Document ypVrVVdBYJvdN6dndjn7759kn

os UIPON January10,2005 Via Federal Express. RERCeEIgViEeD oSf UL RII: 5S `DRoocoumme6n4t28Processing Center(Mail Code 7407M) Attention: 8() Coordinator UOfSf.icEenovfirPoolnlmuetnitoanlPPrreovteencttiioonnaAngdeTnocxyics Wa1s2h0i1nCgotnosnti,tuDtCio2n0A4ve6,0 NW. MRAFLA IE YOuir amsta ior tioeed m AR226-1899 2 BHP -ol05 -0394/ al CONT.ANS NO Dear 8() Coordinator: AmmonSiEuHmQ-P0e3r8fl1u-o0r3o9oc4t.anoate g ox t"ThheisselretuemrPisFtOoAinlfeovrelmsywoiuthoftthehererseuslutlstosoffthteheblaonoaldyasnesdcuorimnpelemteeddictaoldaantaeloyfsitsh.eApcpormopxairmiastoenloyf 32 ==5+ P6e0rfpluoaroorctaanhoaamtvee:ebCeretonssae-nSaelrcytziesodn.aTlhSiusrsvaeimlpllainncegOifpCalritniocfaalnMoenagsouirnegssotfudGye,ne"rAamlmHoeanlituhmStatu51s5 2 Related to a Serum BiomarkerofExposure and Retrospective Cohort Mortality Analysesina o> Polymer Production Plant"of over 1,000 employees at our Washington Works plant. All -* spaurltitc.ipWanhtasthawveearreecerievpeodrttihnegiraviendtihveidrueasluletsxpoofhsuereglreoveulpsedfoarnsaeryucmsoPfFtOhAe haenadltthheiirc`poernsoenaltatcest are completed. Median serum PFOA levelofemployees who work with PFOA was approximately 0.5 ppm with ``awmitah xPiFmOuAmowfasapapprporxoixmiamtaetleyly100.p1ppmp.m.MeTdhieavnasstemraujmorPiFtyOoAfplaervealmoefteemrpslmoeyaeseusretdhawt edroenwoitthwionrk `normal reference ranges and were not associated with serum PFOA levels. There were statistically significant but modest increases in some cholesterol fractions (total, and LDL) and mtroitgalfyfceecrtidHesDiLn tchheolheisgthresotl soerrCu-mrePacFtOivAe epxroptoesiunr(eCgRrPo)uple(v>el1s0.0A0spppbe)c.tSeedr,uamgeP,FbOoAdylemvealss diinddex ta(oanbkdeestnirtiiygn)l,oycaaencrcdidoaeusln.cto.hOTothlheecrroenfsawcuetmroprest,sitosantuicswhteiarcsaelglaeylnsseiotgicncoisnftiarcnianbdtultbiofuretsststyloliegi,hntaclrisenoacsperlseayiansacrihonollsee,esrtbueurtmohluarfvereacantioitdonbasene.n c6liora0robrnoberlwlaoaitottodihroyantnhpbdeaerhutairwmgieehneteenesttrbescslotmon,oacdfyeoncbutoernuadstnpintuoornaiscnooodrfursseexealpanrotduisouumnnrrPebeeF0ltOawtAPee.FdeOntTAohl,eisvseeaerrnuafdmunnndPocFtoctiOohoAenn.real`Tnstdhpioeeornaxsdtpibucoedtysc,whueabrenateongseeaPsdnFoyiOnnAccaa,lnibonnoioeu.crtal markers measured and exposure to PFOA with respect 0 prostate cancer leskenni, or iple myeloma. | IB i i armen waren -- ItHnhgennisdfatitucaadanyrttehaasstooencxieaamitiimoneness"gasinsvaempnashtnohytend"oaoftrabmpoaotlihvnattrshieatscitlohiniiscsaoolnbelsa,ebriovtreiasdtoinroyttuahnenudgsetunaehlraetlxopfpoiornpduurlesatdlaotvines.t]icBalolysse acunnaacullsyeesaiarsnwdhabilolfoagcitcora(lss)imganiyfiaccacnocueontftfhoersteheoobbsseerrvveeddcshtaantigsetsicaalreasusnoccicaatironasn.d rTehqeurierfeorfeu,sbdetrah bthess AAgceonpcyyowfhtehne afvianiallarbelpeo.rtofthe larger ongoing study referred to above wil be submitted to the Sincerely, DAirMecitcohrae~lReKgaupllaatno,rPyhA.fDf.airs and Occupational Health (A3M0K2/) R3W6R-/52R6C0Liclp