Document KJZryzmJM2VYKbpv8V8d71XrQ

CorporatOeccupationMaelWcine 3M CenterB,uildin2g20-3W-05 St.PaulM,N 55144-1000 651'/'4j2730Telephone 6517339066Fax 3. MortalitSytudvatthe3M ChemolitePlant Thisisthefirsutpdateoftheretrospectciovheormtortalitsytudyby Universitoyf Minnesota epidemiologists.T.he originalstudywas completed in 1980 (seestudy# 2). The study populationwas definedas allhourlyemployees who were employed atleast sixmonths intheChemolite (CottageGrove) plantand, inparticulatrh,eChemical Division.The rosterof employees from the initiaClhemolite studywas updated to includenew emplovees hiredsincethefirssttudywas completed. The studyupdated the vitalstatusof employees through 1983. There were no statisticaslilgynificanftindings. There were threeprostatecancer deathsobserved versusone expectedamong Chemical Divisionemployees. A nestedcase-controlstudywas conducted of the prostatecancer deathsatthe Chemolite site.For each case,fourmatched controlswere selected. Individualjob historiewsere reviewed to determineifany job titleosr departmentcodes occurred more frequentlyamong casesthancontrols.There were no significant differencesindepartment codes orjob titlebsetween casesand controls.The authors concluded thatthe Lyreatenrumber of observed prostatecancerdeaths may be due to the higherprevalenceof prostatecancerinMinnesota thanthe U.S. and/ora chance finding due to the largenumber of comparisons thatwere conducted. Mortality Study at the 3M Chemolite Plant Jack S. Mandel, Ph.D., M.P.H. Leonard M. SChaMan, M.D., M.S. January, 1989 Mortality Study At tne 3M CheMolitt Plant introduction A retrospective cohort mortality study of the 3M ChemolitePlant in Cc-Itage Grove, Minnesota was completed in 1980. The purpose of tne study was to determine if the mortality experience of employees at this plant was significantly different from that expected in a conparable population. The results from that study, sumarized in a report issued in February of 1980. found no cause of death among employees which was significiantly greater than expected. on February 16, 1984, a contract was instituted to update the.initial study oy evaluating the mortality experience through 19b3. Specifically, it was agreedthatthevi*@astlatus of all former employees would be ascertained and a statistical analysis conducted to determine if there was any significantly different cause of death among Chemolite Plant employees when compared to tne general population. Tnis paper presents the methods and results of the followup study. Methods The methods employed were essentially the same as those utilized in the initial study. The goal of the study was to determine the vital status of all inactive employees. obtain A copy of the death certificate for those who are deceased. and analyze the mortality data to determine wtietherthere were any signfiicant excesses or deficiencies among Chemolite Plant employees compared to the general population. The study population was defined as all hourly eMloYees who were emloyeo at least six months at the Chemolite plant. !he roster of employees fror.. the initial study (nu3,688) was updated to include: 1. new employees hired since the first study was conducted; 2. terminated (deceased, retired, laid-off, disabled, on leave. @@ransferred)employees since 1978. the closing date of the initial study. Vital status was determined for all inactive employees through Social Security Administration (SSA), the National Death Index (NDI) and tracing of individuals witosestatus could not be resolved by SSA or NDI. On August 1B. 1984, a request was sent to SSA requesting a formal agreement for the ascertainment of vital status. Approval was.received on October !5, 1984, and a computer tape containing 2,668 recoras WAS shipped to SSA on November 1, 19F>4. The results were returned on March 19, 1995. In August of 1984, a request for similar services was sent to NDI. Approval was received an Dctober 16. 1984 and a computer tape was shipped October 29, 1984. The results were received November 20, 1984. Following receipt of the results of the SSA and lidlsearches, death certificates were requested from state health departments for all former employees known or presumed.to be dead. Death certificates were coded by a professional nosologist according to the Eighth Revision of the International Classification of Diseases. Employees for whom no vita! status information was available were indivicually traced using a number of resources such as telephone information, reverse street directories to identify former neighbors, motor vehicle registration, former employers, church affiliations and unions. All date were coded and keyed for computer-assisted analysis. The method of analysis w&5 based on a Comparison of the observed to expected numoer of deaths by cause, adjusted for age, time, sex and race-(Monson, 1974). Expected deaths were obtained from U.S. death rates. Nested Case-Control Study For any significantly elevated standardized mortality ratio, a nested casecontrol study was conducted. Cases were all deaths from the cause which was elevated and controls were four employees individually matched to the case on sex, race, birthyear (+ 3 years). year first employed at 3M years) and vital status (alive at least until year of death of the case). The work histories of the cases and controls were examined to determine if there were any job titles or department codes associated with titedisease. Results A total of 4,086 employees (3,204 =le and 881 female) were eligible for the study. These employees represented 67,684 person-years at risk (68,833 n.alesand 18.851 for fmales). Vital status was determined for 100 percent of the cohort. Two hundred and eighty (7%) were deceased and death certif- icates were obtained for 278. Two died ovierseas;one in Korea and one in South America. Information on cause of death for those two deaths was obtained from the military for the Korean death and a family member for the death which occurred in South America. -3- it took from 20 to 341 days to obtain the death Certificates from the State health departments. Six states took over three months to respond. Table I presents the observed and expected number of male deaths, the ratio of observed to expected (standardizedmortality ratios), the lower and upper 95'.confidence limits and the chi-square value by cause of death. The SMR for all causes of death was 0.61 (95% C.L. - 0.54, 0.70), indica^,ing a significantly lower than expected death rate among the Chemolite employees. A major contributor to this favorable mortality experience was the low rate of cardiovascular disease mortality, Most probably reflecting a healtny worker effect. The SMR for all cancers was 0.76 (95% C.L. 0.58, 0.97), a ratio significantlyless than 1.0. No cause of death has an SMR significantly greater than 1.0. Table 2 presents the results for all male (100) deaths among employees in the CnemiC&l Division. The $MR's were 0.64 (95*0C.L. a 0.52, 0.78) for deaths from all causes, 0.54, (950&C.L. - 0.37, 0.76) for deaths due to diseases of the circulatory system and 0.73 (95'oC.L. - 0.46, 1.10) for cancer deaths. The only statistically significantly elevated SMR was for prostatic cancer deaths where the observed number