Document 7MjJYa8eQDz387k14ovnGDN6a
Toxicological Summary
PFOS
Dietary Chronic Definitive Reproductive Study: Mallard
Test Substance: Perflorooctanesulfonate (PFOS)
Structure:
1-Octanesulfonic acid, 1,12.233.44,5.5,6,678-,h7e,pt8a8decafluoro, potassium salt. CASH 2795.39-3.
Test Remarks: TKhneowtnestassuFbCs-t95a.nceTihseaswahmiptlee pwoawsdesror(ed3MunLdoetr #a2m1b7i)e,ntancdondiistailosnos and purity was determined to be 869% by LC/MS, 'H-NMR, and elemental analysis techniques.
METHODS
Method: OECD 206, FIFRA Subdivision E., Section 71-4, and ASTM Standard E106286 "Type: Dietary Reproduction ear: 2001 in-life phase, 2002-2003 analytical phase, inal report in 2003 Species: Mallard (Anasplatyrhynchos) Experimental Design: Adult mallards were exposed to PFOS at nominal concentrations otrfe0a,tm1e0n,t a50n,docron1tr5o0lpgpromupincotnhteaidnieetd o1v6eprairspoefrimoadlloafrdasp,proonxeimpaaitrelpeyr2p1enw.eeIknsa.ddiEtaiocnh, d4urexitnrgtahpeatiesst.ofTmhaellmaarldlsarwderpaeirmsatihnattawineerde upesredtrfeoraubmleonotdacnodlleucsteidonfdorurbilnogotdhecotlelstecwteirone ntorteatumseendt fgoroauspsebssy Wreeperkodu3c,ttihoen.GeDautcmen{t0 olevveelrwsaisgnrsedoufc(eodxtioit2y0 npoptme.d aTthethe1501/5200ppppm.m reatment group was then terminated at Week 5. The 50 ppm treatment was terminated at Wsiegensko7f,taolxsiocidtyueortoabonvoerrmtasligbneshaovifotro.xiciBtoy.dy AwleligahdtusltwemarlelamredassuwreerdeaotbWseerevkesd2d,a4il,y6,fo6r, afnidomattshteudeyxttrearmipnaaitrioonf. aFdeuletd mcaolnlsaurmdpstiaotnfwiavse-mweeaeskuriendterwveaelsk.ly.AlBlthoeodtwiames coofllacdiueltd termination, blood sampks were collected from all surviving mallards for chemical afnoarltyhsoiss,e efxrcolmudtihneg5m0alalnadrd1s50fr2o0mptphem 1t5r0e/a2tm0enptpmgroturpesa,tmweentregreouutphsa.niAzleld maanldasrudbsj,ecetxecdeptto gfroroshsisnteocpraotphoslyogaitcsatluedxyamteirnmaitniatoinona.nd aAntalytshees.time ofhe necropsy, tissues were collcted
AOdnuclet cmagllaprrdosduwcetrioenbwroausghitnitiinattoedr,epergogdsucwteirvee pwheaeskelybyplpahcoetdositnitmouleattsionfoatiWnceuebakti1o1n. Eggs were candied and developmental stage and abnormalities were recorded for cach
1
629994
esemt.bryoRevpiraobdiluictty,ivheatechnadbpiolitnyt,sanevdalhuaattcehldindgurheianlgththaendstsuurdvyivailn.clAudfeed:r heatgcghinpgr,odmuacltliaornd,
wcheirceksdewteerrmeinfedd.unPtrrieoartetdo deiutthafnoarsi1a4 odfaytsh.e lAast tghreouepndofofoftfhseprsitnugdy(,LocthiJ)c,kbbloodoyd swaemipglhetss
wcheermeiccaollleacntaeldysifsr.om
I1n0_acdhdiictkosn,frotimssbuoetsh
wteherecoanltsool
caonldlc1t0edppfmrotmreatthmeesnet
groups chicks
for for
hailstnoepcartohposlioegidcamlalelxaarmdis,natainodn tahned lcihveermiscaamlplaneaslyswiesr,e cLoilvleerctweedigfhortscwheemriecarlecoarnadleydsifso.r
Sadaimppolseestwisesruee,aalnsdo tBaukresnaoofftFhaebrliivceiru,sbfaoirn,hisktiodpnaetyh,olgoogniacda,l perxoavmeinntaritciuolnusf,rogamlladbullatddaenrd,
offspring mallards.
