Document MM1v1X3Xdm330Rpmj36ZDy7Bk

AR ARG -- HHT H 4 FRANK A. BOWER = DON'T SAY =, IT=WRITE IT PETCHEM-FREON PRDTS LAB-CHESTNUT RON eta on TY Homo Cm tour HASKELL LAB To 366-4356 MEETING WITH 34 MAY 30 owe 5/15/78 co: T. L. CairnsA , CReD--- Wilm. C3.FRR/.BCMGibs:on oErSgaMniiiccaflllAuytotrawocichtoehmdpopuoinssdssiablcieonpyheunmovfainroanppmlaaepsnmetara.lbysToGhuuerycedsiansdocfuTspasvieeorsnflucsooerncicteniraontnienddgeals Bfiavtitlyiaancisdso.f PlTuhoeripnaeperanwdasBiporlegsiceanltedCheamtisatrsyymaptostihuem s17p0otnhsoMreetdtibyng oCofhnedmtihpceuabAllmiesSrhoieccideatniyn,Chteh1em9i76cA.CaSl SSoycmipeotsyi,umChSiecraigeos, 28I,llibnyoitsh,e AAumgeursitcan26, 1375 ARtWtMa/ctahaenents en mron SECURITY 15 AN INDIVIDUAL RESPONSIBILITY iE : ; . RECEIVED MAY 16 1978 BRUCE w, KARRH,Mo; # . Vo . 2 E1071 2 vou 000099 es SS RS DAN Organic Fluorocompounds in HumanPlasma: SY Prevalence and Characterization 1 Br a Gatnsvile, Fla. 32610 Department of Pharmacalogy 1nd Toxicology. University of Rochester, ii `|i `BW. Rs. EBREEY,IRJRi. y, Usvrity of Foi, Grol, Fia.nStLer a 4i - J annSEE ome Fle G0 tained two distinct forms of fluoride (1-4). Only ona of these E ErinmonE,meWLEanI S eaSHeiOrts Slrr,rSr R nTET R R, bow its presence in hussa plasms 1)| {A]) | rEni gTe o ratry prevalence in humm plassa, 2) mR pg ae ae H|| R apis be rtBER AS exchangeable fora vas widespread in buses plasma but did not | SEeoAtRsEee3 ebdnSdGersoaRnsT Len 4 samples of plasaa from 35 blood donors ia Rochester, KT. . i i1) k fneriimnrebmJT ecyaTS8 s siehToplfeoBSngpEdreceistlotefg ce mShienatnLtnn selReiLs 12 i: || E EEEE SihSriRitn dE e =rSLewtG s es eHShEeielSeelmea taiOMsLnntBdesNeeEdreIhtmT eyae HI Si 5RbTii melegsest 1tEaOSos)tslEaeAmTlLeBH pmeoanenyE ntot be"e bom il ofThere prsomiptiet Apparent, and it vould be unnecessary to `postulate such rigorous {i , 000100 Cows OCHS INVOLSING CASONLEONE BONDE 7 rea. Fuoroeomy b1A o0s6soSsAoeahtbiucoaocatouoendrtriTyoidlvepisieaesfcsoheiaaatahtesfsiuisrmvspelpeeufsiborflvifceefrrlveueoaarttcteodrlceli.ecsciutepsepdlvy.iftrhonTdheecseuteovteeaslr0e.o1f eee eTa.erteocohttnhaoennftoperroamfatsvlafeollfueonfrclfiuelduoepro.rfiidhdetoeh.uceotnBhIconeand-teetrhixiaccstkhiiavonsanggyevtfahtnthleeetrherfevolarpsamlcairvsoeamn-sa: ffEuoromthe4ocrieasFEtiiuobdiiereoerdris.geassitecovetrFhaleluoscriLhoinenciaeentsatephaoolfufonadesvttoihufdeteebnflcaooetfoedrs.tmuhagedseiInnatoctneae-dfegpxrotcalhheteacetaidcg{yeEv,sibvtlahes EEE Yeiiooivneidntertuhenlipaelcatsrfeorsp.ohnorseeaims era Vick solvents oo(ff):sleorvuAatptoealtmaprtpisityantliiedkiec(e3h)cetpataaednxetv,reasc= Te B ETn E eeFokFihnteAcrlhbaFaurinmcndioanalelltysh,aoycsluvpcbshiatohntehpcrl(eapverseemrdpaeiacdpegrderoaecebseyrolavsleesllvyetechvrteaerosSppuohrcuoecsrceeisspCsiiifstvuaeltorfeidae 3 a ReEeoRmneattcoeaudthtaTvfeoeadvdtJhaokesnhSitteshhtgeehsafetnuoacolorr-neiuslsaieetdteearfrsrasatfucilpeouienoorsrnmiazcotehreeinagtssioapLisa-zlcol&rxygcefhbnoaoirsucagnedsbtloe Fffirmaocrctiicoen"{cohtdhethrrrsvodauvesgshotpfuauutrrbciuhftseihtreeadcrhpefsalrtraosasmcofat2e0Crishi1izisraceefprteishrpeerorefo.drgpatooaotlcaesdfh"louurmogiraainnipeclasms i Ghmmcterized by fluorioe sar. 3 YJaatceerdtJanSlayslyTacocikdcisoKlgecMthehotehtos3disi.eceVnacleuepbsoerttfivoorenssoargtoafhneitcahmefoulsnuetomreionSfeatoveoceriraegla.ciaclcu 1ityriecrtoaaimb"pnenoitnria(alersiiihumeinpdeigseaapasdrinovdcveenmdaifusxorhereeddpvliietnshmuar0ev.da6smtoo3 lape1rs)epvaoerferelaosvphleadcednez{paies: aOH, 2) these vere dried oo 8 fi4 FoeieeatfTaTaeaascehci,Tvueuatdnned+s0fh{.ule1roduwmacoo(fepllevsashitiriocmfhfarNhoa1nd44o3buetesfnindsepoldatcihefe)isbdufsolrtdoi2-ct4ghabt(rrtoahotem 15 sore vacisble), ad 3) ashed 4|| | Ce E ee