of deaths (4) was four times greater than expected (SMR a 3.94, 95% C.L. a 1.06, 10.08). Tables 3 and 4 present the results for all females and females in the Chemical Division, respectively. Based on a total of 35 deaths there were no statistically significant increased standardized mortality ratios. A nested case-control study was conducted for what were initially five prostaticcancerdeaths in the entire study population. For each death -4- four matched controls were selected. Individualjob historieswere reviewed to determine if any job titles or departmentcodes occurred more frequently among cases than controls. On reviewing the entire job history, it was apparent that one prostatic cancer death was duplicated. This occurred because the employee had been assigned two different identification nurbers and the records contained differentdates of entry into the workforce. Thus, the case-control comparison was limited to four cases and 16 controls. The cases were employed in 16 different departments and had 11 differentjobs, controlswere in 25 differentdepartwnts and had 27 differentjobs. There were no significantdifferencesin deparzmnt codes or job titles between cases and controls. Discussion Employees at the Chemolite Plant were found to have an overall lower than expected death rate than the general population. This occurred for both males and females and for both the witolePlant population and those employed in the Cnemical Division. The only exception was for deaths from pros- :ic cancer among males employed in the Chemical Division where four deaths were observed and 1.02 were expected.. Despite efforts to identify ouplicate records,one pair was not discovered until job historieswere reviewed in the nested case-control study. Removing the duplicate death reduced the SMR from 3.94 to 2.94. Even though this was no longer a stazisticallysignificantSMR. the case-controlstudy was still conducted. No specificjob title or departftntcode was found to occur more often among cases than controls. Two possible explanations for the larger than expected number of prostatic cancer deaths are: (1) prostaticcancer is -5- moreprevalentin Minnesotathan the U.S. and thusa higher ratewould be expected and (2) a chance finding due to the large number of comparisons that were conducted. The conclusionbased on this study is that no statisticallysignificant excess mortality was evident among employees at Chemolite. JAULL I. I)II'll,IIVAIl'lIi)T.Xlltr.11I.I1IA)lit@IIY EAII'l,t %IAIIIIAfAIiElDl PORTAJI TY 95 I'tilEENEt01tritiLtILCl1f.iliSAND (.111--)IlIVIAALIUIEE, IIALTS.EIIL -0 Bit [At$Sgs of st##Il $it llitt=ullt titwti%sits I Att I$WltlVlt #44 PRIASIlit VISIASI I At% Itelatutesto 140 colitimor goitcatCAV1.1vin* pollinviim 149 Coloel* *f olgtgll" #go coilcon or isepshm Is$ ta#oclo w stomem WWA#pg $10 PilillfWltl$f I I##$- APPMIXIIIgkll I le'lle- arpsomillaist tinstwvtstwttles el.ti 1.99 1.42 is #$.to 1.91 @out too% 9.15 0.99 0.96 1.00 9.9 III CAIICIN ow tmoco toolessollelslls. arprmotutal 154 calitte cw otclut fill$- appowilages %$$ sit tl*lttm or tl"m lilts- Atrmmilf^lill llyo# - rplol4al toky Is? tA#Kla or poltolas iolls. Orlpm*lIL41to -160 Calton w ofirlogloNT ivsffll11915- APPRI)xlilm0ll 1.95 t.is 0.6 4.19 6.9 161 CtiftftOr TA*"IN litit-, III$. 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I 41tr 0.69 0. 104 its.is 9.4t 64 tre.46 9,.Io 16.55 qj*r 19.10 0,18 a. 4.36 0.40 9. 3.10 9.11 0. 6.59 1.94 0. It #*.is pol 9. 1.95 1.49 0. 14.16 9.11 9. 4.01 0.00 0. 9 1.41 9.00 0. 0 *.is 0.90 9. 1 0. ?& 1.11 a 1 9.10 6.19 9. 46 71.11 %*,OR 0. 14 40.6? to.?#. 9. 16.17 1.91 0. 14.10 0.54 0. -0.01 TAOLL 2. 