AR226-3061 Study mio TOP Biocfflnpatibility Testing of S-22072.

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StudyTitle AnalyticLaalboratorRyeporton PresencaendConcentratioofn Potassium Perfluorooctanesulfonatien Serum and Liver of Sprague-Dawley' Rats Exposed to PFOS viaGavage REPORT AMENDMENT NO.

CORNINGHazleton MUTAGENICITY TEST ON T-6295 INAN IN VIVO MOUSE NHCRONUCLEUS 11 7?

Argus PK Outline 5/03/2000 One Generation -R-eproductioSntudy of PFOS in Itats Pharmacoldnetic Analy Study Outline Study Objectives:This studywillserveasa follow-upstudyto Combined Oral(gavagg) EtrlW.

3M MEDICAL DEPARTMEENT, CORPORATE TOXICOLOGY ProtocolforStudy No.

CORNINGHazleton MUTAGENICITY TEST ON T-6564 MEASURING CHROMOSOMAL ABERRATIONS IN CHINESE HAMSTER OVARY (CHO) CELLS: WITH A CONFIRMATORY ASSAY WITH MULTIPLE HARVESTS FINAL REPORT AUTHOR HemalathaMurli,Ph.D.

Qualityassu Exposure A QualiAtsysuranPcreojePcltan Abld-CiSttyudSyamplinTgaskM 00666) ReWsioNno.: EffectDiavteeM:ay 14,1999 Pageiofiv QualitAyssurancPerojecPtlan for EmpiricalHuman Exposure Assessment Multi-CityStudy SamplingTask To (Confidendal) May 14,1999 Prepared by Battelle 397 Washington Street Duxbury,NU 02332 (781)934-0571 APPROVALS -D6n-dd Gunder Date SamplingTask Leader Ros.qnn Buhl Date BattellSeampHng Task QA Officer Mfir6iaNishiorca Date BattellPerojectManager Date BattellPerogramQA Office/ Date QualitAyssurancPerojecPtlan Muln-CitSytudySamplinTgask(NIO0666) Joseph Fficsel Marcia Mishioka Suan Abbgy Donald Gunster Rosanna Buhl Wayne TndU ScottMacomber ChrisGapon Kellyhizarry Robert Mandeville RichardRestucci Kim Andrews DistributLiiosnt RevisioNno.

CORNINGHazleton MUTAGENICITY TEST ON T-6342 MEASURING CHROMOSOMAL ABERRATIONS IN CHINESE HAMSTER OVARY (CHO) CELLS: WITH A CONFIRMATORY ASSAY WITH MULTIPLE HARVESTS FINAL REPORT AUTHO Hemalatha Murli,Ph.D.

BIODEGRADATION (BOD/COD) TEST SUBSTANCE Identity:Mixturecontainingperfluorooctanesulfonwahtiech may alsobe referredto as PFOS, FC-95, or as a component of FC-201 F. (1-Octanesulfoniaccid,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-p,otassiumsaltC,AS # 2795-39-3) Remarks: The 3M productionlotnumber was notnoted.

BIODEGRADATION (OECD 301E) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonawthei,ch may alsobe referretdoas PFOS, FC-95,oras a component ofFC-203. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ACUTE TOXICITY TO AQUATIC INVERTEBRATES (EASTERN OYSTER) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may also be referredtoas PFOS, FC-95, or as a component of FC-203. (1Octanesulfoniaccid)(CAS # 2795-39-3).

MICROBICS MICROTOX@ TOXICITY TEST TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredto as PFOS, FC-95, or as a component of FC-787 or FC787X. (1-Octanesulfoniaccid)(CAS # 2795-39-3).