Document QgyQbwJOdvMdzaLaZQRR1B7G4

Summary N-E(FOSE Rabbit Teratology StudyNumbers: 3M T-6316.8, Argus 418.010 3`0C03o7.m3p00o3&9u)Lno9td8:.2N%-puErFeO(SSEM(DN-AEntahlyylt-iPcaelrfRleuqoureosotcy5a2n4e8s9u)lfAonnaalmyitdicoaElthDaoncoulm)en--tLaottioFnMf3l9e2d3al(o3n0g03w5i,th final report. No~tsamee lot asused in two-year rat carcinogenicity study (T-6316, Covance 6329-212). `StudyTie: Oral (Stomach Tube) Developmental Toicity Study of N-EWEOSE in Rabbits ReportDate: 11 January 1999 SdtauildyyoMroanli(tiontruSbautmimona)oryf:N-(EwrIiFtOeSnEbyatMdaosrevlieTnv.elsCaosfe)0,0P.r1e,gn1a.n0t, 2r.a5b,biatndfe3m.a7l5esm,g2/2kgp/edragyroonupd,awyer7se given ctohlrloeucgthed2a0todfagyes2t9atoifong.estTahtieonr.abbAiltlfoeftutsheesfwehtiuscehs hwaedrebeeexnameixnpeodsefdorinsoutfertoisdsuurei(nvgisocregraaln)ocgehnasnigsesweurseinag dAisdseocsteiornelmaitecdrobsocdoypeweaingdhttheefnfeaclt ofcetcuusrrweedreinetxhaemi1.n0e,d2f5or,saknedle3t.a7l5 cmhya/ngkees.dose groups. The difference in fmoeoadncboondsyumwpetiigohntswawsasalsstoatpirsteisceanltlyatsitghneif2i.c5anatnadt3t.h7e52.m5g/akndg d3o.s7e5s.mgN/kogcdoomsepso.unAd srieglnaitfeidcadnetatrhesduocctciuornreind atany dose level aAtbtohretihoingsheosctcutrwroeddoisneosnweecroentcroonlsiddoeer,eidntto wbeoc2o.5mmpogunddoreclsa,teadn.d Tihn efimveea3n.75nummgb/ekrgofdoleast.e fTehseorspbiorotnisons. wweaisghaltseofifneccretahsatedocincutrhree2d.a5t atnhdes3e.7t5womgh/igkhgesftemdaolsees.levTehlewreerdeucineddicfaotoidveocofndsaummpttiooxinciatyn.d adverse body The increased N`noumcboemrpoofunadb-orrteiloantsedansdofltatteisrseuseoorrptsikoenlsetwaelrmealpfroorbmaabtliyosnescwoenrdaerfyotuondthae dam any toxicity. dose level. Thus, the ``TchoempmaotuenrdnawlastnotxoitcfeNoOunErdLtoawbaest0.1omg/gkg,einntheriabbcit. TTehreatfoetgaelntiocxiNc NOOiEEnLtLwhaesra1b0bimtgw/kags,> 375 mg/kg. 3NOMTEEv:iroDmomseentpraelpaArnaatliyotnicsaalmlpalbeosrawteorrey icnolBleicdted2. twLiickeewdiusrei.ngsathmeplsetsudwyearnecdotlhleescetesdafmrpolemsewxetrrae fseenmtal1e0s wasesriegnkeildleads otnoxgiecsotkaitnieotnicdasayte2ll1it(edaanyiamtaelrs l(a3s/tgdroosuep)eaxncdeptthelofwolalnodwihniggshadmopsleesS/wgerrouepc)o.llTehcteesde: asneirmuamlsand alinvdersefnrtom10p3reMgnEavnitrodranmmse.ntfeatlusAensalayntdicpallacleanbtoarsat(oproyoilnedBbIygl2i.terA)tftriomme uterus. of this sTuhmemsaersya,mMplaerschwe1r9e99f,rozen f`iannaallyrsiespoofrtthneorseinsathmipslseusmhmaadryn.ot been done; therefore, these analytical results were not included in the 004181