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AR226-1308-1
F261 T340 P01 FER 11 093 030m
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EIDS84220
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emymeplloogyeeneouastInWlaAespuhrkiielnmgita1o9nv89a,Wsordaknisa.agdnodsiWeetdicoaninanlaacsasSuslme-eyoetafhraatcouldttheemaleexpseacltaerdy
:
snhuozrbtertoifselpeeurkieonida(cJaagneusardyid19n8o3t-Apirniclrea19s8e9)m.easurably in this
. cases vithosbtsaenrdvaerddiazneddesitnicimdaetnecdeexrpaetcitoesdfnourmb1e9r5s6-Aopfrillesk1e9m8i9a are as follovs:
. Ll euke9 niaMIanl% ceisd,ep nceap tWar sshei sinWol grtkso:n
observed [Expected Ratio
sWaalgaery
a
i2.s7
22.02
Total
s
"2
2.14
ss(ttavot-itsatiilceadl)ly significant at the 10% level
Tgersotu)p. 10 ehvaevisctsainodaalrldyizceidgniinrciiodmetnceATrtahteio10o%f l2e.1velfor(ttwhee-staoitiaeld
pcoonwterrolofsttWhuiidsythsittsuhbedeyidvniigalglnionBsietiisaltioenfdi.ttehdi,sAltadhduodauittgeihottnhhieel
csatsaet,istaiccaalse small number
of
aleswsxoecniiaatiocnassesv,iths wmoorrek atrheoarouagnhd cihnevaelsctailgateixopnosuirnecse poisssinie
warranted.
april 1989
y
H
I0s84221
.
i.
.
swoary
the WashingAtnoninWvoersktisgsatiitoeniinntPoarktehreeooncccsu,rreWnVcevaso.fbelgeeuskeinitsera.t fearmpsloiybeees ea xproccRodgcoT ncernH svar recent dlayiees of his
tshteaticsotripcoarRlaoltuyetMiseindgeincisafulircvaDeniitvlilsaeinxoccneeshsbayditnhcneiedteEnprcieedveemsofiioeldloegusykyeSmeiactiaomnongof
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Wlnayosmphshitanatgtiticoe.ntainWcdoarlkhleeymacaticogtpnioivifeeicteaimncpeltoieysweseeuseesfsrmmaoelmritg1an9la5in6lc-yi8e1s.f.roTnwhhietchrhee vFTarasociuaoldsoerro
.
Taukenis; aug eclive eaployess and pensioners' fron 1957-s4
Analyls of cases or deaths occurring after 1583 or
1e9m8p4i,oyoressCpeocntcievrenlyv,ashaTadisnaodt. yeTthibseenstuadcycomepsltiismhateedsacthethemustsiemre
Scoofmmpcaanrseemss tohfI isleutokn emtihae aecxmtpuescTltendumabtetrhediasgintoesetdh.rougihn 1a9d8d8itiaonnd,
-
Weassthiinnagtetdon4E.Wi2ogrhkCtsascaaensmepslexopyoefecetsleeduf.kreommTiah1i9s5o6o-ci8su8r,ArOeCLdomaapmeoGrLneagcdmiaswtliitechala:n
significant excess. However, four cases vers diagnosed since
V`Zteehrpesrelsaoasfnttasscuutarenvenuionlnul-salunyacmleplhypoechryiiigoihdci(nlic.eieu.dkeendacuiers.ing1vo1ef984oc-hf8r8ot)ma,iscw+hiscmhes
myelogenous leukemia, and 1 of acute, unspecified, leukesia.
Seven of the leukenia cases vere deceased by 1388;
no additional cases due to the Epideniology Section's
this cause ors, identified thrangh Mortality Registry. The number of
Vdeaatnhsotdureeatsosktahbelygraoiuffperoafntlyfmrpohnatiaxcpeacntdedh:ematopoietic cancers
- any co Preliminary review of work histories did not reveal
mmonality of exposure. It is recorsended thats Enersigh review of the work areas and potential chemical exposures,
additional cases. *
particularly to benzene and hydrocarbons, be initiated, and `that the site be monitored closely for the occurrence of
)
eroseazzz
. |--
. rane rn rei ne
A INVESTIGATION Timo mE occrmENcE
--L OFEUK ATWE ASHIM NGTOI N WORA KS
[BACKGROUND
CoRATEion tabng thats covorkars tehzeplWoayseheisngAetnxopnriensWvsoereskdtsicgsoainttcieeornniniontvPoearrtkehrreescbeouncrtcgu,r@riWeaVngcnweoasesosfbeolgfeuuntkheimasifaterat
Stage of discasa: Tia types of levers Serceciy SIS 14
rouping o`fThReal-diiggigainsceisesntoitfythoef BlLeouGkeenmfioarecioemyprsiseesssa. diLvierrerssee
firme types of leukemia vary according to ceil type and
four histopathological categories (Linet, 1088):
1)) AE S5c7um3t0ae, Le AynmnpRhEonSccTyitSeiricsaeLneeukInenmniian0c=hiThahtniessv`tipytpeheo1off,leluuekunekomeimotheaiaminmisoggmneeosre
2) @
ChronicJrighoestis Leukemia extremely rare befors age 40,
- This type of and increases
leukemia is in incidence
vith age, especially aftar age 50.
