR and METHOD oMuettlhinoedd:inTthhee sOtrugdayniwzaatsiconofnodrucEtceodnuosmiincgCaooprpoetroactoilobnaasnedd Doenvperloocpemdeunrtes (TeOsEtCtDy)peG:uiSdteatliicn,eaNrtoi.fic2i0al7.soil substrate GLP: Yes Year Completed: 2002 Species: Eisenia fofida Analytical monitoring: Test substance concentrations in soil measured by LC/MS/MS at Days 0 and 14; in earthworm tissues after test termination.

3 .

TELOMER RESEARCH PROGRAM 1200SouTetth( HayesT SroetDSA5vi4n.gFonn, VBirgAie 2I2025060 |4 [ESI =S Clariant WIR February 14.2003 8ZE z otn Mary F.

ARARGC - 1273 TELOMER RESEARCH PROGRAM February 7, 2003 `DRAFTStud Plan:ImpurityAnalysisofArticles pTrhoedufcotlslo(wsicngbeisloaw)p.ropSoasmepdlesstudwyillplbaen cfoolrleacntaeldysifsroomf pPiFlaOAplainnt 1f1acainliictlesesortrewaitledlbbeycotllloemcetre-dbafsreodm commercial manufacturing facies.

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AR a6 _ 124] Telomer Research Program FP AGC --_ ------ = Clariant.

AR226-1398 | irae oni m albino E. 1. ou Pont o Niemnours & Company WILMINGTON, DELAWARE [-- - HD") Serenbets - eep AR R26 -- 1398 : November 23, 1982 PERSONAL & cONPIDENTIAL JP.OLWYwM.

AR ARG -- HHT H 4 FRANK A.

sof ARRQ26 _ 144-889 Review of APME-Sponsored Kinetics I ADE - Reported 1Q/2003 II.

@HwAisZELRENTEOLNN AR 226-0449 Sponsor: st. pa, Himesots FINAL REPORT Study Title: 13-Week PDoireutoatroyncTioaxniocTaittoey.dSt(uCdRAyaStwsNia.th3T6-2551-82061,1)Ammonium DRaetiiaqdueiTrineeme$2n.t1: Author: Matthew J.

FINAL REPORT RECEIVED 0PPT CBIC 20FEB 22 A411: 34 PROTOCOL 418-014 ORAL (GAVAGE) CROSS-FOSTERING STUDY OF PFOS IN RATS SPONSOR'S STUDY NUMBER: T-6295.13 FINAL REPORT DATE: 23 JULY 1999 245 40975 um PROTOCOL 418-014 ORAL (GAVAGE) CROSS-FOSTERING STUDY OF PFOS IN RATS SPONSOR'S STUDY NUMBER: T-6295.13 SUBJECT TAOFBCONLTENETS ' SUMMARY AND CONCLUSION A.