Document y91vaBYeQ5Z3gk5a4j9dRJ3

sof ARRQ26 _ 144-889 Review of APME-Sponsored Kinetics I ADE - Reported 1Q/2003 II. Proteip -- Binding -- 3 manuscripts 3Q/2003 II. Modeling -- o, Rat -- derived compartment model Human model considerations 3Q/2003 7/25/03 GL Kennedy 1 | Project: Inhalation Kinetics -- Rat Purpose: To relate inhalation exposure to an APFO blood level (for comparison to oral data) General Design: 3 exposure concentrations (1, 10, 25 mg/m?) 3 weeks of exposure (6 hr/d x Sd/wk) Both sexes Sample immediately before and after exposure daily (used pilot study to determine timing of blood levels) Date Available: August, 2003 Report Available: October, 2003 G7/L25K/e03nnedy 2 Project: Lactational Transport Kinetics -- Rat Purpose: To determine transfer of APFO to offspring from lactating dam (in a quantitative manner) General Design: Oral doses of 3, 10, 30 mg/kg GD4->1D4,7,14, 21 (follow same rats) Collecting maternal blood, milk and offspring blood Analyze for PFOA Data Available: October, 2003 Report Available: December, 2003 7/25/03 GL Kennedy a 3 Project: Placental Transport Kinetics -- Rat Purpose: To determine transfer of APFO from mother to fetus (in a quantitativemanner) General Design: Oral doses of 3, 10, 30 mg/kg GD 4 10; 4-15; 4-21 Collect maternal blood and conceptus/ fetal "blood" (amniotic fluid, placenta in later gestation) Analyze for PFOA : Data Available: October, 2003 Report Available: December, 2003 7/25/03 GL Kennedy -------------------- W ------ Project: Effect of Age of PFOA-Elimination --Rat Purpose: To determine at what age differential excretion of APFO occurs in male and female rats General Design: Single oral doses (10 mg/kg) Dosed rats at 4 wk, 5 wk, 6 wk, 7 wk, 8 wks of age (separategroups) Blood APFO determined 24 hrs post-dose Data Available: September, 2003 Report Analysis: December, 2003 7/25/03 GL Kennedy ------------------ >s --