Document 2r0pd3MdXK1y3gLwDNb2Brda

AR226-2751 Copies to: L ,,, . . . E. I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711 HASKELL LABORATORY REPORT NO. 635-79 Material Tested Octanoic Acid, Pentadecafluoro-, Ammonium Salt* ' Haskell No. 12,037 Other Hnrloe Study Initiated/ ___ Completed 8 / 13- 9/ 11/79 Material Submitted bv lastic Products & Resins rashington Works EYg_IRRITATION TEST IN RABBITS albino rabbits? '"a "i e r ^ ^ s e ^ n L i 3! 't r e f t e f e y f i ^ v a s h ^ l i i ^ p 8, , V * - b i t r 2 not; r ed; co"Junctlval sac of each of 2 treat" n t * Results: - P 8taln ^ 3 biomleroscope were used at examinations after the day of -- ----- ---------- -- -- -- __________ _ ______ Dose D.l nil (38.3 mg) solid test material Treatment of Eyes Not Washed __ ____ Cornea_________ " Generalized moderate opacity 1 hour-3 days. At 2 days, a small area in the lower cornea had severe opacity. The opa city gradually receded to generalized mild at 7 days excepi or the area in the lower cornea which had moderate opacity with vascularization. This area of opacity persisted through 14 days but gradually receded in size and degree to localized mild opacity with vascularization 2 1-2 8 days. Ocular Effects ____ Tris Slight injection at 4 hours. Moderate conges tion at 1 day. Slight injection at 2 days. Moderate congestion at 14 days. ______ C o n j u n c t i v a _______ Redness: Slight 1-4 hours. Mild at 1 day. Moderate at 2 days. Mild 3-14 days. Swelling: Mild at 1 hour. Moderate at 4 hours. Mild 1-2 days. Slight at 3 and 1days. Discharge: Copious 1 hour and 1 day. Moderate 4 hours, 2 and 3 days (Hemast ix1positive 1 hour-3 days.) Mild at 14 days. Company Sanitized. Doss no! contain TSCACB! Results : (continue') T2 - Dose 0.1 ml (lb.3 mg) solid test materisl Treatment of Eves Washed Cornea Small area of mild opacity at 1 hour increasing to moderate opacity at 1 day and receding to a small area of slight, opacity at 3 days. Ocular Effects Iris None. Conjunctiva Redness: Mild 1 hour-7 days. Swelling; Mild 1 hour-1 day. Slight at 2 days. . ...... Discharge: Copious 1-4 hours. Moderate at 1 day (Hemastix-positive 1 hour 1 day. s it r f jf -*=" ` M f c . i w o - , affa a tatJon (sign of healing). *,, eye dosed l t U I * add ^modJeerta"ttee- cconjunctivitIs'w,ien tested in . , V , ' ----' *" " " meal opacity persisted and at 21-28 d m TM cabb:l* a>,a- lila eulat corneal opacity and dhratiTto^li.hr^1!6 ^ " 0t " rial and promptly washed had j J I , ) ^ <" U d with vascolari- .tld conjunctival redness, which was not d" ."" * " * " 11,6 a*a TM a ""P TM " " tM,,*7 with this* attention. s ar i t "r"ai ^7 ye contact, flush copiously with water and obtain medical " Other Namesr Composition: Df'E: ecg Report No. 635-79 Date Issued; October 1979 P0 by: A , -J Doris F. Edwards Toxicolog ist Approved by: > -- ;i , , . . Gerald L . 'Kennedy Chief, Acute Investigations Section Company SaniJize Dr-9s r.n? contn: