JE Come Cpt noneBtnvs GEE ARL26-0476 3M 8A.mmPolnasimuamChPoelrefclyusotrookoicntiannoaantde PHreopdautcitciEonnzWyomrekse,rCsh.olesterol and Lipoproteins in Toxicology research suggested, to a limited extent, that th incidence of pancreas acinar cell adenomas in ats fed perfluorooctanoic acid may be the result ofa mild but sustained increase in cholecystokinin (CCK) as a consequence ofhepatic cholestasis.

AR 226 _ OS TH SUMMARY OF A STUDYSUCLOFNODNUACTTEE(DPFWOIST) HATPODTUAPSOSNITUM PERFLUOROALKYL Type: Biopersistence Screening Study Species/Strain: Sex/Number: ~~ RMaatles//SC/rgrlo:uCpD.SD(IGS)BR Exposure Period: Frequency of Sor 10 days; 94 daysofrecovery Treatment: Exposure AAdmmloibnitiuummfoprerSfloruo1ro0odcatyasnoate: 20 mg/kg Levels: Method: SPioxtagsrsoiuupms poefrfraltusorwoearlekyaldsmuilnfiosntaetreed(PaFmOmS)o:ni1u0mmg/kg 5pecrofnlsueocrouotcitvaendoaatyes,a1ndgrtohuepotrheecrei5vegdrotuhpestersetcseuibvsetdatnhceetfeosrt bsulbosotdawnaces fcoorll1e0ctdeadysf. roAmpeparcohxirmaattferloym 2thheougrrsouapftdeerstihgenafitrestd dfoosre, 2dohseosu.rsTphoesst-edossaimneg,raatnsdwbelroeodsaacrnidfilcievderosnwteerset dcaolyle5ctaepdp.roTxhiemately wreemraeisnaicnrgifgircoedupasndrehcaedivbeldotohdeatnesdt lsiuvbesrstacnoclelefcotred10ondatyess.t dFaiyvse 1r0ats of(2thhoeurbslopoodstw-daossed)e,te1r3,mi2n4e,d5b2,yoursi9n3g/9a4.WiTchkebotlotdaltofrlcuhorine content sceolmebcutisvteioelnecmtertohdoe.d, Bfoodlylowweeidgbhytsanaanldyscilsinwiicatlh saigfnlsuowreidree iroencorded throughout the test.

AR 226 _ 0850 ACUTE TOXICITY TO AQUATIC INVERTEBRATES (DAPHNIA MAGNA) IESTSUBST ~~AN0C 000E 0 Identity: ArefmeirxrteudretocaonstPaiFnOiSng, pFeCr-f9l5u,oroorocatsanaescuolmfponoanteen,twohficFhC-m7a8y7aolrsoFCb-e 787X. (1-Octanesulfonic acid) (CAS # 2795-39-3).

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BACK TO MAIN '3 Study T i t l o A C U t O TOXiCfty O f N2803-4 to t h o Daphnid, D8phnf. mogna Data ReqUfr.P.nt: Oui.d.lin~ Umber U.8.

i P h o n e : (814)231-8032 BACK TO MAIN Fax: (814)231-1253 or (814)231-1 580 Analytical Report Fluorochemical Characterization of POTW Effluent Pensacola, Florida Centre Analytical Laboratory Report No. 023-014L (Revision 1) Revision Date 3/26/01 Testing Laboratory Centre Analytical Laboratory, Inc. 3048 Research Drive State College, PA 16801 3M Environmental Laboratory Contact Kent R.

3M IMedical Department Study: T-6295.12 BACK TO MAIN Analytical Report: FACT TOX-110 LRN-U2849 Study Title Oral (Gavage) Pharmacokinetic Study of PFOS in Rats Analytical Laboratory Report Title Determination of the Presence and Concentration of Perfluorooctanesulfonate (PFOS) in Serum, Liver, Urine, and Feces Samples Data Requirement' Not Applicable Author 3M Environmental Laboratory Study Completion Dipte at signing Performing Laboratories Urine Analyses Feces Analyses 3M Environmental Laboratory Building 2-3E-09,935 Bush Avenue St.

Benchmark Doses for Tumors in Sprague Dawley Rats fed N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE) Introduction David W.

Toxicological Summary PFOS Dietary Chronic Definitive Reproductive Study: Mallard Test Substance: Perflorooctanesulfonate (PFOS) Structure: 1-Octanesulfonic acid, 1,12.233.44,5.5,6,678-,h7e,pt8a8decafluoro, potassium salt.

`Toxicological Summary PFOS Dietary Chronic Pilot Reproductive Study: Mallard Test Substance: Perfluorooctanesulf(oPnFaOtSe) Structure: p1o-tOacstsanieusmuslaflot,niCcAaSci#d,2719,51-23253..3344,55,6,6,7,8,88-hepladecafluoroTest Remarks: sTthoereedstunsduebrstaamnbcieenistacwohniditteiopnos,wdaenrdp(u3riMtyLowta#s2d1e7t)e.rTmhineesdam{p0bleew8a6s.9% by LC/MS, "H-NMR,andclemental analysis techniques.

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os UIPON January10,2005 Via Federal Express.

AR226-2091 WASHIHSTOH WORKS C-8 INDUSTRIAL HYGIENE EN6INEER2NS CONTROLS NORK RHLES, PROTECTIVE CLOTHING, RESPIRATORY PROTECTION, ETC.