@ WHaAsZaLTREGTTOONN AR226-0270 3 i 4 WY Sw i is wii ANALYSIS OF T-5877 IN A CELL PROLIFERATION ASSAY IN RAT LIVER CELLS EINALREPORT AUTHOR Maria A.

(ven AR)E-0248. p= NOTOX er rm nse REPORT EVALUATION OF THE ABILITY OF Tsans TO INDUCE CHROMOSOME ABERRATIONS IN CULTURED PERIPHERAL HUMAN LYMPHOCYTES (WITH TNDEPENDENT REPEAT) NNDoTTOOXX Spurbosjteacntce11358911697 page 1 of 26 - yi log oo Mi eer e e ce | 3, 496 TT Fl-UILT (eroATg T tec HECEIVED T= NOV ~9 1994 7.0.

----- FEHR J46-373B.F bout:raat 3M SPECIALTY ADHESIVES & CHEMICALS ANALYTICAL LABO(0R0A0T8O11R7Y6.4 2 ) To: Leo Gehlhoff- (309727) -3M Chemicals - 236-24-01 Request #'s 53030 ARI 0561) Erom: Tom Kestner - (3-5633) SA&C Analytical Lab - 236-2B-11 Subject: Fluorochemical Isomer Distribution by "*F-NMR Spectroscopy Date: December 1, 1997 SAMPLE DESCRIPTIONS: OO * FC-95, lot # 217 (T-6295); Nominal product = CsFy7-SOx(-) K(+) INTRODUCTION: `cTohnicsesnatrmaptlieonwsaosftsuhbejefcltueodrotcohaem'icFa-lNiMsoRmesrpescatnradl analysis as many omtehtehroiddetnotidfeistbelremiimnpeutrhietyidceontmiptoiensenantds raeslative possible EXPERIMENTAL: (pArFep5poar3rt0ei3odn0oth.fe4tswh0aea1msp)slaeamcpfqlouerirasenoaldliduysswiisansaagntdoVtsaalhrleiyaadnlisUsosNoaIlcTvqeYudiprlienudDsaM4nS0dO0p-lFodTtgt-eaNdnMtdhRethNsepnMecaRt3ro7smp6eeMtcetHrr.uzm.AFid-aNRMobRbisnpsectrum RESULTS: fTihueor"ocFh-emNiMcaRlsipseocmterrusmawnadsthurseeedottohedretiemrpmuirnietythceomidpeonntietnitessianntdhireslastaimvpelceo.ncTehnterqautailointsaotifvtehaendnominal quantitative summarized cionmTpAosBiLtiEo-n1alornestuhletsfowlhliocwhinwgerpaegdee.rived from the single trial F-NMR spectral analysis are `AyocuohpayvoefatnhyeqNueMstRisonpsecatbrouumttahnedsetNheMsRpercetsrualltas,sspilgenamseentlestdmaetakpnaogwe.arIeaatptoalocghiezdeffoorrytohuerderelfaeyreinnce.

AR 226 _ O/H ACTIVATED SLUDGE RESPIRATION INHIBITION TEST TEST SUBSTANCE Identity: A mixture containing perfluorooctanesulfonate, which may also be OrceftearnreesdutlofoansicPFacOiSd,) (FCC-A9S5#, 2o7r9a5s-3a9-c3o)m.ponent of FC-206CE. (1- Remarks: The 3M production lot number was 502.

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AR226-2968 FOR DU FONT USE ONLY Du Font HLR 632-91 Study Title Approximate Lethal Dose (ALD) of in Rats Author John W.

AR226-2978 Du Font HLR 477-92 TRADE SECRET Study Title STATIC, ACUTE, 96-HOUR L.C5Q OF H-19,173 TO FATHEAD MINNOWS.

AR226-3393 HASKELL LABORATORY C4, C6 PERFLUORODnODOALKANE 1: EMERaEHCY^B^QSm^'llM : 1 ii:i : :1 EEL: 50 ppb (1-60 minutes) Time Limit: 60 minutes Ceiling Concentration: 50 ppb Emergency Exposure Limits (EELs) are to be used for emergency planning purposes only.

Summary PFOS RabbitTeratology StudyNumbers: 3M T-6295.10,Argus418-012 Compound & Lot: PFOS (Perfluorooctanesulfona-teL)ot 217, 98.4% pure (SMD AnalyticalRequest 53030) AnalyticalDocumentation filedalong with finalreport.Note - same lotas used in two-yearrat PFOS carcinogenicitsytudy(T-6295,Covance 6329-183).

LaboratorRyeportA,nalysiosfFCs inSamplesofChildrenS'esra,May 21,1999 The datasubmitteodn perfluorooctanesulfcoonnattaeinasnalytdiactawhen certaigneneraclonditiohnasvebeenmet.

TOXICITY TO AQUATIC PLANTS TEST SUBSTANCE Identity:A mixturecontaininpgerfluorooctanesulfonawthei,ch may alsobe referretdoas PFOS, FC-95,or as a component of FC-603EF. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredtoas PFOS, FC-95, or as a component of FC-787 or FC787X. (1-Octanesulfoniacid)(CAS # 2795-39-3).

A P, A a6_ :0 g6 3M ENVIRONMENTAL LABORATORY REPO R T NO .

CORNING Hazleton MUTAGENICITY TEST ON T- 6294 EER IN AN IN VIVO MOUSE MICRONUCLEUS ASSAY. 225500 | May14 1995 FINALREPORT A aM a Qtrc010> AUTHOR Hemalatha Murli, Ph.D.

Study Tite #R226_ 1092 ORAL (GAVAGE) TWO-GENERATION (ONE LITTER PER `GENERATION) REPRODUCTION STUDY OF AMMONIUM PERFLUOROOCTANOATE (APFO) IN RATS SPONSOR'S STUDY NUMBER: T-6889.6 Data Requirement U.S.