Test Bird Age: Adult mallards were 24 weeksof agea est nation
NanudmbfeemraloefpReerplpiecna.tesI:n Tahdedirteiowna,s41p6aiprasirooffamadlullatrdmsalwlaerrdesmpaeirnttraeiantemdenpterwittrheaotnmeenmtalase part ofa blood monitoring study:
Fsteueddy
taonbdotWhatadeurl:t
mFaololdardasndanwdatofefrspwreinrge.
prFoeveiddecdonsaudmpltiibiotnumwadsurmienagsulrledphoanscees
of the a week
ona per pen bass
Asenraal,ytaicnadl Meogngitcoormipnogn:enCtonscenwterraetiodnesteorfmiPnFeOdSbiyn freeedv,ersree-dphbalsoeodHcPelLlC, liavnedr timsassuse asnpedctCrooomket(r1y9.60E)gagncdoSmtpfoannenetrsaw.e(r1e99s0p).ared using a method characterized by Bemardt
SwtaastipsteircfaolrmMeedthoodesv:alUupatoenscigonmipfliectaintondiofffetrheencsetsudbye,tawneeannatlryesaitsmeonftvgarroiuapnsc.e (DAuNnnOeVttA')s cmounlttriopllse (cDoumnpnaertit,so1n95p5r;oc1e9d6u4r)e. wTahseussaemdplteo ucnoimtpsawreerePFthOeSintdrievaitdmueanltpgernosupwsithwiintheatcheh tbirreda.tmeStnattigsrtoicuapl,aenxacleypstesofofrbaodudlyt bwoeidgyhtwesiwgehrtes cwohnedruecttehed sseapmaprlaeteulnyitfowramsaltheeainnddifveimduaalle bmoebtwhhoidtefoqlulaoiwlisn.g aPrecrscienntsaqgueardeatraoo(tretprraondsfuocrtmiaotniodna.ta)StwateirseticealxaamnianlyesdisuosifntgheDudnatnaetwta'ss Spoefrtfwoarrmeepdacuksaigneg dAevveilaonpeRdebpyroWdiulcdtiifoen InDtaetranatSiyonsatle,mLid(.ARDS) Software, a validated
AbavseirsaagnedDdaiidlynoItnttaakkee i(nAtDoIa)ccoofunPtFpOoStenftoiraleadcihffetrreenactemsenbtetgwreoeunp mwaalseeasntdimfaetmeadloesn waitpheinn ethxepopseun.reduFreaetdiocnonosfutmhpetisotnudaynadndadtuhlet AmaDlIlawradsbcoadlyculwaetiegdhtsdfaotlalowwes,re averaged over the ADI(ogthhe bodySowteigihnidh1teddeasy)) =AA1ve2ra8geFAFovooeorddagCCeoonnBmosudumypmiwpeotinighogngeehscdt)bi ddaayy)), pg (oom FRCS)
2
.
C9995
wTeasstuDseid fPorrewpaerlat.iopnreTphareattiesotndoifssthwefrienalprietp.areHdobmyogiesnieintgyPoRfOtSheintteot3Spubsrtaincethiat
the diet was evaluated throughout the study.