rleoivrisTnohgiee .vblepardcokacbie4sadnvude2rnem5akavdasesiofaunt2e,d5rlN1fa)oc5rh,sa5as0me,Sppilaeserhosadt1i(.tos5rnaamonopbfslfeeofrflaruievosdaertiedtfroeo.r (| feurimotbmoerbdeothBphioassnetes,dvaeTssadtc2voaanls)aFblevadseeriesceapa,pllaeOcsmesmdarfda,diCfafluisfi.onsdhiesohtebesat(Organ J] rofeaemovv5e0adi,iearcieendsevdircvhimt&hpwaotge atSiieotneipal(ai0co.en5d=d1i1,ahb,04.0e11madNlcloppo oS14ar4mepvliueatithof&odresncmrbaelaaltsvebeossleocsateem TL"aaatetoi(pabljoaewccetCeovdrinithahrgo,puegTchhcuottldhe*e TFDooalrre'satvceiisadessfeerinttme6dbweid,me3ddiisrna "aCahidacrktaredapdaptin1giaisssolvpuaticinuoemnsv3a PctraecsternFociteaeo,orfidTsoNveiAsDsHydscetaresemin SFCirlaaibsnectiieactgev,iinpaoarsnes)thoi.vaelrd8evedi CSvaiateputoriraritazetadsticolfaonsrsaoiefngpthaaepaesrs o(fend1ehSruBa0ap1ie,tevaovsretrodenr)o.pveeepe HCTheael'riocsr.SaepauppidlnigndgespoKoliruttc,iieodSnpd4 c"Clooalcupttrpiooidnecvasesndvtathnheeouacceredetoess ScuirofnaciSeansmapolsfeescstvheeofrtewsoraemeadpl uSEcreafoasgceeraessr.to,TshqeusFieilinsbeer,iinc SLcaaaopliyleantaatrnod ackoSeemcasokeneadslooyin Taevsedriaaeggelsdisw4e2addfotrihaestphvereaertpah hese vere chen asvide BEST COPY AVAILAB! LE RR E.L eT NEP 5 2g Jit a 000101 BRT EE R D ERE ACRa E ERTE RRR | | cotta,tesidonwsiteh na gveaetlne,svsirlttagiselvoonnon24 slaboE ratoryEnalar : Aidl fLooer38aaia5to 6re0m1oveN CNOjaibi +2) pfhoersoelatchhalseatsap-lpe-nithcezopthreasppoidnginsdoliuc-e) of the er-vell d iA1 a ve as pn t le acedaiie une hya s1aadlrelopipeooiflyas1t0uayFarcrsTeoinrsoeidantiStocnoaunsipr-laakasisnmt0hape0otkirhteevaaha1scsegeaaithtddoenddimedvtetaahisro0osisntaeh5eiecl%aae,ttdeitnh-e fpo aeaoM nes" Gpdoawlfm uCsoaserwdicocte,ree eTuho2l atL h1h1, 0t0e eh01s0% phceaoi r,c1oWtieelsdaanJcdeew,lahlcvyheiapkusedi)map8fll0es,iiasshtsosadaoaefSlhe 1 1 Fep pchooerearklcata tne aeLuap5nheetdEehaEee,dHe3)E ena(heGorvCTe,eerm26t(haefahyateiidsnedrbvteyeaacbcswrosese,kciu1alsagelstithihveeaerns)eal, Po cEelaEe asceeo,fe4 MoanSedese ttecanye)c.rnoeanlfpeeo(trtceeeodaedtseiodofssSleuUetOcrBEayKrl,ovduiOedcrhi(eoFcnihcbelReeerfcsleeSurapoorrdceihy)deo&c. DCESm loemctbR reatses,ILMeoamnEasne).2amSi aha iicek :dcaaseofdeEl+sarsbhoiavddehatiieahpeecsdheeefnecbeeodviotelostpmwroefecvebrseontth I e CLLU,e D,oCrELtEo).n:eeda aue d end dn cha e follovisg vaKr:e1y0 1 D L [Do noe Ysdrcie reroSmSiaeeanpmslsici g1Kit,eSpriaUnfcetoeTsraDTeiravy.dt1,ane0ewiB:ehcCdckthomhetnaebnvteefaaTlesoeissxsnti.boOlfatCeoeohht.coe,SippPcHosaoutlepfeeosriCoAah1flner8st,o,cht T1|| oegnleestoentmeoteanednscovheeOerRerTaraeedaeldkeeefiornsoretadveerrteeeaordfueaibebneccoruavee.eaeesntdionbdgrradycuektxbepfuteecicrvnteagensdsaccvaseolayinmebcprelaaectsi:eosn G | a eee sr a iiccmatea,hteyhetyvheevinseftrokreoann,fclouonsrocTeedehdeanidcsdLeaioapnncr1tio0oocfneoUsicr1uhreevsexooepmlleppuecelmctreetesssrdioswfdtifoeoecrrdhiha e e E ea e e e oyey re.piritnhsanritatdvhhpeeeiraesvwstaaasrn(sdmsasbaredrlFlacryeuarecvttderi,iopfnlraiolcmaFtseeecsme)pvlewereysreeofen. TEiO RaR =h I{ 1 4 I i 1 il1q | 11 i ii 4]1i ik1 : N al1 1|4 1 1 3{ i|] d I| 4 : i EID107114 | ia z bd 000102 Cw BIOGUESISTRY IYVOLYISG CARBON-FLLORNE 5003 Tener Flom ftlheuosriaFdmlepalset(iuossevutaa.rlely 90 to 957) fn standards treated the same vay (Falcon Plastics) vas used for all snalycical as "shzipcohrcaaiagthttapceecriearlelayc Tovar che pH of the bn TDpirtbooecmreeideussreeasasndocroe+mauvpnoocilsdycvcaeorrnbetoensmaiatnedaetviowolincuhsebcy1,rifcl5uofarnlidadsek10f(ar11o0m0pagolll)ay.sssc.yrenLeiquid pfourndetehant siamnplges =cor purification syacem) < aVecreerRsveeaadsgiesncrtiesldltevadec.rielleFpdluuroiarfnidiedddeeictooonsitfzanenadtu.sseaciAuocnnieftoiircnaKlaGycCildlyovso(dbsloamaneykcsni.tcsal fFEoLeuiurohrisoduuexsp,liensTbiohsfeedhsuipmalana FTrhacd1oeu)hthowdaUshsicrcruhebdbutichneegdsvboyilcuhtpirohanpeaxcvaiamnsegthcyoalntd1itnsu(olsuoosxlluaytsieorvneacpyccoolrnecdai.taai&nFgoClolKloCuvLminatgo vCCeoosnrktaa,ihnaitnhdge 2tc0haepcphsiaenmngegeu Jr"iiyrrb0rbHeisntghFulautlohrevidoseloaltucitolineotnasmviialnsiactobinooeinsleLdaacHdCyo3t0ch,aeenvastsahdirerdeJdvuuosctledubmabesyitcorevrpieetaahotveed V"i5cecoob1s5e8rvbeedabnedtvteheea time. GTihieTnaBbcoucitfolfniesnrgedoftoc+aoli6n.b7ratKhtiirosdnolvusoteliauonmnieevcidftsoherheremeoavmseeatdthehyelfdrrieosmsildtouhnaenles.saimlesincNdoanOeH. d Rcehperobhldaueccktsbrieaincisheieytrivvatirhatinye manodleBsATheesltbuolocarknikdsseolafuonftdivaonetsrhseastsyafpmoirpclaelsslayspalsnehgsoe.udt b0e.t5uememnole0s..2 anTdhe1b.5la 4 STScihhnagiuscee(hds.imrpaTlnhegese cc(oo1ne0-et1af2ld S0e3temsFoaataceltsioerrsflafuoforfreiucdnteaisnahgseddfvgseearocevpelrteyysp;oifctahflellsuyeorsrihadoneugteddu0r.bi1encgmvoealeientsf.0u.s0t3onaad 1a tiBvleooedikPieass.sa.eco wVTeinrsee"x5e7ai%snivnaegfstteitrghaet8e0adcaiivdiaitchyfroofnUFthaet1rasccieosrnp.tlaetauRipencgofvoe2r5.y81H,duofrtihnepglavsodmliauf.mfeusiofonthe oicplcyhanfgoerdattheleFalsutors Samples vere received aSSacometprlaies]oufpetffofleuco7tr.i5doeanl,tcohsetphleTeaxtsoearosoufautpfolfuoocro1ilddeolFd-ieffuuposfitooTnh.(1N0mpTe)hlsee,ahabdstehnneoce CpCaoocnlttlaoiefntiontnghes6T7t.ea5mga2l1clhosf S5tlhoevbefodatchechpoelfafsdamicafefsuaosdftoddnie.ftfeursgIienoncntr.esfnsNioattghetsshheaamkapillnekgalctiohnmetpeasyrsstSpmfieenttahaelascockresadlpiopyviendg "SooflutthieonF.iamWmah.e tDheeca Factor of 1.3 vas am CC2oornlecuaecgnihto.rnatitiononc0,h.e103.s0afLmapNcl,reevsraseseaddirnetgqheuiscroealudtceihseonrf.edicfofupseiroanicbuat.lotvheerloovneirc eCoance5n0c.r1aciboencauofsefolfu Demscocric and aiaim samplerseccaolnltairneicnogvernyeitofheraddpeldasmcaoldsocFladoeetiedregevnatstmheeasured. Ta b"looloudtivoans foabt1aiLneedra1 TUCmeeacctoohvveaessryysvaaafssptlear9s5,% hsreetsedpriefctf3iuvsheeiloydn.ifsfvueTsroiaogsnee.dmpl9e3s% acnodnt9a5lTatsfgorpslahseeds canhde pf capaiEslteorcer(ossohdoelreTsEt-s choauald1`T7bheefdoferigxvceoedlea1tatiolfhenoicrcoghaapnoifuclsudoFsrliunoLeirkiedferapbm-ysmoarisgshacishntegcnsvoEacleruiiofecldoucosfrmripodomeu,nldesss + Sltiaoolvnletedoo,.k v1o9Slethmeap:glee 1va1 aFT-olhuyoovdreroraocxey8t0b%aetneftooratnrdlieipsus-oFrlviuodsleta,otpihbleeesaysclyoalnspafonluinuadoesr.idleikaesdS-bFelnsseoreoruitafcltulo,ride 53 SGTahaeir'sepbvHyasrbebuaesccbhvieeideang3.0c2.oaz S ms eHL mepc.h)odsB (8u)seadnR dheictea S qfuoarnR tsietpaaE tciaotnionA (FolfuoTfrliudoerieSldeecta(rdoidlfef)ulsi(oUeDn)aatre H alee BEST COPY 1 EID107115 000103 Sas AR SO a + correa Flarcompounds in Human Poms m 1 mrEorecntSlaoteetseacretiieen,SMdUeoLvEee,,niaYnshg Sroautiefioonn,soIuntodiepesni,ae1d5ev2iis |! sTidieetotrhieelsssi,.nemloebleEndS,EpS)aEmSEi2 ESRn]SUrvsSetitSitgodOikedit1efmdoapSoniwhTeecrira,TafeirFegdtiaisetdofer LeGcoornvetiaeienaihsmpnlaegs SoTtfrhaepRpsn uiamemisenspoPlPlaLuseactaioevnSevraeUse'cae1bsefeurisveeaaddt,foerfSdedeciovfnifidtelhry,e,ndtistapufmenoprtlieoSosdnrs ee i | 1 FEreedDepteheeeieveteey ofo the shoy ealsycoiwcsaosFoefetthfreeldeearvdaiacdseeSmMEbeatenftntnedsdhuebryedd:ow | Reproseibilisy SG Tn vGaorcikesdmIateastTtP-eO0E.1L5 mien ) and 661 82 phusss, ta plasms vas shestzed fron blood babsakda i| ii nianneltpcilyhovinefegsoCetrdia0e%emLm(seh,tBotrSodenSEeFcETLseooLhGlnapcSiapeoSuchceaahtrrihisenecseineh.nsopnubhb1ece2iicbbtslmweephaeitdheesr,vere ii1 IN SP CClopoulitcloeaeno cirtniheovaeneeTteE7se85ael(oeh1hoefe0A}SDpeEri etiocosS glavnttaoC cbindaacoeiAfdczpaablteseerneusndvefixootcnrceocosrhreeests(ttUio0ses)n Hdi 1 l ffvnenhth0 ctoafmo1srb. emeieapninesTiATOLLAEv,stmuehsaecwpdeidoatrdmmomonerssiagocnne.lthyisVBiofvtaicAsttor 1 i:] De iestoscneciccmse 1ondmsost,s,solrALecchoyIniteinasTo1ubsotNeh{lieery:LsltacetrsopeTriscoicwraxce)et A shTaoloipdr.a SsGoalomsdapselele FEultoeL0XDieiKVeLnL10 arnenbtmvaand1c0pewralci.de Scoemreers ETi uurree vvaascbebeeetvedeenn3.012.5a%nd14 GC.ey TThoen `dbnufoferrewdaisac0i.i1l2e%d W(MHoH)2CaOc3sl 4 i 3; CE . i =z EID107116 = 000104 a A a eH ssi rm oon Ce rey enimaSireL ns of wati er ar 6s Toe SCa toeptedi$a0l0ys.e0da ,LpleansmsE E PvaAsEfrReeoze drF iece de. lant) viceCasioaTnhsarnes | eea o a e contviosnhse wceorsete1n5ee6v3a030 B thanoe l; inlet tesperaatureL vaosn-1GT 0autrStleocht2aph0saetlnsCwroahrrnoeds.ToouetfClhheoatetsdstepaopsetrsa- 4 wI E Das fd race tionataeeLdttLnaicncIe orsdeikngeBetopmtbaheodlmde6thseoodntsdseaoesbiceirseipsbTieeddbebsSyirecdrSyoinaeknottso,s PB D PharmTaciaE FineEo CheEmS icalesh,ueIonscT,.Be,r1hN0e./Y1.e s)e.saartFuoseuavreotdeelel Susheenadthwsvieahrceessuhsoerd,: DrdSLSEe ha Tite ian veces and 0) 1000 31 oD f metht anol/vaatteirE,eie1e/s1v.esnheeutsTsshestinertpsbmiaepiteehhoodossoewmasl esmloouvdetinetfssipeoi dn2teafndodrf3uosk etcrhehametrevo pra 3 Ln BB SEE etna to chlovorns Ton acuhlimm E CTm T i Sy e elife use teh esStaArsi , O10e0-30e0greaet 21 Meope i Esreeem ot seeeiasn pT r] ]| solvents before use. The gradient maker (sodel 5858, set 4, p B verage of e 3 aiE /atn e for thEeTfirost mlicyertorfteotelhauigeentw.assobiTlnhveeteisvaistppshlee Be e.2 Feutrices o 15 ak vabine vote 4i 3! hn a+ P BEST COPY AVAILABLI eetcttect 7 owen Huon or ERE Sunaina boo plasma _-- Blafr moe prray atetss _-- ipseheterbons re te a pa .elie pte i "-- bo ==: rss: aa 000105 EF S Ee r aisE SESSfe R AR)E E S a T AL SR ETRE AahC PE a RS R ERNE EE at . ---- =| ) Tavte 1 3 oF FLPIRDORCOECDOUNRREGUNFDOSR TPURRGIFIBCLAOTGIDONFLSA TFrreaaccteidon Irescment FSreamcotvieodn blood plassa stteeptis1:tieedxHhaaatucosestreiv|e ssomlaulblleer,covmaptoenre-nts i i : plaEessomtcaeatpaarcboeocsuensidsn & step 2: DTyiopehnilas ter i1 Tater sotucion Plrasomtaeipnrohcoeuteods sttepe3a0 tweithmaseol plums protedas Tabstasces easke,s 2v5acCo,un20 Slama lipids stoOeTpehan4uasttecocqoorlauupdmny-- Pasticion on rpLeoaaltpabroaiatloyfpsoaLldoavr Concantants | 4 Sephadex f potar ttpits steOpFv5i:accooplruamsy-- lyaelmlo:w frsaecvteiroanls Sidioerpeioendoa i mt ] i J = Fee Ga aoutnoShwe wee :: Rben foebnti,ngS we D x Tr y - a EID107118 z I RE- Ts 000106 I. [---- i Terma Fuge ee - : ne nfSuaingrrtaenddrce1oeiE)riic L i} ShEEs -- 3 AS Tcosriyceea ircteilfia eTsest(eFs auesesreesd<s .$ la TR een ---- 1 ji Sirona. 2 " 03. the ome epic 5 [ne mscms i! aaGpoecnisaamanmdsaarcevroavryitehlasndsHsinisnpec ati to cre, as i eas= ;i rEi ermaeT nn.teBoveicTtshraaoatdter1tea SEE CaaE, $ E eER iI3 el--em--n gst ve and FFiiee32,. fRueetotndeipsTebdvbueiesrsnengBteCheeocsonncatnta)tnoHf airguenc ] aong'iVaealueTrsostioer atrsotrspeams CCFoioruneacaeemintatreraacttoiemoscnsm1itanraPttahiomenaw of sma=r or 3 oBFFylioBSraeipceevcetbiiuaoesnplvoafsimvadlatuast.esb 3 { 3 i Boch cases. the distribo N with only 3 or 4 indivi: 3UoN%f IAA g \ FY lose &: 4 oa Gftptuhrneetw7,ondianddriiovridsue a$l1s00| 1 ment. for organte fluor of Fai\. os A Me, i1 rcereadFtsueseessstviTansegsvlasOsces1es demi om a hee HeN esr e 2 R {I0 aSE n rame: eena oy Fie 3. Sepeaton of ride and aren fur tn 1 i a DS sueiize acitene oe Rna nr ns rhe 3 J Sono expanse thar S osaeoe nsenDene se he Eph E oreE (nco oen13t) i Bo pFroereakmsfadrooitmheederlifncriatcetaiocnds LF A Po BEST COPY AVAILABLE i wp a on EC z Et 33 EIDI07119 8 e-------------------------------------------- TA R raTE E RE R T L aRL lI n Te e