06')FRVIIAIIDEXPrEttilI,FAIIIBSY EAII',US,lAfi[)ARIIII1L4IO)RTALITYRATI 95 PIR(;EllIlI)Ilrll)llLlICMtI[S A"I)Clil-SIIUAIVtAUI-IIEM,AI.[S,CIIEHICAL L'sAlitau-.Iosr Itself oxoptowig No*famillific ofstgst Ott ltiDlF4UtOgIS tolitte " suctat CAVIII 000 refiloviet tooot#" of elgt%"V" Calitto of gsw"4m lot C141cinforsontac" Mq"tl eggs$- We$ pl*l INOINI I $lil- A#-f-MI41114it A"Mxllo4ltl So$ tolltgm Of IARGI ll"t$lllft fill$- APPRIMIJM;tl 194 calicer ow social fill$. Applwfll#41111 is$ ask CA#ttn w I#"* $It#$. )or cotict* or ratecotas tiols. Appow.11114,rl rplethor I tol!:IkvIllpletti(vMS/I lss lia.it 0.411 is It.$$ 9.11 9.90 or p 9.00 4.41 1.41 0.00 Is* Cotten fw witria4loor STSIIII I I$$%- AprmrA#Imlt I talivitt fill$.$ Igoe. llrrkmtfo4ltl I bit colicto or tile . patiollf we Vd colictoor east litolomil olfts-.11100. kjvt tatictiotr smile of.ruirlsomil I 1.09 ctllttlgw catictit or 119919 otattis 061"14 ttslithi UNIJAIISStirs-ill,fit%-* iiiii- arrs"mtot tells- iorrmxtomteo tag toorlotof itimstv ligis- 4pronxiii4sts $'I$tillEtO W I Vlt filso-it6t 4001,Vl lot CAOIctitof small# lie bilitittilloolatoltolvinnsysitte tipttolitiorr itillois Ialso-lisltsm.Iv 1.160 tvirilegaotmoa a#* offivo its ll~.Illls DISISSI fotio-tit4s- APPN"L$IAIII 0.40 0.66 0.04 9.91 t.06 S.41 0.90 0.91 0.09 0.10 0.00 *Includesdiijillcate All*ALEIJKflllA to$ CA#Xta or ofelln tvivitatic lot Ott tvirlomogttlc coott* TISSUE I ltso.ilgg Inity I Ito stiff=$ litapkastis 200 250 @#"Rigs flittalus elsilksts 11,150-1969awyl too Ottol$ta$tast$to= we SLOW-goolitainmomes119ts.,19.10. log tittofat.psvclomotumotiocne ny4glAtlyT otsmvlns 129 AtL SISCASTS of IXW*VN sysill" me stint oMojl2 I also-RIG* 01ILY1 I" Ott fisthsto W CancuLAINT $Isla" 593 CWIW#IC Olff"IAWIC gl[ANf DISIASIIIVZS- APPMMSIIRII 1 419 84110tiosctt*ol it mahrtt Disease fiectoolin CIO 11925- appaomoluet I 430 &It VASCUtAn tg$lon of CNS 460 Att PISPINAIONV 96' IASIS 11919-tillf- APRMMIIIAFI 1 469 ALL "MOVIIA 139t5-ti9S$- APPMMittAtti 4.91 filPlITSCItA fl9S$-ol95S APPONIIIAIII 491 ASIPRIA 11985;..Itjf- APPONIIIAtill $to Ott esslasts w sigistlvt svsll" SDI Ott eastaic Now SUDKIIAL ULCTO Sri clationts of tivis too Ott sistasts vr ollitle-tesomay systell 141 ttoolle IRFIMIIIS ?of AtL *$$lasts or 1"1 $KillAle CILtutAR tissue pig AlL vistasts Of feltpollts AND oltoolltw tomociff III I"plolspstlllttlvomw stv strilitsttlettion so* Ott INFIFOUL tatr@tsor 84AIN 001 Att ACC$ot"IS $at talc" vtilictfJkctlottlTs 999 suicin nt$jmmt 0 1.36 0.00 1 9.101 1.10 1 3.79 9.96 I.St 0.17 9.09 0 1.41 1 1.81 61.17 1.55 to 45.14 t 9.09 4 6.91 t 2.14 1.21 0.11 8.96 6.11 5.66 0 1.91 By to a 9.30 I t.1? if 34.vf Is fl.)S is lt.94 ?.19 -20.02 0.00 9.95 0:14 0.74 9.94 0.34 0.54 0.00 0.00 4.4? 1.00 1.01 0.99 0.00 9.90 9.90 0.09 &.46 a. ?1 0. ?a 1.00 0.99 0." 0.96 9.91 0. 1? 9.61 0.43 0.04 0.16 0.10 6.96 0.04 0.46 0.21 0.04 0.00 0.00 9.00 9.09 N.Ol 0.51 0.46 9.51 0.19 I 10 c -i .2 a11 I I TABLE 3. ONSERVEI)AND FXPECT[D DEATIISnY CAIISE,STANnAtilliZEMDoRTAtITY 95 PERCENT CONfIDE11CELIMITS AND Elli-SIIUARVEALUE, R[MALES. CIIIHOLITPEL ALL ti%usllsor stikin I ALL futiolato IsuptAsols I ALL lfirectiviive vileAsIllclisfall hit luesuctimis COKIN tw outcat cisvltv$I* pmolvim 149 CAIC90 or ol"sflvo owne me reationut Ilsts- AI.IRNDNIIIAIO I $oil towtso or lismoam livis- APPRMIIIAIII lot tilitinw sloven letcodk#o or &Arm 1"11811111title. AFFMI,04111 194 CUKIN or atcvoatfill$. A"NMIIUIII Is$ ALL CAIRIN w ttvtm Iloil- APPRUJIMSEI $if*, - PROIJAItNyN.y o%? CAIKINat ratmeas #1910.Alltmilmill is*cutto or wispleatent svslltl11910.Arrmilmit I $to CAIKIR or tas"ol I II&S-0 avie. Appowletall1 let ALL,CHMIR of ttnls Its cattle tw $too sit curve or $kill No acealloil $tves-.1110- termaxioult1 arromllialso $r4 CAOicto of astatf 190 CAIKIN OF tl*VIX Volot 19"9-1969 OILV 1 lot CAIKWN or comou ultat lot T$IKIR of ALL viamn 11"9-1969 txmv 1 istio-iist BNVI lei tatxla w *live stilliat onivis fils$-logo ON.VI 164 CAIMIN OF ALL WillfAt ONGAIO its calicinor etxms I III$. arroomitult I lot taittl or Itiollyttgts- it"Molol4lg1 $to Carol of tvt Ilose-Igg"gRy I 0 4.41 0.04 0 :1.94 4.9# 4.99 0.54 0 1.61 1.56 9.44 0 fj *.