.- BESTCOPY AVAILABLE -oyeH PE RECEIVED | TON COLCGY | iSE E S= o i 8r e B. iso prey Din Homany K.

CorrpoorsrateOOcccaupations Medias 25M1CC7eo3nte4r2,3bB0uidiTngetgho2n0e-305 1733 068 Fax AR226-0473 3M 5a.t PChoytstiacgieanGrPolvanet(S19u7m8m-a19r9y1)Reports Regarding Medical Surveillance Program Following reports of the finding of organic fluorine in sera samples, a fluorocheical medical surveillance program began at 3M manufacturing facilities in the mid 1970s "The surveillance program has generally consisted of annual or biannual tests ofclinical chemistries, pulmonary function, blood counts and abiomoritoroffluorochemical + exposure.

AR226-0535 ACUTE TOXICITY TO AQUATIC INVERTEBRATES (E.G..DAPHNIA) TEST SUBSTANCE Identity: aPlesrfolbuoeroroecfteyrlrseudltfoonaasteF,ludoirdoeaclkyylldiammemtohnyliaummmodneriiuvmatisvalet.; may [1- D1,e1c,a2m2i,n3,i3u4m,,4,N5-,d5e,c6y,l6-,N7,,N7,-8d,i8me8t-hhyelp-t,adsealctafwlituhoro-1- octanesulfonic acid (1:1), CAS # 251099-16-8] LR-e1m4a3r9k4s:referTrehdet3o Mbyprtohdeutcetsitolnablootrantuomrbyears was Lot P3025. 1.

ARR26 _ 0L63 ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TESTSUBSTA0N 000C 0000E 00 Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-85, or as a component of FC-803F. (1Octanesulfonic acid) (CAS # 2795-393).

AR 226 -- 0873 ACUTE TOXICITY TO FISH (MUMMICHOG) IEsTsuBsTANCE 000000 Identity: ArefmeirxrteudrteocaosntPaiFnOiSng, pFeCr-f9l5u,oroorocatsanaescuolmfponoanteen,twohficFhC-m7a8y0Ba.lso(1b-e Octanesulfonic acid) (CAS # 2795-39-3).

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RECEIVED - OPPT NCIC aKAY 12 85 9: 10 FINAL REPORT PROTOCOL 418-028 ORAL (GAVAGE) COMBINED REPEATED DOSE TOXICITY STUDY OF T-7706 `WITH THE REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENING TEST SPONSOR'S STUDY NUMBER: T-7706.1 FINALREPORTDATE:31 JULY2003 PROTOCOL 418-028- TOORXAILCI(TGYAVSATGUED)YCOOFMTB-I7N70E6DWRIETPHETAHTEED DOSE SRCERPEREONDIUNCGTITEOSNT/DEVELOPMENTAL TOXICITY SPONSOR'S STUDY NUMBER: T-7706.1 TABLE OF CONTENTS SUBJECT PAGE 1.

Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 1 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Appendix G: Amendments and Deviations (Copies) Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 2 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 3 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 4 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 5 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 6 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 7 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 8 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 9 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 10 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 11 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________ Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendices G] Page 12 of 12 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats _____________________________________________________________________________________________________________

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Toxicological Summary PFOS Dietary Chronic Pilot Reproductive Study: Northern Bobwhite Test Substance: Perfluorooctancsulfonate (PFOS) Structure: Test Remarks: METHODS h1e-pOtcatdaenceasfullufoornoi-cpaoctiads,si1u,m1,s2a,lt2,,3C34A.S4,H5,257.96,56-,319,-73,8.8.88Tw6ha.es9s%tteobtryesdLubuMsntdSaenr,caem"ibHsi-eaNnMwthRci,otneadnipdtoiewoldnesemraenn(td3aplMuraLnioatlyty#wsiass21td7e)ec,thenriTmqhiuenesedsatmopplee Method: ASTM Standard E1062-86and `Type: Dietary Reproduction FIFRA Subdivision E.

StudyTide FC-143:TWoYEARORAL TOXIITY-ONCOSGTUEDNYICNIRATTYS PEER RevoFiOveanwes Authors Peter C.

AR226-1966 ^'"'?

TestResults AR226-2130 !

AR226-2188 ^y Debbie J Mulrooney 08/23/2001 09:53 AM ' To: cc: Subject Chris E Shoop/AE/DuPontQDuPont Question on Source Spreadsheet Chris, I noticed that on the revised spreadsheet you added a column showing the fraction of PM that is C8.