aE CE E Re> T rEAe a 1 vem ac. Flarsconpaunds in Hunan Pama i" 1 easmcaeiryeadiladeCmehneeErrSdeentienartiesniinc8aFllatshose, species oe an me specs HL var hcsand on mney Satan TO 1h pix of E GrreoeerraenneatninnatgGoCwLcalhr sdBvOspiectLteDd E0E8EEPFLS aPAilvoecniskioltfstGnornsaedehrhisegeh+nt oonnneitenforprlastmeosscsgraanmteseflfuorriRdmeEe(ISs) aHndiovrhguaeniscreorLvaehsuoetciiEnsleeion p comemracionfn arid ie lam ehe dwiLeeE HIrI mineideonsnatylbietaweesn okcrvuiues wighiechee se Be wBierntohnley3odx emlbsit LAL dinerivces hee rdaegeornganDiocrfireien | taReoasudriattiescistalulhoeTrmaaiontvineeonsSmnvta1IEfoprui2s3eT3 2750CO.T1 l185o,s0e0)0(a%5ncatietoanneenpesksrpcfLaoocaaredgeidpaaoitndorudcmf.ieaorrham2ecs 3| sm caahatenepCe rpLTueArdi)iiea cS acieonnmpreece BMaAbLsS1and10pSrPUdtTLeiccoavttieeordsnedrfTaEiecactToohtrehrsedcifio2gexsresntter J SCfoorlme1em aoTfsEhLeTt xtpeeiineEeedSSoIIDTtTnIetNn.erssaasashonf hcdiodc,ateifnnese1c2omind IiK 3 ps EID107120 000108 AAR SeTERRY, Ce ad SE eg 125 BIOCHEMISTRY IYYOLYING CARBON-TLLORINE 80303 Table 11 DI(FC5FOEN)RCEENNTTHTRABFTLLIOUOOONDRIDOPEFLAFCSLHOUANGCRESINKDT@ERLAET(SIFO")NFSRAOMIDNFIOTVRKEGEALYCRIIWTCIAETFSELRUOHRASIVUNIPENPGLY ) to Plasma',. (RF) to Plasna,a x 3i Ctioveyr.(Fs)os)dn MSepamn)t Base DPiee.e0.3S esSa(s) fange Ppuer.e0.} 3 R AlbanWy,oWY. 0e.m38 0.C1i4a- 1oe2 0iae- : Go) ote, Go na. ji RNocEheLscoer, 00.18s9: 0h.e3?5 L12e 0e.s5 33 Goy Go 3 CToerpu.s9C)hrtscd, 0LO3:5 0.1670an oLsI Ohkes a2 43 Ei MTielhos), 0L@s5: 0.2660- osttes.. o2w3s6 1258 aose.. 4:i4 ndrevGsh, Tex, Gu3st Lbaa Losoa.ns : Goy a0 E -- "Zae ch vaelueeused n th-- e computation vas the-- average of at least 4 A`ChDressorleuptliiocnatbey msnualicyiepeisytansd4vcasbyco1.r3r.ected for dilution by cakenflucoorbiedetsheeasduirfefderefaaceshbeedtweaedn ucnhaeshwemdouaatliqofuotfsaoorfgantthce seme p sample Sby t-tEeisCtcianscseuabtesgbueesqunalRovrahreistsearcesnidn eAmaacrhevgsroup5 seactieally 3; Sgatticase. 4 Terma H acuossn nreo Fraction GbDus,es2p.l5asTmiate batch) Methanol Extracets exerace rentdue Sephades Colum Feaceton 1 Fractions 10 + 1 , racer stltete hetd cote axfor pak otchoemrbpineesdka fepaetrcsen+t2o0f)the CantiSasecren:based oeaatitfattehbeamsaejdor BEST COPY AVAILABL p tain 5 k 5 = 8 :- EIDI07121 g 000109 BN E O ee eena O asa R RE S NIE P T 7. coreran Fluorocompounds in Human Plasma 12 i 1 Tobte TIE 11 EJurss BALANECsE,sRECOVTEiRYPAUNRDIFFIICRAITFILOCNKTSIYOSNTEX i Soacsten pTeywae. Amfe.eBF RecovrTers" Pucrastsie- iL! Ghoas+2p0)l5asTehseer was 2136 i 3 esas mocuo J-- wa fawoe ksoe ux i Ii : 5: residue --- 1S0i5w a61 - i! septases Column Sraceton 1 - RomA ba = I! atts eT L31a9ne m@a3 WE Fraction 19 om es -- i iI . aw a 1 Stitete sets colem major peak 0 0? 36.5. 2,840 X 3 othperepteaiks - 2u0 18.9 - |= 1 Sooeusan2 s02)hha mouse of 17 1a the origtasd plasma sample, TqagartEitnoaatcene ebbaasmseeaddgooronopweaearikegahiwnagdetrhepecaoknstefnrtosm of tvo graph tubes ia the center BE % CRT 33 C Eg = =g EIDI07122 a 000110 . ws 0 i A ---- BHAUTMCAHN PLASMA pi] 3H 300 2z23 wo oHz2 2 hw8zi 15e Ss2s 300 150 BATCH 2 ii 333 33 3Y3 eaten 3 ifi4 3i3 BATCH 4 gi 3! 34i i3 ; 2s BOVINE PLASMA 1020 30 40 % 60 70 80 %0 10 Fire 4. Distp ributiob n ofraneTdfUeBuEidfrpNoOm.ehumainandbine lama n 3 BEST COPY AV/ T. aww a Fliows wuhaiieahg`bhsoeavmiSpnhleaenskTvaetfhroeerrpi5lh ShLaeetcee"cTmceaamkbpiilenegvtaatshetehesataoairryiee 0SaolnntoSragtafntiDecr.enFcleu,ori(nae FwsaroseluentoihBtouinmm.aafnnouHnppdolsaaisymisnastthoesheeesotf "P"alhaolmvymessdistchooeuftldbs0hiaovsseoprceloam| BsattrcihceTtsheucoairtdrsecsrrpioodnumttiiaoongn iTthutemhrseec1loailcucimhonneusppeasiuysaicaodieo.n catodhmseboyirnbvTiaahnnregti.)es.detaheapTlhefersrviseezcneewdieno: BtCaohdmebbifenoseuadr bussaaetmdcphlefeso.vrasoMtho C"iemnlterashpaorrpetpoenakofabteh EiloriTnoeur: 15,0000 s1a7m,p0l0e0 rsucanns VC5earr'eeaa1t1ceodbnosstihsicofneeenstrvusmih,tohve mPTCiooexnnrttturoifrisevotartshoeheodocwstethadoiseontstoheeaian7s S2 epraSheoxwcepcthafrorthethrea VEbCa)oesnwsChimresaarttdeedfnattorhreevedistahhiscfitthhgea.iss; JFhoaaemseistbpileoycnwtairlotgshrotiuahpe.tphar0e1 BLE - ] 000111 PP ST Rs A TLR LeSE Trl ns "a 7 aera Paroompaunds in Honan Pla JRO, 4 T deA etelctaeblE e L initheE L norigianalarbTYoeovtinenaetR tsDseaamopldlryeepbSsuhttirehatesiohcraotiavfasuerrttchFooeaerfsmshacih,:iesc-k :Lo| EseRiSnTaREPhAAlHLSeRaoESSLfLEeeraittveotraiecnshbamgsiincah as0k ey oie ue tutes 4nd ive pain eo fo bats 4 Leones of semis fone ta frccton toon CTE eTI LeinvnehareeFoahteeeaaavneeykvoFkeeephrsenCngtaeinnSsnaroSsfmetvctoopeocsraesssriitizoetestsevaearsiecbdat 1 caomImen heaRpfSeitm remieedovneTsdoCsieothnratirioaniiseoceTboGahlcoolnno5og TmTtetos:vSaeirfeoeshbdPeeoha:aodf by 1 M CEbE oeEeeLwm acapIepoatk bomem asrtpeersTBom Eno FpGeiseoRecoshpievacRtoImciNnhaecniofnRe:mATchhaa I 1 15000ES0Ss s12u5m0p5onraunensiatSrehcneraTadmSaAn3cbht.hosvm1eaipfuaaicrdtseecnmk5aosfaenosfa154wt,1ih4te5hreBsne { 1| SStI mmea e TaaTerEemcToEtmaScMaia sukta eetsshwifiteahsimastaesrtdTsetihneeeecfooemrpet B 11EE rct rhan ryh rOsaTT ek ar nt tLo oSn Fr upWnecioe tomt rcrre,retsek A A h LRidaErEnaAn heRhpra eteSa] teeeLvofinMeeitathts1vshiasitacftsoaeetarbrtisaiakvsaiTFtneitstrnea2r,scoaiceos J I3 mT Sam LAL, functional group. One explanation for the additional pesks in Bij ; ; 8 EID107124 a 000112 1 sr OE SARIS WT Table 1 RESULTS OF WR SPECTROSCOPIC ANALYSIS [a || pes a Fecrettiiumoartee- Susgested i L Deljession sample Mia mssisemente % 7 vs CSFe,laghroupposinatts : "000 Fccraontmmhremd eLeot,erTsa 4J : 18o1s.1o a-8o2...e rie, "or nent bcot3 s#. i | , PM Ee ns ama ama orrpdeta n N ns SF eaton w pointe 1 6.0 ae Cerimnacrye ExtereniaflcersefeonrienccihnegsstaoreCFCcLx,brveasssehuswedichfosrotmhietecsheamtecchablce b wheretoXloisverlikfeilelydto(Lb.ee.,~COh-iTgher frequency). 4 ii fi3i 33: } i ia 4iJ : Ca) ert 3 Fire 5. NAIR spect of eran fuorocompounds) ltd from haan 73 aww Fee oEceeupprrresesaeenanctiinagccGarrrepgnreeo cFhhuacrheaicenteesrvetiaasralteispovpnitesbasrmee, Sepeorhfeiasovraos-oFrocuanndistoscbie -- of hihmeernecinsdnioensgsviuthg SGhaeirrsiiveessduobfjterccotonmcp1oosmumn1edarscsihcs hLrheaeryve1iafrtoelArvytntvehranetekpomrfceodfcmsaaeivnrea PSTrrreaett"autcecTihofenluoiofrsiianixeneesdeaepe tLiehnetFhsveeerrbiilidoeaordsFioiftnhdiesarpgifnos piroba"bmeleyv'iprrqoeumviateienetnnacileghooafo hTheereparnedva4le1n1ce35of{ntahne apFtoiertgrouirkzoeenvdotgwhwhearassett,aucpeoLco.uelc.elh,despefets CCoomnpcoePunenatdkvseaso(tshaveecrc.osuacnbhtiaaend CFeohrnrorobemaiabnileoygrooittmhsevroslhfaootrvimelee5 LTtihhnaietsa"stthuhisespye. vaopTuphleedayrbacinodre Chhiiacntadt'ssoeenelpusaetnehtpe. fcoiAnvtceacioanr Certain bile actor ia lSaanttTsieeiaandctoytrpoosuinnei.aG BEST of AVAILABLE i 3 Pa 3 ~~ > 4 : .- 2 ay ,g EID107125 su zg= a 000113 a EA YRTa TL RO Poa et 0 A E SAS y FN ETE STPDOeRE EA AS TESRE i 7. cwrrrar Fluorocompounds in Human Plasma 1 1 CEeEEpreroee stenritnie negg CCaFFT.vEgrpeeoewusaptadsltyaosceftdbrhreoamfbnocrrthahneopcrbhgeralnaptiaosccs,ahtfsppl.uokotraisCn,et4hfneodl<lCpoTevysikog1 i E Bree foTundtneteot,beeid2T11sh2eCfdhi3eex5gce0tkdesf3XosrcGconeoodvnr)hts.iaecnahtzcfaltufiolorunio;nreindoefraoddmudriicatgonsl Discussion nese findings suggest that there fs vitdsespFrlessodrcsocnotmepmotuatastion e SE E LEETe e I miaseazviosriane2ssvcr ictuhsatnutthteisscfoontseTihrsuptorreianncteiawto1iiacotenhha.utncshiAeooenplfsaoosmmda e LIese Tveieesep