RESULTS:
MPeFaOsSurceadmCeonn,cenfterdatisaomnpsleosf PwFeOrScoilnletchtedDainetd:aTnoahaveedr.iy tThheecmoenacnecsatainodnssainndtrhae PdeRvOiaStiwoanssosftatbhlee atnesdt ididetnsotardeeggirvaedne r(Tianblge h1)e. uy.Analyses of the diet also confirmed that
"Tab 1. Mean and standard devinion concentrations ofPEOS in the mallrd
diet.NCo*omncenaFtRiOnS ~~ WCeosnmewnetdtiPoRnO.S oCfovafrisftieon PeNoeminoaTlhe
am
om)
C0 Concenition
Contr501o00l (0)
15W00<aL29Oe50Q2l5"05e4 aos1a0ts3
111000282
T 150 A16T 12156 E 266 , 0s
*LOQ indicates limitof quantitation (LOQ= 2.00 ppm)
Morcltie an Clinical Observations: No tment relted morales were observed
Gdwinhilstllrhevtmachatoelnotxlnreseopldwtoeoirfrobe1nt0dheoptfpesnmefmoeittsnreeoldaetustmiogeonnbhtseogarruoneudstptshom.ceecnastNst-oirwoncetalrlidni.nlcoaalmreTmsnhaielegsnssa.pwpHeeorawereaovnbecsree,nrvndeodnbeaethoa1fv0ihoprpsmos,f
emWfxiooputrirhraiirnlnegesttsmhmaeelonlctfaci.rrurdsertslecad7tenbdwtemethkosr5o0tvoapefreptsmtshegcoaacsstctmouufleriyne,ctditgnhtrreyoet.hpeirnWic1ioi5td01eh70ni2tnd0aletphha.pnrmdtDrute3tenswfeeotenhrketssateomgferconuathpe-i.rmeselTtanhtutee-.d iWSietgeneksdo5i,f caonitde,tsuyarlvlaitrveihnmegasimenailndlogasremdsasliinincclteuhdeeidn0trhepehpe1me5d0t3rre0essmpecpnotnrwseeirsmeuelcn,tuwswieegreddcoahota,WseIecokds 5os.ft crouolredidnastpipoenr,adnecper,eslsoiwoen,r tlhimn awpepaekanreasnsc,e,ehlaacrrgiym,atiaodn, scponsvsu.lsions, lower limb rigidity, B(CoaNnsOceeAdnEtoCrna)tciwloanns(cdLleOtsAieEgrnCms)innwedastmodoebreetram10iln,pepdthme50wNpioolmOe.bstehervLaoblweesAtdvOenrsseevaEbffleectACdovnecresnetrEatsiotn
3
12996
Adult Body Weight: Compared to controls, there were no apparentucament related emWfaefleclcaktrsd2so, ntinhbrohedeyw5aw0seiamgnhadtrki1en5d0tha2en0d1p0sotpamtpismcticatarlemlaytesmiegngntirfogiurcpao.nutp e(BdTauascbetldieoon2n).inthHbeooewdeyevlewerec,itgsshttoarnatmibnoogndaygt bweei0ghtp,otmh.e LOAEC was determined be 50 ppm whi the NOAEC was determined fo
mFaeleldarCdosnsinumtphteio1n0:orTh5e0repwpemretrneoattmreenattsmewnhternelactoempeafrfeecdtstoonthfeecdonctoronlssum(pTtaibolne f2o)r wHaowseovebrs,rsstdariinngmailnlaWredsekfsro1m atnhed 12,502e20amppemn.te.amheind. rBedyucWteioenki3,fseocdmecornescuomveprtyioinn cfoeendsumcpotnisounmbpeionng nwoatse oinbtsheerve1d501w2i0lhpp3m tsraetaitsmteinctalgyrouspig.nifTihciasntrecionveeryswasinlifkelcyd dtdeuetesettr,omitnthheedrteoLdbuOceAti5Eo0nCopfofmPo.rFOfSeedconccoenntsruamtpioinosniwtahse fe15d0(popmm 1w50hpimth0e.2N0OpApEm.C Awsaas
