POSF 3M FLUOROCHEMICAL SUBMISSIONS February, 2002 - May 11, 2004 TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE Click on Study Title to View Report Perfluorooctanesulfonyl fluoride Acute Toxicity 1.

3M FLUOROCHEMICAL SUBMISSIONS February, 2002 - May, 2004 INDEX OF 3M'S 2002-2004 AR-226 DOCKET SUBMISSIONS BY DATE Back to Menu February 2004 Click on Study Title to View Report February 24, 2004 February 24, 2004 Submission Cover Letter Final Report, Pharmacokinetic Study of Perfluorooctanesulfonyl Fluoride (POSF) Following a Single Oral Gavage Dose in Rats.

0100-/37% 37i l l UNITED STATES ENVIRONMENTAL PROTECTION AGENCY S WASHINGTON, D.C. 20460 AftSiSU -OG09 July 18, 2000 fa OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES NOTE TO FYI FILE by Terry O'Bryan/RAD/OPPT Reference: FYI-0600-01378 Submission Date: June 14, 2000 The above referenced FYI submission is 3M's response to EPA regarding three reports that appeared to be missing from their 5/4/00 submission (also FYI-01378).

AR226-1894 Reproductive Effects of C8 James Dahlgren, MD Pamela Anderson-Mahoney, PhD November 2004 Reproductive Hormones Male C8 Workers Increased PFOA Levels Lower Testosterone Prolactin Higher Estrogen Prolactin if high alcohol intake Health Study in Residents Near a Large C8 Source Methods 301 fem ales and 296 m ales with docum ented P F O A -E xp o su re >. 0.05 ug/L in drinking w ater standardized questionnaire SEER prevalence data were used for com p arison Demographics for Residential Study Participants A ge C ategory 20 - 34 35 - 4 4 45 - 54 55 - 64 65 - 80 G ender M ale Fem ale R ace/E thnicity W hite African Am erican Others Education Level L e s s th a n 9 th g r a d e 9 1 1 grade 12 lh/ V o c a t i o n a l / S o m e C o lle g e College Graduate N o. 105 104 135 154 80 284 294 558 6 9 17 59 430 65 /o 18.17 17.99 23.36 26.64 13.84 49.13 50.87 97.38 1.05 1.57 2.98 10.33 75.31 1 1.38 Demographics for Residential Study Participants a w-- t i H T i ~-i'll-- nHiMTinrin iiiiMi iii 'iWMiii[ T M "T rrfigrtB n'iii[iririT r-T '-g ^ ,;^ No. ' B ody M ass Index U nderw eight (<23) A verage (23 - 28) O verw eight (>28 ) 106 190 276 % 18.53 33.22 48.25 Sm oking Status N ever smoked S m o k e d less th a n 15 y e a rs S m o k e d m o re th an 15 y ears 252 60.58 72 17.31 92 22.12 W ork H istory Plant 1 Plant 2 N o plant w ork 54 9.42 19 3.32 500 87.26 Reproductive Cancers in Residents Near a C8 Source CANCER TYPE U terin e/C ervical Breast Prostate Number of Cancers 9 5 9 Observed R ates3 (per 100,000) 3,061 1,701 3,169 Expected R atesb (per 100,000) 96 1,579 1633 PR 33.12 1.12 1.96 C lc 1 7 .0 3 -6 4 .4 1 * 0 .4 6 -2 .7 1 0 .9 8 -3 .9 2 Uterine/Cervical Cancer in Residents Near a C8 Source Age Category 20-29 30-39 40-49 50-59 60+ # of C a n ce rs 0 2 2 3 2 N P R P-value 34 0 - 38 56.40 0.0002 64 25.02 0.0008 84 34.18 0.00001 74 31.83 0.0005 Total 9 294 Age at Menopause in Residents Near a C8 Source Age By Category 38 U .S .

AR226-1896 T-7483.1 ST-45 CONFIDENTIAL BUSINESS INFORMATION SUBJECT TO PROTECTION UNDER THE TOXIC SUBSTANCES CONTROL ACT AND OTHER LAWS HAS BEEN REDACTED FROM THIS DOCUMENT Title: Toxicokinetic Screen of FC Methyl Carboxamide (T-7483) In Rats.

AR226-2421 S ROGER, HD HERE ARE JIM YOAK THE OH RESULTS 11/19/91?

AR226-2494 IQY- mm 1T123 08/31/01 11:01 0 :06/13 NO:150 nwrniicorr eHOfUMOV JwFant jBwse-II'SI'iiks w^%mai3-s2i?

AR226-2547 _____ Andrew S Hartten________________________04/12/1999 04:40 PM To: "Robert L.

AR226-2594 s/rV ?

RECYCLED \ cn l CD AR226-2669 AR226-2669 September 2002 Through August 2003 Air Dispersion Modeling Analysis of APFO Emissions (Revised) May 24,2004 Page 1 of 9 SEPTEMBER 2002 THROUGH AUGUST 2003 AIR DISPERSION MODELING ANALYSIS OF APFO EMISSIONS (Revised) DuPont Washington Works Facility Parkersburg, West Virginia Prepared for: West Virginia Department of Environmental Protection Division of Air Quality 7012 MacCorkle Ave, SE Charleston, WV 25304-2943 Prepared by: DuPont Engineering Technology (DuET) Environmental Section Wilmington, DE 19898 C:\c8\c8_0803_report_revised May 24,2004 1 September 2002 Through August 2003 Air Dispersion Modeling Analysis of APFO Emissions (Revised) May 24,2004 Page 2 of 9 1.

AR226-2704 26 AR226-2704 TORONTO WORKSHOP MATERIALS September 13-14,2004 Fluorotelomer Alcohol and Fluorotelomer-Based Polymer (Blo)degradatlon Bob Buck DuPont Chemical Solutions Enterprise, Wilmington, DE ?

AR226-2751 Copies to: L ,,, . . .

AR226-2777 FOR DU PONT USE ONLY REVISED REPORT E. 1. du Pont de Nemours and Coapany Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711 HASKELL LABORATORY REPORT NO. 589-80 Material Tested Octanolc Acid, Pentadecafluoro-, Ammonium Salt* Haskell No. 12,057 Other Codes Study Inltiated/Completed 10/17/79 - 12/14/79 Material Submitted J>1 'Polymer Products Washington Works RAT SKIN ABSORPTION SUBACUTE STUDY U I T H ~ B B B y I.

AR226-2778 FOR DU PONT USE ONLY E.

AR226-2976 Study Trtte STATIC, ACUTE, 48^0U R #Q 5Q OF H -t9,520 TO Daptmiamagna Data Requirement Organisation fo r Economic Co-Operation and Development (OECD) Guideline for Testing Chemicals: 202 Author Keith B.