lce mwhneeetId ceotfrofoemimdmbarusriucnpciesserl)laaynL d3foTtrehaetchhTeeoris.rmue lOpaotttheienrotnsuusoreSfifsaFcr ltrionactneltutvdaeipsretonshpeer.Ls E ee e mreaertFeeuiFnTrohoabstetlaotortadedhleaortreedhvieiarsecotthLhetiahttpetulbtcelhoieoncrccevonnanotcereeaorntrcigrosaanuntpilopcfolynf,Lioavfseoorrdgiaane= epehontoyveiecooeeniestieoatnutBnaaielnainaossfoslutsroacrceogestahn1eis0rcu4cthfohflaaun8ocrhhietunhmee1ss0ae61.ap(bl)usaassrne spalalamlrpslisensqLkeuCeaeenspctiiencdgses. E BTe eRae eMaeonottoet.h.ethepheerprafariistutieonirgcreulmsaaftrtautedtcryyoimaaplcaivfdoohdras(dcCfaomacCeohosl)eabutaredcadecnrhiisevasadthicovheasr,6ac1s || eOe EeAne 0SToetsndotneedfrtehfniorrbde1boafvetshtshee2f5orraaicngtdiinoan3ls0 oicnrodgntiaavniiindciunafgll,sotrhsieansdse paouenndesonC(esereevsfaaotbrhlmtaesnaTothfIeFDio.sgrauperueacih&carfsalucsacotsresoaictzoiemndpgoubcynhdasmt.axbussTpthpaeeysptalraisenmathe 3 a T LeeH. ovuereiosdtyyabteiSiionsdreFeecrsoteapcepotonicidonsdbIssynttLswihookeleusbsofimdriaeiltotyhuytrsiecetsaoilinvncseeertcyhhieotpdofsilosauurrdstoelhudibppii1uf2drusil i 1?cTaeemitcioeccneatcaaitcenadlivusneedgrndytitiopcooohlnnaterattooafsuacttoohsuosproitsukseofdfaacgetaL,hsiegkltemiheeoutrrhesiosedd,ceosuopsdhseeadsmday1dlaa- H 331 Sa e rTreonutsdss. (LTDo.e aCsoempofnreancttsioonfcotnhtaasiensotvhaerterpesaokslubalsee ' {im N JC Sn : SG ha SRE 8 : EIDI07126 Z Co ae 000114 ca i sors mst ss : 2a Eess e polar TthIanaBtheeTSchompeosuonedksTi1ce nacitohnee spreeedrosrt"anpatanrtpeSeoankresesiconeos seca dnectsviSalheiicaviuceeslta aacTiaSldrmpiefenrniaeccttIiFssohanoesoocframiaohysseeuapLlneosrroiceRTshxcseieoosvTrnteirneBssdioeJnsscTeooesoIrnhelneyneeaI ebFioasusteihEoamlsf. <] 3 ener eye lr Reig r thEesaeeeeh cortmeppoaoecuaenrddHsoehibsoeeicomosaevstoeeorktReofdcyooptkooergskip inosoermtgaironotisy ecceesfinlfukoakrceoitodidemkdeil vuereeninbog]keA arsehiictgs }: HroE ye ecnoceh Smenhe eTteretceeeCvu R oenhelnE nlom sJp2ae1fpiages 5 i LconsnAerieE TeSbesaE e published aboutttheeHmeicabtotsec basting end 3 EEenraeiiorpeepdenrs tIoattofhreacwtihosnipeornestihoemsceommmeurbLieecchtvsiessekoSoffep2ErmoasiConseiceorieein EE E TR h paotis hdye| ] B cseentcraeoteinonesoE nsteinneeinrltariatioSofctnfyhrooesepeipnifoiottueendhshoaeirscetnflfu:orgotrthoomorogbeaomnsteocnpfllofauosoormrirsinnnoeee.,sy De }; TrhreeierrhabraceoinetteerbryaerSiiaohnhinopfetrheycehnnlotarr nidieShonheAls0A.DR i0msongeeheoaaaeette]erFrems 3|]3 VoDrotueknEkne eTecahoetyori2etsaaeadaTbafee1r b9eT89ernoeetbheeseseep rmviAasrnesFheapnsercyeinnSmseaetcSorSomasptseepssnat,e : 3: L rECiaT bmaS hE aries SNach E py eobed fFronat tmaeee Mek a Hires Fy thr owt, 3! 1ae .35EWi.e ThMerieftotreer,tatsphebrseinmaoacyieohnavaseleobnepeaenbnao as dSBeachrreeadscmehfioirnnenitche,es 1r0y ] i 4 BEST COPY AVAILAS E _-- =. % wos Hom Sthe alSneapleynceticealFhemoestthoosds" hi h LumanTa bloode t etxcepe tevhe: Cheegni crheerr m,d & epE laeseaefmlueorap indetrsdeatteeorss panelbtnriieTeiietpTeoeeoSaol:aets Fa toroe rneetaeraaanta bToethtepooennsmaaemiesserhdpeaoennne p conceReu mteatr imat eaes Toh nScene Lth n P 231h TfTooave vveee,!s DDBIt Ea utMe aacewueeses & trBtehieieahri2bt.,nni,vvoerrtieviieiercye:"e 7"SaTsteir,oonenr k11. 