wLieveernWoecidghnt:hWeh1e0npcpommptarreeadtmetontcognrtoruolps,fonoeirtheesremnalteraenladtefdemfaelcetasduolnt bliivredrs w(eTiagbhlte 2) Based on thse results, the NOAEC was determined tobe 10 pin,
Table 2. Feed consumption, body and liver weight, and average daly ine (ADD) for
adult mallards at study Avera termination. *
om "Treatment (ngAhDyIitsy) GeCoondsbuimnpttiinony)~~ Sex @ Body weight Liver weight
Control
00
<LOQ"
B01
2105353 3MMFoON11S1267S44a416D00e50 a211906.6s40s25i+4036s836l
Foollasis 42215102
50
150
6361.05
209720
11245
98s
MMF91o10s6 6i1780a90
NAP
NA
Vi Sormetea 10 po vemos samp WeeckrSrEwhse s0e5mn130 pv
D2SC0oe10ortrsSeenyde10d7Fa0OWySkkucepo(cnndgiFW5n. kaOrevSpsneod3l0y.o8rwpoSieasndpdec1o38mppo. e(16) bii wo mk 30 fo
RAC nde NA= Not applicable; em ne no sample reported. mh conto sme tp <1
GHrroaowisemvseenPrta,tehflooaltogemyda:lcefNsfeccftrsoompnstythhreeesu11l00tsppooprmm atrleasisumrtevnnitvti,nggrtofhuermpealwwehasesni5ncodmmiapcraktreetddati0ntcthreheraecsownteirneoltshn,eo
incidence of small este siz (7 of 16 birds) when compared t controls (2 of 16 bird)
4
29997
hatrawamserneaument related. Al other findings were considered incidental and not related
bHfuirrsostmaoptohafethF1oa0blropigpcyim:ustNrweoeartmeeefnfcteo.cntssiIidnnermtehadeletlrimveeaarlt,lmaeKnritdd.snreweyli,attbherdasiinln,liprttoeevsertneta,rlioctnuleousrc,oonaftdfrsioplproi(s1negoimfsas2lu)lea,arndodsr tefudobuuurcltetsir.oenatTiendhet(h4eotnohufemrb7)ceorbnoitrodlsabaesnxedhnicboeintoeefdmtardteeauctrreidenagsbiemrdadtsueprxeehrimbsaiptteoergdmeandteeosgizesonaeacithnearltaahcetteesorepimhziyendioffberytohuaes sisinezmehi,enisfpneeurrmomubasetortgueonfleecseiltslhwlaaaywsearsnsocorhfmaarglaecrtamesirnicazolemdpebpaiyrtehadenloiaubmsc.eonncItenooloftbhmiearrdtsub.rierdTsshewpsieehrareneaddluascedsdeucgriegsaetssse phraotcesPsR.OSBasmeadyonhatvheesaceceelcetra,tetdhepoLsOtrAcEpCrodwuacstidveevreeignreesdsiton,ba 1n0orpmpaml. physiologieal rsRieegapntrimofeidncuta.cnttiBdoianfs:feedrWeonhnceetsnheisnceaoenmeypocatfrset,dhtehteoreNptOrhoeAduEccCtoinvwteoslpadrgeartmoeeurtpme,irnsetdhfoetrroebmaewlel1ra0redpsmn.ion hseiti1s0icpalply 1oO0fffhhseapcrchiolnnitgnrgoGslrso.owrtT1hh4e:-rdeTahyweerlredewaoesfrfoespnnrooinsgeatasiumrsevinicvtaolrryselsiaintgetrdhieeffc1fa0encptispfomeneetnahectemmseenaitn whvheeerbnowcdeyoimgwphetaisrgehodtf uoflf,sprwienagkefnroemd ctohnedi1t0iopn,pmfotoruelaetmleenstiognrso,unp.d sWuhgiglieshcnliensiscawleorbesesrevratvieondsisnutchhe a1s0npeocmk