STLS E V E R N TRENI STL Chicago 2417 Bond Street University Park, It 60466 Tel: 70B 5 3 4 5 2 0 0 Fax: 7 0 8 5 3 4 5 2 1 1 www.

AK - \tj-8l TSCA NCIC Notification Form for CBI Documents Docket Number: 7 3 7 __________ __ Document Control Number: 7 7 7 Document Date: 7 3" - ( - 7>____________________________ Document Type: b o c t F ___________________ 5c_t 0--aa5mo0 -nm x^ocron oo mo (TChBe Id) o u c n u d me er nt Se re ct fer io n e1n4coefd above the To is cl xic S aim ed ubsta a n s c c o nfiden tial es Control A bu ct s(TinSeCsAs )in.

Precise Research.

AR 1%-oiGi REPORT AMENDMENT NO. 1 TWO YEAR ORAL (DIET) TOXICITY/CARCINOGENICITY STUDY OF FLUOROCHEMICAL FM-3924 IN RATS Experiment NO.0281CR0012 The attached pages include revisions in the first paragraph on page 3 of the Summary and in the third paragraph of page 22 of the Discussion.

AR17J6-033I Feces3MMPerMothtoEocdDoDIlCfeoAvreLSlotDpumEdyPeAnNtRoM.TTeMt-Da6Eb3eNor1il6Tvis.a,1mtC7iv,OSeTtsRu-.6dP2yO9fR5o.A2r1PT,eETrf-T7luO1o3Xr2oI.o3C;cOtSaLTnOe-4sG1ulYfonate SFfTetlhcuuieodssrysimtnuOeedbtAyajebnicsoatlldiiyvteteeis:ciaganlnaCelydhsetiosm. gisetnryerTaeteamspteociumseenfsofrodretvheelo3pMmEenntvairnodnvmaelindtaatliLonabaomraetothroyd of Research O ient: 33SMMainCSt pPeenacuteilar,l,tMyBNuCihl5de5imn1gi4c42a3ls6Division Sponsor: 33SMMainSCtpPeenacutiealr,l,tMyBCNuihl5de5min1ig4c4a2l3s6Division Study Location: 33SMMainSCt tPernaatuteelgr,,iMcBTNuiol5dx5iinc1go4l42o7g0y-L3Sab-0o6rartooorym SB314 Study Director: PA33TSMMhaoni.xd:nMiCrt6cePo5ewenal1dout-Mieg5clr,y7a.

BACK TO MAIN Centre Analytical Laboratories, Inc. 3048 Research Drive State College, PA 16801 www.centrelab.com ^P h on e : (814) 231 -8032 Fax: (814) 231 -1253o r (814) 231 -1580 Analytical Report Fluorochemical Characterization of POTW Effluent Port St.

3M Medical Department Study: T-6295.12 Analytical Report: FACTTOX-110 LRN-U2849 Table 7: Ambient-Temperature Stability of PFOS in Rat Serum After 24 Hours Run 11 QC (Theoretical Cone.)

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r > r' \2-44 Rivi/ mm ISUtnsmoiBc; E. du Pont de N em ours & C o m pan y IN COR PORATE O W il m in g t o n , D e l a w a r e 19898 POLYMER PRODUCTS DEPARTMENT EXPERIMENTAL STATION PERSONAL AND CONFIDENTIAL A.

The miracles f science' 000003 Dordrecht Works C-8 Sampling Summary Groundwater Sampling Results March 2003 Site Conceptual Model Primary source area (I.e., C8 and chlorocarbons) is freatic (shallow) i aquifer underlying FP process area.

A R 2 2 6 -2 0 6 8 VW SAFETY, HEALTH AND ENVIRONMENTAL C8 AMMONIUM PERFLUORO-OCTANOATE FC--1 43 ANIONIC FLUOROCHEMICAL SURFACTANT MGF by 3M COMPANY v -5 o DuPONT AEL: 0 .01 m g /M 3 (0 .5 6 ppb, 8 hr TWA) o IRRITANT via INHALATION.

AR226-2459 From: Rik A Brandenburg on 05/26/99 09:14 AM CED To: Roger J Zipfel/AE/DuPont@DuPont cc: Seiichi Tanaka/PO/DuPont@DuPont Subject: Re: C-8 in drinking water | | Roger, W e have no data for c-8 in drinking water and a lot of data on C-8 in ground water.

AR226-2474 To: Ton RoelenyEUR/DuPont@>DuPont, David M Rurak/AE/DuPont@DuPont, Katsunosuke Kitagaw a/PO /D uPont@ D uPont cc: Frenk Hulsebosch/EUR/DuPont@DuPont, Oscar T Garza/AE/DuPont@DuPont, Roger J ZipfeI/AE/DuPont@DuPont, Toni S Hess/HO/DuPont@DuPont, Paul K Mathur/CL/DuPont@DuPont, Patrick E Lindner/AE/DuPont@DuPont, Michael E McCord/AE/DuPont@DuPont Subject: TEST M ATRIX FOR C-8 FROM DIFFERENT SOURCES Ton, Dave and Kitagawa-san, Attached is a chart summarizing the tests performed (or successfully used) for C-8 from various sources.

