SPiBn :veNmoRTeOchX i REPORT EVALUATION OF THE MUTAGENIC ACTIVITY oF Tsar IN AN IH VITRO MAMMALIAN CELL GENE MUTATION TEST WITH L5178Y HOUSE LYMPHOMA CELLS (WITH INDEPENDENT REPEAT) NNOOTTOOXX SPurbosjteacntce11356512617 - page 1 of 22 - Ee T te S5r >1 I HH Ti CETIA CEIVED I-Ie eh oe TOXICGLOGY - .0. 80xT3o4l760,7532043HDa1mLb9"a+k75eH5newseFetoegurreibrnegoh3.aTyhesNetherands 004523 : or T-537M,37 REPORT EVALUATION OF THE MUTAGENIC ACTIVITY OF T-5874 IN AN IN VITRO MAMMALIAN CELL GENE MUTATION TST WITH L5178Y MOUSE LYMPHOMA CELLS (WITH INDEPENDENT REPEAT) NNOOTTOOXX SPurbosjteacntce11358912817 - page 1 of 22 - RECEIVED Nov -9 1594 004524 21 TOAICULOGY T5874 NOTOX Project 115921 2 S--T_AT--EMENT OF GLP COMPLIANCE NOTOX B.V.., *s-Hertogenbosch, The Netherlands BTohsetstruedcyentdeesdcirtiiboend oifn: this report was conducted in compliance with the i The OECD Principles of Good Laboratory Practice which are essentially in conformity with: RTehgeulUantiitoendsSPtaarttes58F.ood and Drug Administration.

ARNG 0309 2-[N-ethyl-N-perfruoloalkyl(C=1~ 8)sulfonylanino]ethylacrylate Gstudy number 2862) T-t6322.5 Sample pl Tx nclegend; fest BML, Ine, [wom] EGEIVE] 05259 QUALITY ASSURANCE CERTIFICATE TitleofSy :eMtahytlaagcyniiatlyitnebsatcitnegroifal2rNe-eeste attpeirroaslsoaayslgiC1) ulfomylamin] StudyNumber: 2 8 6 2 Thisstudywasconductedtncompliawnicteh * StandardstobeObservedbyMutageniTcesittinyg Institutions *(Notification No.76, Ministry of Labour, Japan, September1, 1968)and * GLPStandards aNpEpralviSeidonteohIendBAuasgtsereicaIylndCNshoet.mri2ic9saBolasfrTMteh(eNPohtMaiirfsmiactcarteyiuotonifNcoal.eA3rf9aftoifotnhBseePsTlsra,andiMeniagnnaidsntIdrnCydoouofsrHtdreiyanlaatthpiaoenn,Bd1u5wree1la5fx6,r9e,& hcaertthetrheaptorttheedmreetsuhlotsdrseaflectptohceertooedsasteadaccutrhateetleys,taredescribedrei inthe alreport, and Thechcumstancesofauditsexd tpectionsares follows.

TM TL 5; " CR EL {Te " Handling 1 [1] '* FLUOROPOLYMER RESINS |" RIC RTT ---------------------------------------------- d`Ceotnasiullstotfhperfooplelrowhianngdilnifnogramnatdiuosneoinffifrleueomreorpgoelnycmieerss ainndthoitshGeuriedem.ergQeunecsiteiso.nsBaebsouurteptroorpeevrieuwstehoef fluoropolymer resins should be directed to the resin supplier.

i AR2R6 ~ 1234 RECEIVED

v AR 286 -- 126] Ce: R.C.

`-AG Fluoropolymers ARG _ 18469 Me 265578 April 14,2003 aR 936 EE ) B2a6yoannse 2Si2ted Se wwwluoropolymecrosm COMPANY SANITIZED.

AR&8G - 1286 March 31,2003 To: UM.aSr.yEFn.viDroomnimneinatkal Protection Agency EPA East (Mail Code 7405M) W1a2s0h0iPnegntnosny,lvDaCnia20A4v6e0nue, NW.

AR ARG -- HHT H 4 FRANK A.

AR ARG. 46!

OCTANOLMATER PARTITION COEFFICIENT TEST SUBSTANCE Identity: Nre2f-e(rNr-emdettohyalspeNr-flMueoFrOooScEtAa,nesourlMfeonFaOmSidEoA).

ARL26-0MIB ZE.

Submitted to: BIOSEARCH.

.

AR R26 -- 0667 PFOA Acute Toxicity - 3 000847 EP HAEZE RLEETE ON 5Karen Armstrong Toxicology Services Building 220-2-02 St.

AR226 -0715 ACUTE TOXICITY TO FISH (RAINBOW TROUT) IEST~S ~ UBSTANCE Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-203. (1Octanesulfonic acid) (CAS # 2795-39-3).