ith She thereatters (3) AT accuuttee mNRe ooynno-olyytmipv sh,ocysreiuste sLeauMkyrset lmoiuyla=lec,sThisaooetcsataegoirray inniethe
forms. Fifty percent of adult Incidence is lov before age 30,
leukemias are of this SE but increases progressively
.
(
4)
JTCoehuurkkoEEeennaiilcssGirBertsRnananyiuHliBsogecytrFaietcpaonrr(aiede
to ae relocytic) Ele
chronic sonryetitetisd Leukamia - This type of thy Sliaee agud ac58+
EAITou and fone of these chemicals bay blso be Soriearoeint . bsyecudliafrfepraitnTthgeerdsneesm,odgirasastpihvnieclctlt(yaapsgea,vsarsoefyxi,n1gsrnhakycepemoitaahnsedsaeirtzeohehndiacaritaticyst)ieorgaiinzsdssd
(Linet, 1985). associated with
Exposure to radiation has been known to be leukemia, except for the chronic lymphocytic
type. Various chemicals have been shown to ba toxic tebone
Benzene has shown strong evidence of crising leukents, mostly
sotfudtihees.acuOtregannoincslhyymdprhoocoayrtbioontsyphea,ve isn hsouwvnessaolmeoecvciudpearnicoenaolf
cLoavuoscitnegdlTeou'keamaivae.'seuVkaerimcougsentthceproabpaenuctiiscl,adennctisubhianvge hBeisenyleting
aaagpsepsneotacsriauttsoieopdnlahiyanscabaerneocnleerdecimhnoetnmhostethreaerttaeipdoyli.ongyIanovffpeecrtliiemououknascmeialgg:eantnTshtiasslso
.
--
ToT
EID584223
.
-
studies, and has been supported by studies of in utero exposure
and through documentation of clusters in humans.
Previonsleukemia InoidengoamdMeweality a8 UadiiusbwnWeida
the CorporaRtoeutMiendeicsaulrvDeiivlilsainocnediAdrndotEFpeivdaesmliolnoygyrSeemcatrikoanbleof
oeenxfpclelosyyssepehisantciifcdreonmacned19h5o6ef-m8al3te,oupkoenimoeirtaaincaymtoiensxgscWeuasesshmaimlnoigrgttnaoalnnictWiyoerskf,srowmahctithcievhegroup
include leukemia, among active toployecs and pensioners from
:
a1n95d7-m8o4r,talasi.tcyomfpiagriezdestoareheshorvesntbeolfow: the Corporation. Incidence
=
* BLeeuukkeeanliee Incidence at Washington Works
observed | Expected Ratio
sWaalgaery
22
22.1
01.29
Total
`
3.3
1.2
-- Lymphatic/HematopoMieatliecsN,olrotSa7lointey at Washingtdn Works
observed Expected Ratio
wage
`
"8
os
Salary
A
aa
3
Total
s
7.9
1.0
SR TUDA Y TION ANA DDELSIE GN
.