AR226-2626 RECYCLED CVL PROJECT SRCNAME SAMPLING 7/04 CVL 001-EFF SAMPLING 7/04 CVL 602-EFF SAMPLING 7/04 CVL DB-2 SAMPLING 7/04 CVL DB-3 SAMPLING 7/04 CVL PW-4 SAMPLING 7/04 CVL PW-5 SAMPLING 7/04 CVL PW-6 SAMPLING 7/04 CVL PW-6 SAMPLING 8/04 - CVL EHWC-AT SAMPLING 8/04 - CVL EHWC-AT SAMPLING 8/04 - CVL EHWC-BT SAMPLING 8/04 - CVL EHWC-W3 SAMPLING 8/04 - CVL EHWC-W4 SAMPLING 8/04 - CVL EHWC-W5 SAMPLING 8/04 - CVL EHWC-W6 SAMPLING 8/04 - CVL FBLK-1 THEME Surface Water Surface Water Groundwater Groundwater Groundwater Groundwater Groundwater Groundwater Drinking Water Drinking Water Drinking Water Drinking Water Drinking Water Drinking Water Drinking Water Blank Water DATESMPL SMPLT 7/8/2004 FS 7/8/2004 FS 7/8/2004 FS 7/8/2004 FS 7/8/2004 FS 7/8/2004 FS 7/8/2004 DUP 7/8/2004 FS 8/30/2004 DUP 8/30/2004 FS 8/30/2004 FS 8/30/2004 FS 8/30/2004 FS 8/30/2004 FS 8/30/2004 FS 8/30/2004 FB SAMPLE_NUMBER CVL-W-001-EFF CVL-W-602-EFF CVL-G-DB-2 CVL-G-DB-3 CVL-G-PW-4 CVL-G-PW-5 CVL-G-PW-6-DUP CVL-G-PW-6 CVL-D-EHWC-AT-DUP CVL-D-EHWC-AT CVL-D-EHWC-BT CVL-D-EHWC-W3 CVL-D-EHWC-W4 CVL-D-EHW C-W 5 CVL-D-EHWC-W6 CVL-K-FBLK-1 TOP BOTTOM 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C 8 results Envista 111104.xls Page 1 FILTERED 0T OT 0T OT 0T OT 0T 0T 0T 0T 0T 0T 0T 0T 0T 0T CASNO 3825261 3825261 3825261 3825261 3825261 3825261 3825261 3825261 3825261 3825261 3825261 3825261 3825261 3825261 3825261 3825261 ANALYTE FC-143 FC-143 FC-143 FC-143 FC-143 FC-143 FC-143 FC-143 FC-143 FC-143 FC-143 FC-143 FC-143 FC-143 FC-143 FC-143 RsltPost 6240 14800 <10 489 <10 <10 <10 <10 <10 <10 <10 <10 <10 <10 <10 <10 RsItVal UNITS 6240 NG/L 14800 NG/L 5 NG/L 489 NG/L 5 NG/L 5 NG/L 5 NG/L 5 NG/L 5 NG/L 5 NG/L 5 NG/L 5 NG/L 5 NG/L 5 NG/L 5 NG/L 5 NG/L Hit LAB_ANALYTE 1 FC-143 1 FC-143 0 FC-143 1 FC-143 0 FC-143 0 FC-143 0 FC-143 0 FC-143 0 FC-143 0 FC-143 0 FC-143 0 FC-143 0 FC-143 0 FC-143 0 FC-143 0 FC-143 QUALJEPA AR226-2626 QUALJNHOUSE REVIEW METHODNO 01M-008-046 01M-008-046 01M-008-046 01 M-008-046 01 M-008-046 01M-008-046 01 M-008-046 01 M-008-046 01 M-008-046 01 M-008-046 01M-008-046 01 M-008-046 01 M-008-046 01 M-008-046 01 M-008-046 01M-008-046 PREPMTHD NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS PREPREP NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS C8 results Envista 111104.xls CVL LAB_NUMBER L0002858-8 L0002858-7 L0002858-1 L0002858-2 L0002858-3 L0002858-4 L0002858-6 L0002858-5 L0003262-3 L0003262-1 L0003262-2 L0003262-4 L0003262-5 L0003262-6 L0003262-7 L0003262-8 RSLTMOD < < < < < < < < < < < < < RESULT 6240 14800 10 489 10 10 10 10 10 10 10 10 10 10 10 10 UNIT NG/L NG/L NG/L NG/L NG/L NG/L NG/L NG/L NG/L NG/L NG/L NG/L NG/L NG/L NG/L NG/L MDL 100 1000 10 10 10 10 10 10 10 10 10 10 10 10 10 10 PQL 500 5000 50 50 50 50 50 50 50 50 50 50 50 50 50 50 DUPNO Page 2

grtorf - iw if AMM- 3t* H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_________________________________________________________ DuPont-6554 TRADE SECRET Study Title H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Volume 4 of 4 Laboratory Project ID: DuPont-6554 Test Guidelines: U.S.