AR226-3200 TRADE SECRET Study Title H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 4 of 5 Laboratory Project ID: DuPont-5386 TEST GUIDELINES: U.S.

3M MEDICAL DEPARTMENT CORPORATE TOXICOLOGY To: AndrewSeacat220-2E-02 cc:John Butenhoff 220-2E-02 From: Marv Case 220-2E-02 Subject:PathologyReview Date: 22 July1999 On 19 July1999 duringmy visiattCovance,Madison,I dida slidereviewof selected tissuesectionosn thePFOS six-monthmonkey toxicitsytudy(Study6329-223).

CAS Number 24448-09-7 3M Company Voluntary Use and Exposure Information Profile N-methyl perfluorooctanesulfonamido ethanol 1.

ENCoomioogm n.weto5n370t7c7545 + Dlr 1100 Kan Bods Madion, 1 5374 608.241.4471 608.241.7F2a2x7 Sponsor: mn St.

AR226-052| MICROBICS MICROTOX TOXICITY TEST TEST SUBSTANCE Identity: `PaesrPflFuOorAooacmtamnooniciuacmids,alat,mAmmonmiounmiusamlt;pemrfalyuoarlosooctbaencraetfee,rrPedFOto, FC-116, FC-126, FC-169, or FC-143.

TOXICITY TO AQUATIC PLANTS AR 226 -- 0727 | Identity: A mixture containing perfluorooctanesulfonate, which may also be OrecftearnreesdultofoansicPFacOiSd,) (FCC-A9S5#, 2or79a5s-3a9-c3o)m.ponent of FC-203. 1- iRseFmCa-r2k0s3:. diethylene gClyuTcrohrleenbt3utMiynlfpeortrohmdeaurtc,ito3ino7n.in8ldo5ti%cnauwtaemtsbeeirt,ris2wa0as%minxeotttuhryneloetoendef.gl1yT.c3ho4el%, PteFsOtsSa,m3pl5e% 2.66 % Sultone foamer, 3% sodium octyl sulfate, 0.1% sodium lauryl sulfate, and 0.05% tolyltriazole.

BIODEGRADATION (BOD/COD) AR 226_ 819 Identity: A mixture containing perfluorooctanesulfonate; may also be referred to as FC-206CF-X.

AR226-1747 PFOS: A DIETARY LC50 STUDY WITH THE NORTHERN BOBWHITE WILDLIFE INTERNATIONAL LTD.

3M Environmental Technology and Services PO Box 33331 St.

.3M Environmental Technology and Services CO Box 33351 St.

PHYSICAUCHEMICAL PROPERTIES TEST SUBSTANCE Identity:[2-(N-Ethylperfluoroocetsaunlfonamido) ethylacrylate;may also be referredtoas B1228, D-1, ETFOSEA, or FX-13.(2-Propenoicacid,2[ethy[lheptadecafluorooctyl)slufonyl]amnio]ethylester,CAS # 423-825) Remarks:Materiiaslan ambersolid.

CAS Number 25268-77-3 3M Company Voluntary Use and Exposure Information Profile N-Methyl perfluorooctanesulfonamido ethyl acrylate I.

NITRIFICATION INHIBITION TEST SUBSTANCE Identity:Mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredto as PFOS, FC-95, oras a component of FC-203CF-X or FC-203CF.

P. 1 3M ENVlRONMEN TAL LABORATOR Y REPORT NO.

CT 3M MEDICAL DEPARTMENT CORPORATE TOXICOLOGY AR216-0150 To: Andrew Seacat 220-2E-02 cc: John Butenhoff 220-2E-02 From: Marv Case 220-2E-02 Subject: Pathology Review Date: 22 July 1999 On 19 July 1999 during my visit at Covance, Madison, 1 did a slide review of selected tissue sections on the PFOS six-month monkey toxicity study (Study 6329-223).