*I ItI CAIXER OF GRAIIIAIM OffifnCtiliNALligAVUUSSySigilI1925- AprnuXlltAlIt 191 cAittR or itromalo 11950-1949 OKY 1 800 LV#r#lO$ARCCIIAAIM RIETICULOSANCOIIA IIISO-1969 IROLVI 191 #ODMS"*$ DISIASE il"o-olgig- appnoxllult 1 104 t#tMtltllA00 ATICKE"IA is* CAICIN or olota twrutlt 099 Att I"PLKWGIIFEC toorte Ilssue 11950.1949altv1 110 $11419H #KtWtANIS 140 150 DIASITIS 11ILLITUS DISEASES 11956-1969 T*KVI see Att vistasts or stem me Bit twillat OPSYCIMIEUROTat one stooo4onsits MOAIO pangmtltv olsomeas 119tg-olg@- APPRONIII filso-itat ciftyl 310 Att DISEASES W T*RVM SVSIEII Ole ago= MCUS Its att DISEASES lw CIFMAIONI systa" its tmmlic almul4itcMANY finaget1919-AFMMUIAII 416 ARttAtOKIENOtCIMA%F 51$14SI#lilCtUbltiOM 11989-AIIPMWIIIAICI 439 ALL VAKULAJI912104 OF tHS 460 Att RISPINATORY012#A$g$41925-oltl$-AFNMIIUlg I 490 ALL PWISIMOIA 1291!1-oltif- APPRMIIMIRI 49t 4[HPNVstlu 41150-02951 APPOMI"Att 1 495 ASFINU 11925-sitg$- APPMIIUTI 1 $It ALL DISEASES or viosit" systim til ALL 2ASTAIC XS DUMIIAL III cloot"osls or tivilit ULCIS 500.ALL DISIOSES OF Ctfliff-MilMOT Sylit" $$I tnikolic lerimilis If? ALL DISEASES Of TIOE SKI" AM CfLtUtAt VISSM ?it ALL DISIASIS OF T"ll DO*$ MO OPONS Of IWVIII[flf 199 ILL lifltlgf COVOITIMIS S" ALL EXIINIAL CAUSIS W FMAIII 1 1.49 1.60 0 0.05 0.00 9 9 0.11 0.99 0 0.13 0.00 1 O.Gi 0.09 9.41$ 6.60 1.60 0.11 9.00 3.00 I.Si 0.00 1.10 0.00 0-ts 9 0.31 1 0.90 0.09 0.90 1.11 It 16.16 6.66 0.99 4.60 0.16 6.60 3.95 0.30 t 2.49 0.00 0.99 0.80 9.12 4.00 0.19 9.19 3.16 4.19 0.61 6.60 %.,OR 0.00 9.79 4.00 0 0.21 0.60 9 9.99 0.04 1 0.91 6.00 1 4.11 1.40 4 6.IS 9.6% TAOLE 4. OUSERVED AND EXPECTED O[AtilS DY EAIISE, STAIIDAP-Oll[DMORTALITY RATI( 95 PERCENT CONFIDENCE L114ITS ANI) CIII-SQIIAREVALUE. FEMALES. CIIENIC) Att CAUSES or DJAIII I ALL IMLIQIAI#F ll[WtAgis I ALL me linimcuteggg PARASIVIC 149 tattoo w Oxcat CAffely no 149 CAlitiN or elfg$llvg VNUt2 Me ptNllol@t4A, Its cattle w asormam ,Joe@- Atoffmiol4ist 191 CAICIN W giovgu as$ cattle or tan" alloastati#tRoss- Arrmoolt4lot 190 CMXIN 4W PITTM APFOMIIUIII AS$ Alt cuicto W ILI"M Ilots. oj"oxl"4110 flyes - "$OVARY OILY Is? C=ltt4 IW FNICORAS #III$- APPROOIIKIII of fttwinaloof STSIO" I itte- art-polemic I is& catican 6f tam"sc fills-* III$. APPM11141ti 161 ALL COICIN of tOn - relloollas ncosiol 1191$-Oltlo- apppoktllalt# IfS CAOXCR Of ICOOK APPMWIIFAIII III cattle w mile ltq catcle of magair is$ CAIKIN w toovix vital &at caliclo ow CORM wtot III"-olsl O#LVO 11"9-19&t oltyl lot CAIM&A Or ALL VilON I$$ CA#Kfm of GINA williAL onnis ieq CAIMIN Of ALL Gtl#ilAt*none fill$-8969 attv 1 lift*-9969UKTO 100tAtICENOr *tA*N* #III$-APPOWAIIIASID lop callets of Riamy I ivis- appamill4flo $if caticto w III CNKV1 3.60 St 0.61 a 0.21 0.00 0.31 0.00 4.66 9.90 1 1.19 & O.Of 0.00 1 0.56 9.11 4.9? 1.80 4.99 0.99 6.51 *.Of 0 1.91 0.09 1 1.84 1.44 I 1." 