rirsealsisumtsee,dntthneagtNruorOuepA,oEfCthtehiseneoefoffbfsespcertrisvnagitniwoabnsostdhweetcreoenmtirnnooeltdactnoodnbseitdr1es0riempdepnr.tegarmoeupnst,relBiaesdedduoen 1thehsee cChoenmciecnatlraatniaolynssisooffPbFloOoSd ainnd BllivoeordsaamnpdlesLisvheorweodf tAhdautlatdulMtalmlaalrldasrd:sRienshuels1o0fptohme es{treatemmaeietnmaatepirnpoetranot,xgmirelmoniautvteperglraayocnuScdpu-met(uinTlmauasbmtlegedPrF3)eP.OeFSOtWcShhoainncldeutenrhteitrnhmageteriaetoshnwuesraiessndtuamcdyaos.lnxec-sesnptfFeauocrtmitihfoenctrshemdofinr1fe0ff,erpmeapnaltcmeestrhioeenamtmsitesusntudhteye mw`ceaoasnsceusnritmeridaltairoo,nnlsa,yptphirenoxrmiaatmilaoltoaefrldyPsF1rO.5oSmfionrtbhlbeootochdonssteerxroeulsm.atnodStihna1tc0einpclopinmvceernt(trSre:aaLtmieroannttsi,o)ofafoPrqEbuGotSahnwseetxreies dreevlaetlioopnesdh.ip between PFOS exposure and liver or serum concentrations was not
s
:
cna998
s`Ttaubdlyet3e.rLmiivnaetriaonndA serum PFOS concentrations in adult mallards at
TTreament (pom)
_ LiverCone
Sex
ge)
Serum Conc. (ig/ml)
Control TMF
<<LLO0QQ
0001692003094
10
MF 610098184955
817636+112230
rGelpoyrtceodrroanlanwedt 0wepipgmhsbaamspsl.esweeanalyzed om ey Allvas ae
t#wLa0sQ0=0~4L-im0it1o0f4qu.atiaron: or live it wes 0.02.- 0.0502 gig whiteforserum
sMteuadsyuriendmiecnattedofthPatFOPSFOcSoncaecncturmautliaontsedininblmoaoldlacrodlsleicntebdotthhraoutgihmoeutantdheserxedpreopdeuncdteionnt manner (Table 4).
d`Tuarbilneg4t.heSestruudym. P*FOS concentrations (g/mL) in adult mallards at various time points
T Teme
(ppm) Sex
5
Wek
10
1s
Control
MFM <<0L0QQ
<T0Q <L0Q
<L0Q <L0Q
10
M Fo
9355265 7695155
125+206 8512392
138180 9303.10
TT 50
W M e 388 s We6k43?
TTConcentations are eporeFd ss meas a3nd0s5andr evitons. 633
*L=0LimQitofquantiation:LOQ was 0.01 gi.
`BcyonWceenetrkati1o0n,sseixn-spmeaclifeicmdailflfaerrdesnceweirnesesriugmniPfiFcaOnStlycongcreenattreartitohnanbecthaomsee nootbasbelrev.ed.Thien ffermoamlesW.eekPFO10S ccoonncceennttrraattiioonnss itno sweereukm o15f. femTahleesddeeccrreeaasseedinbysearpupmrocxoinmcaetnetlryat8i5on%s `cmoailnlcairddsedwewirtehpatrhteitoinosneitngofPFthOeSegignt-olaeygignsgdpuhraisneg itnhethreepsrtoudduyctainvedlyinadcitciavteesphthaastefoefmatlhee cstoundcye.ntraItnioncobntyraWset,ekm1a0l.eandsdeirdunmotcsotnatciesnttircaaltliyodnisfferrefaocrhtehde raenmaianpdpearorefntthesasttuurdayt.ion
CcoolnlceecntterdaattioenaschosfamPpFliOnSg twiemree(Taalbsloe m5)e.asured in red blood cells of blood samples
6
n0399
`Table 5. Red blood cell PFOS time points during the study. *
concentrations
(g/mL)
in
adult
mallards
at
various
Treatment
Week
(ppm) Sex.