1984, respeAcntailvyesliys, ohfacdaRsoets oyertdbeeaetnhsaSceccoxuprliinsghedafatterth1e983timoer
employee concern vas raised." This study estimates the number
-
nCfomcpaasreess tofhisletuokemtihae eacxtpueacltedmuamtb.erthadiaogintoesetdh.reugh 1908 aul
identifiedCafsreosm tofhelEepuikdeemmiiaoldoigaygnSoescetdioanft'esrCa1n9c83ervReergeistry and
cSaagtteaegogarotirzeiddaiagnboysihsi.ssttooppsathoo)loogsical type,yyeear oofdiagnAloagsmeictsand
The expected nusber of Cases, based on the Du Pont
\
fQoorrpt8ohr3ea.tap-ewriidoed w1a9p8w4s-i8w8ncaen,d waadsdedesttoimtahteeaextporecWtaesdhinnugmtboenr Wfoorrks
:
7
EIDS84224
esa
ra ors ros
BEACH FT calculatingIxtpheectaidncnruesabseersperofyelaerukeianiathecaesxepsecwteerde
estimated
nusberof
by
cases for Washington 1956-77 and 1956-83,
WaonrdkaspbpleytiwnegenthtihsesuchravnegielltaonctheepeSr-iyoedasr
IdentifofiLc eukaemtiaiCaosn es
RELL loukenia
From cases
the records of the pusEotedanon
Du Pont aetive
Cancer Registry, employees at the
four
Cn SHEe rip moerEpoorTteETa ErLollI )E eTar he$N 5 fetemB eDhemEtEierres HtEa2n records,howte hisv cae ser vas, def
tobe a lymphoma
vere
Thus available
Aforleannkaelnyisaisc.asesDes(c6riwpatgei,ve 3 isnafloarrmya)ticfsivomn 1`9t8he-swey
-
eight casas ix in the Appendix.
RESULTS
.-
DistrbyiYb earuoftDii ago nosn is
Year of histopathological
diagnosis type:
is
distributed
as
follows
by
Acute
~Shrenic
Lymphocytic Leukenia
1976
-- Non-Lyaphooytic a 196, 1978, 1977, 1386
: .
SeeA me ig Eh en =LL identifiedFsoiunrcceatshees l(a5s0t3 osfurtvheeiltloatnacle cpaesreiosder(iie.se). dhuarvienbgeen
1984-88). Among an au. population of 80,
Distribution of the histopathological category is
leukemia cacos as follows:
by
.
oo
.
LeLuykspehaoicaytic TNeounx-eLayimaphooytic
Unspecified Total
--dqute
1 (22.5%)
4050.08) ios (12.0%)
chronic. _Tota
1 (2sy
2 (25.08)
0 3 (25.08)
6 (75.08) 1gasy 8
.
1eakeing,ntas, TLcE5YombiPSetrecntenvtitohf Cthoemeccaaysepsopaurleataciuotne,finndoinn-glsy.mphocytic
n3nodn-l1y0mapzhoOaofcyutttiechellee4uukkreeemmciieaan,tolfy1 Uvdnaissapgecnchoirsfoeindeidccamctyoysep,el.og2enwoeurse Jaecwurteemia
Distrbiy AbgeuattDiiagnoosnis
agnosis Disisatsrifboultlioowns:of tha leukesia cases by age at
LLeyuakpehnoicaytic ZNeounk<eLaytmsphooytic Unspecified
--Awmute
" 3(6m,ean43,= 44i4l,s)57
5
_chrenig (m3e8a, =a'140)
uS2an9rcoonm4im0coninsoinTun-hnieacyghmecapsarnsaoe2cc5ty-oet6fr0ii.casctluietScueiknfceloemryimattphshheio.iscnyictcnriecelcialdselentescyupekveei,nGtifhawhaidacgciuehatregniemo.nsded at : ygoiusntgribbuuttiwointhoifntnhoersmsaltyrpaensgea.t Washington Works may betshieightly | mEyreilhogeepnaocuiAstgeecsasnaooanf-nltdyhme5p3h4orcfyeotcriecnthteclaysacedusit,aeg,n4o4sunefsdoprecctaihsfeeisecdvherproaensiec4.2 and 44
LndateofIsuxenisIncidence
TlaetuikcesntafordOib1as9g5an6ro-vs8ee8dd aaarnmedonSeghsetwikmaemStpeliodyseee.sxapancdtesdtannduamrbdeirzsedof{cnaesiegsonocfy
.
TTT
TT q
E1Dses2z26
.
i.
.
Leukemia ITnhcaidleensc;ela9t5WgagshgiTrgotonn MOWorks
Shserved Dmactes Ratlo
sage
sag
2.2
Salary
2
As
2.3
Total
8
4.2
1.9
.