0.11 9 9.12 0.11 $.It 9.90 0.00 SltlktAlIfM f)llitCf(llitNAL1114VM SISOIII1111!1-&rrn(Wlf$AlIt its catict"of T"TNOIV 11950-1949alltv1 100 LTOWIMANCDIA Ali*PtIlCUtOSARCCRIA 11990-1969 GIOLVI lei Nooullfls alstast APPIIONIIIAI1I to% tttjRtlllA Lum Atieks"14 as$ Cott" w *Two t"*rmaflc Tissm ligge-1969 OILY$ lot ALL L"riem9gric cotan #if simal lituptages 149 AttfUlt attOMPSIN via favotit d4UlNg 1IGIIAL OISIASIS 150 DIASNI(IlSitLtIM fIt$$-Agfg WILVI 100 ALL OISEASIS OF *LOW At* btdn-FMUIOR anon 4191S.tivis- Arpmxltl 219 14#ITAL@PSVCMIRIMOTIC#IAPMIRMIAttlSYISOMNOS 11950-116GtISLVI 910 ALL itst&sts or taitvon sysit" pjipst"n owtin if$ ALL 9151ASIS w CIKUTATORY systt" Iff COOPOiliRtflttlttlNIICANT DISSASIII"S-MPROKS"Afti 416 ANINNIO$CttIMWIASRCF IISIASI*I#CtUICPMS1f8ill$ArPMAIMIll 410 ALL VASCULAR I&SIVIS OF CM 460 ALL OfSPINA10011 IISIASKI liftg-*9919- APPINIIIAIII 440 ALL not$AUIIA41915-olgl$A-PPMMIIUTII %it I*mstm figs@-figs$ APPOMIllafto 493 ASION6411989-title- AMPORIft4fts $to att sistasts or sinswlvt systltt all att eastaic or& WJMImt uttle III CIRRI$"[& w LIVIN see ALL als4ksls or catille.t4tltapf ITSII" lot cmallic litromitis 199 ALL gl$fa$tg OF JIM Skill AIIN tttitOLAN TISSM IJI ALL 01$tASt$ Of liltIMMS IWO NOUN W "Mlittly fig SVIVIOBoStilitilloNO JLt OtritiEl tON9111012 "0 ALL txttwlat coms or IIAIN I.tt 9 0.02 0.00 0.00 0.01 9.09 0 0.11 4.90 4 0 9.1? 9.90 0 0.91 0.00 0 #. it S." 0 0 u.St *.it 0 0.44 0.40 0.00 0." 0.11 9.09 0 0.39 0." 0 9 6.5$ *.?F 9 0 0.35 . 0." 0 1 1.40 0.66 9 1 1.21 9.19 a 0.99 V." 0 0.13 6 0 0.15 0.90 9 O.tf 0.66 0 1.10 9.94 a I.Of 6.40 '9 6.69 0." 1 0.49 1 0 0.06 9.90 0 0.91 9.40 0 0.11 0.80 9 0 I.to 0.60 1.03 IP.49 Lsn UNIVERSITY OF MINNESOTA TWIN CITIES Divisioonf Environmental and OccupationalHealth School of PublicHealth Box 197 Mayo 420 Delaware StreetS.E. Minneapolis,Minnesota 55455 April 6, 1989 Larry R. Zobel , M.D. Staff Physician 3M Center Medical Department 220-2E-02 St. Paul, MN 55144-1000 Dear Larry; Enclosed please find the tables containing the results of the comparison with the Minnesota population. As I mentioned on the telephone, these must be interpreted cautiously because of the uncertainty regarding the Minnesota rates prior to 1959. Deaths among the study cohort occurred in 41 states; therefore, the U.S. rates may be more appropriate. As you will see from the tables, the results are similar to those presented previously which used the U.S. rates. The only consistent finding between the two comparisons is for prostatic cancer which we addressed in our initial report. For cancer of the digestive organs and peritoneum there was a statistically significant excess (SMR=176, 95% C.L.=1.09, 2.69) for the entire cohort. However, this was not found among the Clinical Division employees. Furthermore, no single site within the gastrointestinal tract was elevated suggesting that this was probably due to chance. Also worth noting is the fact that these are not sites typically associated with chemical exposures. If you have any questions please feel free to call me at 626-4810. Yo incerely, ,@,16 S. Mandel, Ph.D. sociate Professor S?O c is HEALTH SCIENCES JAULL 5. OBSERVED AND EXPECTED DEATHS BY CAUSE, STANDARDIZED MORTALITY RATIO (SMR), 95 PERCENT CONFIDENCE LIMITS AND CHI SQUARE VALUES, MALES, CHEMICAL DIVISIO (COMPARED TO MINNESOTA DEATH RATES) , GAIL CMISES OF DEAYII lAtL IIALIGIUIT IIEOPLASIIS tAtL TIVICTIVE ATID PARASITIC DISEASE 9AtL notacutosis 14KNICtit Of KXCAL CAVITY At#D PIIARYIIX 149CMICER OF OTGESTIVE ISKNICEN Of ESMIIAGUS ISICNICEN Of STOIIACII ORGAIIS ATIO PERITOIJETSO 1192S-APPROXIIIATE) 11925-APPROXTHATE 1 ISSCMCER Of LARGE TOITESTIOIE 4192S-APPRWAIIIATE) 154CMICEN OF BECNXI 1192S-APPROXI"ATE) ISSALL CAIICEN OF LIVER 1192S-APPROXIIIATE) 36?CMICEA Of PMXREAS 41925-APPROXIMATE) 1970 PLTIS-PRIIIARY Clit.Y 164CUICEN OF RESPIRATORY SYSTEM 9192S-APPROXIHATEI I&SCAICEN OF LARYIIX 11925-#1930- APPROXIMATE) 16IAtL