H
10
15
Control M <L0Q
<10Q
<10Q
10
MFo 21<5L207Q38 21<0L208Q85
<LOQ 58.6443
F 1412490 39.6225.1 3803.94
Week
Week 7
50
M 60.6
274
POS concentrationsasr F rteporated 5nm1e1da8nsaandrd devi4a1ti2ons
"LO=Q Limit ofquantitation; LOQ was0.01 mg/L.
Overall, the `measured iin
creodncbelnotroadticeolnls.ofHPowFeOvSeri,n
serum was the relative
greater than concentrations of PFOS volumes of serum and red blood cells.
in whole PFOS in
blood blood
were could
not not
given in the analytical be conducted and the
report. As partitioning
aofrePsuFlOt,Sabemtaswseebnalsearnaceanodf
RBC was not between serum
evaluated. Furthermore, and red blood cell PFOS
there were sex-specific concentrations. At Week
differences observed 5, male serum PFOS
concentrations were approximately fold greater `while for females this difference was approximately
than red 1.9-fold.
blood
cell
concentrations
`The trend observed
in for
PFOS concentration red serum concentrations.
blood cells throughout the Sex-specific differences
study in red
was similar blood cell
to that PFOS
tchoanncetnhtorasteiomnesaswuerreedaipnpafreemnatlebyfrWoemekthe15sawmitehttrheeatcmoennctengtrroautpi.onsBiyn
males Week
being greater 15, male red
blood cell in females.
PFOS concentrations were approximately This trend agreed with serum PFOS
15-fold greater concentrations
than those measured
measured in these
`mallards,
aCnodncleinvterrastaimopnlsesoffrPoFmOjSuveinnilBelomoaldlaarndds LiinvdiecratoefdJtuhvaetnPilFeOSMawllaasrdpsre:seAnntaliynsitsheobfirsdesru1m2
pwepemkstrpeoasttm-ehnattcgh.roTuhpeoPveFrOSthactonmceeanstruarteidonisn
in both liver the control
and serum group, but
increased were less
in the 10 than the
`concentrations adult mallards,
measured in adult mallards no sex specific differences
from were
the same observed
treatments (Table 6). in either liver or serum
Unlike PFOS
concentrations.
7
:
61000
Table 6. Liver mallards *
and
serum
PFOS
concentration
in
2
week
old
juvenile
Treatment
Tiver Cone.
Serum Cone.
(ppm)
Sex
(ge)
Conwol M__ <LOQ"
(g/m) 0.068" 0.037
10
F
<L0Q
M
307130
<L0Q 44120931
TFConcenmrations
3smean
F and
standard
3.61126 deviations.Dats
gven
sswet
4971.12 weight
2 T<hLe.0mQal=eessesruthmanavleirmaigteof(qnu=a3n)tiwtaasticoanlcfuolaitvederus(i5n0gn%g/gt)heaLndOsQerwuhmer(e10s0amnpgl/emsl)were
below the LOQ (1-2).
`The ratio of PFOS concentrations juvenile mallards averaged 140.
in serum to that This value was
in liver in similar to
both male and female that observed in adult
`mallards,
Concentrations were measured
inofegPgFsOcSollinectEegdgfrCoommptohneencotnst:rolCoanncdent1r0atpipomns
of PFOS treatments.
in egg Eggs
yolk were
tsreeleacttmeedntfgrroomup.WeeYoklsk 1(9w,ho2l0e,) acnodmpo2s1itaensdweyorleksthewneraenalsyezpeadraftoerd PaFnOdSc(oTmapbolseit7)e. d
by In
addition, from the
to 10
better understand the distribution of PFOS ppm treatment were also fractionated into
in the egg yolk, yolk composites 3 components, Very Low Density
Lipoprotein (VLDL), phosvitin, and lipovitellin. determined in each yolk faction (Table 7).