4h3ndd ou Arne 1%0. sTTaivnreinst,te,r2e,d,!aTdulahe BEeIn igi,vTirsoe 15 1, tSiStDsIaFyrdeas,e 5 Hmm h ais 4 - i - i Bd EID107127 a 000115 Ee na 7. cr eran Florcompounds in Human Plasma 1 3 SthteeeadnOaclghyietasiiecealvfalslueoocerhsiondecso1svoarctydh.ieffperreednocmeisnanftn the sazple populations form of fluorine fn i= . ThCuaasbkalaienbTgih)o:ovdatTeehrxicse1ptthosighgehotrhee(rtatvhiwethihCcohntcheecnasfteirnadFcilinuogonrirofdepeofrlptureoedrdiomdhieenraefcaetsh,atsee 3 | "SThhsyearnediace5afr7ll0uioesrrpipeascceauanttdesirneol(ra8)gtaiSnooincshriefpllaubtoeirtoinvdseeheinipntvhpaleesacsofensocuhenendltprbasettiveoexntpsalaoifn i :3 DPCihlnauttmesunhcefsolfumoerttihhedoedpdsusbtslepirecmcviiasfseidcesffsonurpspailhnyeo.drgasTnihimecpledfsalcu4ao2rdifdaetchaesbtlfeelaupoIprTliidseehso,w ]{ 33 3 SCCehlheeoampauvbrrleailtcaetsvi.aocnesrhThiupssu,bpeptltvyheess(aebe4Fcalvueo2s0arid0see.e1diaanhp0lap3s.om6satpurl4a0a)dtecflatsnhoebreiedxeisftaence { 2z cfoflounocwraecinhdteraitagisoornsosuugsgfeosrhtoessdsaodesiatvreicldiuiscelrsco(nL8)ti.rvoilnAgsveeicrnhaagtnehiespelssaisesfaocifclpyuloarsamisadereported i| eDLeoritechroaentftleeaicudtibcortnheea Bpbiainslesaricavele oesvtearblpiesrhieoddsbeofiveyeeancsf.luorTihdeeseinfibnldoiongds hoseOSCASic Control sechanism fa do | o"vneirchTrbheoelnaevtaiSlvueielnsyesps]rheosdesetmneptreedpsevhrieisrogedssfoo4rfa bttlihoneoad.avfelruaogreidienocrogmasneinccrfaltuioornide Rcaovnicnegntraabotuiton1ofpppe lfalsuifdrsominindtihveidvuastlesr sLuipvpilnyg asre8ccoonmsmisutneintty Vita Eecent tinbings of others using siatlar sethods (1b, 19. I Saves, Dik. ature (1966), 211, 192. I 2. Taves, D.R., Nature (1968), 217, 1050. 523.. PGTTuarovyeve,vesa,,l0e.nDD5cI..eRR..,,)"FFlNuTuaraotilrufaorincectcesar(pi(1o1o9u69na86d)8as,9n',d2o10Cf50h,,aHra5a1a80cn20t.5e,Frliassaatsi:onA,naldyoscttso,ral 67.. TSTiihvneegsseirs,,,DLU..%n.i,vbeodJr.edADtrmyesctoarflonRgRo,acsh,We.sD(t.1e,9r7n1)Ra,olc.5h0e,sCthee7rn8,.3.N(.1E9.5,9),193712,. 105. 5 SSinnrger, L. snd Armatrons, W.D., J. Appl. Fiyadol. (1360), 13, 4 9. aves, D.R., Talanta (1969), 13, 965. 34:) 110. iFSzri,asnkcoo,tnosn.M,.S.ARa.ndeRnodssR,ousJers.,, JGu.yW.,J. Smcieern.ceO1(119C6h6e),m.15S4o,c. 15(5139.63) 3] 12. ACBcrhayedcmee,miiscUtGrP.iry,ea"ss"T,IinvHdo.urXsi.t,creia1Cl9h64ea.nntdatUreyd"l,ieaVroli.an,AsJpeNc.tsSiosfcnF,lueordiene 13. Haaslsey),L37e3s; Rdaoisd,. 1.5. 494 Satch, G.E., J. Aner. Chem. Soc. Il H 4a 125] SSingeer, L. aad Arremasttrroonngg,. W..DD..,, MArocchh.enO.raNledB.o.(1(917936)9,)',31,8,1431653.. |{ 3 | pl a AE g EID107128 2 . 000116 nf E-- 14 [---- AQSeTveItvowfeanuodlerdrganc1ie6creyaofiulnulotyrriinbeeed witinocthecroearpsrete:ilnagtetwoihtahvien fadividuals the this aforaacion SbHouottuhteurnssfo'prurtheuanhiacathdelayi2g0hvtereScctaeeinvnaeodtlsiupeplLtiyoriiccnoena-dctonbtthoiiinsnsiotsitmems.nesstAohnefreixtcpsedofiat- 2 iCcnhudeiislvsdibdbiulcaohlo.sd vplTiacsneUgso.ulida ailssoloatbeedofregsinocnesreahtavetoorkfneoawivehefcihuaorriae fa : SiAcorheDoit,d?yo1uatdaa.y the sample analyzed by ar contatned sechyl :' aQ.t_ teM"eckTylhaelmcoholecvtiruln'rSelsyc,t vSehreyrrearpi,dlJyevpietahsnftluohrattoatofed il APpruecsiecfnihccieantoiofolnmevstayhssycelaal.ssoateuTrsheedderr1aiavasttphieevceiLsrausstof itpshercereotnisisietrseitpsneanttoefvsittFhhaecetyhe i1 Zelda" (Cece) aad his branched isomer. 5 @ fi y i - i+i i3f _ : BEST Copy AVAILABLE #3 .: EImnutrlasvieonnosusinIntfhuesRi0 ohn CLod CoEAROcHLLYOoNFcpoAFriaE)a,NnMlRk IDens`aBEyp SROaBVERTrMoORE Mare7% Pioco: Bni tIRD Incroduction anraentetiIsenicaseluzrevsbtilvoeotddn btcehhgeeabnproesss4 FopanAnSytE)h.eSysumSbpijonecscetti.cmhCaBD)avtsiiaemdves's+ SpSiucgbrnleiiestnhieecdda.nf:orqAutafhniatscietpsiucruepa,obsee bmIeyicaabuysLeta,htehaescmtbeooruduypc,elreLfsaoscrgmpeihlnyga aScnohdtatbcoormnopltyloentcehdo4aseoutrhceoitnretsasttitnargt DfpieevwretrlGuaaoitnro+diencraeclshisenoafbu(ltPeuFDr.)esteinm uCVaiAtnyciSitnaiceteshaevaenmndoouuseseanua1esb.evpeAraeyr cuClhlaasdye,blc`oeaopndodroaccehdearGaborneo-anhsootmnhs,es osffuarkt4eheprrhoettosecnsotlsmoffnaokre1yi3,tsmopTnhokines aPaDa: eTao"loerr idcoahtneas.,1t9ammcdolnukd4aerwdies,bha.x| =b1eaetnSoaabseiedLcatiteedreptroac{eldlus1cara1r 000117