CAICEN Of LLRIG-PRIKARY AtiO SECOIIOARY 11925-,1930-APPROXIIIATE) IMMEEN OF MOE IIIZS-al930,1945-APPROXII1IATE litculeto OF =I" lo$;MMa OF P*WTATE fi925--APPhoRt@A*le')- I"CANCEN IS"Cfl Of TESTIS (OTHER GEIIITAL ORGAIM-192S-49) OF BLADDER 1192S-APPROXItIATE) 1192S-,1930-AI'P$IOXIIIA -I&OCUCEit Of KIDIMY 1192S-APPROXIMATE) 19KA"Cfa OF EYE 11950-1969 GIILYI IIIU"R OF BRAIII ATID OTHER CENTRAL fiERVOUS SYSTEM 11925-APPROXItIATE) 193CUCEN Of THYROID (1950-1969 ONLY) -ZDK"RWSARCOMA AIM RETICULOSARCOHA 419SO-1969 OIILY) ZSI"0=111'S DISEASE (1940-,1945-APPROXIIiATE) OBSERVED 100 23 0 0 0 & 1 0 3 0 0 2 5 1 4 0 1 1 0 0 0 1 0 0 0 EXPECTED 89.79 16.39 0.68 0.20 0.52 4.23 0.40 0.71 1.40 0.4S 0.27 o.aa 4.66 0.19 4. If1, 0.12 0.40 0.51 0.38 0.26 o.s3 0.02 0.87 0.04 G.SZ O.SS OBS/EXP 1.11 1.40 0.00 0.00 0.00 1.42 2.49 0.00 2.14 0.00 0.00 2.28 1.07 5.16 0.91 0.00 Z.49 .?.&o 2.61 0.00 0.00 0.00 I.IS 0.00 0.00 0.00 tL 0.91 0.69 0.00 0.00 0.00 0.52 0.03 0.00 0.43 0.00 0.00 0.26 0.36 0.07 0.24 0.00 0.03 2.10 0.03 0.00 0.00 0.00 0.02 0.00 0.00 0.00 IIL 1.3s 2.11 S.41 18.48 7.OS 3.09 13.83 5.16 6.2S 8.21 13.68 a.23 2.50 28.73 2.32 29.60 13.85 1.9.96 14.55 14.05 6.91 181.46 6.4Z 93.44 7.04 6.62 Cill 1. 2. 0. 0. 0. 0. 0. 0. 0. 0. 0. 0. 0. 0.4 0.( 1.1 0.0 17,3 0.0 0.2 0.0 11.3 0.1 5.4 0.0 0.0 204LEUKEII[A AIID ALEUKEIIIA 20KPJXER OF DTIIER LYIIPIIATICTISSUE (1950-1969 ()IILY) ZOIALL LVIWIN)POIETIC CAIXER 210KIOIGIO IJEOPLASITS (PLUS t)I?SPECIFIED) ZiGALLERGIC,EIVMRIIIE*lIETA13OLICalit)YRITXOIIALDISEASES (1950-1969 (itit,y) ZSWIABETES HELLITUS 280ALL DISEASES OF BLOOD JitiOBLOOU-FOIIIIIIIGORGAIIS 11925-,1930-APPnOXIIIAT 31%lEtffAL,PSYCIIOIIEUROYICt AIM PERSONALITY DISORDERS (1950-1969 OIILYI 32"LL DISEASES Of IIERVOUS SYSTEII AIIO SEIISE ORGAtiS 3"ALL DISEASES OF CIRCULATORY SYSTEII 39SCHRMSIC PliELItIATICIIEART DISEASE (1925-APPROXIIiATE 1 410ANTERIOSCLEROTIC IIEART DISEASE p IIXLUDIIIG CIID I 1925-APPROYIIIATE 430ALL VASCULAR LESTOITS Of CIIS 44GAtL RESPIRATORY DISEASES 11925-91930-APPROXIHATE) 4$CALL PliEtAKNIZA (1925-*1930-APPROXIIIATE 1 492fliNrISEIIA11950-,1955 APPROXltL4TE 1 491ASTINIA 41925-,1930-APPROXIMA7E MOALL DISEASES OF DIGESTIVE SYSTEII SSIALL "STRIC At*) DUOOEISAL ULCER S?ICI&Vmls or LIVER SGML DISEASES Of ClillTO-URItIARYSYSIEII SGZCNMIIC IEPIIRITIS 7"ALL n%tt DISEASES OF TIIE SKIN AtM CELLULAR TISSUE DISEASES Of TIIE B(NIES AIM ORGUIS OF tiOVEIIEIJT -7MVIIPTMS,SEIIILITY,AISO ILL DEFIIIEO CC)IODITIOIIS WGALL EXTERAIAL CAUSES OF DEATH BOIALL ACCIDENTS AINSTOR VEHICLE ACCIDENTS -959"CIOE TOTAL RESIDUAL 0 2.63 0.00 0.00 1.40 1 3 1.42 2.11 0.4Z 6.15 0 6 6.69 0.90 0.33 1.95 0 0 0.49 0.00 0.00 7.50 0 4 4.74 o. a4 0.23 2.16 0 3 3.71 0.01 0.16 2.36 0 1 0.44 2.28 0.03 12.66 0 1 1.86 0.54 0.01 3.00 0 3 3.21 0.94 0.19 2. ?3 0 104 96.75 1.08 o.as 1.30 0 3 2.89 1.04 0.21 3.03 0 alro 72.88 7 10.58 1.15 0.66 0.92 0.26 1.4r3, 1 1.36 0 7 8.66 0.81 0.32 1.66 0 3 3.09 0.97 0.20 2.04 0 1 1.9s 0.51 0.01 2.86 a I O.f*3 2.34 0.03 13.02 0 12 11.45 1.05 0.5-ri 1.83 0 a 1.12 1.78 0.20 6.44 0 3 6.88 0.44 0.09 1.27 1 0 Z.16 0.00 0.00 1.70 1 a 0.91 0.00 0.00 4.04 0 0 0.14 0.00 0.00 26.14 0 1 0.52 1.94 0.01 10.78 0 1 1.66 0.60 0.01 3.36 0 46 52.17 o.ae 0.6s 1.18 0 34 38.27 0.89 0.62 1.24 0 27 21.42 1.26 0.83 1.83 1 9 lo.a6 0.83 0.3a 1.57 0 1 -65.06 -0.02 CATXER RESIDUAL 13 3.00 4.33 TABLE 6. OBSERVED AND EXPECTED DEATHS BY CAUSE, STANDARDIZED MORTALITY RATIOS (S 95 PERCENT CONFIDENCE LIMITS AND CHI SQUARE VALUES, MALES, CHEMOLITE PL (COMPARED TO MINNESOTA DEATH RATES) DAIL CATJSES Of DEATII IALL "ALIGHAIIT POEOPLASIIS 2ALL IIWECTIVE AIID PARASITIC DISEASE VALL TUBERCULOSIS lf#OCANICENOF BTXCAL CAVITY AfM PIIARYISX 