~ PFOS
concentrations
were
then
`Table 7. collected
Egg yolk and yolk component PFOS during Weeks 19-21ofthe study. *
concentrations
(g/g)
in
mallard
eggs
Treatment
'PFOS Concentration
(ppm) Control
Yolk Fraction Yolk-Whole.
(ug/mD) <L0Q'
10
Yolk-Whole
528+0.58
Yolk- VLDL Yolk-Lipoprotein
422050 8.870057
Results
given
35
mans
snd
standard
`Yolk-Phosvitin deviations ona wet weight
bass
The
3.590014 samdard deviation caprsses
p "PTrheecliismiiotnooffqthueparneptairtatai(toLniOoaQn)ndwaasn1a0 polgf/mdyulpsliciatess for the same unique sample, an ggcomposite.
yReosluklstsfrionmditchaeteaddutlhtathaetns10asppcmo,mptahrereed wtaoscoantsrioglns.ificNanot PacFcOuSmuwlaatsioqunanotfifPiFeOdSininctoontergolg einggadyuolltks.femTahleesraattiowoefetkhe21cowncaesnt3r.1a,tionThoef PraFtOioSeigngthyeolekggtoyoaldkultto ftehamtaline blliovoerd PseFrOuSm `concentrations at week 21 was approximately 4.8. The greatest concentration of PFOS in
8
7100%
ltihpeovyiotlekllnwaansdapshsooscvitatiend with the VLDL fraction (approximately 77%) followed by CONCLUSIONS: tM1r0ael2al1tamrewdnesteskwsew.reereeDxutpeeorsm(ie0ndasttioegdnPasFoOftShoeavetendrdieottaif7rcyiatcyno,dnc5eandwutelrteaktmisao,lnlsreaosrpdfesc,tiinv10e,tlhy5e.05a0Wnhdane1dn501co3pm0pp2ma0rfeoprdpustpo catohbnestrererovwlsea,ds 1wa0nheinPnFcraOdeSua-lsrteemilnatltelhdaerdiefsnfceiwcdetersnecoefneodfasd1mu0alltplpbtmoedstiyns twsheieziegfhaetneddodr(eTcafrbeeleaedse8cd,osnTpsneurmampauttiloognemanwlceeisri,es apthys1i0olpoogmica(lTabplheen8)o.meTnhouns,iwnhibliredse,adlPypFOo.stmreapyrodhuacvteiveaccpehlaersaetesde.prhcsssiopnroscaesspowhme!n cfeormtipliatry,edhattochaunbtirletayteodr obfirfdssp.ringFihneaallltyh, otrhesruervwievarle innotthree1a0tmpepntmreelaaitmeedntr.eduBctaisoends o1nm tmAhadelvsleearrsedefsfeEacftfnsed,cttohfCefosnpNcreoinntgOrbawsteaiorsnvad(beLlteOeArAmEdiCvn)eerdfsoetro mEfbafeleec1tm0aClpolnpacrmednstwwrhaiatlseiodnethte(erNLmOioAnweEedsCt)0Ofbboesre1rf0veampbapllmee j((uTNvaeObnlAieEleL8).)tisaPsunRedsOSaLrocewosenucsemtnmtaOrrbaistezireovndasibanlseTsaoAbcildaevtee9rdsweitEhfftehcetNLoevOeblse(rLvaObAlEeLA)dvienrbsoetEhffaedcutltLeavnedl
Table 8. Measurement endpoints and associated dietary NOAEC and LOAEC values for PFOS
in a chronic study with mallards and their offspring. *
ADULT Endpoint
Dictary NOAEC
Diary LOAEC
BMoordtaylwietiyght Feed consumption
110
5500
50
150
GLirvoesrswpeaitghhotlogy
Male10<s 10
Males = 10
HiRsetporpoadtuhcotliovegy.
