TNO-report of study 3M-02 PFAS in ApoE3Leiden mic Final report CONFIDENTIAL TNO-report T h e e f f e c t o f 3 P e r f l u o r in a t e d A lk y l SULPHONATED ON CHOLESTEROL/BlLE ACID METABOLISM IN 1 5 % -F A T FED E 3 -L E ID E N T r a n s g e n ic m ic e In Viv o a n d o n f a t t y a c id CONVERSION INTO CHOLESTEROL IN RAT h e p a t o c y t e s In Vit r o .

/ ft m -o M 0 5 BIODEGRADATION TEST SUBSTANCE Identity: Perfluorooctanesulfonylamido(ethyl)acetate; may also be referred to as PFOSAA, FC-128 or as the major component of FC-127, FC-129, FC-109, FC-109-X or R1904.

/ ft m -o M 0 5 BIODEGRADATION TEST SUBSTANCE Identity: Perfluorooctanesulfonylamido(ethyl)acetate; may also be referred to as PFOSAA, FC-128 or as the major component of FC-127, FC-129, FC-109, FC-109-X or R1904.

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AR226-2921 FOR DU PONT USE ONLY E.

Afc-o1 ACTIVATED SLUDGE RESPIRATION INHIBITION TEST SUBSTANCE Identity: Perfluorooctanesulfonylamido(ethyl)acetate; may also be referred to as PFOSAA, FC-128 or as the major component of FC-127, FC-129, FC-109, FC-109-X or R1904.

A M & 'W lf BIODEGRADATION TEST SUBSTANCE Identity: Perfluorooctanesulfonylamido(ethyl)acetate; may also be referred to as PFOSAA, FC-128 or as the major component of FC-127, FC-129, FC-109, FC-109-Xor R1904.

A R 226-1736 Laboratory R ep ort-R evision 1 Analytical Report of Data for PFOS Dietary LC50 Study with Mallards (Sera and Liver) Laboratory Report No.

[ RECEIVED 06/04 18:02 1903 AT 7034138111 JUN.04' 2003 10:58 PAGE 3 (PRINTED PAGE 3) ] #1498 P .003/003 !

ARnt- ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity: e2rFPet9Cehf9er-yf11rllr-u2-eN5o7d1-r,[o-(tF7oho)Cecatp-as1tna2Ped9Fse,OucFlaSfCofAl-nu1Ayo0,lra9oFm,oCFcid-tC1yo-l2()1es80tuh9olyf-roXl)anasyoclrte]h-Rt,ea1ptem9o;0taa4mjso.asriy(ucGomalmlyscsopianolbetn,e,eCNnAt-Sof# Remarks: The test sample is FC-129 referred to by the test laboratory as R1904.

A M & 'W lf BIODEGRADATION TEST SUBSTANCE Identity: Perfluorooctanesulfonylamido(ethyl)acetate; may also be referred to as PFOSAA, FC-128 or as the major component of FC-127, FC-129, FC-109, FC-109-Xor R1904.

/1IUX-0M7 ACUTE TOXICITY TO AQUATIC PLANTS (ALGAE) TEST SUBSTANCE Identity: Perfluorooctanesulfonylamido(ethyl)acetate; may also be referred to as PFOSAA, FC-128 or as the major component of FC-127, FC-129, FC-109, FC-109-X or R1904.

P M X S rO H 0 <\ MICROBIOS MICROTOX TOXICITY TEST TEST SUBSTANCE Identity: Perfluorooctanesulfonylamido(ethyl)acetate; may also be referred to as PFOSAA, FC-128 or as the major component of FC-127, FC-129, FC-109, FC-109-X or R1904.

BACK TO MAIN Laboratory R eport-Revision 1 Analytical Report of Data for PFOS Dietary LC50 Study with Mallards (Sera and Liver) Laboratory Report No.