+
z1(ot%rvovToaetnacihle:dTBeetaaftsseittes)ect.aidEcanerd)i1is:zie9gdnfidofnrictciaghenencceteootatrlaBtthiegyorsoTuofpporaJlpIperuTokaecnht:aboetf3.i2s
Observed and estinated expected nuabers of deatha dus
SBtonoo13wonhbeeariaostwi:oc/nhenaTtopeoletAic maAligTnaSnnie1s,. taamonngg gemuepllooyyoonoesaanndd
-
Lymphatic/Hematopoietic Cancer Mortality
--_--
Males.2957-88
at
Washington
Works
wTaogteal obs1e.rved D06ae..c33ted m11a23ss Salary
"4
4.0
pH
Sevesi of the 12 deaths in this category vere dus to lenkenia (5 wage, 2
incidence analyses.
ealary). All 7 ware cases No additional casesSA0ng
duluded in the JStive exploysas
or ponoionors vars identified Lisuugh the Nos lity Registry.
FatatWeaashdinogrtAosWnessutnRoVTiErng,ianniaanavie(rmsaaciTonoafT]eG21ak5ma0enemarlfeossoecamitptaleRojryoeesreessBrooer
year
hice
males as follows,
119965007-6595:: 971.07//210000,,000000 (Average = 3.4/100,000)
1970-79: 8.4/100,000
Foor, Tor the tiaa'veriod 1/1/1087 Lo 13/00/1088 (03 parce), ) 0.181 deaths from leukemia would be expected at tha site
we wouldhi from leukemia
fro5.m8 19l5e7u-k8e8miiasdenaotthss.tatiSsetviecnaldleyasthisgnoibfsiercvaendt'ly
different from the 5.8 leukemia deaths expected.
To
1007
rmsesazr
. . J.
oe ETO Pn FER sz one
RISCUSSTON
tlheiusketmnyipaae iaoOnfvcneicdr,oemntpechaseer,ivemsanostinisorenbeesgseslrttevaucetdtdtiyssopteinrciagolldyac(tw1ii9vo5e6n-i8We8al)so,hainantgntoeRnxocvWeoosvrsekrso,f
year of diagnosis. Had evenly over the study
these
the distribution of
cases bean distributed
dagenyby
more
. nltohenius-koecfmiconugdpeianntgiiconvasogluelndtfsamctososurtpcsehrlioaiotckde,trlbayadbcnieodatamaimcooetncr`ieoxbfpuotbseeunnrrseeesnvetooidkennotwinfied,
fianonis iHosveuvneers,perttheet.disWthriilbeutdiocnacoofocvaesrees by yealairmsceodfduring
`the surveillance identified from
period 1984-83.
from 1956-83, the remai Datas of diagnosis for
4 vere these 4 cases
vers from 1/86 to 7/48.
indicate laukenia
excess cases
leukemia
Since analysis incidence, the
through 1983 did apparent Cluster
not of
-
attention.
diagnosed in recent years warrants particular
p2r0ae7rv,tiiCecovumlomafernlAtayhLepitrtoewylobiroekmfnihzneieaxanrpreyoasaurrrineeedv.siheyavdnIrdtoofcpiaowsrtobarronekntcsi,ohamilesaetmncoyihreeidmaeiscetadhliadtsxnapouttshurererevesee,agln CCsahosoneucsle.dntbreatmioonnitoonretdheclroesceelnyt fcaosrest,heboecciunrirteiantceed.of Tahdeditsiiotenal
The various suspected
differences batveen cell types,
etiologies
of
leukemia,
rtaiahrndisistathtaiiisnsoovnecs,sittuaidbtygee,nadzteivlnoiientm,.hittcGhhteeehnmeedotetcivhoecenlrcaoalsppumesveuaiantnoltidnlcstohafhagesieLcneestuhnmksvae,ilcnrlaioanannrn.dmbueemn{bsdTneirireseaewontnfCiianccfsiatrsosomemss
a$Xgaemnptlse,haovnee amlallabeefnromimtphliiscactaesde isnerlieoukcemhoagdanPerseivsi.ousFlyorLue
tsreecaotneddaryfotrotthryreoaitdmecnatncfeorr, tahnadt hneiospllaesumk.emiaHomweavyerh:avhe ibeeamnoss
.
nexoptospurroecsl.ude a thorough investigation of his work history ana
)
1
10504220
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rman '
:
F261 T30 F010 FEB 11 19208:3
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REFERENCES
1. LNienwetY,orkN:.S.Ox(f1o98r5d)UTnhievelresuikteyniFnraes:s.EpidemiologicAspects. 2. MRWoiargstghaailnni,gttyoWn.R,Ba.t,DeC:sMaasnodNnC,TIr/TEe.PnJAd..s,.e1t95a0l-.197(91.983)WS.Cancer
'
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EIDs84229
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wm uw Hf
wame wg
Ce ee ow em 4 wm
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wa un wa om
aby doy
Fa=cmr mm wm
5 aw Me
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