AR226-3371 DuPont Central Research and Development April 11, 1994 3M Center Bldg?

3M MMDICAL DEPARTTYIENT TOXICOLOGY SERVICES cc:John Butenhoff From: Marv Case Subject: Covance Study6329-222 Date: 27 July1998 On 22 July1998 when I was atCovance Madison, I reviewedthemicroscopiclivertissue sectionsof themonkeys on the4-week oralrangefmderstudyofPFOS (Covance study 6329-222).There was no evidenceof compound-relatedeffectisntheliveerven inthe highdose animals.Our toxicologyconsultanthsad askedthequestionwhetherthehigh dose monkeys had any evidenceoflivernecrosisor any othermicroscopicevidence adverselivereffects.The answer isnegative.

CORNINGHazleton Sponsor. 3M SL Paul,Minnesota 19@ 190 F9 5 FINAL REPORT Study Title: 5 DailyDose OralToxicitSytudywithT-6669inRats Author: SusanM.

BIODEGRADATION (MANOMETRIC RESPIROMETRY -ANAEROBIC) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh;i,ch may alsobe referredtoas PFOS, FC-95, or as a component ofFC-304 1. (1Octanesulfonicacid)(CAS # 2795-39-3).

INCORPORATED 200 GirardStreet,Suite200, Gaithersburg,MD 20877 301-921-0168 Fax: 301-977-0433 Client: 3M MEDICAL DEPARTMENT 3M CENTER BUILDING 220-2E-02 ST.

p. 1 -kR oU 6 36W 3M ENVIRONMENTAL LABORATORY REPORT NO.

3M MEEDICAL DEPARTMENT, CORPORATE TOXICOLOGY Protocol for Study No.

-- CAS Number 1691-992 3M Company AR R26 0582 Voluntary Use and Exposure Information Profile N-Ethylperfluorooctylsulfonamido ethanol L CHEMICAL IDENTIFICATION Chemical Name: N-Ethylperfluorooctylsulfonamido ethanol (ECFOSE) CAS Number: 1691-992 IL COMPANY IDENTIFICATION Company Name: 3M Site Location: 10746 Innovation Road Cottage Grove, MN 55016 1400 State Docks Road Decatur, AL 35601 TPehcohnnei:cal Contact: W65.1A/.73W3e-p6p3n7e4r Address: 3M Center, Building 236-1-10 St.

AR R26 - 0764 ACTIVATED SLUDGE RESPIRATION INHIBITION TEST TEST SUBSTANCE Identity: MreifxetrurreedctoonatasiPniFnOgSp,erFfCl-u9o5r,ooocrtaansesaulcfoomnaptoen,ewnhtiocfhFmCa-y20a3lsCoF-bXe or FC-203CF. (1-Octanesulfonic acid) (CAS # 2795-39-3).

3M General Offices 3M Center St.

AR226-2459 From: Rik A Brandenburg on 05/26/99 09:14 AM CED To: cc: Subject: Roger J ZipfeI/AE/DuPont@DuPont Seiichi Tanaka/PO/DuPont@DuPont Re: C-B in drinking water || Roger, We have no data for c-8 in drinking water and a lot of data on C-8 in ground water.

(fflTJnHT^ ''-Uy.

'lit At-Ia.I 14q2)n;--, 65 L-IevietSciencePuhli%hersB.V.

3M Environmental Technolop_v and Services PO Box 33331 St.Paul,MN 55133-3331 6127786442 Protocol #FA C T- TOX- I 10 Study Title Oral (Gavage) Pharmacokinetic Study of PFOS in Rats PROTOCOL Author LisaClemen Date: June8,1999 Performing Laboratory 3M EnviromnentalTechnology& SafetyServices 3M EnviromnentalLaboratory 935 Bush Avenue St.Paul,MN 55106 Laboratory Project ldentirication FACT-TOX- 110 U2849 3M EnvironmentaLlaboratory Page Iof 10 Protoco#lFACT-TOX-110 StudyIdentification Oral(Gavage)PharmacokinetSitcudyofPFOS inRats TestMaterial Perfluoroocstualnfeonaiccipdotassisuamlt (T-6295) Sponsor 3M ToxicologyService-sMedicalDepartment 3M Center,Building220-2E-02 St.Paul,MN 55144-1000 Sponsor Representative Marvin T.

ARBRE _ 124-0 DRAPT REPORT WASHINGTON, WDOROYD RCUONUNCTRYE,EKWEST VIRGINIA NOVEMBER 1997 5TE RY --T_---T-- I =SZZo33n3% E3z8< PREPARED BY: EnvMiarroknmD.entSaplrenRgeesrp,onsPeh.DT.eam ap U.S.