349CAHM *Of UICESTIVLT OftOAtISAIID PERITOIIEIXI 1192S-APPROXIIIA'IE 1 35MMICEN Of ESOPIIAGUS (1925-APPRUKI"AYE) ISICAIICER Of STOOIACII 155CMICEN Of LARGE ZIOTESTIIIE 4192S-APPROXIIIATE) 154CAWXER Of RECTLRI I 1925-APPROXIIIATE ISSALL CARXER Or LIVER 41925-APPROXIIIATE) 167CAISCER OF PJUXREAS 1192S-APPROXIIIJkTE) 1970 PLtr&-PRIIIARY ()IILY I&OCAIXER OF RESPIRATORY SYSTEII 4192S-APPROXIIIATE) IGICAISCEN Of LARYII)((192S-tllSO- APPROXIIIATEI 162ALL CAIXER Of Lt*IG-PRllt4RY AND SECOIJOARY 1IL9ZS-,1930-APPROXIIIAIE) I?KMSCEN Of BOIIE 11925-PI93Ovl945-APPROXIIIAYE 1 172CM$Cflt OF SI(lti iowmict* at 'PwmrATE I 192S-AIIPROXIIIATE1 I"CUMER OF TESTIS (OTIIER GEIIITAL ORGAIIS-192S-fi9l 1192S-ol930-APPROXIIIA I&KOJICEII Of BLADDER (IL925-'APPROXIIIATEI '189CMEEN Of KIDIIEY 1192S-APPROXIIIATE) I"CojlcfR Of EYE 11950-1949 OIILY) 191AIlCEN OF BRAIII AIJO OTIIER CETITRAL IIERVOT)SSYSTEII I 1925-APPROXIIIATE 1 193CUKER Of TIIYROID IIISO-1969 OIILY) ZOOLYIVIIOSI%RCOIIA AOID RETICULOSARCOIA 11950-1969 OIILY) 2011M)DGKIII'SDISEASE 41940-,1945-APPROMItIATE) 013SERVED EXPECTED 245 231.44 63 C4.1.24 1 1.74 1 0.56 1 1.42 21 11.1)3 3 1.14 4 2.06 7 3.89 1 1.27 1 0.76 4 2.47 10 12.95 1 0.54 9 12.27 0 0.28 1 0.96 1 0.81 1 0.79 1 1.45 0 0.06 3 2.16 0 0.10 1 1.32 2 1.2s WS/EXP 1.06 1.41 0.67 1.78 0.70 1.7b' 2.63 1.94 i.ao 0.78 1.32 1.62 0.77 1.84 0.73 0.00 I.GS 1.24 1.27 0.69 0.00 1.39 0.00 0.76 1.59 LL 0.93 1.09 0.01 0.02 0.01 1.09 0.53 O.SZ 0.72 0.01 0.02 0.44 0.37 0.02 0.33 0.00 0.01 0:96 0.02 0.02 0.01 0.00 0.28 0.00 0.01 0.10 UL 1.20 1.51 3.19 9.88 3.91 '2.49 7.69 4.97 3.70 4.37 7.32 4.15 1.42 10.22 1.39 12.97 5.82 6.91 7.07 3.at# 61.43 4.06 35.80 4.23 5.76 00@201.EIIKftllA AND AtEuKEttrA ZOWNCER OF OT$IER LYHPIIATIC TISSUE 11950-1969 OIILYP 209ALL LYtWllOPOIETIC CANCER ZIGOFISI(21 NEOPLASMS IPLUS IMISPECIFIED) 240ALtERGIC,EtIDOCRIIIE,HETABOLIC,I&)TRITICAIAL ZSODIABETES FIELLITI)S DISEASES 11950-1969 OIILY) ZGGALL DISEASES OF BLOOD AIJO BLOOD-FORliltig ORGAISS 1192S-sl9lO-APPIkOXIttAr SINIElffAL.PSYCIIOIIEUROTIC, AIM PERSOIIALITY DISORDERS 11960-1969 OIILY) 329ALL DISEASES OF ISERVOUS SYSTEM ATIO SENSE ORGANS 3"ALL DISEASES OF CIRCULATORY SYSTEM 393CIOMilC RIIEUtiATIC )IEART DISEASE (192S-APPROXIIIATEI 41@ANTTRIOSCIEROTIC IIIEARTDISEASE,, 111CLUDIfIG CliD 11925-APPRDXIHATE) 430ALL VASCULAR LESIOPIS OF CHS 460ALL RESPIRATORY DISEASES 1192S-,1930-APPROXIIIATE) 480ALL PIIELJIOJIA 1192S-,1930-APPRM(IIIATE) 492ftWHYSEIIA 41950-,1955 APPROXI"ATE) 493ASTINIA (192S-PI930-APPROXIMATE) SZOALL DISEASES OF DIGESTIVE SYSTEII 531ALL GASTRIC AIJO DUODEIIAL ULCER 571CIMIDSIS OF LIVER S"ALL DISEASES OF GElitTO-URIIIARY SYSTEM UZCIMMJIC IIEPIIRTTIS 709&LL DISEASES OF Tilf SKIN MM CELLULAR TISSUE 739ALL DISEASES Of TIIE 801$ES ATIO ORGANS Of tiOVEIIE14T @199SYMPTOtISPSEIJILITY #AIM ILL DEFTIJED COtIDITIO11S SODALL EXTERISAL CAUSES OF DEATII GOIALL ACCIDEPITS siotioiroitVEIIICI.EACCTOIEIITS -9somcIDE TOTAL RESIDUAL 1.06 0.55 1 2.69 0 0.19 2 1.85 I 1.4S 0 0.18 a 0.72 1 1.32 33 34.09 1 1.09 2a 25.6s 2 3.61 4 3.10 2 1.13 0 0.64 1 0.16 9 4.36 2 0.40 2 2.63 0 0.84 0 0.36 0 0.05 0 0.20 1 0.66 27 24.62 is 16.19 13 10.59 7 4.94 0 -22.74 0.00 1.89 0.37 0.00 1.08 0.69 0.00 0.00 0.76 0.97 0.91 1.0'9 0.55 1.29 1.77 0.00 6.37 2.07 4.96 0.74 0.00 0.00 0.00 0.00 I.Si 1.10 0.99 1.23 1.42 0.00 0.00 0.02 0.00 0.00 0.12 0.01 0.00 0.00 0.02 0.67 0.01 0.71 0.06 0.35 0.20 0.00 O.Oa 0.94 0.56 0.09 0.00 0.00 0.00 0.00 0.02 0.72 0.59 0.65 0.57 1.47 10.54 2.07 18.85 3.91 S. a4 zo. 7a 5.06 4.21 1.36 5.09 1.56 2.00 3.30 6.39 6.71 35.42 3.92 17.91 2.74 4.36 10.06 67.s6 18.37 8.40 1.60 1.56 2.10 2.92 0000@ CAIXER RESIIDUAL 4 1.16 3.46 to