Femal11e00s = 10
Females = 50
OFFdSaPyRsIuNrvGivability
10
HaJtucvhenliilneglijvuevrewneiilgehbtodyweight TOAECwas based ov cress dens afsl ee
1100 decreed em TeFeo Fo
rIOpoiner lia ty estrone pe en Ae ford rs
_
}
.
9 611.002
c`Tharbolneic9.diNeOtaAryEsLtuadnydwLitOhAPEFLOSv.alues in various matices in adult and offspring mallards in a
"MeAaDsUuLrTesMoAfLPFEOSS Exposure *
NOAEL LOAFL"
ADoDsIe((mpgpmP)FOSkg body weighteday) over 21-week period
11.409
LSievreurm((uuggPPFFOOSS//gm)La)t sattusdtyudtyertmeirnmaitniaotnio(n21(-2w1e-ewkese)ks)
873 609
ADDoUsLeT(pFomE)MALES
0
SAeDrIum(m(g1gPPRFOOSkS/gmLb)odayt pwreei-gthetpordoadyu)ctoivveerp2h1a-swee(e5k-wpeeerkiso)d
149 769
LSievreurm((uuggPPFFOSO/Sg/)mLat)sattudsytutdeyrmtienramtiinoanti(o2n1(-2w1e-ewkese)ks)
166 108
OFYoFlSkP(RuIgNPGFOS/mL)
27
SLievreurm((uuggPPFOFSO/Sg/)mL'
436399
TOCoRncEenLtrawtaisonas esonpcdaornloy pwocestewpedriogfhucaisv.e phase regression Sa mle om Top even AT
NmoeasnudrLeoewstcfcvavacl.uesfor die and ADI rebasedon dictayconcnaion. Serumandfiver ff valuesar.
Offpin vrand serum LOAEL ales are averagesofeal nd mleconcnttions.
DATA QUALITY: Reliability: Klimish ranki=n1g
REFERNCES: `Bemardt and Cook. 1960. BBA 44: 86.96.
`Dqeucakleer,ggEy.oRl,k.FlEaxhyergteyn, RJeMp.ort2N0o0.3.0A2n3a-l0y7s0i.s of perluorooctane sulfonate in mallard and wDuintanhec,ontCr.oWl.. J19A5m5.er:ASmautlst.iplAesscooc.mp$a0r:is1o0n96p-r1o1c2e1d.ure for comparing several treatments 4D5u2n.n4e9t1, C.W. 1964, New tables for multiple comparisons witha control. Biometrics 20: sGatluldaygwhietrh, Sma.lPl,arVdsa.n HFionvaelnr,epRorLt., WBiealvdeirfse,I1nBt.emaJtaiboenra,l,M.Li2d0,03P.rojPecFtOSN:o.A45r4e-p1r0o9d.uction
10
.
---__
g"003
GCeallllsagahenrd, SS.er2u0m03.forEAxntarlacytsiiosnuosfinPgotHaPsLsCi-uEmlePecrtfrlousoprroaocya/tMnaesssulSfpoencattreomfertormy.RedExBylgoeond Research, Exygen Study Number 023-066. RYoelakg.en,ExWygKe.n R2e0s0e2a.rch.AnaElxyysgiesnoRfepPoerrtflNuoo.ro0o2c3i-a0n7c0s.ulfonate in Mallard and Quail Egg `Smtaelvlearnds.on3,ML.EAn.vi20r0o3n.menAtnaallyLtaibcaolrapthoarsyeSrteupdoyrtNof.orEPOFIO-1S2:56A. reproduction study with the St~ifcaongin,aSt.e, Nliigmapnfd,s Ja.,nSdchonoeciydteer,reWcJe.pto1r9s9-0t.heVibtienldliongegnessitiesifnoXrevnioteplulsogelninaiasenldovccahtiiecdksoenn ipovitelin-L.. Biol. Chem. 265: 882-888. `Wildlife Intemational, Ltd. 1994. Avian Reproductive Data System (ARDS), Version 2.
OTHER Last changed: 5/05/04
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